Correction
Medicine, Research & Experimental
Bimit Mahat, Etienne Chasse, Jean-Francois Mauger, Pascal Imbeault
Summary: The amended version has been published and can be accessed through the original article.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Zhixiong Ying, Robin van Eenige, Rosa Beerepoot, Mariette R. Boon, Niels J. Kloosterhuis, Bart van de Sluis, Alexander Bartelt, Patrick C. N. Rensen, Sander Kooijman
Summary: Activation of brown adipose tissue (BAT) with the β3 receptor agonist mirabegron can promote fat oxidation and reduce fat accumulation, but it exacerbates atherosclerosis. However, in the APOE*3-Leiden.CETP mouse model, mirabegron treatment can reduce dyslipidemia and atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Physiology
Rens L. J. Van Meijel, Ping Wang, Freek Bouwman, Ellen E. Blaak, Edwin C. M. Mariman, Gijs H. Goossens
Summary: This study demonstrates for the first time that MIH exposure affects the human adipose tissue proteome, particularly in pathways related to redox systems, cell adhesion, cytoskeleton organization, and energy metabolism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Isis Cortes, Gutemberg Alves, Cesar Claudio-Da-Silva, Leandra Santos Baptista
Summary: This study found that different subpopulations of adipose stem/stromal cells (ASCs) exhibit distinct physiological properties in a 3D spheroid culture. ASC spheroids from superficial subcutaneous adipose tissue (sSAT) showed the highest response to adipogenic induction, while spheroids from deep subcutaneous adipose tissue (dSAT) showed the greatest lipolytic capacity. Spheroids from superficial retinacula cutis (sRC) exhibited a greater secretory capacity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Juliane Weiner, Lisa Roth, Mathias Kranz, Peter Brust, Anita Boelen, Nora Kloeting, John T. Heiker, Matthias Blueher, Anke Toenjes, Paul T. Pfluger, Michael Stumvoll, Jens Mittag, Kerstin Krause
Summary: This study identified a previously unknown endocrine loop where leptin acts in concert with the HPT axis to stabilize body temperature in hypothyroid mice. Leptin regulates body temperature not only by directly affecting heat production, but also by stimulating the HPT axis to maintain TH serum levels.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Hee-Hoon Kim, Young-Ri Shim, Ha Neul Kim, Keungmo Yang, Tom Ryu, Kyurae Kim, Sung Eun Choi, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyemi Shin, Jae Myoung Suh, Youngae Jung, Geum-Sook Hwang, Won Kim, Seok-Hwan Kim, Hyuk Soo Eun, Je Kyung Seong, Won-Il Jeong
Summary: Obesity-induced hypoxic stress in white adipose tissue leads to inflammation and interferon-y (IFN-y) production by natural killer (NK) cells. This study reveals that hypoxia promotes glutamate excretion and CXCL12 expression in white adipocytes, recruiting CXCR4+ NK cells. The spatial proximity between adipocytes and NK cells induces IFN-y production by stimulating metabotropic glutamate receptor 5 (mGluR5), which triggers inflammatory activation of macrophages and increases xCT and CXCL12 expression in adipocytes. Inhibition of xCT, mGluR5, or IFN-y receptor in adipocytes or NK cells alleviates obesity-related metabolic disorders in mice and elevated glutamate/mGluR5 and CXCL12/CXCR4 levels are observed in obese patients, suggesting a potential therapeutic target for obesity-related metabolic disorders.
