Journal
NEW PHYTOLOGIST
Volume 220, Issue 2, Pages 609-623Publisher
WILEY
DOI: 10.1111/nph.15291
Keywords
Arabidopsis; cell proliferation; GIF1; AN3; GRF; GIF regulatory module; leaf growth; leaf senescence; ORE15; PLATZ
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Funding
- Institute for Basic Science [IBS-R013-D1]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [2015R1A 2A2A01005820, 2017R1A2B4012714]
- Woo Jang-Choon Project of the Rural Development Administration (RDA) [PJ01093902]
- National Research Foundation of Korea [2017R1A2B4012714] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Plant leaves undergo a series of developmental changes from leaf primordium initiation through growth and maturation to senescence throughout their life span. Although the mechanisms underlying leaf senescence have been intensively elucidated, our knowledge of the interrelationship between early leaf development and senescence is still fragmentary. We isolated the oresara15-1Dominant (ore15-1D) mutant, which had an extended leaf longevity and an enlarged leaf size, from activation-tagged lines of Arabidopsis. Plasmid rescue identified that ORE15 encodes a PLANT A/T-RICH SEQUENCE- AND ZINC-BINDING PROTEIN family transcription factor. Phenotypes of ore15-1D and ore15-2, a loss-of-function mutant, were evaluated through physiological and anatomical analyses. Microarray, quantitative reverse transcription polymerase chain reaction, and chromatin immunoprecipitation as well as genetic analysis were employed to reveal the molecular mechanism of ORE15 in the regulation of leaf growth and senescence. ORE15 enhanced leaf growth by promoting the rate and duration of cell proliferation in the earlier stage and suppressed leaf senescence in the later stage by modulating the GROWTH-REGULATING FACTOR (GRF)/GRF-INTERACTING FACTOR regulatory pathway. Our study highlighted a molecular conjunction through ORE15 between growth and senescence, which are two temporally separate developmental processes during leaf life span.
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