Article
Engineering, Biomedical
Cansel Ficici, Ziya Telatar, Osman Erogul
Summary: A method analyzing gray matter reduction in brain magnetic resonance images was proposed to identify epileptogenic focus of temporal lobe epilepsy (TLE) patients. Experimental results showed that the proposed algorithm can reveal subtle Gray matter reduction in the temporal lobe and limbic lobe areas, thus providing an automated medical support system for the expert in identifying the epileptic focus of TLE patients.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Behavioral Sciences
Karoline Leiberg, Jane de Tisi, John S. Duncan, Bethany Little, Peter N. Taylor, Sjoerd B. Vos, Gavin P. Winston, Bruno Mota, Yujiang Wang
Summary: Neuroimaging captures brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure for drug-resistant temporal lobe epilepsy (TLE). This study examines the effects of ATLR on brain morphology, showing significant changes mainly in regions near the resection and structurally connected to the anterior temporal lobe.
Article
Clinical Neurology
Bo-yong Park, Sara Lariviere, Raul Rodriguez-Cruces, Jessica Royer, Shahin Tavakol, Yezhou Wang, Lorenzo Caciagli, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Marina K. M. Alvim, Clarissa Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Barbara A. K. Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Michael Rebsamen, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J. O'Brien, Meng Law, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M. Desmond, Charles B. Malpas, Elaine Lui, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kalviainen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Bernd Weber, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Costanza Parodi, Domenico Tortora, Sean N. Hatton, Sjoerd B. Vos, John S. Duncan, Marian Galovic, Christopher D. Whelan, Nuria Bargallo, Jose Pariente, Estefania Conde-Blanco, Anna Elisabetta Vaudano, Manuela Tondelli, Stefano Meletti, Xiang-Zhen Kong, Clyde Francks, Simon E. Fisher, Benoit Caldairou, Mina Ryten, Angelo Labate, Sanjay M. Sisodiya, Paul M. Thompson, Carrie R. McDonald, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt
Summary: This study compared the spatial distribution of grey matter asymmetry and atrophy in temporal lobe epilepsy using the ENIGMA-Epilepsy dataset. The results showed marked differences between the two measures, with asymmetry revealing anomalies in ipsilateral limbic circuits and atrophy displaying diffuse and bilateral patterns. Additionally, cortical atrophy was correlated with disease duration and age at seizure onset.
Article
Clinical Neurology
Wei Li, Yuchao Jiang, Yingjie Qin, Xiuli Li, Du Lei, Heng Zhang, Cheng Luo, Qiyong Gong, Dong Zhou, Dongmei An
Summary: This study explored dynamic changes in cortical thickness before and after successful anterior temporal lobectomy in patients with unilateral mesial temporal lobe epilepsy. The study found significant changes in cortical thickness before and after surgery, with postoperative cortical thickening observed in some regions.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Majdi Jber, Jafar Mehvari Habibabadi, Roya Sharifpour, Hengameh Marzbani, Masoud Hassanpour, Milad Seyfi, Neda Mohammadi Mobarakeh, Ahmedreza Keihani, Seyed Sohrab Hashemi-Fesharaki, Mohammadreza Ay, Mohammad-Reza Nazem-Zadeh
Summary: Patients with left TLE showed more prevalent and widespread changes in subcortical volumes and cortical thickness, mainly in the left hemisphere. Hippocampus, thalamus, and pallidum were vulnerable to TLE. Volume changes in hippocampus alone could lead to accurate lateralization of TLE.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Kong, Nan Cheng, Feng-juan Qiu, Lei Yao, Ming Gao, An-qiang Chen, Qing-xia Kong, Gu-qing Zhang
Summary: This study demonstrates that multimodal MRI combined with PET metabolic parameters has high detection value in patients with TLE-DP and can provide independent prognostic information for those who undergo surgery.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Ezequiel Gleichgerrcht, Tanja S. Kellermann, Daniel L. Drane, Simon S. Keller, Carrie R. McDonald, Chris Rorden, Jens Jensen, Bernd Weber, Kathryn A. Davis, Ruben Kuzniecky, Leonardo Bonilha
Summary: The study found that patients with temporal lobe epilepsy have reduced integrity in white matter pathways, leading to cortical disconnection, particularly involving limbic structures, which is associated with verbal memory performance.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Xi Zhang, Guojun Zhang, Tao Yu, Cuiping Xu, Jin Zhu, Xiaoming Yan, Kai Ma, Runshi Gao
Summary: This study analyzed the surgical outcomes of patients with temporal lobe epilepsy (TLE) who underwent temporal and insular SEEG recordings. The findings suggest that insular involvement may be associated with failed anterior temporal lobectomy (ATL) and poorer seizure outcomes. The study also identified temporal-insular spreading time (TIST) as an independent predictor of postoperative seizure-free outcomes in these patients.
