Article
Endocrinology & Metabolism
Heather Cuff, Katherine Lord, Lance Ballester, Tryce Scully, Nicole Stewart, Diva D. De Leon
Summary: This study evaluated the effectiveness and safety of lanreotide in individuals with HI, showing that lanreotide is a well-tolerated treatment resulting in a longer duration of fasting and simplification of treatment regimens.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Chisa Inoue, Kota Nishihama, Aoi Hayasaki, Yuko Okano, Akinobu Hayashi, Kazuhito Eguchi, Mei Uemura, Toshinari Suzuki, Taro Yasuma, Takeshi Inoue, Tohru Yorifuji, Shugo Mizuno, Esteban C. Gabazza, Yutaka Yano
Summary: The patient is a 28-year-old Japanese man diagnosed with severe congenital hyperinsulinemic-hypoglycemia. He developed necrotizing acute pancreatitis at 28 years of age, which was thought to be caused by diazoxide. After surgery, his hypoglycemia improved.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Rana Al Balwi, Dalal Bubshait, Raed Al Nefily, Omar Al Ghamdi
Summary: Congenital hyperinsulinism (CHI) is a condition characterized by dysregulated insulin secretion leading to severe hypoglycemia. Mutations in the ABCC8 and KCNJ11 genes are common among CHI patients, with autosomal recessive CHI being the most prevalent type among Saudi patients. Implications of novel compound heterozygous variants in the ABCC8 gene in a Saudi infant with diazoxide-unresponsive CHI were discussed, highlighting the potential pathogenicity of the variants.
Review
Endocrinology & Metabolism
Congli Chen, Yanmei Sang
Summary: Congenital hyperinsulinemia (CHI) is a clinically diverse disorder that causes persistent and recurrent hypoglycemia in infancy and childhood. There are 16 subtypes of CHI-related genes, with phosphomannomutase 2 hyperinsulinemia (PMM2-HI) being an extremely rare subtype. This review highlights the genetic pathogenesis, and current diagnostic and therapeutic advances of PMM2-HI to raise awareness among clinicians.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Wafaa Laimon, Hadil Mohamed Aboelenin, Noha T. El Tantawi
Summary: ABCC8 mutation was the most common genetic mutation in this study, and patients with biparental homozygous ABCC8 mutation may respond to combined octreotide and diazoxide therapy. More than 50% of patients had neurodevelopmental impairment at follow-up. Delayed referral, delayed diagnosis, and longer hospital stay are significant predictors of neurological disability in CHI cases.
PEDIATRIC DIABETES
(2021)
Article
Chemistry, Medicinal
Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Emmanuel Sturchler, Julie Nguyen, Hannah Tan, Christine Staley, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Lance Goulet, Rosa Luo, Melissa Fowler, Jon Athanacio, Stacy Markison, R. Scott Struthers, Yunfei Zhu
Summary: The activation of SST5 receptors strongly inhibits insulin secretion, and a newly discovered nonpeptide selective SST5 agonist shows potential for managing blood glucose levels in congenital HI patients. The agonist exhibits excellent potency and selectivity against other receptors and has promising pharmacokinetic profiles in animal models.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Endocrinology & Metabolism
Henrike Hoermann, Marcia Roeper, Roschan Salimi Dafsari, Felix Koestner, Christina Reinauer, Ertan Mayatepek, Thomas Meissner, Sebastian Kummer
Summary: Transient hyperinsulinism (THI) is a hypoglycemia disorder associated with perinatal stress. The study found that diazoxide is effective in treating children with THI, but further research is needed to establish criteria and procedures for treatment initiation and discontinuation. Establishing consensus diagnostic criteria/definitions for THI would improve comparability between studies.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Saloua Ait Souabni, Antoine Harvengt, Camille Legat, Philippe A. Lysy
Summary: Kabuki syndrome is a congenital condition characterized by facial dysmorphic features, but it can also present with other symptoms such as hypoglycemia in newborns with a specific gene variant. Treatment with diazoxide can be started and replaced with lanreotide if glycemic control is not achieved. We report a case of a newborn with hyperinsulinemic hypoglycemia and a KDM6A gene mutation who was initially treated with diazoxide and later with lanreotide due to side effects.
