Article
Biotechnology & Applied Microbiology
Xiaoyue Liu, Tianhao Zhou, Yongmei Wang, Min Pei, Guifeng Wang, Wendi Chu, Qi Wang, Shaoqian Du, Hongxia Wang, Chunhe Wang
Summary: This study investigated the expression levels of TROP2 in Chinese breast cancer patients and explored its value as a biomarker for patient-tailoring and prognosis. The results showed that TROP2 overexpression was significantly associated with the incidence of TNBC. Additionally, the levels of TROP2 expression were correlated with the therapeutic responses to TROP2-directed ADC drugs.
ONCOTARGETS AND THERAPY
(2022)
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kerstin Huebner, Katharina Erlenbach-Wuensch, Jan Prochazka, Ilir Sheraj, Chuanpit Hampel, Blanka Mrazkova, Tereza Michalcikova, Jolana Tureckova, Veronika Iatsiuk, Anne Weissmann, Fulvia Ferrazzi, Philipp Kunze, Enise Nalli, Elisabeth Sammer, Annemarie Gehring, Marie M. Cheema, Markus Eckstein, Eva-Maria Paap, Agnes Soederberg, Corinna Fischer, Sushmita Paul, Vijayalakshmi Mahadevan, Benardina Ndreshkjana, Melanie A. Meier, Susanne Muehlich, Carol Geppert, Susanne Merkel, Robert Grutzmann, Adriana Roehe, Sreeparna Banerjee, Arndt Hartmann, Radislav Sedlacek, Regine Schneider-Stock
Summary: In colorectal cancer, low levels of ATF2 are associated with worse prognosis and tumor aggressiveness. TROP2 is identified as a novel inhibitory target gene of ATF2. In vitro studies demonstrated that high levels of TROP2 are critical for cell de-adhesion and increased cell migration. In vivo experiments confirmed that ATF2(KO)/TROP2(high) status promotes tumor invasiveness. Evaluation of ATF2(low)/TROP2(high) expression status may help identify high-risk CRC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Huichen Zhao, Huihui Hu, Beibei Chen, Weifeng Xu, Jing Zhao, Chen Huang, Yishu Xing, Huifang Lv, Caiyun Nie, Jianzheng Wang, Yunduan He, Sai-Qi Wang, Xiao-Bing Chen
Summary: Gastric cancer ranks fifth in global cancer incidence and third in cancer mortality. E-cadherin is crucial in tumorigenesis, tumor progression, metastasis, with soluble E-cadherin playing a role in promoting invasion and metastasis in gastric cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Han Wang, Xin Chen, Yanshan Jin, Tingxian Liu, Yizuo Song, Xuejie Zhu, Xueqiong Zhu
Summary: This study aims to clarify the role and underlying molecular pathways of DYNLT3 in breast cancer tumorigenesis. Differential expression of DYNLT3 was detected in breast cancer tissues and cells, showing that DYNLT3 may act as a tumor-promoter in age-associated breast cancer. Knockdown of DYNLT3 suppressed cell growth, migration, and invasion, and induced cell apoptosis, highlighting its potential as a therapeutic target for breast cancer.
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Kamil Cebulski, Aleksandra Piotrowska, Alicja Kmiecik, Katarzyna Haczkiewicz-Lesniak, Urszula Ciesielska, Jedrzej Grzegrzolka, Karolina Jablonska, Hanna Romanowicz, Beata Smolarz, Piotr Dziegiel, Marzenna Podhorska-Okolow, Katarzyna Nowinska
Summary: It has been discovered that FNDC5/Ir can be found in breast cancer cells and may inhibit the process of epithelial-mesenchymal transition (EMT), which has significant implications for breast cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dapeng Sun, Chenguang Li, Fengxiang Zhang
Summary: This study aimed to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. The results showed that miR-206 mimics suppressed CALR expression, inhibited the proliferation and metastasis ability of breast cancer stem cells, and induced cellular apoptosis. Over-expression of CALR could effectively attenuate the cytotoxic effect of miR-206. Further studies demonstrated that EVI-1 could be served as a key regulator of miR206-mediated CALR expression.
