Review
Neurosciences
Parth Shirolkar, Santosh K. Mishra
Summary: The TRP channel superfamily responds to various stimuli, including itch. Six TRP channels are involved in itch perception, primarily in the skin and dorsal root ganglia. Mutations and activations of these channels can cause discomfort and disease.
NEUROSCIENCE LETTERS
(2022)
Article
Medicine, Research & Experimental
Sabrina Qader Kudsi, Bruna Candia Piccoli, Daniel Ardisson-Araujo, Gabriela Trevisan
Summary: This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset, the transcriptional levels of these channels were investigated and compared in 95 human subjects representing 33 different tissues, providing essential suggestions for further studies on these proteins.
Review
Cell Biology
Sipin Zhu, Xiaoyong Hu, Samuel Bennett, Yuliang Mai, Jiake Xu
Summary: TAFA4 is a member of the TAFA chemokine like ligand family and involved in the regulation of various biological processes, including chemotaxis and phagocytosis of macrophages. It is predominantly expressed in nociceptors and plays a role in pain perception. TAFA4 mediates the chemoattraction and inflammatory response of macrophages through binding to the receptor FPR1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Aidan McGinnis, Ru-Rong Ji
Summary: Preclinical studies have found that glial cells play a crucial role in the development and maintenance of neuropathic pain in conditions such as diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) exhibit similar characteristics and functions in the genesis of neuropathic pain. However, SGCs are not simply peripheral astrocytes and have unique roles and interactions. Recent findings also suggest that SGCs are enriched with proteins related to fatty acid metabolism, which may have implications for novel therapeutic approaches targeting glial cells.
Article
Neurosciences
Zijing Chen, Maggie Kerwin, Orlaith Keenan, Craig Montell
Summary: This study identified the structural requirements for TRP channel function in Drosophila photoreceptor cells, including the roles of the S4-S5 linker and the TRP domain, as well as the differential requirements for two highly conserved motifs in the TRP domain for activation and protein stability. Genetic complementation experiments revealed an intrasubunit interaction between the S4-S5 linker and the S5 segment in Drosophila photoreceptor cells, which contributes to channel activation.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Hannes Schmidt, Alexandra Bottcher, Tilman Gross, Achim Schmidtko
Summary: The cGMP signalling pathways play crucial roles in the somatosensory system, regulating physiological processes from embryonic development to adulthood. During embryonic development, a cGMP-dependent signalling cascade is essential for axon bifurcation, while in adulthood, various cGMP signalling pathways in different cell populations are involved in pain and itch processing.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Xiao-Xing Song, Lin-Yu Jin, Qiang Li, Xin-Feng Li, Yan Luo
Summary: This study investigated the antinociceptive effects of selective ER beta agonists on discogenic low back pain (DLBP) related behavior by regulating substance P in the spinal cord and dorsal root ganglia. The results showed that activation of ER beta could improve both axial and radiating behavioral disorders of DLBP and decrease substance P content. This study provides a therapeutic target for managing DLBP in the clinic.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Lei Yang, Beibei Liu, Shang Zheng, Longsheng Xu, Ming Yao
Summary: Bone cancer pain is a complex condition characterized by persistent, sudden, spontaneous pain accompanied by hyperalgesia. It is caused by bone metastases or primary bone tumors. The perception and transmission of pain signals involve peripheral nerves, spinal cord, and the brain. The mechanisms of bone cancer pain within the brain are not fully understood, but with advancements in brain science and technology, further research is being conducted.
Article
Medicine, Research & Experimental
Jianshu Ni, Takahisa Suzuki, Sergei V. Karnup, Baojun Gu, Naoki Yoshimura
Summary: The neutralization of nerve growth factor (NGF) can reverse the Na+ channel plasticity of bladder afferent neurons in mice with spinal cord injury (SCI), which may be a possible underlying mechanism of bladder afferent hyperexcitability and detrusor overactivity after SCI.
