Article
Biochemistry & Molecular Biology
Linyu Zhang, Xin Li, Xiangyan Liu, Xiaoran Wu, Qiurong Xu, Jianyu Qu, Xiaowen Li, Yuanyuan Zhu, Lixin Wen, Ji Wang
Summary: This study compared the effects of high-fat, high-calorie diets and high-carbohydrate, low-fat diets on glucose-lipid metabolism in mice. High-fat diets led to obesity and hepatic lipid deposition, while high-carbohydrate diets induced cholesterol deposition in the liver. Optimal metabolic homeostasis in mice was observed with a diet containing 25% fat.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Lin Yan, Sneha Sundaram, Bret M. Rust, Daniel G. Palmer, LuAnn K. Johnson, Huawei Zeng
Summary: The study hypothesized that consumption of a high-fat diet alters metabolic rhythms in pubertal mice. The results showed that the high-fat diet affected the expression of certain genes related to metabolism in the liver of mice, with the greatest changes occurring during the dark phase. These alterations in metabolic rhythms may disrupt metabolic homeostasis during puberty and contribute to the development of metabolic disorders.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Marija Pinteric, Iva I. Podgorski, Marijana Popovic Hadzija, Ivana Tartaro Bujak, Ana Tadijan, Tihomir Balog, Sandra Sobocanec
Summary: This study found that high fat diet can lead to weight gain, increased expression of NAFLD and oxidative stress-inducing genes, and impaired response of antioxidative system in mice with ovariectomy and Sirt3 depletion. Ovariectomy increases Sirt3 and fatty acid synthesis, maintains mitochondrial function, and decreases levels of lipid hydroperoxides, providing protection against harmful effects of high fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Haining Yu, Bixian Yu, Xiuyuan Qin, Weiguang Shan
Summary: This study found that high-fat diet is associated with depression and metabolic disturbance. Through experiments on mice, it was found that high-fat diet leads to depression-like behaviors, impaired serotonergic system, and disordered lipid metabolism. In addition, levels of inflammatory mediators were increased, suggesting a possible link between depression and inflammation. High-fat diet also enhances the linoleic acid metabolic pathway, further exacerbating lipid metabolism disorders. These findings contribute to the understanding of the relationship between depression and metabolic disturbance.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Lu Lu, Jingming Ren, Tong Yuan, Xinran Lu, Yinping Dong, Wenxuan Li, Xinyue Wang, Qidong Huo, Junling Zhang, Deguan Li, Saijun Fan
Summary: A high-fat diet increases the risk of malignant tumors, while ionizing radiation is used as a treatment in oncology. This study examined the effects of an 8-week high-fat diet on radiation tolerance and the influence of melatonin. The results showed that the high-fat diet altered radiation tolerance in female mice, but not in males. However, pre-treatment with melatonin attenuated radiation-induced damage and affected the composition of gut microbiota and metabolites in both males and females.
Article
Ophthalmology
Kai Kang, Qiang Zhou, Lander McGinn, Tara Nguyen, Yuncin Luo, Ali Djalilian, Mark Rosenblatt
Summary: Diet-induced gut dysbiosis in mice led to significant alterations in gut microbial diversities, delayed wound healing in high-fat diet group post-corneal injury, and a normalization of wound closure rates after fecal transplantation. Differentially expressed genes were related to response to external stimulus, cell proliferation, migration, adhesion, defense response, and leukocyte migration. Top over-represented pathways included ECM-receptor interaction, Cytokine-cytokine receptor interaction, Focal adhesion, and Leukocyte trans-endothelial migration.
