Article
Endocrinology & Metabolism
Peter Bang, Michel Polak, Artur Bossowski, Mohamad Maghnie, Jesus Argente, Marta Ramon-Krauel, Caroline Sert, Valerie Perrot, Sarah Mazain, Joachim Woelfle
Summary: This analysis of the Eu-IGFD data aimed to identify the frequency and predictive factors for hypoglycemia adverse events (AEs) in children treated with rhIGF-1. The results showed that patients with a prior history of hypoglycemia and/or Laron syndrome were more likely to experience hypoglycemia AEs, and they should be carefully monitored throughout treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Ana-Belen Ariza-Jimenez, Isabel Leiva Gea, Maria Jose Martinez-Aedo Ollero, Juan Pedro Lopez-Siguero
Summary: The study found that patients with isolated growth hormone deficiency (IGHD) and idiopathic short stature (ISS) who received growth hormone treatment had similar final heights, with treated groups being taller than untreated groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Huahong Wu, Yang Li, Hui Li
Summary: This study analyzed the prevalence of BDA3 in children with short stature and its effect on GH therapy. The results showed that BDA3 is more common in the short stature group, with a predominance in females. BDA3 occurrence is independent of the GH pathway and does not affect the therapeutic effect of GH on short stature children.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Peter Bang, Michel Polak, Valerie Perrot, Caroline Sert, Haris Shaikh, Joachim Woelfle
Summary: This study analyzed pubertal growth outcomes of children and adolescents with severe primary IGF-1 deficiency treated with rhIGF-1. Results showed an increase in height SDS in prepubertal years, despite delayed puberty and slightly lower pubertal peak height velocity (PPHV). Overall, the height SDS gain during puberty was maintained.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Gajanthan Muthuvel, Andrew Dauber, Eirene Alexandrou, Leah Tyzinski, Melissa Andrew, Vivian Hwa, Philippe Backeljauw
Summary: This study aimed to evaluate the efficacy and safety of recombinant human growth hormone (rhGH) therapy for linear growth in children with ACAN deficiency. The results showed that rhGH treatment improved linear growth in these patients and no adverse events related to rhGH were observed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Xiaoxiao Zhu, Sheng Nie, Yamin Zhu, Yiming Chen, Bo Yang, Wang Li
Summary: Two space-borne LiDAR missions, GEDI and ICESat-2, have been evaluated for their performance in extracting terrain and canopy heights in short-stature vegetation. ICESat-2 outperforms GEDI in terrain height extraction, while both missions perform similarly in canopy height retrievals. The results also highlight the influence of factors such as terrain slope and canopy height on retrieval accuracies. These findings demonstrate the potential of ICESat-2 data in short-stature vegetation areas and provide insights for future applications of LiDAR data.
Article
Endocrinology & Metabolism
G. Akin Kagizmanli, D. Ozalp Kizilay, O. Besci, K. Yuksek Acinikli, S. Ozen, K. Demir, R. D. Goksen Simsek, E. Bober, S. Darcan, A. Abaci
Summary: This study evaluated the effects of combined AI and rhGH therapy for 1 year in adolescent males with GHD. The results showed that using AIs in addition to rhGH treatment can slow down bone age maturation in boys with GHD, and the therapy was found to be safe during the observation period.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Pediatrics
Veronica Grigoletto, Alessandro Agostino Occhipinti, Maria Chiara Pellegrin, Fabio Sirchia, Egidio Barbi, Gianluca Tornese
Summary: This study identified three different types of familial short stature, including target height-related short stature, suspected autosomal dominant short stature, and constitutional familial short stature. Adequate measurement and consideration of children's and parents' heights are crucial in the clinical evaluation of children with short stature.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Joseph Freer, Joanna Orr, Joan K. Morris, Robert Walton, Leo Dunkel, Helen L. Storr, Andrew J. Prendergast
Summary: Short stature at age 3 is associated with lower language development scores from 3 to 11 years of age in UK children, and this association remains significant after adjusting for other factors.
Article
Medicine, General & Internal
Mohsina Noor Ibrahim, Nadeem Noor, Mehrun Nisa, Taj Muhammad Leghari, Yasir Naqvi Khan, Jamal Raza
Summary: By conducting insulin tolerance test (ITT) on 348 children, it was found that the peak growth hormone levels were mostly achieved at 60 minutes, followed by 90 minutes and then 30 minutes. Samples taken at 0, 30, 60, and 90 minutes are adequate to confirm the diagnosis of growth hormone deficiency.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Endocrinology & Metabolism
Hyun Wook Chae, Il-Tae Hwang, Ji-Eun Lee, Cheol Hwan So, Young-Jun Rhie, Jung Sub Lim, Eun Byul Kwon, Kyung Hee Yi, Eun Young Kim, Chae-Ku Jo, Kye Shik Shim, Ha-Yeong Gil, Min-Jeong Seong, Chung Mo Nam, Ji-Su Moon, Jin Soon Hwang
Summary: This study aimed to investigate the height development of ISS patients in Korea who received GH treatment. The study found that starting treatment at an early age and using automatic pen or electronic devices can increase the likelihood of reaching the target height.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Integrative & Complementary Medicine
Aram Jeong, Beom-Chan Park, Hee-Yeon Kim, Jun-Yong Choi, Jinhong Cheon, Joung-Hyun Park, Bae-Jin Lee, Kibong Kim
Summary: This study suggests that fermented oyster extract supplementation may help increase children's height, potentially mediated by its effects on IGFBP-3 levels.
