Journal
NEUROSCIENCE LETTERS
Volume 688, Issue -, Pages 26-36Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2018.04.035
Keywords
Eyeblink conditioning; Climbing fibers; Olivocerebellar system; Associative learning; Purkinje cell
Categories
Funding
- Dutch Organization for Medical Sciences (ZonMw)
- Life Sciences (ALW)
- European Community
- Netherlands Organization for Scientific Research (NWO)
Ask authors/readers for more resources
The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available