Article
Cell & Tissue Engineering
Leandra Santos Baptista, Isis Cortes, Bianca Montenegro, Cesar Claudio-da-Silva, Marielle Bouschbacher, Lara Jobeili, Celine Auxenfans, Dominique Sigaudo-Roussel
Summary: The study investigated the characteristics of the superficial fascia derived from superficial subcutaneous adipose tissue, revealing higher content of pre-adipocytes and adipogenic potential, as well as increased expression of adipocyte fatty acid-binding protein and C/EBP alpha.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Physiology
Alberto Mestres-Arenas, Joan Villarroya, Marta Giralt, Francesc Villarroya, Marion Peyrou
Summary: The study found that PVAT depots increase the expression of specific genes under cold-induced thermogenic activation, suggesting that both thoracic and abdominal aortas would experience intense local exposure to these PVAT-secreted batokines. In contrast, under short-term high-fat diet-induced thermogenic activation, the thoracic aorta specifically experiences a local increase in BMP8B, FGF21, and KNG2 originating from PVAT. These findings support the idea that acquisition of a brown/beige phenotype in PVAT involves upregulation of specific batokines that can affect the vascular system differentially.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Francesca Toia, Elena Lo Presti, Anna Barbara Di Stefano, Marta Di Simone, Marco Trapani, Anna Maria Corsale, Carmela Picone, Francesco Moschella, Francesco Dieli, Adriana Cordova, Serena Meraviglia
Summary: This study analysed the immunomodulatory properties of spheroids from adipose stem cells (SASCs) and compared them to adipose stem cells (ADSCs). SASCs showed stronger immunomodulatory abilities in heterologous experimental settings compared to ADSCs. SASCs also demonstrated greater anti-inflammatory properties.
Article
Cell & Tissue Engineering
Pengyu Hong, Xiaoyang Xu, Xin Hu, Hao Yang, Yue Wu, Juan Chen, Kun Li, Zhangui Tang
Summary: The study demonstrated that sEV-LT promoted adipose tissue regeneration by accelerating proliferation, migration, and adipogenic differentiation of ADSCs in vitro and recruiting adipocytes and promoting angiogenesis in vivo. sEV-LT could serve as an alternative cell-free therapeutic strategy for generating adipose tissue, showing promising application prospects in tissue engineering.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Giuseppe Petito, Federica Cioffi, Elena Silvestri, Rita De Matteis, Davide Lattanzi, Pieter de Lange, Assunta Lombardi, Maria Moreno, Fernando Goglia, Antonia Lanni, Rosalba Senese
Summary: This study demonstrates that T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation. Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Ioannis G. Lempesis, Nicole Hoebers, Yvonne Essers, Johan W. E. Jocken, Kasper M. A. Rouschop, Ellen E. Blaak, Konstantinos N. Manolopoulos, Gijs H. Goossens
Summary: The study found that low physiological oxygen partial pressure can increase leptin expression and secretion in adipocytes, while reducing the expression and secretion of some inflammatory factors in abdominal and femoral adipocytes of obese individuals.
Article
Engineering, Biomedical
Peng-Cheng Liu, Qiu-Wen Tan, Yi Zhang, Hua Wang, Li Zhou, Qian-Ru Yang, Li Xu, Tao He, Hui-Qi Xie, Qing Lv
Summary: The study found that HAPA had a positive impact on ADSCs proliferation, VEGF secretion, and adipogenic differentiation in vitro, and demonstrated improved volume retention and angiogenesis, as well as reduced cell apoptosis in in vivo study compared to ADSCs-assisted lipofilling and pure lipofilling.
