Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma

PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability

(2017) Berkley E. Gryder et al.   Cancer Discovery

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

(2017) Inês M Tenente et al.   eLife

Intensive Multiagent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide and Vincristine/Doxorubicin/Cyclophosphamide, Irinotecan, and Radiation, in Patients With High-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group

(2016) Brenda J. Weigel et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of Fibroblast Growth Factor Receptor Inhibitors: Kissing Frogs to Find a Prince?

(2015) Jeremy Lewin et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma

(2015) Masafumi Seki et al.   Nature Communications

Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation

(2015) Timothy McKinnon et al.   Oncotarget

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts

(2014) Julia Pöschl et al.   ACTA NEUROPATHOLOGICA

Lineage of origin in rhabdomyosarcoma informs pharmacological response

(2014) J. Abraham et al.   GENES & DEVELOPMENT

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

(2014) Lesley A. Mathews Griner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of oncogenic I B kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors

(2014) M. Ceribelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

(2014) T. Perova et al.   Science Translational Medicine

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

(2014) J. F. Shern et al.   Cancer Discovery

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

FGFR4 Blockade Exerts Distinct Antitumorigenic Effects in Human Embryonal versus Alveolar Rhabdomyosarcoma

(2012) L. E. S. Crose et al.   CLINICAL CANCER RESEARCH

High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis

(2011) Vera Paulson et al.   GENES CHROMOSOMES & CANCER

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer

(2010) L. Cao et al.   CANCER RESEARCH

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

(2010) Daniel Williamson et al.   JOURNAL OF CLINICAL ONCOLOGY

Cross-species genomics matches driver mutations and cell compartments to model ependymoma

(2010) Robert A. Johnson et al.   NATURE

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

(2010) Steven D. Knight et al.   ACS Medicinal Chemistry Letters

Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005

(2009) Simona Ognjanovic et al.   CANCER

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

PAX3–FOXO1 fusion gene in rhabdomyosarcoma

(2008) Corinne M. Linardic   CANCER LETTERS