Journal
NICOTINE & TOBACCO RESEARCH
Volume 21, Issue 9, Pages 1220-1227Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ntr/nty104
Keywords
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Funding
- British American Tobacco (Investments) Limited
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Background: Smoking is a leading cause of numerous human disorders including pulmonary disease, cardiovascular disease, and cancer. Disease development is primarily caused by exposure to cigarette smoke constituents, many of which are known toxicants. Switching smokers to modified risk tobacco products (MRTPs) has been suggested as a potential means to reduce the risks of tobacco use, by reducing such exposure. Methods: This randomized, controlled study investigated whether biomarkers of toxicant exposure (BoE) were reduced when smokers switched from smoking combustible cigarettes to using a novel (gloT/THP1.0) or in-market comparator (iQOS/THS) tobacco heating product (THP). One hundred eighty Japanese smokers smoked combustible cigarettes during a 2-day baseline period, followed by randomization to either continue smoking cigarettes, switch to using mentholated or non-mentholated variants of gloT, switch to using a non-mentholated variant of iQOS, or quit nicotine and tobacco product use completely for 5 days. Baseline and post-randomization 24-h urine samples were collected for BoE analysis. Carbon monoxide was measured daily in exhaled breath (eCO). Results: On day 5 after switching, urinary BoE (excluding for nicotine) and eCO levels were significantly (p <.05) reduced by medians between 20.9% and 92.1% compared with baseline in all groups either using gloT or iQOS or quitting tobacco use. Between-group comparisons revealed that the reductions in the gloT groups were similar (p >.05) to quitting in many cases. Conclusions: gloT or iQOS use for 5 days reduced exposure to smoke toxicants in a manner comparable to quitting tobacco use. THPs are reduced exposure tobacco products with the potential to be MRTPs.
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