CLINICAL CASE REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Olesja Rogoza, Kaspars Megnis, Marija Kudrjavceva, Aija Gerina-Berzina, Vita Rovite
Summary: Somatostatin receptors play a crucial role in the treatment of neuroendocrine tumors, delaying tumor progression and regulating hormone overproduction. The expression level of SSTRs has predictive value in therapeutic response and patient survival rate. Future research will focus on other epigenetic regulators affecting somatostatin signaling and combination therapy strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Neha Malhotra, Daphne Yau, Annaruby Cunjamalay, Buddhi Gunasekara, S. Athanasakopoulou, Clare Gilbert, Kate Morgan, Mehul Dattani, Antonia Dastamani
Summary: This study aimed to investigate the effectiveness of low-dose (<5 mg/kg/day) diazoxide in the treatment of transient hyperinsulinism (THI). The results showed that doses of diazoxide below 5 mg/kg/day were effective in treating THI, with mild side effects.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa J. States, J. Christopher Davis, Steven M. Hamel, Susan A. Becker, Hongming Zhuang
Summary: Congenital hyperinsulinism is a condition characterized by persistent hypoglycemia due to excessive insulin secretion, with varying clinical course and potential cure through surgical resection of focal lesions.F-18-6-fluoro-L-dopa PET/CT plays a vital role in detection and management of this condition.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Shoshana Newman-Lindsay, Satyan Lakshminrusimha, Deepika Sankaran
Summary: Hypoglycemia in neonates is often caused by hyperinsulinemic hypoglycemia, and diazoxide is the recommended medication for treatment. However, the use of diazoxide in neonates can lead to adverse effects such as pulmonary hypertension, especially in preterm infants with pre-existing risk factors. This article reviews the mechanism of action and adverse effects of diazoxide and presents a case series of neonates treated with diazoxide, highlighting the importance of thoughtful management in preterm neonates with risk factors for pulmonary hypertension.
Review
Endocrinology & Metabolism
Mirjam E. van Albada, Pratik Shah, Terry G. J. Derks, Sabine Fuchs, Judith J. M. Jans, Valerie Mclin, Hubert P. J. van der Doef, IRCPSS
Summary: In physiological glucose homeostasis, the liver plays a crucial role in glucose extraction and storage, as well as insulin elimination. Patients with a congenital porto-systemic shunt provide important insights into the role of the portal circulation and hepatic function in different phases of glucose homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Paul S. Thornton, Diva D. De Leon, Susann Empting, David Zangen, David M. Kendall, Sune Birch, Eva Boge, Jelena Ivkovic, Indraneel Banerjee
Summary: This study evaluated the efficacy and safety of continuous subcutaneous infusion of dasiglucagon as an add-on treatment for children with CHI and persistent hypoglycemia. Dasiglucagon was found to significantly reduce the frequency and severity of hypoglycemic episodes, and was well tolerated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Environmental Sciences
Muhammad Irfan, Xianhua Liu, Khalid Hussain, Suraya Mushtaq, Jonnathan Cabrera, Pingping Zhang
Summary: This study conducted a quantitative and qualitative bibliometric analysis on cadmium pollution research, highlighting the contributions of China, the USA, and India. The main sources of cadmium are mining, industry, wastewater, sedimentation, and agricultural activities. In developing countries, people are mainly exposed to cadmium through air, freshwater, and food.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Muhammad Mahroz Hussain, Irshad Bibi, Fawad Ali, Zulfiqar Ahmad Saqib, Muhammad Shahid, Nabeel Khan Niazi, Khalid Hussain, Sabry M. Shaheen, Hailong Wang, Qamar Shakil, Jorg Rinklebe
Summary: This study explores the impact of different ameliorants on the geochemical distribution of arsenic in two soils and highlights the pivotal role of organic amendments, particularly biochar, in immobilizing arsenic under paddy soil conditions.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Computer Science, Cybernetics
Mudassir Husnain, Fauzia Syed, Khalid Hussain, Qingyu Zhang, Muhammad Usman, Muzhar Javed
Summary: This study investigates the phenomenon of brand hate and seeks to understand the underlying mechanism of brand hate. The findings reveal that brand embarrassment triggers brand hate, which in turn leads to brand detachment. Consumer vanity enhances the effects of brand embarrassment on brand hate, and this relationship is more pronounced among young consumers. This study provides valuable insights for brand managers in understanding the consequences of embarrassing situations and developing preventive strategies.
