Article
Clinical Neurology
Isabelle Lambert, Nicolas Roehri, Julie Fayerstein, Bernard Giusiano, Bruno Colombet, Christian-George Benar, Fabrice Bartolomei
Summary: This study investigated changes in thalamo-cortical and cortico-cortical connectivity during different sleep stages using stereoelectroencephalography (SEEG) recordings in humans. The results showed stronger connectivity between the thalamus and other brain regions during N2 and REM sleep compared to N3 sleep, while N3 sleep exhibited stronger cortico-cortical connectivity. The thalamus played a driving role in thalamo-insular connectivity during REM sleep.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Anesthesiology
Gabriel Riegner, Grace Posey, Valeria Oliva, Youngkyoo Jung, William Mobley, Fadel Zeidan
Summary: For a long time, mindfulness was thought to reduce pain by reducing self-appraisals of noxious sensations. Recent research suggests that mindfulness meditation-induced pain relief is associated with unique cortico-thalamo-cortical nociceptive filtering mechanisms, but the underlying neural connections are still unknown.
Article
Neurosciences
Lauren Wagner, Megan Banchik, Nana J. Okada, Nicole McDonald, Shafali S. Jeste, Susan Y. Bookheimer, Shulamite A. Green, Mirella Dapretto
Summary: Despite growing evidence, it remains unclear how alterations in thalamic functional connectivity emerge early in human development in autism spectrum disorder (ASD). In this study, researchers investigated the thalamocortical functional connectivity in infants at high and typical familial likelihood for ASD. The findings suggest that ASD may be characterized by early differences in thalamic gating, which could underlie atypical sensory processing and attention to social vs. nonsocial stimuli observed in ASD.
Article
Respiratory System
Sarah L. Finnegan, Olivia K. Harrison, Catherine J. Harmer, Mari Herigstad, Najib M. Rahman, Andrea Reinecke, Kyle T. S. Pattinson
Summary: This study focused on 91 participants with mild-to-moderate chronic obstructive pulmonary disease (COPD), utilizing unsupervised machine learning techniques to model brain-behavior-breathlessness links. The results successfully stratified participants into four key factors corresponding to mood, symptom burden, and capability measures, leading to the identification of high and low symptom burden groups with distinct brain activity patterns. This highlights the importance of multimodal models in understanding breathlessness burden and identifying behavioral phenotypes.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Neurosciences
Raquel Pestana Araujo, Patricia Figueiredo, Joana Pinto, Pedro Vilela, Isabel Pavao Martins, Raquel Gil-Gouveia
Summary: This study found that there are alterations in brain connectivity during migraine attacks, specifically decreased connectivity between the sensorimotor network and the posterior insula. These changes in connectivity may be associated with the perception of pain and heightened sensitivity to stimuli experienced by migraine patients.
Article
Clinical Neurology
Freek ten Doesschate, Willem Bruin, Peter Zeidman, Christopher C. Abbott, Miklos Argyelan, Annemieke Dols, Louise Emsell, Philip F. P. van Eijndhoven, Eric van Exel, Peter C. R. Mulders, Katherine Narr, Indira Tendolkar, Didi Rhebergen, Pascal Sienaert, Mathieu Vandenbulcke, Joey Verdijk, Mike van Verseveld, Hauke Bartsch, Leif Oltedal, Jeroen A. van Waarde, Guido A. van Wingen
Summary: A recent multi-center study found no consistent changes in correlation-based resting-state connectivity after ECT, but effective connectivity may provide more insight into the working mechanism of ECT.
Article
Clinical Neurology
Jing Qi, Bo-Zhi Li, Ying Zhang, Bei Pan, Yu-Hong Gao, Hao Zhan, Yong Liu, Yong-Cong Shao, Xi Zhang
Summary: This study found that after total sleep deprivation, there were significant alterations in insular functional connectivity, with enhanced connectivity with the prefrontal cortex and inferior temporal gyrus, while reduced connectivity with temporal, parietal, and occipital regions. Furthermore, the changes in insular functional connectivity were correlated with PVT performance.
