Article
Oncology
Lei Chen, Yue-Yang Wang, Deng Li, Cheng Wang, Shi-Yuan Wang, Si-Hui Shao, Zheng-Yang Zhu, Jing Zhao, Yu Zhang, Yuan Ruan, Bang-Min Han, Shu-Jie Xia, Chen-Yi Jiang, Fu-Jun Zhao
Summary: The study identified LMO2 as a target gene of AR in prostate fibroblasts and found that its overexpression due to AR deactivation promotes the growth of PCa cells through IL-11 and FGF-9 release in a non-cell-autonomous manner.
Article
Cell Biology
Boya Zhang, Mingpeng Zhang, Chunyi Shen, Guancong Liu, Fan Zhang, Jingyu Hou, Weitao Yao
Summary: The study revealed the key role of LncRNA PCBP1-AS1 in drug resistance of castration-resistant prostate cancer, by stabilizing the AR/AR-V7 complex to prevent degradation. Targeting PCBP1-AS1 can significantly restore drug sensitivity in resistant tumors.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zhengfang Liu, Cheng Liu, Keqiang Yan, Jikai Liu, Zhiqing Fang, Yidong Fan
Summary: The huaier extract demonstrated potent antiproliferative effects in both hormone sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CRPC) cells by downregulating AR-FL and AR-V7 mRNA levels via targeting the SMYD3 signaling pathway, and enhancing proteasome-mediated protein degradation of AR-FL and AR-V7 by downregulating USP14. Additionally, the extract inhibited AR transcriptional activity and their nuclear translocation, and could re-sensitize enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vitro and in vivo models.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Wout Devlies, Florian Handle, Gaetan Devos, Steven Joniau, Frank Claessens
Summary: This review investigates the existing methods to study treatment resistance to androgen receptor targeted therapies in prostate cancer, including the role of preclinical models and understanding of resistance mechanisms. Understanding resistance will greatly improve insights into tumor pathophysiology and future treatment strategies in prostate cancer.
Article
Oncology
Neele Wuestmann, Konstantin Seitzer, Verena Humberg, Julia Vieler, Norbert Grundmann, Julie Steinestel, Dorothee Tiedje, Stefan Duensing, Laura-Maria Krabbe, Martin Boegemann, Andres Jan Schrader, Christof Bernemann, Katrin Schlack
Summary: This study found that the level of AR-FL and the appearance and increase of AR-Vs are associated with elevated levels of AR pre-mRNA in prostate cancer cells. The levels of AR-FL and AR-Vs also increase during disease progression. In patients undergoing ARTA treatment, AR-FL shows prognostic value but not predictive value. Additionally, even AR-V positive patients show a significant clinical response to ARTA treatment. Therefore, AR-FL and AR-V may be considered as prognostic biomarkers in mCRPC patients, but not predictive biomarkers.
BIOMARKER RESEARCH
(2023)
Article
Oncology
Lin Gao, Wenbo Zhang, Jing Zhang, Junmei Liu, Feifei Sun, Hui Liu, Jing Hu, Xin Wang, Xueli Wang, Peng Su, Shouzhen Chen, Sifeng Qu, Benkang Shi, Xueting Xiong, Weiwen Chen, Xuesen Dong, Bo Han
Summary: The study reveals that KIF15 contributes to enzalutamide resistance by enhancing AR signaling, and suggests that cotargeting KIF15 and AR may be an effective therapeutic strategy for prostate cancer.
Article
Multidisciplinary Sciences
Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme, Dong Lin, Haoyue Sheng, Ladan Fazli, R. Jeffrey Karnes, Rafael Jimenez, Liguo Wang, Liewei Wang, Martin E. Gleave, Yuzhuo Wang, Lei Shi, Haojie Huang
Summary: Resistance to next-generation anti-androgen enzalutamide in castration-resistant prostate cancer (CRPC) is a major challenge. Through genome-wide ChIP-seq profiling, it was found that AR-dependent transcription of noncanonical targets drives an ENZ-resistant mechanism, making resistant cells susceptible to dual inhibition of BET and CBP/p300 signaling.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Tao Shen, Bingning Dong, Yanling Meng, David D. Moore, Feng Yang
Summary: GATA2 degradation driven by COP1 is a direct mechanism for regulating AR expression and activation, PCa growth, and castration resistance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Minyu Wang, Wanying Huang
Summary: This study found that FOXS1 activates the Hedgehog (Hh) signaling pathway by blocking the ubiquitination of Gli1, thereby promoting the growth and metastasis of prostate cancer cells. High levels of FOXS1 were associated with worse tumor stage and shorter survival in prostate cancer patients.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Article
Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biology
Omar Salem, Siyang Jia, Bin-Zhi Qian, Carsten Gram Hansen
Summary: The Hippo signalling pathway plays a crucial role in regulating cell growth, proliferation, and cancer. In prostate cancer, androgens activate YAP/TAZ through the androgen receptor (AR), with AR regulating YAP translation and inducing TAZ transcription. The activation of YAP/TAZ by AR is mediated by the transcriptional mediator SRF. This study highlights the interplay between YAP, TAZ, and SRF in prostate cancer cells and their potential therapeutic implications.
LIFE SCIENCE ALLIANCE
(2023)
Article
Oncology
Anmbreen Jamroze, Gurkamal Chatta, Dean G. Tang
Summary: This article discusses how AR heterogeneity affects the response of prostate cancer to treatment, emphasizing the de novo resistance to ARSIs exhibited by AR-/lo PCa cells/clones. Several potential combinatorial strategies are proposed, such as combining ARSIs with stem cell targeting therapeutics, to co-target both AR+ and AR-/lo PCa cells and metastatic clones.
Article
Multidisciplinary Sciences
Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian D. Robinson, Arul M. Chinnaiyan, Mark A. Rubin, Christopher E. Barbieri, Pengbo Zhou
Summary: This study reveals that G3BP1 acts as a competitive inhibitor of SPOP, promoting tumorigenesis in prostate cancer by activating androgen signaling. Furthermore, AR directly upregulates G3BP1 transcription to amplify G3BP1-SPOP signaling in a feed-forward manner.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Iroda Saydullaeva, Bilge Debelec Butuner, Kemal Sami Korkmaz
Summary: Inflammation plays a synergistic role in the development and metastatic spread of aggressive prostate tumors. However, the exact mechanism by which inflammation promotes prostate cancer remains unclear. This study used the CRISPR/Cas9 system to suppress the expression of the tumor suppressor gene NKX3.1 and observed phenotypic changes in cell migration. Furthermore, quantitative proteomic analysis revealed that different cell subpopulations exhibited distinct phenotypes and genetic compositions during the process of cellular migration.