BIOMEDICAL MATERIALS
(2021)
Article
Gastroenterology & Hepatology
Takehiro Noda, Hidekazu Takahashi, Mitsuyoshi Tei, Naohiro Nishida, Taishi Hata, Yutaka Takeda, Masayuki Ohue, Hiroshi Wada, Tsunekazu Mizushima, Tadafumi Asaoka, Mamoru Uemura, Shogo Kobayashi, Kohei Murata, Taroh Satoh, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the clinical outcomes of neoadjuvant chemotherapy for resectable colorectal liver metastasis (CRLM) according to patient risk status. The results showed that patients in the intermediate-risk group who received neoadjuvant chemotherapy had significantly better recurrence-free survival, but overall survival was not improved.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Masaaki Miyo, Tsunekazu Mizushima, Junichi Nishimura, Taishi Hata, Mitsuyoshi Tei, Yuichiro Miyake, Yoshinori Kagawa, Shingo Noura, Masakazu Ikenaga, Katsuki Danno, Atsuhiro Ogawa, Yoshinao Chinen, Tsuyoshi Hata, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Hirofumi Yamamoto, Kohei Murata, Yuichiro Doki, Hidetoshi Eguchi
Summary: This multicenter retrospective study examined the impact of the COVID-19 pandemic on colorectal cancer treatment in Japan. The study found that the pandemic resulted in a reduction in the number of surgeries and colonoscopies performed for colorectal cancer and hindered the detection of early-stage cancers. The impact varied depending on the size of the hospital.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Masakatsu Paku, Mamoru Uemura, Masatoshi Kitakaze, Norikatsu Miyoshi, Hidekazu Takahashi, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study aimed to evaluate the relationship between perioperative serum CEA/carbohydrate antigen 19-9 levels and prognosis in locally recurrent rectal cancer. The results showed that preoperative serum carbohydrate antigen 19-9 level was correlated with poorer prognoses, and postoperative serum CEA >= 5 ng/mL was significantly correlated with a worse prognosis. At the time of diagnosis of re-recurrence, there was a high rate of serum CEA elevation.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Multidisciplinary Sciences
Masatoshi Kitakaze, Shiki Fujino, Norikatsu Miyoshi, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: Approximately 10% of colorectal cancer patients with submucosal invasion have lymph node metastasis. Tumor-infiltrating T cells have been found to be associated with lymph node metastasis in these patients, and the levels of CD8(+) tumor-infiltrating T cells are positively correlated with lymph node metastasis. Combining the numbers of CD8(+) tumor-infiltrating T cells and CD103(+) tumor-infiltrating T cells can provide high predictive values for lymph node metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka
Summary: Obesity is a significant risk factor for end-stage kidney disease. Lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease. However, the regulatory factors involved in countering renal lipotoxicity are largely unknown.
Article
Chemistry, Analytical
Yuka Fujito, Yoshihiro Izumi, Kohta Nakatani, Masatomo Takahashi, Yoshihiro Hayakawa, Mitsuo Takayama, Takeshi Bamba
Summary: Supercritical fluid chromatography (SFC) is often coupled with electrospray ionization mass spectrometry (ESIMS) for analyte detection. The ionization mechanism in SFC/ESI-MS is different from liquid chromatography due to the use of CO2 as a mobile phase. The formation of methoxylcarbonic acid contributes to ion generation and detection in positive-ion mode, but interferes with ionization in negative-ion mode.
ANALYTICA CHIMICA ACTA
(2023)
Article
Oncology
Masatoshi Kitakaze, Mamoru Uemura, Tomoaki Hara, Ryota Chijimatsu, Daisuke Motooka, Toshiro Hirai, Masamitsu Konno, Daisuke Okuzaki, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Ken Ofusa, Tsunekazu Mizushima, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii
Summary: This study found that the number of CD103(+)/CD8(+) tumor-infiltrating lymphocytes (TILs) is a favorable prognostic factor in colorectal cancer (CRC). Additionally, they identified the expression of ZNF683 as a candidate marker for cancer-specific tissue-resident memory T (Trm) cells. The activation of Trm cells in tumors involves IFN-gamma and TCR signaling, as well as ZNF683 expression, which could be promising targets for cancer immunity regulation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Masatoshi Nomura, Yuhki Yokoyama, Daishi Yoshimura, Yasuhisa Minagawa, Aki Yamamoto, Yukiko Tanaka, Naoko Sekiguchi, Daiki Marukawa, Momoko Ichihara, Hiroaki Itakura, Kenichi Matsumoto, Yoshihiro Morimoto, Hideo Tomihara, Akira Inoue, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Hidenori Takahashi, Mamoru Uemura, Shogo Kobayashi, Tsunekazu Mizushima, Takahisa Anada, Masaki Mori, Yuichiro Doki, Masaru Tanaka, Hidetoshi Eguchi, Hirofumi Yamamoto
