Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Objective: We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). Methods: We performed a meta-analysis on the association between the four gene polymorphisms and RA. Results: Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR = 1.057, 95% CI = 0.782-1.429, p = 0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR = 1.294, 95% CI = 1.063-1.576, p = 0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR = 1.363, 95% CI = 1.126-1.651, p = 0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR = 1.366, 95% CI = 1.093-1.707, p = 0.006) and in Asians (OR = 1.402, 95% CI = 1.059-1.855, p = 0.014). Conclusions: Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.