Journal
ONCOGENE
Volume 37, Issue 25, Pages 3426-3439Publisher
SPRINGERNATURE
DOI: 10.1038/s41388-018-0215-2
Keywords
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Funding
- China Postdoctoral International Exchange Program
- National Natural Science Foundation of China [81402193, 31271461, 81472583, 81528017]
- Postdoctoral Innovation Project of Shandong Province [147751]
- Postdoctoral Science Foundation of China [2015M570597]
- National Key R&D Program of China [2017YFC1308600]
- Taishan Scholar Program of Shandong Province
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Plasmacytoma variant translocation 1 (PVT1) is an lncRNA that plays vital roles in breast cancer (BC) pathogenesis. Increasing evidence suggests that miRNAs that reside in the PVT1 locus are the main driver of the oncogenic roles of PVT1 in cancer. However, the oncogenic role and underlying mechanism of miR-1204, located in the PVT1 locus, in human cancer is still unclear. In this study, we discovered that increased expression of miR-1204 is associated with poor prognosis in BC. Moreover, miR-1204 promotes proliferation, epithelial-mesenchymal transition and invasion of BC cells both in vitro and in vivo. Mechanistic investigations demonstrated that VDR is a novel target gene of miR-1204. Interference of VDR restored miR-1204-mediated BC cell proliferation, tumorigenesis, and metastasis. Collectively, our results demonstrated that the miR-1204-VDR pathway exerts oncogenic effects in BC with potential therapeutic applications in blocking BC development and progression.
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