The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy

Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin−/− mice

(2014) Aiping Lu et al.   HUMAN MOLECULAR GENETICS

A Wnt-TGF 2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice

(2014) S. Biressi et al.   Science Translational Medicine

RhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice

(2013) Xiaodong Mu et al.   FASEB JOURNAL

Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders

(2013) Thibaut Quillard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Notch activation induces endothelial cell senescence and pro-inflammatory response: Implication of Notch signaling in atherosclerosis

(2012) Zhao-Jun Liu et al.   ATHEROSCLEROSIS

Notch1-mediated signaling regulates proliferation of porcine satellite cells (PSCs)

(2012) Lili Qin et al.   CELLULAR SIGNALLING

Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation

(2012) W. Liu et al.   DEVELOPMENT

Notch signaling mediates TGF-β1-induced epithelial–mesenchymal transition through the induction of Snai1

(2012) Yosuke Matsuno et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dystrophin and utrophin “double knockout” dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities

(2012) Christian Isaac et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells

(2012) Y. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

(2012) Stefan M. Gehrig et al.   NATURE

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Cardiac dysfunction and pathology in the dystrophin and utrophin-deficient mouse during development of dilated cardiomyopathy

(2012) Ju Lan Chun et al.   NEUROMUSCULAR DISORDERS

The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice

(2012) Preena Nagpal et al.   PLoS One

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

(2012) Yixiong Chen et al.   PLoS One

Human myostatin negatively regulates human myoblast growth and differentiation

(2011) Craig McFarlane et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression

(2011) Xin-Hua Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers

(2011) S.-i. Fukada et al.   DEVELOPMENT

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation

(2011) Y. Zhao et al.   DIABETES

Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation

(2011) Grace L. Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

La voie Notch

(2011) Alicia Mayeuf et al.   M S-MEDECINE SCIENCES

Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer

(2011) P. M. McGowan et al.   MOLECULAR CANCER RESEARCH

NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells

(2011) Aiping Lu et al.   MOLECULAR THERAPY

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Stem cells for skeletal muscle repair

(2011) J. L. Shadrach et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

(2011) Philippos Mourikis et al.   STEM CELLS

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

(2011) Christopher R.R. Bjornson et al.   STEM CELLS

Epigenetic regulation of satellite cell activation during muscle regeneration

(2011) F Jeffrey Dilworth et al.   Stem Cell Research & Therapy

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

(2010) H. Sheldon et al.   BLOOD

The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia

(2010) Lluis Espinosa et al.   CANCER CELL

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

(2010) Alessandra Sacco et al.   CELL

Notch and Transforming Growth Factor-β (TGFβ) Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation

(2010) Yuefeng Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Three-dimensional porous scaffold allows long-term wild-type cell delivery in dystrophic muscle

(2010) Silvia Carnio et al.   Journal of Tissue Engineering and Regenerative Medicine

New role of Notch-mediated signaling pathway in myocardial ischemic preconditioning

(2010) Yang Yang et al.   MEDICAL HYPOTHESES

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

C Histomorphology of neuromuscular junction in Duchenne muscular dystrophy

(2010) MARY C THEROUX et al.   PEDIATRIC ANESTHESIA

Dlk1 Is Necessary for Proper Skeletal Muscle Development and Regeneration

(2010) Jolena N. Waddell et al.   PLoS One

Notch3 Null Mutation in Mice Causes Muscle Hyperplasia by Repetitive Muscle Regeneration

(2010) Takeo Kitamoto et al.   STEM CELLS

Targeting the jagged/notch pathway: a new treatment for fibrosis?

(2010) Andrew Leask   Journal of Cell Communication and Signaling

Notch Signaling Induces Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells

(2009) Takehisa Shimizu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ectopic Calcification is Caused by Elevated Levels of Serum Inorganic Phosphate in Mdx Mice

(2009) Namiko Kikkawa et al.   CELL STRUCTURE AND FUNCTION

Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells

(2009) Fernando Ugarte et al.   EXPERIMENTAL HEMATOLOGY

TNF induction of jagged-1 in endothelial cells is NFκB-dependent

(2009) Douglas A. Johnston et al.   GENE

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

The Notch Effector Hey1 Associates with Myogenic Target Genes to Repress Myogenesis

(2009) Matthew F. Buas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

(2008) Andrew S. Brack et al.   Cell Stem Cell

Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

(2008) Eran Meshorer et al.   JOURNAL OF CELL BIOLOGY

Inhibition of myogenesis by Notch: Evidence for multiple pathways

(2008) Matthew F. Buas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Isolation of a slowly adhering cell fraction containing stem cells from murine skeletal muscle by the preplate technique

(2008) Burhan Gharaibeh et al.   Nature Protocols

Targeting Notch signaling in autoimmune and lymphoproliferative disease

(2007) D. T. Teachey et al.   BLOOD

Ectopic mineralization of connective tissue inAbcc6-/-mice: effects of dietary modifications and a phosphate binder - a preliminary study

(2007) Jennifer LaRusso et al.   EXPERIMENTAL DERMATOLOGY