Article
Nutrition & Dietetics
Juliane Weiner, Sebastian Dommel, Claudia Gebhardt, Martha Hanschkow, Yulia Popkova, Kerstin Krause, Nora Kloeting, Matthias Blueher, Juergen Schiller, John T. Heiker
Summary: The study compared the effects of a high-sucrose diet and a high-fat diet on metabolic health in mice. The results showed that the high-fat diet led to more severe obesity, glucose intolerance, and insulin resistance, while the high-sucrose diet resulted in more pronounced hepatic steatosis and inflammation.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Isy F. de Sousa, Amanda P. Pedroso, Iracema S. de Andrade, Valter T. Boldarine, Alexandre K. Tashima, Lila M. Oyama, Lilla Lionetti, Eliane B. Ribeiro
Summary: The experiment compared the effects of high-fat and normal-fat intake of extra-virgin olive oil on the liver proteome, revealing that high-fat intake induced hepatic adjustments that partially counteracted the detrimental effects of a high-fat diet. In contrast, normal-fat intake of olive oil had beneficial effects on body fat, body weight gain, and blood lipid levels, without significant modifications in the hepatic proteome.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Nutrition & Dietetics
Nancy E. Murphy, Christopher T. Carrigan, Lee M. Margolis
Summary: The use of high-fat, ketogenic diets to support physical performance has gained popularity, but the impact of such diets on performance remains controversial. A systematic review of 17 studies found that while ketogenic diets may have varying effects on endurance and power/strength performance, overall they do not significantly improve or impair physical performance compared to mixed macronutrient diets. Various factors such as duration of diet consumption, training status, performance tests, and sex differences may contribute to the conflicting results observed in different studies.
ADVANCES IN NUTRITION
(2021)
Article
Environmental Sciences
Elizabeth Marchlewicz, Carolyn McCabe, Zora Djuric, Mark Hoenerhoff, John Barks, Lu Tang, Peter X. Song, Karen Peterson, Vasantha Padmanabhan, Dana C. Dolinoy
Summary: Perinatal diet and BPA exposure have a greater impact on metabolic outcomes in offspring than on hepatic steatosis. Alterations in dam phenotype by diet and BPA exposure appear to impact offspring health trajectory.
Article
Nutrition & Dietetics
Barbara Mota, Miguel Ramos, Sandra I. Marques, Ana Silva, Pedro A. Pereira, M. Dulce Madeira, Nuno Mateus, Armando Cardoso
Summary: High-caloric diets, especially those rich in saturated fats and sugar, have detrimental effects on the cognition and emotions of aged rats. The high-fat-high-sugar diet impairs spatial learning, memory, working memory, and increases anxiety levels in aged rats, while reducing the number of doublecortin cells and increasing the number of glial fibrillary acidic protein cells in the hippocampus. In contrast, the effects of the high-fat diet are milder, mainly impairing spatial memory and working memory, and also reducing the number of doublecortin cells in the hippocampus.
Article
Neurosciences
Amparo L. de la Fuente-reynoso, Eliana Barrios De Tomasi, Jorge Juarez
Summary: The chronic administration of the selective serotonin reuptake inhibitor citalopram affects food intake differently in female and male rats, depending on the type of macronutrients consumed.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Adam Lepczynski, Malgorzata Ozgo, Katarzyna Michalek, Alicja Dratwa-Chalupnik, Marta Grabowska, Agnieszka Herosimczyk, Kamila P. Liput, Ewa Polawska, Andrzej Kram, Mariusz Pierzchala
Summary: The study found that different high-fat diets had an impact on the structure and protein expression of the murine heart, with SFA-rich diets leading to severe cardiac hypertrophy and fibrosis, while diets rich in n-3 PUFA resulted in less pronounced changes.
Article
Endocrinology & Metabolism
Miaomiao Du, Xueyun Li, Fangyi Xiao, Yinxu Fu, Yu Shi, Sihan Guo, Lifang Chen, Lu Shen, Lan Wang, Huang Cheng, Hao Li, Anran Xie, Yaping Zhou, Kaiqiang Yang, Hezhi Fang, Jianxin Lyu, Qiongya Zhao
Summary: This study demonstrates the importance of SERAC1 protein in lipid metabolism in mice. Serac1 deficiency prevents high-fat diet-induced obesity without affecting energy expenditure. It impairs cholesterol transfer from the liver to the serum and leads to an imbalance in cholesterol distribution. Moreover, Serac1 deficiency may decrease the risk of diet-induced hepatic steatosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Yuanrui Hua, Wenshu Meng, Jing Wei, Yongtao Liu, Youhe Gao
Summary: Cardiovascular disease, particularly atherosclerosis, is the leading cause of death globally. Early diagnosis of atherosclerosis is crucial for effective management of cardiovascular disease. This study demonstrates that urinary proteomics can sensitively monitor changes in the body and has the potential to identify early biomarkers of atherosclerosis.
