Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation

(2016) Gerjon J. Ikink et al.   Nature Communications

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2–Targeted Therapies in Breast Cancer

(2015) Ian J. Majewski et al.   JOURNAL OF CLINICAL ONCOLOGY

The roles of ERAS during cell lineage specification of mouse early embryonic development

(2015) Zhen-Ao Zhao et al.   Open Biology

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors.

(2015) Robert Callahan et al.   Oncotarget

Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis

(2014) Irina Vyazunova et al.   PLoS One

Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients

(2013) M. J. Engstrøm et al.   BREAST CANCER RESEARCH AND TREATMENT

Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors

(2013) Christiaan Klijn et al.   PLoS One

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

(2013) A. B. Hanker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of Somatic Cell Reprogramming by ERas-Akt-FoxO1 Signaling Axis

(2013) Yong Yu et al.   STEM CELLS

The Genomic Landscape of Breast Cancer as a Therapeutic Roadmap

(2013) Matthew J. Ellis et al.   Cancer Discovery

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

(2012) Jose M. Polo et al.   CELL

Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer

(2012) S. Chandarlapaty et al.   CLINICAL CANCER RESEARCH

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors

(2011) M. J. Koudijs et al.   GENOME RESEARCH

Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer

(2010) Eiji Kubota et al.   AMERICAN JOURNAL OF PATHOLOGY

PTEN, PIK3CA, p-AKT, and p-p70S6K Status

(2010) Francisco J. Esteva et al.   AMERICAN JOURNAL OF PATHOLOGY

Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells

(2010) Aoyama   INTERNATIONAL JOURNAL OF ONCOLOGY

Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer

(2010) Kimberly L. Blackwell et al.   JOURNAL OF CLINICAL ONCOLOGY

Selected SALM (Synaptic Adhesion-Like Molecule) Family Proteins Regulate Synapse Formation

(2010) W. Mah et al.   JOURNAL OF NEUROSCIENCE

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Prognosis of Women With Metastatic Breast Cancer byHER2Status and Trastuzumab Treatment: An Institutional-Based Review

(2009) Shaheenah Dawood et al.   JOURNAL OF CLINICAL ONCOLOGY

A Central Role for HER3 in HER2-Amplified Breast Cancer: Implications for Targeted Therapy

(2008) S. T. Lee-Hoeflich et al.   CANCER RESEARCH

Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235

(2008) P. J.A. Eichhorn et al.   CANCER RESEARCH

Common Integration Sites for MMTV in Viral Induced Mouse Mammary Tumors

(2008) Robert Callahan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth

(2008) Philip Y. Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE