Article
Pathology
Pejman Molaei, Marzieh Savari, Ali Mahdavinezhad, Rezvan Najafi, Saeid Afshar, Negin Esfandiari, Ramin Khorrami, Mehrdad Hashemi
Summary: Colorectal cancer (CRC) is a global problem that poses a threat to thousands of lives annually. Circular RNAs, a class of noncoding RNAs, have various functions in cancer cells and play a critical role in cellular processes like differentiation, proliferation, invasion, and apoptosis. This study investigates the involvement of circRNAs in the induction or inhibition of apoptosis in CRC, aiming to achieve better outcomes in cancer treatment by targeting these biomolecules and modifying their expression. However, challenges and limitations may arise when using this approach.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Lucas W. Thornblade, Ernest Han, Yuman Fong
Summary: Patients with colorectal cancer ovarian metastasis have favorable long-term survival. Survival rates are higher if the tumor is isolated to the ovary or if metachronous to the primary cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Gastroenterology & Hepatology
Xiaoling Ding, Jie Zhang, Ziqin Feng, Qianru Tang, Xiaorong Zhou
Summary: In colorectal cancer, the downregulation of miR-137-3p and upregulation of KDM1A are associated with disease progression. Inhibiting miR-137-3p leads to increased KDM1A expression and promotes CRC cell invasiveness. Targeting KDM1A inhibits CRC cell migration and invasion by regulating the EMT process.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Multidisciplinary Sciences
Janhavi R. Raut, Ben Schoettker, Bernd Holleczek, Feng Guo, Megha Bhardwaj, Kaya Miah, Petra Schrotz-King, Hermann Brenner
Summary: This study proposes a blood-based microRNA signature for identifying high-risk populations for colorectal cancer screening. Circulating microRNAs (miRNAs) are found to improve colorectal cancer risk prediction, with a 7-miRNA score showing higher predictive ability compared to environmental and polygenic risk scores.
NATURE COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Rohit R. Badia, Dreaux Abe, Daniel Wong, Nirmish Singla, Anna Savelyeva, Nathan Chertack, Solomon L. Woldu, Yair Lotan, Ryan Mauck, Dan Ouyang, Xiaosong Meng, Cheryl M. Lewis, Kuntal Majmudar, Liwei Jia, Payal Kapur, Lin Xu, Lindsay Frazier, Vitaly Margulis, Douglas W. Strand, Nicholas Coleman, Matthew J. Murray, James F. Amatruda, John T. Lafin, Aditya Bagrodia
Summary: miR-371a-3p shows superior sensitivity for detecting viable germ cell tumor compared to conventional serum tumor markers, with high specificity and sensitivity, potentially serving as a valuable adjunct to clinical decision making.
JOURNAL OF UROLOGY
(2021)
Article
Genetics & Heredity
Thelma Alessandra Sugranes, Maeve Flanagan, Charlene Thomas, Vivian Y. Chang, Michael Walsh, Christopher Cunniff
Summary: This study describes the spectrum of cancers observed in Bloom syndrome, as well as the survival and age of first cancer diagnosis. The findings highlight significant differences in survival and age of diagnosis among different tumor types and genotypes.