Article
Engineering, Biomedical
Khalid Hussain, Suhaib Ajaz Khan, Mehreen Muzaffar, Zaynab Rashid Khan, Sheikh Umar Farooq
Summary: Early detection of COVID-19 infection is crucial to prevent fatalities. Chest radiography has been proven effective and affordable for detecting the virus. This study evaluates the performance of various CNN architectures on a dataset of 5902 chest X-ray images, and finds that the DenseNet-121 model performs best in terms of accuracy, sensitivity, and specificity.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Review
Genetics & Heredity
Amira Kohil, Atiyeh M. Abdallah, Khalid Hussain, Mashael Al-Shafai
Summary: This study reviewed the genetic basis of Woodhouse-Sakati syndrome (WSS) and reported the genetic variants and clinical phenotypes associated with the disease. A total of 25 studies with 185 patients from 97 families in 12 different countries were included. Consanguineous marriages were common in the Greater Middle East region. Thirteen different DCAF17 variants were associated with WSS development, with the most frequent variant being a frameshift deletion variant unique to Arabs.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Plant Sciences
Amna Shahzadi, Khalid Hussain, Khalid Nawaz, Zainab Abdul Rouf, Mehreen Javeria, Iqra Iqbal, Noshia Arshad, Huma Riaz, Rida Akram, Rida Zainab, Durre Nayab
Summary: Experiments were conducted to alleviate the negative effects of drought on two tomato varieties, Rio Grande and Yaqui, using plant growth regulators IAA and NAA. Drought stress significantly reduced growth, physiological attributes, and yield. Yaqui variety exhibited more severe effects from drought compared to Rio Grande. Antioxidant enzyme activities were increased under drought stress. Higher levels of drought stress (50%) had more adverse effects than lower levels (25%). Foliar applications of NAA and IAA effectively mitigated the negative effects of drought, with NAA being more effective. Overall, drought stress markedly decreased growth parameters, biochemical, physiological, and yield attributes in both tomato varieties, but foliar applications of NAA and IAA improved growth and yield under drought stress.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Maida Khaliq, Khalid Nawaz, Khalid Hussain, Mehreen Javeria, Iqra Iqbal, Noshia Arshad, Ayesha Attique, Rida Zainab, M. O. H. A. M. M. A. D. Qurban
Summary: This experiment aimed to alleviate the detrimental effects of salt stress on two wheat varieties. The results showed that foliar application of sorbitol helped to ameliorate the negative impacts of salt stress on plants, and it also had beneficial effects under normal conditions.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Environmental Sciences
Fazila Younas, Irshad Bibi, Muhammad Afzal, Fahad Al-Misned, Nabeel Khan Niazi, Khalid Hussain, Muhammad Shahid, Qamar Shakil, Fawad Ali, Hailong Wang
Summary: This study investigated the distribution, speciation, hydrogeochemical behavior and environmental risks of chromium in tannery wastewater in Kasur district, Punjab, Pakistan. The concentration of chromium was higher in winter compared to summer, and exceeded the national environmental quality standard. The presence of chromium was mainly in the form of hexavalent and trivalent chromium, controlled by iron and magnesium minerals. Environmental risk assessment categorized the tannery wastewater as 'worst quality' and unsuitable for crop irrigation without treatment.
