Article
Biochemistry & Molecular Biology
Xiaohan Luan, Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun
Summary: CypA positively regulates the IL-6 trans-signaling pathway by inhibiting degradation of IL-6 membrane receptor gp130 and enhancing its dimerization, while its expression is negatively regulated by SOCS1. SOCS1 interacts with CypA and promotes its degradation through ubiquitination, thus inhibiting the IL-6 trans-signaling pathway.
Article
Psychiatry
Keane Lim, Oon-Him Peh, Zixu Yang, Gurpreet Rekhi, Attilio Rapisarda, Yuen-Mei See, Nur Amirah Abdul Rashid, Mei-San Ang, Sara-Ann Lee, Kang Sim, Hailiang Huang, Todd Lencz, Jimmy Lee, Max Lam
Summary: This study established a five-factor PANSS model from a large multi-ethnic sample, validated its consistency with existing PANSS models through meta-analysis, and evaluated its temporal stability and generalizability to individuals at ultra-high risk (UHR) of psychosis. The findings provide crucial evidence for a common PANSS structure that can enhance our understanding of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Pernille Kolbaek, David Dines, Johanna Hansen, Mark Opler, Christoph U. Correll, Ole Mors, Soren D. Ostergaard
Summary: Most staff members in a Danish psychiatric hospital conducted accurate PANSS-6 ratings after a brief video-based training program, supporting the implementation of PANSS-6 in clinical settings to facilitate measurement-based care.
SCHIZOPHRENIA RESEARCH
(2021)
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Article
Biochemistry & Molecular Biology
David G. Hill, Amy Ward, Lindsay B. Nicholson, Gareth W. Jones
Summary: IL-6 family cytokines play important roles in regulating immune homeostasis, host defence, hematopoiesis, and development, while dysregulation of these activities may lead to autoimmunity, chronic inflammation, and cancer. Ectopic lymphoid structures (ELS) can support local antigen-specific responses and are associated with disease progression in autoimmune conditions and favorable prognosis in cancer.
Article
Psychiatry
Milica M. Borovcanin, Slavica Minic Janicijevic, Natasa R. Mijailovic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic, Katarina Vesic
Summary: This study suggests a potential association between uric acid levels and inflammatory responses in different phases of schizophrenia. However, the exact mechanism underlying the involvement of uric acid in the pathogenesis of schizophrenia remains uncertain.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Fredrik Hieronymus, Christoph Ulrich Correll, Soren Dinesen ostergaard
Summary: The study found that greater initial severity is positively correlated with the difference between antipsychotic and placebo and trial dropout. Analyzing patient-level data from 18 placebo-controlled trials, the researchers discovered a significant relationship between initial severity and antipsychotic-placebo separation on PANSS-30 and its subscales. These findings suggest that initial severity can serve as a predictor of antipsychotic efficacy and trial dropout.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Lone Baandrup, Peter Allerup, Mette O. Nielsen, Signe W. Duering, Kirsten B. Bojesen, Stefan Leucht, Silvana Galderisi, Armida Mucci, Paola Bucci, Celso Arango, Covadonga M. Diaz-Caneja, Paola Dazzan, Philip McGuire, Arsime Demjaha, Bjorn H. Ebdrup, Wolfgang W. Fleischhacker, Rene S. Kahn, Birte Y. Glenthoj
Summary: This study aimed to examine the scalability and clinical performance of the PANSS scale, but found lack of statistical fit of the Rasch model, suggesting the need to consider the measure of uncertainty when using the PANSS-30 total score.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhou, Bo Tian, Hai-Bin Han
Summary: This meta-analysis found that serum IL-6 levels are elevated in schizophrenia, supporting the role of inflammatory abnormalities in the pathogenesis of the disease. Additionally, post-treatment, there is a significant decrease in serum IL-6 levels in schizophrenia patients, suggesting that an anti-inflammatory mechanism may be effective during antipsychotic treatment.
Article
Clinical Neurology
Pu Peng, Dongmei Wang, Qianjin Wang, Yanan Zhou, Yuzhu Hao, Shubao Chen, Qiuxia Wu, Tieqiao Liu, Xiangyang Zhang
Summary: Emerging studies suggest that oxidative stress may be involved in deficit syndrome in patients with schizophrenia. Homocysteine, a marker of oxidative stress, is closely associated with schizophrenia. This study found a high incidence of hyperhomocysteinemia and deficit syndrome in patients with schizophrenia. Age, homocysteine levels, and psychiatric symptoms were independently associated with deficit syndrome. Regular monitoring of homocysteine is important for early detection of deficit syndrome in patients with schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Simao Kagan, Hugo Cogo-Moreira, Matheus Ghossain Barbosa, Daniel Cavalcante, Andre Shinji, Mariane Noto, Bernardo Haguiara, Quirino Cordeiro, Sintia Belangeiro, Rodrigo A. Bressan, Cristiano Noto, Ary Gadelha
Summary: The study found that the PANSS negative unidimensional model is suitable for assessing the longitudinal change of negative symptoms in first-episode schizophrenia patients, while the two-correlated model did not show longitudinal invariance.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Review
Cell Biology
Thelma Beatriz Gonzalez-Castro, Carlos Alfonso Tovilla-Zarate, Isela Esther Juarez-Rojop, Yazmin Hernandez-Diaz, Maria Lilia Lopez-Narvaez, Rosa Felicita Ortiz-Ojeda
Summary: Inconsistent data were found in studies investigating the association between the IL-6/IL-6R axis and schizophrenia susceptibility. A meta-analysis showed increased IL-6 levels in plasma, serum, or CSF and decreased IL-6R levels in serum in patients under treatment. Further studies are needed to clarify the correlation between the IL-6/IL-6R axis and schizophrenia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Psychiatry
Alan Shafer, Federico Dazzi
Summary: Previous meta-analyses of the BPRS-E and PANSS were combined to analyze a total of 77 factor analyses from 68 studies involving 32,896 individuals. Five consistent factors were identified across all solutions: Positive Symptoms, Affect, Negative Symptoms, Disorganization, and Activation-Mania. The factors were defined by a combination of original BPRS items, additional PANSS items, and additional BPRS-E items. The results were more comprehensive and clearer compared to previous analyses, suggesting future research could benefit from utilizing all items from both scales.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Javier Manchon, Maria Jose Quiles, Yolanda Quiles, Sofia Lopez-Roig
Summary: The study evaluated the Spanish version of the Positive-Negative Emotional Eating Scale in a sample of 628 participants, confirming the original two-factor structure of Negative Emotional Eating and Positive Emotional Eating. The results showed that Positive Emotional Eating significantly predicted binge eating and acted as a partial mediator variable, demonstrating the success of the adaptation process.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Cecilie Marie Nielsen, Pernille Kolbaek, David Dines, Martin Locht Pedersen, Andreas Aalkjaer Danielsen, Camilla Holmgard, Sanne Wissing, Anne-Mette Esbol, Nina Friis Bak Fuglsang, Tuan Dang Nguyen, Ole Mors, Mark Opler, Christoph U. Correll, Soren Dinesen Ostergaard
Summary: This study confirmed the validity of PANSS-6 ratings derived from SNAPSI in assessing the severity of schizophrenia symptoms among outpatients. These ratings were found to be acceptable and can be used as a tool for evaluating the severity of the disease.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)