Aicar effect in early neuronal development

Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice

(2016) Sarah K. Tschirner et al.   LIFE SCIENCES

A review of the implication of hypoxanthine excess in the physiopathology of Lesch–Nyhan disease

(2016) R. J. Torres et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Sonic Hedgehog Signaling and Hippocampal Neuroplasticity

(2016) Pamela J. Yao et al.   TRENDS IN NEUROSCIENCES

Hypoxanthine deregulates genes involved in early neuronal development. Implications in Lesch-Nyhan disease pathogenesis

(2015) R. J. Torres et al.   JOURNAL OF INHERITED METABOLIC DISEASE

New biomarkers for early diagnosis of Lesch-Nyhan disease revealed by metabolic analysis on a large cohort of patients

(2015) Irène Ceballos-Picot et al.   Orphanet Journal of Rare Diseases

Striatal Neurodevelopment Is Dysregulated in Purine Metabolism Deficiency and Impacts DARPP-32, BDNF/TrkB Expression and Signaling: New Insights on the Molecular and Cellular Basis of Lesch-Nyhan Syndrome

(2014) Ghiabe-Henri Guibinga et al.   PLoS One

The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation

(2013) Tae Hyuk Kang et al.   PLoS One

HPRT Deficiency Coordinately Dysregulates Canonical Wnt and Presenilin-1 Signaling: A Neuro-Developmental Regulatory Role for a Housekeeping Gene?

(2011) Tae Hyuk Kang et al.   PLoS One

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

(2011) T. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

(2011) S. Amato et al.   SCIENCE

Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis

(2009) I. Ceballos-Picot et al.   HUMAN MOLECULAR GENETICS

Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis

(2009) Ghiabe-Henri Guibinga et al.   MOLECULAR THERAPY

Is ZMP the toxic metabolite in Lesch–Nyhan disease?

(2008) José M. López   MEDICAL HYPOTHESES

Abnormal Purine and Pyrimidine Nucleotide Content in Primary Astroglia Cultures from Hypoxanthine-Guanine Phosphoribosyltransferase-Deficient Transgenic Mice

(2003) Dori Pelled et al.   JOURNAL OF NEUROCHEMISTRY