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Giada Bianchetti, Carmine Bruno, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Pierfrancesco Bassi, Alfredo Pontecorvi, Domenico Milardi, Francesca Mancini
Summary: This study investigated the role of PTTG1 in the EMT process in seminoma. The results showed that PTTG1 transcriptionally represses E-Cadherin through its cooperation with the transcriptional repressor ZEB1. It also demonstrated that PTTG1 and ZEB1 strongly localize together in the periphery of the tumors. These findings suggest that PTTG1 is a prognostic factor in seminoma clinical management.
Article
Oncology
Huiting Xu, Runzhi Chen, Qian Shen, Dongmei Yang, Hui Peng, Jin Tong, Qiang Fu
Summary: The study demonstrated that the down-regulation of circ_0013587 contributes to acquired resistance to erlotinib in pancreatic cancer cells by mediating the miR-1227/E-cadherin pathway, suggesting circ_0013587 as a potential target to overcome erlotinib resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Meng Luo, Jinfan Li, Qi Yang, Song Xu, Kun Zhang, Jing Chen, Suzhan Zhang, Shu Zheng, Jiaojiao Zhou
Summary: This study identifies N4BP3 as a new regulator that promotes breast cancer metastasis by regulating the ubiquitination and degradation of E-cadherin. It uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
Article
Biochemistry & Molecular Biology
Hye-Jeong Kong, Dong-Hyun Kang, Tae-Sung Ahn, Kwang-Seock Kim, Tae-Wan Kim, Soo-Hyeon Lee, Dong-Woo Lee, Jae-Sung Ryu, Moo-Jun Beak
Summary: This study reveals the oncogenic effect of CPNE7 in CRC, showing that CPNE7 is significantly up-regulated in CRC patient tissues and cell lines. Inhibition of CPNE7 expression reduces CRC cell growth and invasion, and leads to changes in genes associated with epithelial-mesenchymal transition (EMT). CPNE7 may serve as a potential diagnostic biomarker for CRC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Su-Chi Ku, Hsin-Liang Liu, Che-Yu Su, I-Jeng Yeh, Meng-Chi Yen, Gangga Anuraga, Hoang Dang Khoa Ta, Chung-Chieh Chiao, Do Thi Minh Xuan, Fidelia Berenice Prayugo, Wei-Jan Wang, Chih-Yang Wang
Summary: The study found that mRNA levels of CDH1/2/4/11/12/13 genes were overexpressed in breast cancer cells compared to normal cells and correlated with poor prognosis in breast cancer patients. The high expressions of these genes were significantly associated with cell adhesion, extracellular matrix remodeling, EMT, WNT/beta-catenin, and interleukin-mediated immune responses, suggesting they could be potential biomarkers for breast cancer progression and metastasis.
Review
Oncology
Pengbo Wang, Zengkuan Zhu
Summary: Expression of E-cadherin is closely associated with the risk, clinical features, and prognosis of pancreatic cancer, suggesting it may serve as an effective biomarker for clinical assessments and predicting prognosis in patients with pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Communication
Tingting Liu, Chris K. K. Tan, Xiaobing Yang, Miao Li
Summary: The live-streaming industry in China is huge and highly competitive, leading to the formation of "live-streaming guilds" where streamers join forces to improve their rankings on various platforms. This article explores one such guild that operates on the Zhubei platform, revealing how these guilds optimize streamers' performances based on algorithmic parameters disclosed by the platforms. Interestingly, the guilds also manipulate audience reactions by having male workers pose as female streamers to attract generous tipping from straight male viewers.
