S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life

Novel immunoassays to detect methionine adenosyltransferase activity and quantify S -adenosylmethionine

(2017) Xiujuan Hao et al.   FEBS LETTERS

Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease

(2017) Elizabeth M. Ellison et al.   JOURNAL OF NEUROCHEMISTRY

Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation

(2017) S. Brummelte et al.   NEUROSCIENCE

B Vitamin Deficiency Promotes Tau Phosphorylation Through Regulation of GSK3β and PP2A

(2017) Vincenzina Nicolia et al.   JOURNAL OF ALZHEIMERS DISEASE

A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

(2016) Domenico De Berardis et al.   CNS & Neurological Disorders-Drug Targets

Glucocorticoid receptor DNA methylation, childhood maltreatment and major depression

(2016) Angela C. Bustamante et al.   JOURNAL OF AFFECTIVE DISORDERS

Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease

(2016) Porcelli Stefano et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease

(2016) Andrew J. Phipps et al.   NEUROBIOLOGY OF AGING

Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome

(2016) Rima Obeid et al.   NEUROMOLECULAR MEDICINE

Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

(2016) Emily A. Saunderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

(2016) Russell E. Nicholls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Responses of bovine early embryos to S-adenosyl methionine supplementation in culture

(2016) Habib A Shojaei Saadi et al.   Epigenomics

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

(2016) David Kennedy   Nutrients

Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia

(2016) Yiting Zhang et al.   PLoS One

Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer’s Model

(2016) Sonia Do Carmo et al.   Scientific Reports

One-carbon metabolism and epigenetics: understanding the specificity

(2015) Samantha J. Mentch et al.   Annals of the New York Academy of Sciences

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase

(2015) Monique G P van der Wijst et al.   Epigenetics

Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells

(2015) Huan Liu et al.   EUROPEAN JOURNAL OF NUTRITION

Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications

(2015) Moshe Szyf   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

(2015) Anthony Cleare et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

(2015) Huimei Yu et al.   NATURE NEUROSCIENCE

Genomic DNA Hypomethylation Is Associated with Neural Tube Defects Induced by Methotrexate Inhibition of Folate Metabolism

(2015) Xiuwei Wang et al.   PLoS One

Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2

(2015) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

(2015) Mengying Liu et al.   G3-Genes Genomes Genetics

Effect of the one-carbon unit cycle on overall DNA methylation in children with Down's syndrome

(2015) CUI SONG et al.   Molecular Medicine Reports

Homocysteine and migraine. A narrative review

(2014) Giuseppe Lippi et al.   CLINICA CHIMICA ACTA

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

(2014) A. L. Teh et al.   GENOME RESEARCH

TET enzymes and DNA hydroxymethylation in neural development and function — How critical are they?

(2014) Mafalda Santiago et al.   GENOMICS

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial ofS-Adenosyl-l-Methionine (SAMe) Versus Escitalopram in Major Depressive Disorder

(2014) David Mischoulon et al.   JOURNAL OF CLINICAL PSYCHIATRY

S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome

(2014) Marta Varela-Rey et al.   NEURON

S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages

(2014) Anna C. Pfalzer et al.   PHYSIOLOGICAL GENOMICS

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

(2014) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assay Development for Histone Methyltransferases

(2013) Kurumi Y. Horiuchi et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase

(2013) Jean-Louis Guéant et al.   BIOCHIMIE

Autoimmunity, Inflammation, and Psychosis: A Search for Peripheral Markers

(2013) Veerle Bergink et al.   BIOLOGICAL PSYCHIATRY

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

Folate: Metabolism, genes, polymorphisms and the associated diseases

(2013) Fakhira Hassan Nazki et al.   GENE

Nutritional Control of Epigenetic Processes in Yeast and Human Cells

(2013) Meru J. Sadhu et al.   GENETICS

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation

(2013) Atsushi Iwata et al.   HUMAN MOLECULAR GENETICS

DNA 5-Methylcytosine Demethylation Activities of the Mammalian DNA Methyltransferases

(2013) Chun-Chang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Navigating the B12Road: Assimilation, Delivery, and Disorders of Cobalamin

(2013) Carmen Gherasim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid in Rett syndrome and the effect of folinic acid supplementation

(2013) Eveline E. O. Hagebeuk et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

(2013) Christina Gros et al.   NUCLEIC ACIDS RESEARCH

Regulation of Lineage Specific DNA Hypomethylation in Mouse Trophectoderm

(2013) Masaaki Oda et al.   PLoS One

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study

(2013) Domenico De Berardis et al.   TheScientificWorldJOURNAL

Randomized Multicenter Investigation of Folate Plus Vitamin B12Supplementation in Schizophrenia