INTEGRATIVE MEDICINE RESEARCH
(2021)
Article
Endocrinology & Metabolism
Lukas Plachy, Shenali Anne Amaratunga, Petra Dusatkova, Klara Maratova, Vit Neuman, Lenka Petruzelkova, Dana Zemkova, Barbora Obermannova, Marta Snajderova, Stanislava Kolouskova, Zdenek Sumnik, Jan Lebl, Stepanka Pruhova
Summary: The genetic etiology of short stature in children with diagnosed growth hormone deficiency (GHD) was studied. It was found that the primary cause of short stature in these children was growth plate disorders, not deficiency in growth hormone.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Yaping Ma, Ruofan Jia, Bingyang Xia, Bin Tang, Zhuangjian Xu
Summary: This study demonstrates that the combination of growth hormone and letrozole can enhance adult height in pubertal boys with short stature, without significant side effects.
Article
Pediatrics
Tal Ben-Ari, Gabriel Chodick, Varda Shalev, Dalit Goldstein, Roy Gomez, Zohar Landau
Summary: A decade-long study in Israel assessed growth hormone treatment patterns and outcomes, finding that most treated children were males with a height standard deviation score of -2.36 and an average age of 9.8 years at initiation. The study also revealed that the mean treatment period was 3.5 years, with good adherence declining over time.
FRONTIERS IN PEDIATRICS
(2021)
Article
Neurosciences
Patricia Rivera, Santiago Guerra-Cantera, Antonio Vargas, Francisca Diaz, Rocio Garcia-Ubeda, Ruben Tovar, Maria Teresa Ramirez-Lopez, Jesus Argente, Fernando Rodriguez de Fonseca, Juan Suarez, Julie A. Chowen
Summary: This study aimed to investigate the long-lasting effects of maternal malnutrition during gestation/lactation on inflammation, lipid metabolism, and endocannabinoid signaling in the adult offspring hypothalamus, as well as the role of hypothalamic astrocytes in these changes. The results showed that maternal malnutrition caused sex-specific alterations in hypothalamic endocannabinoid signaling and lipid metabolism. Additionally, hypothalamic astrocytes were found to play a possible role in this process.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Peter Bang, Michel Polak, Valerie Perrot, Caroline Sert, Haris Shaikh, Joachim Woelfle
Summary: This study analyzed pubertal growth outcomes of children and adolescents with severe primary IGF-1 deficiency treated with rhIGF-1. Results showed an increase in height SDS in prepubertal years, despite delayed puberty and slightly lower pubertal peak height velocity (PPHV). Overall, the height SDS gain during puberty was maintained.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Acoustics
Adrian P. Regensburger, Alexandra L. Wagner, Vera Danko, Joerg Juengert, Anna Federle, Daniel Klett, Stephanie Schuessler, Adrian Buehler, Markus F. Neurath, Andreas Roos, Hanns Lochmueller, Joachim Woelfle, Regina Trollmann, Maximilian J. Waldner, Ferdinand Knieling
Summary: Proximal spinal muscular atrophy (SMA) is a rare genetic motor neuron disease with limited treatment monitoring biomarkers. A study demonstrated that handheld Multispectral Optoacoustic Tomography (MSOT) can visualize and quantify muscle wasting in pediatric SMA patients, showing significant differences in optoacoustic signal patterns compared to healthy volunteers. This non-invasive imaging approach could potentially provide a valuable tool for assessing disease burden in SMA patients.
Article
Endocrinology & Metabolism
Katharina Warncke, Alexander Eckert, Thomas Kapellen, Sebastian Kummer, Klemens Raile, Desiree Dunstheimer, Jurgen Grulich-Henn, Joachim Woelfle, Sandra Wenzel, Sabine E. Hofer, Axel Dost, Reinhard W. Holl
Summary: This study describes the clinical presentation and long-term outcomes of patients with ABCC8/KCNJ11 variants in diabetes. ABCC8/KCNJ11 variants should be suspected in children diagnosed with diabetes, as many patients can switch from insulin to oral antidiabetic drugs. Despite some patients temporarily stopping medication, they are still able to maintain good metabolic control.
PEDIATRIC DIABETES
(2022)
Article
Pediatrics
Anna Kern, Pia H. Kuhlmann, Stefan Matl, Markus Ege, Nicole Maison, Jana Eckert, Ulrich von Both, Uta Behrends, Melanie Anger, Michael C. Fruehwald, Michael Gerstlauer, Joachim Woelfle, Antje Neubert, Michael Melter, Johannes Liese, David Goettler, Andreas Sing, Bernhard Liebl, Johannes Huebner, Christoph Klein, COVID Kids Bavaria Consortium
Summary: The multi-center, open cohort study (COVID-Kids-Bavaria) investigated the distribution of acute SARS-CoV-2 infections among children and staff in daycare facilities and elementary schools in Bavaria, Germany. The study found that during the initial waves of the pandemic, the risk of a positive SARS-CoV-2 result was positively correlated with the local 7-day incidence. However, there was unlikely to be an increased risk of SARS-CoV-2 transmission in daycare and elementary school settings.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Vinicius N. Brito, Ana P. M. Canton, Carlos Eduardo Seraphim, Ana Paula Abreu, Delanie B. Macedo, Berenice B. Mendonca, Ursula B. Kaiser, Jesus Argente, Ana Claudia Latronico
Summary: The etiology of central precocious puberty (CPP) is diverse, including congenital and acquired causes, with associations to structural and functional brain alterations. All causes of CPP lead to premature secretion of hypothalamic GnRH, resulting in premature reactivation of the hypothalamic-pituitary-gonadal axis. Excitatory factors and inhibitory factors play important roles in the mechanisms of CPP, which are delicately balanced. Hypothalamic hamartoma is the most well-known congenital cause of CPP, and genetic and epigenetic factors have been found to be influential in the etiology of CPP.
Article
Dermatology
Antonio Torrelo, Laura Pericet, Isabel Hernandez-Surmann, Gabriel Martos, Ana Mateos-Mayo, Lucero Noguera-Morel, Angela Hernandez-Martin, Jesus Argente, Isabel Colmenero
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Review
Endocrinology & Metabolism
Jesus Argente, Leo Dunkel, Ursula B. Kaiser, Ana C. Latronico, Alejandro Lomniczi, Leandro Soriano-Guillen, Manuel Tena-Sempere
Summary: Puberty, a major maturational event, is determined by genetic factors and influenced by endogenous and environmental cues. Research progress has been made in understanding the neuroendocrine networks governing puberty, but the precise timing and mechanisms of puberty and its alterations are still being deciphered. This review provides a comprehensive overview of the physiological basis of puberty, including the roles of kisspeptins and other central transmitters, the underlying molecular and endocrine mechanisms, and the pathways involved in pubertal modulation. Molecular features of precocious and delayed puberty are also summarized. The review highlights the need for further research in this active field of endocrinology.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Infectious Diseases
Alisa Baer, Sabina Schmitt-Grohe, Juergen Held, Julia Lubig, Gregor Hanslik, Fabian B. Fahlbusch, Heiko Reutter, Joachim Woelfle, Adriana van der Donk, Maria Schleier, Tobias Hepp, Patrick Morhart
Summary: This single-center study provides insight into the clinical dichotomy of bacterial colonization and infection rates in neonates. The findings suggest that colonization with multidrug-resistant Gram-negative bacteria and Serratia marcescens might promote infection in some cases.
Article
Primary Health Care
H. L. Storr, J. Freer, J. Child, J. H. Davies
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Editorial Material
Primary Health Care
Justin H. Davies, Jenny Child, Joseph Freer, Helen L. Storr
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Editorial Material
Endocrinology & Metabolism
Jesus Argente, Manuel Tena-Sempere
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Peter Bang, Michel Polak, Artur Bossowski, Mohamad Maghnie, Jesus Argente, Marta Ramon-Krauel, Caroline Sert, Valerie Perrot, Sarah Mazain, Joachim Woelfle
Summary: This analysis of the Eu-IGFD data aimed to identify the frequency and predictive factors for hypoglycemia adverse events (AEs) in children treated with rhIGF-1. The results showed that patients with a prior history of hypoglycemia and/or Laron syndrome were more likely to experience hypoglycemia AEs, and they should be carefully monitored throughout treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medical Laboratory Technology
Gregori Casals, Roser Ferrer Costa, Eulalia Urgell Rull, Hector F. Escobar-Morreale, Jesus Argente, Gemma Sesmilo, Betina Biagetti
Summary: Accurate and reproducible laboratory results for sexual steroids are crucial for diagnosing and treating a wide range of disorders. However, the currently available chemiluminescent immunoassays have limitations that significantly impact clinical scenarios. This position statement examines these limitations and recommends incorporating steroid hormone analysis by mass spectrometry in national health systems, a methodology that international societies have endorsed for a decade.
ADVANCES IN LABORATORY MEDICINE-AVANCES EN MEDICINA DE LABORATORIO
(2023)
Article
Pediatrics
Colin A. Goebel, Emma Brown, Fabian B. Fahlbusch, Alexandra L. Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Spaeth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P. Regensburger, Ferdinand Knieling
Summary: In this study, label-free raster scanning optoacoustic mesoscopy (RSOM) was used to visualize and quantify murine renal vasculature in explanted organs. The results demonstrated the capability of RSOM for high-resolution imaging of vascular morphology in ex vivo murine renal tissue, suggesting its potential for further preclinical and clinical imaging applications.
MOLECULAR AND CELLULAR PEDIATRICS
(2022)