Article
Clinical Neurology
Leonardo Favi Bocca, Thiago Pereira Rodrigues, Thiago Bortholin, Elza Marcia Targas Yacubian, Henrique Carrete Jr, Mirian Guaranha, Ricardo Silva Centeno
Summary: Sotos syndrome is a genetic disorder caused by NSD1 gene haploinsufficiency, with some patients experiencing epilepsy, including drug-resistant seizures. A 47-year-old female patient with Sotos syndrome had focal-onset seizures in the left temporal lobe, left-side hippocampal atrophy, and cognitive impairment. After undergoing left-side temporal lobe resection, the patient achieved complete awake seizure control and significant improvement in quality-of-life during the 3-year follow-up. Resective surgeries may be beneficial for improving seizure control and quality of life in selected patients with Sotos syndrome.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alexey M. Yakimov, Elena E. Timechko, Irina G. Areshkina, Anna A. Usoltseva, Kristina D. Yakovleva, Elena A. Kantimirova, Nikita Utyashev, Nikita Ivin, Diana V. Dmitrenko
Summary: Mesial temporal lobe epilepsy is the most common type of epilepsy and surgery is often the only treatment option. This study focuses on miR-654-3p as a potential biomarker for surgical outcome, while also considering other miRNAs as indicators of relapse. The research on miRNAs as predictive biomarkers of surgical outcome is urgent, but several factors need to be taken into account.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto
Summary: Pharmacological and surgical treatments of epilepsy have limited success, therefore a more targeted and on-demand approach is desired. The authors demonstrate the use of inhibitory chemogenetics to attenuate cortical seizures and subsequent convulsions in nonhuman primates. These results highlight the efficacy of DREADDs for treating epilepsy in a primate model.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Ke Xu, Xiongfei Wang, Jian Zhou, Yuguang Guan, Tianfu Li, Guoming Luan
Summary: This study investigates the clinical discrepancies and predictors of anterior temporal lobectomy (ATL) in children and adults with temporal lobe epilepsy (TLE). Significant differences in clinical manifestations, MRI examinations, number of preoperative AEDs, and pathologies were observed between TLE children and adults. The early complete resection of MRI-detected epileptogenic focus in TLE children predicts favorable seizure outcome, while the concordance of MRI-detected focus with EEG-detected epileptogenic zone predicts favorable seizure outcomes in TLE adults.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Sanjay M. Sisodiya, Christopher D. Whelan, Sean N. Hatton, Khoa Huynh, Andre Altmann, Mina Ryten, Annamaria Vezzani, Maria Eugenia Caligiuri, Angelo Labate, Antonio Gambardella, Victoria Ives-Deliperi, Stefano Meletti, Brent C. Munsell, Leonardo Bonilha, Manuela Tondelli, Michael Rebsamen, Christian Rummel, Anna Elisabetta Vaudano, Roland Wiest, Akshara R. Balachandra, Nuria Bargallo, Emanuele Bartolini, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Benoit Caldairou, Sarah J. A. Carr, Gianpiero L. Cavalleri, Fernando Cendes, Luis Concha, Patricia M. Desmond, Martin Domin, John S. Duncan, Niels K. Focke, Renzo Guerrini, Khalid Hamandi, Graeme D. Jackson, Neda Jahanshad, Reetta Kalviainen, Simon S. Keller, Peter Kochunov, Magdalena A. Kowalczyk, Barbara A. K. Kreilkamp, Patrick Kwan, Sara Lariviere, Matteo Lenge, Seymour M. Lopez, Pascal Martin, Mario Mascalchi, Jose C. V. Moreira, Marcia E. Morita-Sherman, Heath R. Pardoe, Jose C. Pariente, Kotikalapudi Raviteja, Cristiane S. Rocha, Raul Rodriguez-Cruces, Margitta Seeck, Mira K. H. G. Semmelroch, Benjamin Sinclair, Hamid Soltanian-Zadeh, Dan J. Stein, Pasquale Striano, Peter N. Taylor, Rhys H. Thomas, Sophia I. Thomopoulos, Dennis Velakoulis, Lucy Vivash, Bernd Weber, Clarissa Lin Yasuda, Junsong Zhang, Paul M. Thompson, Carrie R. McDonald
Summary: Epilepsy is a common and serious neurological disorder. MRI has been instrumental in advancing our understanding of epilepsy, and the ENIGMA-Epilepsy project aims to strengthen epilepsy research by increasing sample sizes and collaborating with scientists and clinicians.