Review
Multidisciplinary Sciences
Bridget A. Matikainen-Ankney, Alexxai V. Kravitz
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2018)
Article
Neurosciences
Jessica Tooley, Lauren Marconi, Jason Bondoc Alipio, Bridget Matikainen-Ankney, Polymnia Georgiou, Alexxai V. Kravitz, Meaghan C. Creed
BIOLOGICAL PSYCHIATRY
(2018)
Review
Neurosciences
S. Bariselli, W. C. Fobbs, M. C. Creed, A. V. Kravitz
Article
Neurosciences
Wambura C. Fobbs, Sebastiano Bariselli, Julia A. Licholai, Nanami L. Miyazaki, Bridget A. Matikainen-Ankney, Meaghan C. Creed, Alexxai V. Kravitz
JOURNAL OF NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Bridget A. Matikainen-Ankney, Mohamed A. Ali, Nanami L. Miyazaki, Sydney A. Fry, Julia A. Licholai, Alexxai V. Kravitz
Article
Neurosciences
Jacob C. Nordman, Xiaoyu Ma, Qinhua Gu, Michael Potegal, He Li, Alexxai V. Kravitz, Zheng Li
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Sebastiano Bariselli, Nanami L. Miyazaki, Meaghan C. Creed, Alexxai Kravitz
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Miguel Skirzewski, Marie E. Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai Kravitz, Andres Buonanno
Article
Multidisciplinary Sciences
B. Sofia Beas, Xinglong Gu, Yan Leng, Omar Koita, Shakira Rodriguez-Gonzalez, Morgan Kindel, Bridget A. Matikainen-Ankney, Rylan S. Larsen, Alexxai Kravitz, Mark A. Hoon, Mario A. Penzo
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Eric Casey, Maria Elena Avale, Alexxai Kravitz, Marcelo Rubinstein
Summary: The distribution and role of D2 receptors (D2Rs) in the central nucleus of the amygdala (CeA) were investigated in mice. The study found that postsynaptic D2Rs in the CeA attenuate behavioral reactions to potential environmental threats.
Article
Neurosciences
Alex A. Legaria, Bridget A. Matikainen-Ankney, Ben Yang, Biafra Ahanonu, Julia A. Licholais, Jones G. Parker, Alexxai Kravitz
Summary: Fiber photometry can record neuronal calcium dynamics in awake mice, but the biological source of the signal is still unclear. Through various experiments, the authors found that fiber photometry signal in the striatum primarily reflects nonsomatic changes in calcium.
NATURE NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
Summary: By using ultrasound to activate specific neurons in the hypothalamus, researchers have successfully induced a torpor-like state in rodents, characterized by hypothermia and reduced metabolic rate. This noninvasive technique involves closed-loop feedback control of ultrasound stimulation and automated detection of body temperature. The study identifies TRPM2 as an ultrasound-sensitive ion channel in the hypothalamus preoptic area, and demonstrates the feasibility of ultrasound-induced hypothermia and hypometabolism in non-torpid animals.
Article
Multidisciplinary Sciences
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi
Summary: Mitochondrial morphology, regulated by fission and fusion, plays a crucial role in the thermogenic capacity of brown adipocytes. TMEM135 has been identified as a critical mediator in the regulation of mitochondrial fission and thermogenesis, providing a potential target for therapeutic activation of brown adipose tissue.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Jonathan Krynitsky, Alex A. Legaria, Julia J. Pai, Marcial Garmendia-Cedillos, Ghadi Salem, Tom Pohida, Alexxai Kravitz
Article
Neurosciences
Bridget A. Matikainen-Ankney, Marcial Garmendia-Cedillos, Mohamed Ali, Jonathan Krynitsky, Ghadi Salem, Nanami L. Miyazaki, Tom Pohida, Alexxai Kravitz