Article
Neurosciences
Yiming Qiao, Liren Li, Liying Bai, Yan Gao, Yin Yang, Li Wang, Xueli Wang, Zongyi Liang, Ji-Tian Xu
Summary: This study investigated the role and underlying mechanisms of lysine-specific demethylase 6B (KDM6B) in inflammatory pain. The results showed that upregulation of KDM6B in the dorsal root ganglia (DRG) and spinal dorsal horn aggravated inflammatory pain by facilitating the expression of TNF-alpha. Treatment with GSK-J4 and AAV-EGFP-KDM6B shRNA alleviated mechanical allodynia and thermal hyperalgesia, and inhibited the overproduction of TNF-alpha in the DRG and dorsal horn.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Xiaoxiong Wang, Wenxiang Li, Jianping Zhang, Jinze Li, Xianjin Zhang, Min Wang, Zhijian Wei, Shiqing Feng
Summary: This study reveals that axon regeneration after conditioning lesion is more pronounced in young mice than in old mice. The mechanism behind this difference is not clearly explained. By analyzing gene expression and constructing networks, AGTR1a is identified as a potential therapeutic target for spinal cord injury treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jennifer Fan, Santosh K. Mishra
Summary: Understanding the mechanisms of itch in cutaneous allergic diseases is crucial for developing new therapeutic approaches to relieve itch. Recent studies have focused on endogenous mediators released from immune/nonimmune skin cells and the receptors on sensory neurons, offering potential for more effective treatment of allergic itch.
Article
Neurosciences
Stephanie Puig, Howard B. Gutstein
Summary: The analgesic effect of opioids decreases over time due to the development of analgesic tolerance. In this study, we found that inhibition of the PDGFR-p signaling eliminated morphine analgesic tolerance in rats. PDGFR-p and PDGF-B were expressed in neurons and oligodendrocytes in the spinal cord, and their distribution did not change after chronic morphine exposure. However, PDGFR-p expression was downregulated in the substantia gelatinosa and upregulated in the dorsal root ganglia. These findings suggest potential mechanisms underlying opioid tolerance.
Article
Cell & Tissue Engineering
X. Jia, G. Huang, S. Wang, M. Long, X. Tang, D. Feng, Q. Zhou
Summary: The microRNA miR-381 derived from MSC-EVs can promote the recovery of SCI through the BRD4/WNT5A axis, providing a new perspective on SCI treatment.
BONE & JOINT RESEARCH
(2021)
Article
Medicine, Research & Experimental
Tyler S. Nelson, Heather N. Allen, Paramita Basu, Pranav Prasoon, Eileen Nguyen, Cynthia M. Arokiaraj, Diogo F. S. Santos, Rebecca P. Seal, Sarah E. Ross, Andrew J. Todd, Bradley K. Taylor
Summary: Neuropeptide Y targets the Y1 receptor to produce analgesia in the spinal dorsal horn. The Y1-INs, which express the Y1 receptor, are necessary and sufficient for neuropathic hypersensitivity. This study identified three subpopulations of Y1-INs based on their coexpression with gastrin releasing peptide, neuropeptide FF, and cholecystokinin. Among these subpopulations, the Grp/Npy1r-INs were found to be conserved in higher order mammalian species and may represent a promising target for the treatment of neuropathic pain.
Article
Oncology
Mamoru Hashimoto, Takahito Nakayama, Saizo Fujimoto, Shunsuke Inoguchi, Mitsuhisa Nishimoto, Takashi Kikuchi, Shogo Adomi, Eri Banno, Marco A. De Velasco, Yoshitaka Saito, Nobutaka Shimizu, Yasunori Mori, Takafumi Minami, Kazutoshi Fujita, Masahiro Nozawa, Kazuhiro Nose, Kazuhiro Yoshimura, Hirotsugu Uemura
Summary: This case report describes a 60-year-old patient with metastatic renal cell carcinoma who experienced grade 3 DIC after switching from nivolumab plus ipilimumab combination therapy to pazopanib treatment. The report emphasizes the need for careful monitoring when patients receive molecular targeted therapy after ICI-based immunotherapy.