Summary: In this study, a simple detection method using poly(2-methoxyethyl acrylate) (PMEA)-coated plates was established for the detection of circulating tumor cells (CTCs) in colorectal cancer (CRC) patients' blood samples. The efficacy of PMEA coating was confirmed through adhesion and spike tests. The study enrolled 41 CRC patients, and CTCs were successfully captured using PMEA. Cytological examination and cell culture provided valuable information about the presence and characteristics of CTCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu
Summary: A novel type of focal adhesion remodelling involving the replacement of active FAK with FRNK was identified under genotoxic stress. FRNK stabilized focal adhesions and protected normal tissues against genotoxic stress, but facilitated cancer progression. FRNK depletion inhibited cancer dissemination and progression in a mouse model and was predominantly expressed in metastatic human cancers.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Takeshi Kato, Toshihiro Kudo, Yoshinori Kagawa, Kohei Murata, Hirofumi Ota, Shingo Noura, Junichi Hasegawa, Hiroshi Tamagawa, Katsuya Ohta, Masakazu Ikenaga, Susumu Miyazaki, Takamichi Komori, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Chu Matsuda, Taroh Satoh, Tsunekazu Mizushima, Yuko Ohno, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi
Summary: A prospective study found that a daily dose of 120 mg of Regorafenib showed significant efficacy and safety in the treatment of colorectal cancer, which may be beneficial to specific patient populations.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui
Summary: Intestinal immune cells are important for eliminating bacteria during mucosal injury, but their excessive accumulation can promote inflammation and delay tissue repair. This study found that cholesterol sulfate (CS) suppresses immune reactions by inhibiting Rac activation mediated by DOCK2. CS acts on inflammatory neutrophils to prevent excessive gut inflammation. CS administration may be a novel therapeutic strategy for inflammatory bowel disease and non-steroidal anti-inflammatory drug-induced ulcers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takuya Morikawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kosei Moriyama, Gohsuke Hattori, Ryuta Fujioka, Shiroh Miura, Hiroki Shibata
Summary: Hereditary spastic paraplegia is a genetic neurological disorder characterized by spasticity of the lower limbs. Spastic paraplegia type 28 is a hereditary neurogenerative disorder caused by loss of function of DDHD1. Phospholipid quantitative changes, specifically oleic acid-containing PI, could serve as a potential blood biomarker for SPG28 diagnosis.
Article
Biochemistry & Molecular Biology
Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi
Summary: The excessive inflammatory response of macrophages is regulated by the metabolic alteration involving cysteine and its related metabolites. Activation of the cystine transporter xCT increases cysteine uptake by macrophages and contributes to the production of supersulfides, creating a negative feedback loop to limit excessive inflammation. Understanding the finely tuned regulation of macrophage inflammatory response by sulfur metabolism is important for disease pathogenesis and potential therapeutic strategies.
Article
Medicine, General & Internal
Hiroshi Nakao, Maki Yokomoto-Umakoshi, Kohta Nakatani, Hironobu Umakoshi, Masatoshi Ogata, Tazuru Fukumoto, Hiroki Kaneko, Norifusa Iwahashi, Masamichi Fujita, Tatsuki Ogasawara, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Izumi, Takeshi Bamba, Yoshihiro Ogawa
Summary: This study demonstrates that the unbalanced production of adrenal steroid metabolites from both tumor and non-tumor tissues contributes to the pathogenesis of endogenous steroid-induced osteoporosis (SIOP) in premenopausal women with autonomous cortisol secretion (ACS).
Article
Nutrition & Dietetics
Takuya Yamane, Momoko Imai, Takeshi Bamba, Susumu Uchiyama
Summary: This study aimed to determine the effects of daily NMN ingestion on plasma levels of NMN and NAD+. The results showed that oral administration of NMN increased the plasma concentrations of NMN and NAD+, as well as postprandial serum insulin levels. However, the elevation levels varied among individuals. No adverse symptoms were observed in the participants.
CLINICAL NUTRITION ESPEN
(2023)