Article
Neurosciences
Joao Castelhano, Isabel C. Duarte, Ricardo Couceiro, Julio Medeiros, Joao Duraes, Sonia Afonso, Henrique Madeira, Miguel Castelo-Branco
Summary: In recent years, there has been increased focus on the neural correlates of software programming skills. Studies have shown that the insula plays a pivotal role in error-monitoring during deep-level code inspection.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Youxue Zhang, Xueli Cai, Mingjun Duan, Hui He
Summary: Worry is a repetitive negative thought that can lead to anxiety disorder, especially in individuals with high worry-proneness. This study investigated the relationship between worry and the interoception network in high worry-proneness individuals. The results showed that deficient insular function may play a key role in high worry in healthy subjects.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yangyang Wang, Xuhong Yang, Lifei Xiao, Wenchao Li, Xianhao Huo, Chaofan Wang, Mei Li, Tao Sun
Summary: Sleep deprivation is a significant cause of cognitive impairment. This study investigated the relationship between functional connectivity of anterior insular subregions and cognitive impairment following total sleep deprivation. The results suggest that altered functional connectivity in these subregions may serve as a neuroimaging biomarker for cognitive impairment after sleep deprivation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Weidong Cai, Srikanth Ryali, Ramkrishna Pasumarthy, Viswanath Talasila, Vinod Menon
Summary: Working memory is a crucial component of cognition, but its mechanisms are not well understood. The study reveals distinct roles of the SN and FPN in systems control, and shows that network controllability decreases with an increase in working memory load.
NATURE COMMUNICATIONS
(2021)
Article
Neuroimaging
S. Duke Han, Melissa Lamar, Debra Fleischman, Namhee Kim, David A. Bennett, Tene T. Lewis, Konstantinos Arfanakis, Lisa L. Barnes
Summary: Self-reported experiences of discrimination are associated with differential insula functional connectivity in older adults, suggesting a link between discrimination and trust perception in the brain. No significant findings were found in the amygdala analyses.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Mohit H. Adhikari, Tamara Vasilkovska, Roger Cachope, Haiying Tang, Longbin Liu, Georgios A. Keliris, Ignacio Munoz-Sanjuan, Dorian Pustina, Annemie Van der Linden, Marleen Verhoye
Summary: This study examined functional changes in the brain using resting-state functional magnetic resonance imaging (RS-fMRI) in a mouse model of Huntington's disease (HD) at different ages. The results revealed significant temporal and spatial changes in brain function, with the most pronounced alterations observed at 10 months of age. These findings provide insights into the functional architecture of the brain in HD and suggest potential biomarkers for early detection of the disease.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Zi-Min Cao, Yi-Chao Chen, Guo-Yun Liu, Xu Wang, An-Qi Shi, Lu-Fan Xu, Zhi-Jun Li, Jian-Wei Huo, Ya-Nan Zhang, Ni Liu, Chao-Qun Yan, Jun Wang
Summary: This study investigated the altered functional connectivity in brain regions of migraine patients using data-driven and regions of interest approaches. The findings suggest that patients with migraine exhibit abnormalities in the functional connectivity of the bilateral thalamus, which may serve as a mechanism for the development of migraine.
Article
Neurosciences
Yun Ai, Thomas Hummel, Haoyu Nie, Juan Yang, Pengfei Han
Summary: Acute stress can alter olfactory perception, particularly for pleasant odor stimuli. This study found that acute stress leads to a decrease in brain activation in response to pleasant odors, and this effect may be related to changes in cortisol levels and functional connectivity between brain regions.
Article
Psychology, Developmental
Soren Kuitunen-Paul, Anna Eichler, Melina Wiedmann, Lukas A. Basedow, Veit Roessner, Yulia Golub
Summary: Both self-reports and parental reports are important in the treatment of substance use disorders in adolescents. Parental reports are more accurate in assessing externalizing problems, while no differences were found in internalizing problems.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Judith T. Mack, Nicole Wolff, Gregor Kohls, Andreas Becker, Sanna Stroth, Luise Poustka, Inge Kamp-Becker, Veit Roessner
Summary: This study examined the pathological link between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) using the Autism Diagnostic Observation Schedule (ADOS Module 3) and the Autism Diagnostic Interview-Revised (ADI-R). The results showed that in the presence of both ASD and ADHD, there is an additive model of symptomatology across areas of communication, social interaction, and stereotyped behaviors and restricted interests. This suggests that the phenotypic overlap of ASD and ADHD may be less complicated than suspected, at least in terms of ASD symptomatology, and that ASD symptomatology can be well measured with diagnostic instruments.
Article
Neurosciences
Maria Bretzke, Nora C. Vetter, Gregor Kohls, Hannes Wahl, Veit Roessner, Michael M. Plichta, Judith Buse
Summary: This study investigates the role of uncertainty in loss processing and avoidance. The results show slower response times in adolescents compared to adults when it comes to avoiding loss, and adults show higher brain activation during the anticipation of potential monetary loss compared to adolescents.
