Review
Medicine, Research & Experimental
Yang Liu, Suliman Khan, Lin Li, Timo L. M. ten Hagen, Mojtaba Falahati
Summary: Thyroid cancer is the most common malignancy of the endocrine system, with recent research suggesting a significant role of non-coding RNAs in its progression, particularly in the competitive endogenous RNA networks. Understanding these mechanisms could lead to early diagnosis of thyroid cancer patients and the discovery of effective therapeutic targets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Oncology
Qian Bai, Zhenjie Pan, Ghulam Nabi, Farooq Rashid, Yang Liu, Suliman Khan
Summary: Thyroid cancer is the most common endocrine malignancy, and non-coding RNAs play important roles in its development. Competing endogenous RNA is a mechanism of regulatory interactions, and multiple ceRNA networks are deregulated in thyroid cancer development, metastasis, and drug resistance. Further research on these deregulations is needed for early detection and effective treatment of thyroid cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zijun Xiao, Shanshan Wei, Jie Huang, Jiaqin Liu, Jian Liu, Bikui Zhang, Wenqun Li
Summary: This study systematically investigated alterations in the expression levels of ncRNAs in a DIC mouse model through deep RNA sequencing, identifying aberrantly expressed lncRNAs, circRNAs, miRNAs, and mRNAs. Comprehensive ceRNA networks were constructed and functional enrichment analyses were performed for differentially expressed genes.
DNA AND CELL BIOLOGY
(2022)
Review
Oncology
Median Zhao, Jianguo Feng, Liling Tang
Summary: CeRNAs can regulate biological processes through complex networks, potentially leading to cancer when imbalanced; Dysregulated RNAs in lung cancer may serve as ceRNAs to regulate various biological functions; CeRNAs are also being explored as potential prognostic and diagnostic biomarkers in lung cancer.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Genetics & Heredity
Liang Cen, Ruochen Liu, Wei Liu, Qianqian Li, Hongjuan Cui
Summary: The ceRNA mechanism plays a crucial role in gliomas, with dysregulated networks leading to abnormal expression of cancer driver genes and the establishment of glioma hallmarks. These findings open up new avenues for understanding gliomas and provide potential new targets for treatment.
FRONTIERS IN GENETICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Article
Dermatology
Lian Wang, Yu-Jia Wang, Dan Hao, Xiao-Yun Wang, Xiao-Xue Li, Qian Zhao, Yan-Mei Li, Gu He, Xian Jiang
Summary: The study conducted the first genome-wide lncRNA profiling of paired lesioned and non-lesioned skin samples from rosacea-afflicted patients, revealing that the NEAT1/miR-196a-5p/S100A9 axis may play a crucial role in inflammatory responses.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Psychiatry
Rongjie Li, Qiaoye Wang, Yufen Qiu, Youshi Meng, Lei Wei, Hao Wang, Ruikang Mo, Donghua Zou, Chunbin Liu
Summary: This study investigated the relationship among ceRNA, autophagy, and Schizophrenia by analyzing gene expression profiles of SZ patients. Enrichment analysis revealed associations with cellular responses to oxygen concentration and pathways such as ErbB, AMPK, and mTOR signaling. The study also constructed an autophagy-related ceRNA network and found high diagnostic efficiency of miRNA in SZ, particularly hsa-miR-423-5p and hsa-miR-4532.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Natalia Gil-Jaramillo, Andres Felipe Aristizabal-Pachon, Maria Alejandra Luque Aleman, Valentina Gonzalez Gomez, Hans Deyvy Escobar Hurtado, Laura Camila Giron Pinto, Juan Sebastian Jaime Camacho, Alexis Felipe Rojas-Cruz, Yeimy Gonzalez-Giraldo, Andres Pinzon, Janneth Gonzalez
Summary: Neurodegenerative diseases (NDs) are characterized by progressive deterioration of neuronal function, leading to motor and cognitive damage in patients. This study presents a comprehensive competing endogenous RNA (ceRNA) network to explore the key regulatory mechanisms related to NDs, using transcriptomic data and experimentally validated non-coding RNA (ncRNA) interactions. The findings provide insights into the pathogenesis of NDs and potential targets for diagnostic molecules and pharmacologic treatments.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao
Summary: This study identified key lncRNAs associated with sepsis through constructing a ceRNA network. Several significant KEGG pathways and hub proteins related to sepsis were discovered. Functional experiments demonstrated that silencing of LINC00963 affected cell proliferation, cytokine expression, and inflammasome activation in sepsis.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Genetics & Heredity
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao
Summary: This study established a ceRNA network associated with sepsis, identified key lncRNAs, and uncovered some biological pathways related to sepsis pathogenesis. Experimental validation showed that silencing of LINC00963 could impact cell functions, indicating its crucial role in sepsis.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jianmin Zhang, Fang Wang, Haihui Zhang, Mingbo Cao
Summary: The study revealed that circ_HN1 is overexpressed in human gastric cancer and its depletion inhibits cancer cell proliferation, invasion, and migration while promoting apoptosis, as well as regulating NT5E expression. miR-628-5p affects circ_HN1's regulation of NT5E through competitive interactions. This research identifies a novel ceRNA network and suggests circ_HN1 inhibition as a promising targeted treatment for gastric cancer.
Article
Clinical Neurology
Li Liu, Huixue Zhang, Xiaoyu Lu, Lifang Li, Tianfeng Wang, Shuang Li, Xu Wang, Si Xu, Lei Li, Qian Li, Tingting Yi, Tao Wu, Zhimin Chen, Hongyu Gao, Jianjian Wang, Lihua Wang
Summary: This study revealed that LINC00680 is associated with the severity of MG by sponging miR-320a to upregulate MAPK1.
FRONTIERS IN NEUROLOGY
(2022)
Article
Genetics & Heredity
Xiaoping Tan, Yang Liu, Taiming Zhang, Shuyan Cong
Summary: Our study systematically analyzed gene expression profiles of neural progenitor cells (NPCs) from HD patients and controls, identifying DE mRNAs and DE lncRNAs and creating a ceRNA network. Functional analysis revealed that DE lncRNAs are mainly associated with transcriptional regulation, and KEGG enrichment analysis showed their involvement in various signaling pathways. The PPI network indicated that transcription factors in the ceRNA network interacted with each other, suggesting lncRNAs may play a role in transcriptional regulation in HD.
BMC MEDICAL GENOMICS
(2021)
Article
Cell Biology
Sara Uhan, Nina Hauptman
Summary: Epithelial-mesenchymal transition (EMT) is a fundamental physiological process in embryonic and organ development. In cancer, EMT is hijacked by cancer cells to promote uncontrolled metastatic dissemination. The competing endogenous RNA (ceRNA) hypothesis suggests that gene expression alterations, both coding and non-coding, contribute to EMT progression in cancer through a large-scale regulatory network. This regulatory diversity is exerted through various epigenetic factors beyond transcriptional control. This review aims to uncover the competitive relationships between ceRNA transcripts that share miRNA-200 family, which play a crucial role in EMT associated with cancer dissemination. Understanding the non-genetic factors influencing neoplasia and modulating the expression levels of various ceRNAs could lead to the development of novel prognostic/diagnostic markers and potential targets for disrupting cancer-related EMT.