HUMAN BRAIN MAPPING
(2022)
Review
Clinical Neurology
Jessica Royer, Boris C. Bernhardt, Sara Lariviere, Ezequiel Gleichgerrcht, Bernd J. Vorderwuelbecke, Serge Vulliemoz, Leonardo Bonilha
Summary: Hubs, as key regions connecting different parts of the brain, play a critical role in brain network organization and related disorders.
Article
Biochemistry & Molecular Biology
Zhiqiang Sha, Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Boris Bernhardt, Sven Bolte, Geraldo F. Busatto, Sara Calderoni, Rosa Calvo, Eileen Daly, Christine Deruelle, Meiyu Duan, Fabio Luis Souza Duran, Sarah Durston, Christine Ecker, Stefan Ehrlich, Damien Fair, Jennifer Fedor, Jacqueline Fitzgerald, Dorothea L. Floris, Barbara Franke, Christine M. Freitag, Louise Gallagher, David C. Glahn, Shlomi Haar, Liesbeth Hoekstra, Neda Jahanshad, Maria Jalbrzikowski, Joost Janssen, Joseph A. King, Luisa Lazaro, Beatriz Luna, Jane McGrath, Sarah E. Medland, Filippo Muratori, Declan G. M. Murphy, Janina Neufeld, Kirsten O'Hearn, Bob Oranje, Mara Parellada, Jose C. Pariente, Merel C. Postema, Karl Lundin Remnelius, Alessandra Retico, Pedro Gomes Penteado Rosa, Katya Rubia, Devon Shook, Kristiina Tammimies, Margot J. Taylor, Michela Tosetti, Gregory L. Wallace, Fengfeng Zhou, Paul M. Thompson, Simon E. Fisher, Jan K. Buitelaar, Clyde Francks
Summary: Small average differences in the left-right asymmetry of cerebral cortical thickness have been observed in individuals with autism spectrum disorder (ASD). This study used a large sample of data to examine the structural network effects of these regional alterations. The findings suggest that altered asymmetrical brain development in ASD may affect networks involved in executive functions, language-related processes, and sensorimotor processes.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Neurosciences
Boris C. Bernhardt, Jonathan Smallwood, Shella Keilholz, Daniel S. Margulies
Article
Neurosciences
Raul Rodriguez-Cruces, Jessica Royer, Sara Lariviere, Dani S. Bassett, Lorenzo Caciagli, Boris C. Bernhardt
Summary: This manuscript reviews recent literature on the brain network substrates of cognitive and affective dysfunction in common epilepsy syndromes. The authors discuss prior work that has shown both shared and distinct brain network signatures of dysfunction across the epilepsy spectrum. This review improves our understanding of structure-function links and interindividual heterogeneity, and can aid in screening and monitoring of therapeutic strategies.
NETWORK NEUROSCIENCE
(2022)
Article
Biology
Meichao Zhang, Boris C. Bernhardt, Xiuyi Wang, Dominika Varga, Katya Krieger-Redwood, Jessica Royer, Raul Rodriguez-Cruces, Reinder Vos de Wael, Daniel S. Margulies, Jonathan Smallwood, Elizabeth Jefferies
Summary: During reading, our minds can wander to unrelated autobiographical information, leading to a loss of narrative comprehension. This study used functional magnetic resonance imaging (fMRI) and functional connectivity analysis to investigate the neural mechanisms behind this wandering state. The results revealed that memory retrieval activated the medial regions of the default mode network (DMN), while reading comprehension recruited left temporal and lateral prefrontal regions of the DMN as well as ventral visual cortex. Additionally, individuals with more self-generated mental content and poorer comprehension showed greater decoupling between visually connected DMN sites and primary visual cortex. These findings suggest that mind-wandering occurs because the generation of autobiographical mental content relies on DMN regions that are functionally decoupled from the ventral visual regions involved in reading.
Article
Biology
Zhen-Qi Liu, Bertha Vazquez-Rodriguez, R. Nathan Spreng, Boris C. Bernhardt, Richard F. Betzel, Bratislav Misic
Summary: The study revealed that the coupling between structure and function in the human brain is regionally heterogeneous, with dynamic structure-function coupling patterns being region-specific. This provides a new perspective to study structure-function relationships and highlights the importance of considering regional differences in brain connectivity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Oualid Benkarim, Casey Paquola, Bo-yong Park, Jessica Royer, Raul Rodriguez-Cruces, Reinder Vos de Wael, Bratislav Misic, Gemma Piella, Boris C. Bernhardt
Summary: Brain function is determined by the wiring of the brain, but the rules governing this relationship are still unknown. Researchers have proposed a new method to predict functional interactions by emulating random walks on the structural connectome. This method has been validated in healthy adults and highlights the increasing relevance of polysynaptic communication mechanisms in transmodal cortical networks.