(2013) Joshua L. Roffman et al.   JAMA Psychiatry

Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome

(2012) Wei Xie et al.   CELL

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

(2012) Miao Yu et al.   CELL

Forecasting PM10 in metropolitan areas: Efficacy of neural networks

(2012) H.J.S. Fernando et al.   ENVIRONMENTAL POLLUTION

Bioavailability ofS-Adenosyl Methionine and Impact on Response in a Randomized, Double-Blind, Placebo-Controlled Trial in Major Depressive Disorder

(2012) David Mischoulon et al.   JOURNAL OF CLINICAL PSYCHIATRY

Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model

(2012) Rima Obeid et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity

(2012) Douglas Tsao et al.   Molecular Pain

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

(2012) Tarang Khare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice

(2012) Andrea Fuso et al.   NEUROBIOLOGY OF AGING

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

(2012) Sílvia Fernàndez-Roig et al.   Nutrition & Metabolism

Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects?

(2012) James B Kirkbride et al.   Epigenomics

Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins?

(2011) Andrew E. Czeizel et al.   ANNALS OF NUTRITION AND METABOLISM

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Folinic Acid Supplementation in Rett Syndrome Patients Does Not Influence the Course of the Disease: A Randomized Study

(2011) Eveline E. O. Hagebeuk et al.   JOURNAL OF CHILD NEUROLOGY

Clinical and Electroencephalographic Effects of Folinic Acid Treatment in Rett Syndrome Patients

(2011) Eveline E. O. Hagebeuk et al.   JOURNAL OF CHILD NEUROLOGY

S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway

(2011) L. Gobejishvili et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder

(2011) Shabnam Nohesara et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1

(2011) Vitali Stanevich et al.   MOLECULAR CELL

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Genomic mapping of 5-hydroxymethylcytosine in the human brain

(2011) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase

(2011) Douglas Tsao et al.   PLoS One

Folate supplementation in schizophrenia: A possible role for MTHFR genotype

(2011) Michele Hill et al.   SCHIZOPHRENIA RESEARCH

Rett syndrome: Revised diagnostic criteria and nomenclature

(2010) Jeffrey L. Neul et al.   ANNALS OF NEUROLOGY

From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia

(2010) Dennis R. Grayson et al.   Epigenetics

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

(2010) Vittoria Infantino et al.   MOLECULAR GENETICS AND METABOLISM

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Structural Biology of Human H3K9 Methyltransferases

(2010) Hong Wu et al.   PLoS One

Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities

(2009) Andrew E. Czeizel   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Homocysteine and lipids: S-Adenosyl methionine as a key intermediate

(2009) Rima Obeid et al.   FEBS LETTERS

Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil

(2009) J.M. Biselli et al.   GENETICS AND MOLECULAR RESEARCH

On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

(2009) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Study of the Treatment of Rett Syndrome With Folate and Betaine

(2009) Daniel G. Glaze et al.   JOURNAL OF CHILD NEUROLOGY

Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia

(2009) María del Rosario García-Miss et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency

(2009) Andrea Fuso et al.   NEUROBIOLOGY OF AGING

Maternal Vitamin B12 Status and Risk of Neural Tube Defects in a Population With High Neural Tube Defect Prevalence and No Folic Acid Fortification

(2009) A. M. Molloy et al.   PEDIATRICS

Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child

(2009) Régine P. Steegers-Theunissen et al.   PLoS One

An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes

(2009) A. Zhubi et al.   SCHIZOPHRENIA RESEARCH

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review

(2009) Francesco Panza et al.   TheScientificWorldJOURNAL

S-adenosylmethionine and proliferation: new pathways, new targets

(2008) Nuria Martínez-López et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression

(2008) Jae-Min Kim et al.   BRITISH JOURNAL OF PSYCHIATRY

Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A

(2008) Yongna Xing et al.   CELL

Improvement of aggressive behavior and quality of life impairment following S-Adenosyl-Methionine (SAM-e) augmentation in schizophrenia

(2008) Rael D. Strous et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

(2008) Ainhoa Iglesias Ara et al.   HEPATOLOGY

High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease

(2008) Paul S. Aisen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A B  Subunit Expression That Correlate with Enhanced Tau Phosphorylation

(2008) J.-M. Sontag et al.   JOURNAL OF NEUROSCIENCE

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice

(2008) Andrea Fuso et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls

(2008) Simmi K. Ratan et al.   PEDIATRIC SURGERY INTERNATIONAL

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One