Article
Urology & Nephrology
Nobutaka Shimizu, Daisuke Gotoh, Mitsuhisa Nishimoto, Mamoru Hashimoto, Tetsuichi Saito, Kazutoshi Fujita, Akihide Hirayama, Naoki Yoshimura, Hirotsugu Uemura
Summary: The study investigated the effectiveness of vibegron in treating lower urinary tract dysfunction in mice with spinal cord injury. Vibegron was found to reduce nonvoiding contractions during bladder filling and decrease the expression of certain receptors and inflammatory cytokines in spinal cord injury mice, indicating its potential as a treatment option for detrusor overactivity induced by C-fiber afferent activation after spinal cord injury.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Editorial Material
Urology & Nephrology
Eisuke Tomiyama, Kazutoshi Fujita, Mamoru Hashimoto, Hiroshi Miyamoto, George J. Netto, Norio Nonomura
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Joonbeom Kwon, Eun-Ju Lee, Hyun-Jung Cho, Ji-Ae Jang, Min-Su Han, Eunkyoung Kwak, Haesoo Kim, Jihyun An, Donghwi Park, Seungwoo Han, Nobutaka Shimizu, Takahisa Suzuki, Ei-Ichiro Takaoka, Naoki Yoshimura
Summary: Nintedanib improves bladder dysfunction and fibrosis in SCI mice, while also reducing expression of C-fiber afferent markers, suggesting modulation of bladder C-fiber afferent activity to improve detrusor overactivity (DO).
NEUROUROLOGY AND URODYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Yurika Hata, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Hideaki Ono, Takaaki Aratake, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: This study investigated the effects of central CRF on micturition and the involvement of CRF receptor subtypes and glutamatergic receptors. The results suggest that stimulation of brain CRFR1 may facilitate rat micturition via brain NMDA/AMPA receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Eisuke Tomiyama, Kazutoshi Fujita, Kyosuke Matsuzaki, Ryohei Narumi, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yoko Koh, Makoto Matsushita, Yujiro Hayashi, Mamoru Hashimoto, Eri Banno, Taigo Kato, Koji Hatano, Atsunari Kawashima, Motohide Uemura, Ryo Ukekawa, Tetsuya Takao, Shingo Takada, Hirotsugu Uemura, Jun Adachi, Takeshi Tomonaga, Norio Nonomura
Summary: In this study, a potential diagnostic biomarker for bladder cancer was identified and evaluated by analyzing cancer-specific proteins secreted in urinary extracellular vesicles (uEVs). An enzyme-linked immunosorbent assay (ELISA) was developed to quantify the uEV protein biomarker, leading to a non-invasive early clinical diagnosis of bladder cancer. The study also revealed the functional role of Ephrin type-A receptor 2 (EphA2) in bladder cancer progression.
BRITISH JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Nobutaka Shimizu, Tetsuichi Saito, Naoki Wada, Mamoru Hashimoto, Takahiro Shimizu, Joonbeom Kwon, Kang Jun Cho, Motoaki Saito, Sergei Karnup, William C. de Groat, Naoki Yoshimura
Summary: This article summarizes the current progress in fundamental studies of lower urinary tract dysfunction (LUTD) after spinal cord injury (SCI). Animal models of SCI have allowed researchers to investigate the effects of SCI on micturition control and the underlying neurophysiological processes. SCI disrupts the normal reflex circuits that regulate bladder and urethral sphincter function, leading to involuntary and inefficient voiding. These findings provide a better understanding of the pathophysiological mechanisms of LUTD after SCI and may contribute to the development of novel therapies for SCI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Takahira Kuno, Kenji Tamura, Nobutaka Shimizu, Hideo Fukuhara, Satoshi Fukata, Shingo Ashida, Takashi Karashima, Hirofumi Satake, Kohji Sawada, Ichiro Yamasaki, Fumito Komatsu, Hajime Kuroiwa, Motoaki Saito, Keiji Inoue
Summary: In this study, the treatment effects of vibegron on elderly Japanese patients with overactive bladder were evaluated. The results showed that vibegron significantly improved OABSS and OAB-q SF, especially in patients aged 80 and above. Furthermore, switching from mirabegron to vibegron also resulted in significant improvements to residual urine volume.