Article
Clinical Neurology
Ildefonso Rodriguez-Leyva, Karla Cantu-Flores, Arturo Dominguez-Frausto, Anna Elisabetta Vaudano, John Archer, Boris Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Paolo Federico, William D. Gaillard, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Irene Wang, Shuang Wang, Luis Concha
Summary: The ILAE Neuroimaging Task Force published educational case reports on neuroimaging in epilepsy. Neurocysticercosis is highly endemic in resource-limited countries and is increasingly seen in non-endemic regions due to migration. This article presents two cases with different clinical features to illustrate the varying severity of symptoms caused by this parasitic infestation, as well as examples of imaging characteristics that emphasize the central role of neuroimaging in diagnosing neurocysticercosis.
EPILEPTIC DISORDERS
(2023)
Article
Multidisciplinary Sciences
Vincent Bazinet, Justine Y. Hansen, Reinder Vos de Wael, Boris C. Bernhardt, Martijn P. van den Heuvel, Bratislav Misic
Summary: This study annotates brain networks with microarchitectural attributes and finds that the interaction between connection patterns and biological annotations shapes regional functional specialization. The conventional graph model abstracts away the rich biological detail of each regional node, while this study quantifies assortative mixing in annotated connectomes based on the similarity of micro-architectural attributes. By bridging scales of cortical organization, this work lays the foundation for next-generation annotated connectomics.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Bin Wan, Seok-Jun Hong, Richard A. I. Bethlehem, Dorothea L. Floris, Boris C. Bernhardt, Sofie L. Valk
Summary: Autism is a neurodevelopmental condition characterized by atypical sensory-perceptual functions, language deficits, and socio-cognitive impairments. Previous research has shown that individuals with autism exhibit subtle alterations in brain structure asymmetry and reduced functional activation laterality compared to non-autistic individuals. However, whether these functional asymmetries reflect altered intrinsic systematic organization in autism is still unclear.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Robert Leech, Reinder Vos De Wael, Frantisek Vasa, Ting Xu, R. Austin Benn, Robert Scholz, Rodrigo M. Braga, Michael P. Milham, Jessica Royer, Boris C. Bernhardt, Emily J. H. Jones, Elizabeth Jefferies, Daniel S. Margulies, Jonathan Smallwood
Summary: Recent theories of cortical organisation propose that the spatial arrangement of brain regions determines their functional features. Association cortex, located farthest from action and perception systems, is interwoven with adjacent regions exhibiting different functional connectivity patterns. The study findings show that function changes more gradually with distance in sensory-motor cortex compared to association cortex. Importantly, systems within the same type of cortex exhibit similar profiles. The differentiation between primary and association cortex lies in how function changes over space, highlighting the importance of topographical features in estimating their contribution to cognition and behavior.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Sofie Louise Valk, Philipp Kanske, Bo-yong Park, Seok-Jun Hong, Anne Boeckler, Fynn-Mathis Trautwein, Boris C. Bernhardt, Tania Singer
Summary: Research shows that different types of social mental training can alter brain function and structure. Attention-mindfulness and socio-cognitive training can change the function and microstructure of brain regions associated with attention and interoception, while socio-affective and socio-cognitive training can affect the microstructure of brain regions involved in interoceptive and emotional processing.
Article
Biology
Benjamin Haenisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff, Juergen Dukart, Bratislav Misic, Sofie Louise Valk
Summary: This study investigates the role of neurotransmitter transporter and receptor molecules in the structure-function relationships in the human brain. Using positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors, the researchers discovered three main spatial gradients of chemoarchitectural similarity in the cortical and subcortical regions of the brain. The findings show that the organization of the receptome shares similarities with functional and structural brain anatomy.
Article
Biology
Qirui Zhang, Jiao Li, Yan He, Fang Yang, Qiang Xu, Sara Lariviere, Boris C. Bernhardt, Wei Liao, Guangming Lu, Zhiqiang Zhang
Summary: Atypical brain network hierarchy organization is observed in Rolandic epilepsy, which is related to seizure incidence, cognition, and connectivity deficit. The altered connectivity hierarchy is a system-level substrate of Rolandic epilepsy and indicates impairment in information processing across multiple functional domains. This study establishes a framework for investigating brain hierarchical organization.
COMMUNICATIONS BIOLOGY
(2023)