INFORMATION COMMUNICATION & SOCIETY
(2023)
Article
Environmental Sciences
Jikang Wan, Bin Yong, Xiaofeng Zhou
Summary: With the rapid development of China's economy and improvement of people's living standards, large-scale infrastructure constructions have increased. This study focused on the environmental thermal changes of Beijing Daxing International Airport before and after its construction and operation. The results showed that the urban surface heat island effect in the area significantly increased after the construction and operation of the airport. The random forest classification algorithm was used to analyze the relationship between land types and the urban heat island effect, revealing that the thermal pollution from the airport had a greater impact on ground objects within a range of 7.5 km.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Genetics & Heredity
Yuan Zhao, Deyin Zhang, Xiaoxue Zhang, Fadi Li, Dan Xu, Liming Zhao, Xiaolong Li, Yukun Zhang, Jianghui Wang, Xiaobing Yang, Weiming Wang
Summary: This study investigated the expression features of the FTO gene and its polymorphisms associated with tail fat weight traits in Hu sheep. The results showed that FTO gene was highly expressed in tail fat tissue and a specific polymorphism was significantly related to tail length and tail fat weight.
Article
Environmental Sciences
Jikang Wan, Yang Liu, Bin Yong, Xiaofeng Zhou
Summary: New construction alters the surface radiation, thermal properties, and humidity in urban areas. Our study shows that the construction and operation of airports have a significant impact on the thermal environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Wang-jun Yang, Rong-chang Cao, Wang Xiao, Xiao-lou Zhang, Hao Xu, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Jun-ling Zeng, Shu-ji Li, Min Luo, Yan-jiang Han, Xiao-bing Yang, Guo-dong Feng, Yu-heng Lu, Yuan-yuan Ni, Chan-gui Wu, Jun-jie Bai, Zi-qi Yuan, Jin Jin, Guo-wei Zhang
Summary: This study investigated the role of efferocytosis in chronic pancreatitis (CP) and its underlying mechanisms. The findings suggest that impaired efferocytosis and dysregulated phospholipid metabolism contribute to the development of CP. The acinar Atp8b1/LPC pathway, regulated by the transcription factor Bhlha15, plays a protective role in CP. These findings provide potential therapeutic targets for improving current CP therapies.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Anqi Li, Zhanfeng Zhang, Xiaochen Ru, Yanfeng Yi, Xiaoyu Li, Jing Qian, Jue Wang, Xiaobing Yang, Yunliang Yao
Summary: Through gene expression analysis, a total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The analysis showed significant differences in the infiltration of 25 cells, and 603 immune-related genes were obtained through WGCNA, with 270 DEIRGs identified. Enrichment analysis indicated that DEIRGs were associated with immunity-related biological processes, and 4 candidate biomarkers were identified through the PPI network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Civil
Pengfei Shi, Tao Yang, Bin Yong, Chong-Yu Xu, Zhenya Li, Xiaoyan Wang, Youwei Qin, Xudong Zhou
Summary: The Markov Chain Monte Carlo (MCMC) method is increasingly popular in uncertainty analysis of hydrological simulation. However, the estimation of the constant standard deviation (02) in the approach is subjective, hindering performance improvement. This study investigates the statistical meaning of parameter 02 and develops a new label called Confidence Level of Model (CLM) to interpret it. The MCMC method based on CLM performs well in generating regular posterior distributions and narrow, symmetrical confidence intervals.
JOURNAL OF HYDROLOGY
(2023)
Article
Oncology
Yiguan Qian, Yang Li, Luwei Xu, Ke Chen, Ning Liu, Xiaobing Yang, Qian Lv, Rongfei Li, Changcheng Zhou, Zheng Xu, Ruipeng Jia, Yu-Zheng Ge
Summary: In this study, a novel circRNA called circ-PRKCI was found to promote the proliferation of renal cell carcinoma (RCC) through the miR-545-3p/CCND1 signaling pathway. It was also discovered that tumor cell-derived exosomal circ-PRKCI could enhance the proliferation, migration, and invasion of RCC cells while inhibiting apoptosis. This study provides new insights into the molecular mechanisms of RCC progression.
Article
Oncology
Xiaobing Yang, Jiahui Zhao, Dechao Wei, Tao Feng, Pengju Guo, Qiankun Li, Yongxing Wang, Yili Han, Mingchuan Li, Yongguang Jiang, Yong Luo
Summary: The study aimed to investigate the anti-tumor effects and underlying mechanisms of Enzalutamide (ENZ) and Arsenic trioxide (ATO) co-treatment on castration-resistant prostate cancer (CRPC). The combination of ENZ and ATO significantly inhibited cell proliferation, angiogenesis, and induced cell arrest and apoptosis in C4-2B cells. The effects were further verified in subcutaneous tumor models and tissue sections from the xenografts. ENZ combination with ATO synergistically improved the therapeutic effects and suppressed CRPC progression through regulation of the ATR-CHEK1-CDC25C pathway.