RESEARCH AND REPORTS IN UROLOGY
(2023)
Article
Pharmacology & Pharmacy
Nobutaka Shimizu, Takahiro Shimizu, Youichirou Higashi, Suo Zou, Hideo Fukuhara, Takashi Karashima, Keiji Inoue, Motoaki Saito
Summary: In our previous study, we found that & alpha;7 nicotinic acetylcholine receptors in the brain inhibited the rat micturition reflex, and we investigated the relationship between & alpha;7 nicotinic acetylcholine receptors and hydrogen sulphide (H2S) as H2S also inhibits the rat micturition reflex in the brain. Through cystometry in male Wistar rats, we examined the effects of H2S and H2S synthesis inhibitor on the activation of & alpha;7 nicotinic acetylcholine receptors in prolonging intercontraction intervals. Our results suggest that brain H2S may be involved in inhibiting the rat micturition reflex induced by activation of brain & alpha;7 nicotinic acetylcholine receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Takahisa Suzuki, Takahiro Shimizu, Sergei Karnup, Nobutaka Shimizu, Jianshu Ni, William C. de Groat, Naoki Yoshimura
Summary: This study found that p38 MAPK activity plays an important role in the electrophysiological properties of capsaicin-sensitive bladder afferent neurons in SCI mice, especially in the changes in KA currents. Evaluating the changes in KA currents is crucial for understanding the hyperexcitability of these neurons in SCI mice.
Review
Urology & Nephrology
Eisuke Tomiyama, Kazutoshi Fujita, Mamoru Hashimoto, Hirotsugu Uemura, Norio Nonomura
Summary: Bladder cancer is a common urological cancer, and early detection is important for prognosis. However, the current detection method, cystoscopy, is invasive and expensive. Therefore, researchers have been focusing on finding urinary markers for bladder cancer detection. Although some markers have been approved, their use in clinical practice is limited. Prospective clinical trials are needed to facilitate clinical application of potential urinary markers.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Mamoru Hashimoto, Nobutaka Shimizu, Saizo Fujimoto, Ken Kuwahara, Mitsuhisa Nishimoto, Shogo Adomi, Eri Banno, Takafumi Minami, Kazutoshi Fujita, Kazuhiro Yoshimura, Akihide Hirayama, Hirotsugu Uemura
Summary: This study aimed to elucidate the pathophysiology of post-micturition dribble (PMD) by analyzing pressure flow study (PFS) findings and symptoms questionnaire. The results showed that PMD was significantly associated with larger prostate volume (PV) and higher bladder outlet obstruction index (BOOI) evaluated by PFS. Furthermore, PMD was found to significantly exacerbate the quality of life (QOL). The severity of PMD and other m-IPSS sub-scores (except nocturia) could have intercorrelation with each other.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Suo Zou, Takahiro Shimizu, Atsushi Kurabayashi, Masaki Yamamoto, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: In this study, it was found that hydrogen sulfide pretreatment can prevent bladder dysfunction caused by cyclophosphamide treatment by suppressing the activity of bladder afferent nerves, rather than by inhibiting bladder inflammation. Therefore, hydrogen sulfide may be a new candidate as a protective drug for bladder dysfunction induced by cyclophosphamide chemotherapy.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Review
Urology & Nephrology
Naoki Wada, Sergei Karnup, Katsumi Kadekawa, Nobutaka Shimizu, Joonbeom Kwon, Takahiro Shimizu, Daisuke Gotoh, Hidehiro Kakizaki, William C. de Groat, Naoki Yoshimura
Summary: This review article summarizes the recent advancements in basic research on lower urinary tract dysfunction following spinal cord injury, focusing on neurophysiologic mechanisms and changes in micturition control in animal models of SCI. It discusses how SCI impairs voluntary control of voiding and normal reflex pathways, leading to bladder hyperreflexia but inefficient bladder emptying.
UROLOGICAL SCIENCE
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)