Review
Endocrinology & Metabolism
Huseyin Demirbilek, Dogus Vuralli, Basma Haris, Khalid Hussain
Summary: Hypoglycaemia in diabetic patients is a common problem due to the imbalance between food intake and insulin injections. Improved insulin analogues and novel formulations of glucagon have helped in reducing and preventing hypoglycaemia. However, access to these technologies remains a challenge for many patients.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Business
Gustave Florentin Nkoulou Mvondo, Fengjie Jing, Khalid Hussain
Summary: This study investigates the advantages and risks of the blind box selling strategy, which involves consumers purchasing packages without knowing the contents. A new framework is developed, incorporating hedonic benefits, perceived risk, risk propensity, customer delight, and brand evangelism. The survey results of 486 respondents show that hedonic benefits positively influence customer delight, while perceived risk has a negative effect, with risk propensity moderating this relationship. Customer delight also stimulates brand evangelism and acts as a mediator between hedonic benefits, perceived risk, and brand evangelism. This research emphasizes the importance of the blind box selling strategy and provides valuable insights for brand managers.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Article
Management
Muhammad Waheed Akhtar, Thomas Garavan, Muzhar Javed, Chunhui Huo, Muhammad Junaid, Khalid Hussain
Summary: This study investigates the impact of responsible leadership on green innovation in service firms, mediated by organizational ethical culture. The results indicate a positive relationship between responsible leadership and green innovation, with organizational ethical culture playing a mediating role. The study also finds that the strategic posture of the organization moderates this relationship.
SERVICE INDUSTRIES JOURNAL
(2023)
Article
Chemistry, Analytical
Basheer Riskhan, Halawati Abd Jalil Safuan, Khalid Hussain, Asma Abbas Hassan Elnour, Abdelzahir Abdelmaboud, Fazlullah Khan, Mahwish Kundi
Summary: Cyberattacks in the modern world are becoming increasingly sophisticated, with DDoS attacks being the most common. Effective approaches, such as traffic shaping and pushback, have been proposed in the distributed setting to mitigate such attacks. This study introduces a heuristic-based technique called SYN Flood Attack Detection and Mitigation Technique (SFaDMT), which demonstrates improved detection of SYN attacks.
Review
Chemistry, Multidisciplinary
Sultana Rahman, Abdul Haleem, Muhammad Siddiq, Muhammad Khalid Hussain, Samina Qamar, Safia Hameed, Muhammad Waris
Summary: The financial progress of a country depends heavily on the energy sector, which is crucial for the growth and development of various industries. The use of renewable resources is essential to overcome the energy crisis and reduce the negative impact of hydrocarbon fuels on the environment. This review focuses on the dyes used in dye-sensitized solar cells (DSSC) and discusses the progress in both inorganic and natural dyes.
Article
Pharmacology & Pharmacy
Muhammad Salman Rasool, Muhammad Akbar Hassan, Kauser Siddiqui, Faisal Mazhar, Akhtar Hussain Shar, Khalid Hussain Rind, Nadir Ali Rind, Fasih Uddin Ansari, Shahana Urooj Kazmi
Summary: Plasmid borne antibiotics resistance is a global threat in healthcare facilities. It can be stably inherited and horizontally transmitted among bacteria. Eliminating such resistance plasmids is crucial for controlling the spread of antibiotics resistance.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
U. A. Khan, R. Qadri, M. T. Akram, M. A. Khan, N. Nisar, M. Azam, M. M. Khan, K. Hussain
Summary: This study investigates the physical and biochemical attributes of eight jujube genotypes at different ripening stages in the Cholistan desert of Pakistan. The results show significant variations in fruit traits and biochemical composition during the ripening stages, with the highest values observed at the fully ripe stage for most parameters. The genotypes Gola, Mehmood wali, and Dehli white performed well in the climatic conditions of Cholistan, while Dilbahar, Anokee, Karela, and Bahawalpur selection had high phenolic and flavonoid contents.
JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
(2023)