JOURNAL OF CHEMOTHERAPY
(2023)
Article
Plant Sciences
Hongfei Chen, Yingjie Yang, Xiaobing Yang, Xiaomin Pang, Caihong Shao, Zhong Li, Changxun Fang, Wenxiong Lin
Summary: Reasonable water and nitrogen management significantly improves root physiology and rhizosphere microbial community structure, promoting the growth and yield of ratoon rice. The study demonstrates that proper management increases endogenous hormone levels and enhances rhizosphere microbial diversity, leading to improved root and axillary bud growth and increased productivity.
PLANT GROWTH REGULATION
(2023)
Article
Environmental Sciences
Zehui Zhou, Dekai Lu, Bin Yong, Zhehui Shen, Hao Wu, Lei Yu
Summary: This study evaluates the performance of IMERG products in different spatial and temporal scales during the summer seasons in mainland China. The results show that IMERG can capture the spatial patterns of precipitation characters, but it tends to overestimate precipitation amount and intensity while underestimating precipitation frequency. The performance of IMERG improves when scaled up to coarser scales, and it shows better performance in larger regions and during longer periods.
Article
Andrology
Jing He, Jiahui Zhao, Yong Luo, Yongxing Wang, Mingchuan Li, Dechao Wei, Xiaobing Yang, Zhu Hou, Yongguang Jiang
Summary: This study established an effective diagnostic model that can predict the risk of perioperative complications for retroperitoneal laparoscopic adrenalectomy by considering factors such as operative time, lesion laterality, intraoperative blood loss, pheochromocytoma, body mass index, and preoperative comorbidities (respiratory diseases, cardiovascular diseases). It is of great significance in improving perioperative strategy due to its accuracy and convenience.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Business, Finance
Tianlei Pi, Xiaobing Yang
Summary: This study investigates the influence of board culture on bank innovation and explores the mechanisms involved. Using the cultural context of the East and state-owned bank attributes, data from China's A-share listed banks between 2003 and 2018 were analyzed. Results indicate that indicators of masculinity, indulgence, and cultural diversity are positively correlated with bank innovation, while power distance and uncertainty avoidance are negatively correlated. Further analysis reveals that the impact of Oriental culture on bank innovation is mediated by human capital investment, efficiency, and risk-taking. The findings remain robust after controlling for endogenous issues and factors such as Confucian culture.
INTERNATIONAL REVIEW OF ECONOMICS & FINANCE
(2023)
Article
Chemistry, Organic
Hong Qin, Zhen Zhang, Kai Qiao, Xinran Chen, Wei He, Chengkou Liu, Xiaobing Yang, Zhao Yang, Zheng Fang, Kai Guo
Summary: This study developed an efficient method for C3-fluoroalcoholation of indole derivatives by merging C-F cleavage and C-C bond coupling. The method constructs derivatizations through modifiable carbon-oxygen bond and obtains a range of structurally valuable organofluorine products with excellent functional group tolerance. Furthermore, it simplifies the process by utilizing easily accessible materials.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Food Science & Technology
Shaodan Chen, Zhenqiang Mu, Tianqiao Yong, Jiangyong Gu, Yifan Zhang, Xiong Gao, Yizhen Xie, Chun Xiao, Huiping Hu, Xiaobing Yang, Xiangmin Li, Manjun Cai, Qingping Wu
Summary: In this study, a novel bis-gamma-butyrolactone compound named grifolamine A (1) was isolated from the byproduct of Grifola frondosa polysaccharides preparation process. The structure of grifolamine A (1) and its inhibitory mechanism against alpha-glucosidase were determined through spectroscopic analysis and computational calculations. The results revealed a strong interaction between grifolamine A and alpha-glucosidase, providing valuable information for the design and development of novel alpha-glucosidase inhibitors based on the gamma-butyrolactone skeleton.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