COGNITIVE NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Julius Steding, Franziska Ritschel, Ilka Boehm, Daniel Geisler, Joseph A. King, Veit Roessner, Michael N. Smolka, Florian Daniel Zepf, Stefan Ehrlich
Summary: This study investigated the neural responses related to reward processing in individuals with a history of anorexia nervosa (recAN) during acute tryptophan depletion (ATD). The results suggested a normalization of reward-related neural responses in recAN during ATD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Marie-Louis Wronski, Daniel Geisler, Fabio Bernardoni, Maria Seidel, Klaas Bahnsen, Arne Doose, Jonas L. Steinhaeuser, Franziska Gronow, Luisa V. Boeldt, Franziska Plessow, Elizabeth A. Lawson, Joseph A. King, Veit Roessner, Stefan Ehrlich
Summary: This study is the first to investigate amygdala nuclei volumes in patients with anorexia nervosa (AN). The results show that the volumes of several specific nuclei in the amygdala are significantly reduced in AN patients compared to healthy individuals, while others are less affected. Additionally, the study finds a positive association between leptin levels and alterations in certain nuclei.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biology
Jadna Bogado Lopes, Anna N. Senko, Klaas Bahnsen, Daniel Geisler, Eugene Kim, Michel Bernanos, Diana Cash, Stefan Ehrlich, Anthony C. Vernon, Gerd Kempermann
Summary: By continuously tracking the behavioral activity of mice in an enriched environment for 3 months and using ex vivo structural magnetic resonance imaging, it was found that behavioral activity can shape the connectivity of the mouse brain. Furthermore, there are differences in brain structural covariance between mice with different behavioral trajectories.
Review
Clinical Neurology
Ashley D. Harris, Houshang Amiri, Mariana Bento, Ronald Cohen, Christopher R. K. Ching, Christina Cudalbu, Emily L. Dennis, Arne Doose, Stefan Ehrlich, Ivan I. Kirov, Ralf Mekle, Georg Oeltzschner, Eric Porges, Roberto Souza, Friederike I. Tam, Brian Taylor, Paul M. Thompson, Yann Quide, Elisabeth A. Wilde, John Williamson, Alexander P. Lin, Brenda Bartnik-Olson
Summary: Magnetic resonance spectroscopy (MRS) is a powerful and non-invasive imaging technique that quantitatively measures brain metabolites and has utility in diagnosing and characterizing neurological diseases. However, its impact has been limited by small sample sizes, methodological variability, and intrinsic limitations. This manuscript provides an overview of MRS data harmonization, including key considerations for retrospective and prospective studies, and various approaches to harmonization. The goal is to provide knowledge for conducting MRS data harmonization studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Victoria-Luise Batury, Friederike I. Tam, Inger Hellerhoff, Marie-Louis Wronski, Katrin Borucki, Kerstin Weidner, Veit Roessner, Wei Gao, Stefan Ehrlich
Summary: Anorexia nervosa (AN) is a complex psychiatric disorder that affects endocrine system. Previous short-term measurement methods have shown altered levels of sex steroid hormones in AN patients. This study aimed to use hair-based assessments to investigate sex steroid hormone levels in underweight AN patients compared to healthy controls, as well as the changes in hormone levels during inpatient treatment. The results indicate that hair hormone levels of DHEA were similar between the groups, but progesterone was suppressed in underweight AN patients. There was no significant change in hair hormone levels during weight restoration. Hair analysis can be used to detect suppressed progesterone levels in severe AN patients.
Article
Psychology, Clinical
Inger Hellerhoff, Fabio Bernardoni, Klaas Bahnsen, Joseph A. King, Arne Doose, Sophie Pauligk, Friederike I. Tam, Merle Mannigel, Katrin Gramatke, Veit Roessner, Katja Akguen, Tjalf Ziemssen, Stefan Ehrlich
Summary: This study investigated the potential association between serum-based protein markers of brain damage and cortical thinning in patients with acute anorexia nervosa (AN). The results showed a correlation between higher baseline levels of neurofilament light (NF-L), an established marker of axonal damage, and lower cortical thickness in several regions. This association was not found in the control group.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Marie-Louis Wronski, Charlotte Hohnemann, Fabio Bernardoni, Klaas Bahnsen, Arne Doose, Dominic Arold, Katrin Borucki, Laura M. Holsen, Elizabeth A. Lawson, Franziska Plessow, Kerstin Weidner, Veit Roessner, Stefan Diestel, Joseph A. King, Maria Seidel, Stefan Ehrlich
Summary: This study provides first evidence for the relevance of specific amygdala substructure reductions regarding cognitive symptom severity in AN and points toward novel mechanistic insight into the relationship between hypoleptinemia and rumination, which might involve the amygdaloid complex.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychology, Clinical
Fabio Bernardoni, Joseph A. King, Inger Hellerhoff, Martin Schoemann, Maria Seidel, Daniel Geisler, Ilka Boehm, Sophie Pauligk, Arne Doose, Julius Steding, Katrin Gramatke, Veit Roessner, Stefan Scherbaum, Stefan Ehrlich
Summary: People with anorexia nervosa show more stable decision conflict in delay-discounting tasks, which might help them achieve their long-term weight goals.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)