GENETICS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Direnis Erdinc, Alejandro Rodriguez-Luis, Mahmoud R. Fassad, Sarah Mackenzie, Christopher M. Watson, Sebastian Valenzuela, Xie Xie, Katja E. Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Joanna Poulton, Hector Garcia-Moreno, Paola Giunti, Carlos A. de Moura Aschoff, Jonas A. Morales Saute, Amelia J. Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Grainne S. Gorman, Andrew M. Schaefer, Claes M. Gustafsson, Robert W. Taylor, Maria Falkenberg, Thomas J. Nicholls
Summary: TOP3A is an enzyme responsible for removing torsional strain and interlinks between DNA molecules. Pathogenic variants in TOP3A can cause a disorder similar to Bloom syndrome, while bi-allelic variants result in an adult-onset mitochondrial disease with specific clinical characteristics. The severity of the TOP3A catalytic defect determines the clinical outcome, with milder variants causing the adult-onset mitochondrial disease and more severe variants leading to a Bloom-like syndrome with mitochondrial dysfunction in childhood.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jia Liu, Binglin Chen, Man Yang, Yun Qian, Qian Shen, Hai Chen, Yunqiu Dong, Lu Wang, Jiandong Jiao
Summary: This study conducted a nested case-control study in a community-based population in China and identified three plasma miRNAs (miRNA-29a, miRNA-125b, miRNA-145) significantly associated with colorectal cancer risk, which may serve as potential biomarkers for early detection and individual risk prediction of colorectal cancer.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ann-Marie K. Shorrocks, Samuel E. Jones, Kaima Tsukada, Carl A. Morrow, Zoulikha Belblidia, Johanna Shen, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Andrew N. Blackford
Summary: The study reveals that the BTR complex contains multiple conserved motifs that interact cooperatively with the single-stranded DNA-binding protein RPA, facilitating BLM recruitment to stalled replication forks for promoting their restart after replication stress.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shuhei Fukunaga, Dan Nakano, Takumi Kawaguchi, Mohammed Eslam, Akihiro Ouchi, Tsutomu Nagata, Hidefumi Kuroki, Hidemichi Kawata, Hirohiko Abe, Ryuichi Nouno, Koutaro Kawaguchi, Jacob George, Keiichi Mitsuyama, Takuji Torimura
Summary: This study found that MAFLD, especially non-obese MAFLD, is the most important factor associated with the prevalence of colorectal adenoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yehuda M. Danino, Lena Molitor, Tamar Rosenbaum-Cohen, Sebastian Kaiser, Yahel Cohen, Ziv Porat, Hagai Marmor-Kollet, Corine Katina, Alon Savidor, Ron Rotkopf, Eyal Ben-Isaac, Ofra Golani, Yishai Levin, David Monchaud, Ian D. Hickson, Eran Hornstein
Summary: This study reveals a novel role of Bloom's syndrome protein in the regulation of cytoplasmic processes. It demonstrates that BLM can unwind RNA G-quadruplexes and acts as a negative regulator of stress granule formation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Pathology
Bruce G. Rottmann, Natalie Patel, Muhammad Ahmed, Yanhong Deng, Maria Ciarleglio, Monika Vyas, Dhanpat Jain, Xuchen Zhang
Summary: This study investigates the prognostic significance of tumor-infiltrating neutrophil (TIN) in colorectal carcinomas (CRCs). The results show that high TIN is associated with higher histological grade, right-sided tumor location, advanced TNM stage, and higher rate of MMR-deficient CRCs. Patients with neutrophil-rich (NR) CRCs have significantly poorer 5-year recurrence-free survival compared to neutrophil-intermediate (NI) or neutrophil-poor (NP) CRCs. High TIN remains an independent risk factor for poor prognosis. NR CRCs are more commonly seen in MMR-deficient CRCs, and MMR-deficient NR CRCs have similar 5-year recurrence-free survival compared to MMR-proficient NR CRCs.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Hematology
Rayna J. S. Anijs, El Houari Laghmani, Betul Unlu, Szymon M. Kielbasa, Hailiang Mei, Suzanne C. Cannegieter, Frederikus A. Klok, Peter J. K. Kuppen, Henri H. Versteeg, Jeroen T. Buijs
Summary: This study aimed to identify novel tumor-expressed miRNAs associated with VTE in colorectal cancer. Through sequencing analysis, 19 differentially regulated tumor-expressed miRNAs were identified, which may provide insights into the biological mechanism and serve as potential predictive biomarkers.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Mingqun Deng, Miao Yu, Ruizhi Jiajue, Kai Feng, Xinhua Xiao
Summary: Bloom syndrome (BS) is a rare autosomal recessive disorder, with only one reported case without diabetes in the Chinese population. This study presented the first case of BS with diabetes in China, identifying a new pathogenic variant in the BLM gene and highlighting BS as a rare cause of diabetes in the Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Martha Patricia Gallegos-Arreola, Asbiel Felipe Garibaldi-Rios, Jose Israel Cruz-Sanchez, Luis Eduardo Figuera, Carlos Alberto Ronquillo-Carreon, Monica Alejandra Rosales-Reynoso, Belinda Claudia Gomez-Meda, Irving Alejandro Carrillo-Davila, Ana Maria Puebla-Perez, Hector Montoya-Fuentes, Valeria Peralta-Leal, Guillermo M. Zuniga-Gonzalez
Summary: Colorectal cancer is a significant health challenge globally and ranks among the top 10 cancers in Mexico. This study examined the association between two variants (rs8720 and rs12587) of the KRAS gene and colorectal cancer risk in the Mexican population. The findings suggest that these variants are associated with an increased risk of colorectal cancer and may influence KRAS regulation through miRNAs.