AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells

Role of neutral ceramidase in colon cancer

(2016) Mónica García-Barros et al.   FASEB JOURNAL

Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine

(2016) Anees Rahman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ramucirumab in metastatic colorectal cancer: evidence to date and place in therapy

(2016) Helena Verdaguer et al.   Therapeutic Advances in Medical Oncology

Global Cancer Incidence and Mortality Rates and Trends--An Update

(2015) L. A. Torre et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metastatic Colorectal Cancer: Current State and Future Directions

(2015) Marwan G. Fakih   JOURNAL OF CLINICAL ONCOLOGY

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase

(2015) Michael V. Airola et al.   STRUCTURE

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation

(2014) Kuntal Halder et al.   PLoS One

Sphingolipids in colon cancer

(2013) Mónica García-Barros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Epigenetic and genetic features of 24 colon cancer cell lines

(2013) D Ahmed et al.   Oncogenesis

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

(2012) K. Alexa Orr Gandy et al.   BIOCHEMICAL JOURNAL

Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer

(2012) Ashok Kumar et al.   CARCINOGENESIS

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease

(2012) Ashley J. Snider et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer

(2011) H. Symolon et al.   MOLECULAR CANCER THERAPEUTICS

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

(2011) Jonathan Clark et al.   NATURE METHODS

The Akt–SREBP nexus: cell signaling meets lipid metabolism

(2010) James R. Krycer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation

(2009) Bill X. Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

(2009) Margaret A. Knowles et al.   CANCER AND METASTASIS REVIEWS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial

(2009) Thierry André et al.   JOURNAL OF CLINICAL ONCOLOGY

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

(2008) C MAO   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

AKT Signaling in Regulating Angiogenesis

(2008) Bing-Hua Jiang et al.   CURRENT CANCER DRUG TARGETS

Combinatorial patterns of somatic gene mutations in cancer

(2008) Chen-Hsiang Yeang et al.   FASEB JOURNAL

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

Outside-in Signaling through Integrins and Cadherins: A Central Mechanism to Control Epidermal Growth and Differentiation?

(2008) Eliane J. Müller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE