Review
Immunology
Ying Sun, Harald F. Langer
Summary: This article discusses the activation and response mechanisms of innate and adaptive immune processes in neuroinflammation. It also emphasizes the clinical importance of neuroinflammatory mediators and the potential translational relevance of involved mechanisms, with a focus on non-classical immune cells such as microglia cells and platelets. Examples of novel agents like Anfibatide and Revacept are provided to demonstrate the interconnectedness of neuroinflammation and thrombosis, highlighting the need for further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Marialuisa Zedde, Giacomo Portaro, Laura Ferri, Francesco Cavallieri, Manuela Napoli, Claudio Moratti, Fabrizio Piazza, Franco Valzania, Rosario Pascarella
Summary: Anemia, especially iron-deficient anemia, is associated with a higher risk of thrombotic events such as ischemic stroke and cerebral venous thrombosis. This article presents a case study discussing the diagnostic pathway of multiple thrombotic manifestations related to iron-deficient anemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Lily W. Zhou, Amy Y. X. Yu, Long Ngo, Michael D. Hill, Thalia S. Field
Summary: This study examined the incidence of cerebral venous thrombosis (CVT) in British Columbia, Canada, and found that it has increased over time. The literature on CVT incidence showed significant heterogeneity and possible publication bias.
Review
Medicine, General & Internal
Afshin Borhani-Haghighi, Etrat Hooshmandi
Summary: The COVID-19 pandemic and its vaccines have drawn attention to cerebral venous thrombosis (CVT), which is more common in women and young patients. CVT is caused by various factors such as pregnancy, oral contraceptive pills, trauma, and infections. Common symptoms include headache, seizures, neurological deficits, and cranial nerve palsies. Diagnosis is based on imaging and blood tests, and treatment involves anticoagulation, reducing intracranial pressure, and addressing underlying diseases.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Clinical Neurology
Vahid Reza Ostovan, Razieh Foroughi, Mahtab Rostami, Mostafa Almasi-Dooghaee, Manouchehr Esmaili, Ali Akbar Bidaki, Zahra Behzadi, Farzane Farzadfard, Hoda Marbooti, Abbas Rahimi-Jaberi, Maryam Poursadeghfard, Nima Fadakar, Mahnaz Bayat, Maryam Owjfard, Mohammad Saied Salehi, Seyedeh Shaghayegh Zafarmand, Farzad Mardi, Anahid Safari, Shima Shahjouei, Ashkan Mowla, Mahmoud Reza Azarpazhooh, Ramin Zand, Etrat Hooshmandi, Afshin Borhani-Haghighi
Summary: This study reported six cases of confirmed CVST and SARS-CoV-2 infection, with four patients presenting no respiratory symptoms. Patients with SARS-COV-2 associated CVST were older, with lower female/male ratio and higher mortality rate compared to CVST not associated with COVID-19. Despite receiving treatment, four patients died.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Yifan Zhou, Huimin Jiang, Huimin Wei, Lu Liu, Chen Zhou, Xunming Ji
Summary: This article reviews the pathophysiological mechanisms and clinical features of stroke, focusing on arterial stroke and cerebral venous thrombosis. It provides guidance for further research on cerebral venous thrombosis and summarizes the etiology, epidemiology, symptomatology, diagnosis, and treatment heterogeneity of this condition.
FRONTIERS IN NEUROLOGY
(2022)
Review
Hematology
Birgitte G. Tondel, Vania M. Morelli, John-Bjarne Hansen, Sigrid K. Braekkan
Summary: This systematic review identifies several potential risk factors and predictors for VTE in individuals with ischemic stroke. However, further confirmation is needed as there were few high-quality studies on each factor.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Clinical Neurology
Piers Klein, Liqi Shu, Thanh N. Nguyen, James E. Siegler, Setareh Salehi Omran, Alexis N. Simpkins, Mirjam Heldner, Adam de Havenon, Hugo J. Aparicio, Mohamad Abdalkader, Marios Psychogios, Maria Cristina Vedovati, Maurizio Paciaroni, Rascha von Martial, David S. Liebeskind, Diana Aguiar de Sousa, Jonathan M. Coutinho, Shadi Yaghi
Summary: Risk factors for poor neurological outcome in patients with cerebral venous thrombosis were identified, and a prognostic score was derived and validated. This score showed better accuracy in predicting poor outcomes compared to existing scoring systems and could be useful for clinical decision making and targeted therapy.
Review
Clinical Neurology
Gabriel Marinheiro dos Santos-Bezerra, Yasmin da Silveira Cavalcante, Paulo Roberto Matos-Neto, Joaquim Francisco Cavalcante-Neto, Keven Ferreira da Ponte, Diana Aguiar de Sousa, Paulo Roberto Lacerda Leal, Espartaco Moraes Lima Ribeiro
Summary: This study reviewed the risk factors, clinical and radiological characteristics of cerebral venous thrombosis (CVT) in Latin America and compared the findings with data from worldwide literature. The results showed that headache was the most common symptom, oral contraceptives were the main risk factor, heparin was commonly used in the acute phase, and oral anticoagulation was widely used at hospital discharge. The mortality rate was low, and most patients achieved complete recovery in Latin America.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Julia Devianne, Nicolas Legris, Isabelle Crassard, Celine Bellesme, Yannick Bejot, Celine Guidoux, Fernando Pico, David Germanaud, Michael Obadia, Diana Rodriguez, Philippe Tuppin, Manoelle Kossorotoff, Christian Denier
Summary: Cerebral venous thrombosis (CVT) in adolescents is rare and complex, with differences in clinical presentation and associated conditions between sexes, and more severe outcomes than in adults. Specialized management and follow-up are recommended.
Article
Clinical Neurology
Simon Fandler-Hoefler, Stefan Pilz, Marion Ertler, Melanie Haidegger, Markus Kneihsl, Gerit Wuensch, Thomas Gary, Christian Enzinger, Thomas Gattringer
Summary: This study investigated the frequency and clinical characteristics of thyroid dysfunction in CVT patients, finding a high prevalence of thyroid dysfunction in CVT patients including both hyperthyroidism and hypothyroidism. Further studies are needed to determine if there is a causal relationship, but screening for TSH in CVT patients is recommended due to the frequent coexistence of the two diseases.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
L. Kuiper, M. Sanchez van Kammen, B. A. Coert, D. Verbaan, B. J. Emmer, J. M. Coutinho, R. van den Berg
Summary: One-third of patients with dural AVFs in this study were diagnosed with cerebral venous thrombosis. In almost two-thirds of patients, cerebral venous thrombosis was diagnosed prior to or concurrent with the dural AVF. In 97% of patients, there was an anatomic association between the dural AVF and cerebral venous thrombosis.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Review
Nursing
Han Fu, Dongjiang Hou, Ran Xu, Qian You, Hang Li, Qing Yang, Hao Wang, Jing Gao, Dingxi Bai
Summary: This study systematically reviewed published studies on risk prediction models for DVT in patients with acute stroke and found a high risk of bias. Future studies should focus on developing new models with larger samples, rigorous study designs, and multicenter external validation.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2024)
Review
Radiology, Nuclear Medicine & Medical Imaging
XiaoQing Cheng, JiaQian Shi, Hang Wu, WuSheng Zhu, GuangMing Lu
Summary: This review summarizes the potential and current status of CT densitometry-based methods in quantifying net water uptake as a biomarker for ischemic stroke management. Net water uptake can predict malignant brain edema and hemorrhagic transformation, evaluate lesion age, and predict the efficacy of reperfusion therapy and long-term clinical prognosis.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Erik Lindgren, Alexandros Rentzos, Sini Hiltunen, Fabiola Serrano, Mirjam R. Heldner, Susanna M. Zuurbier, Suzanne M. Silvis, Maryam Mansour, William Allingham, Martin N. M. Punter, Blake F. Giarola, Jeremy Wells, Mayte Sanchez van Kammen, Eike Piechowiak, Nicole Chiota-McCollum, Carlos Garcia-Esperon, Christophe Cognard, Timothy Kleinig, Masoud Ghiasian, Jonathan M. Coutinho, Marcel Arnold, Antonio Arauz, Jukka Putaala, Katarina Jood, Turgut Tatlisumak
Summary: Dural arteriovenous fistulas are found in at least 2% of CVT patients, and are associated with older age, male sex, chronic CVT onset, and sigmoid sinus thrombosis. Most CVT-related dAVFs are detected simultaneously or subsequently to the diagnosis of CVT, and do not have a significant impact on clinical outcomes at last follow-up.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Andrew W. Kraft, Amine Awad, Joseph A. Rosenthal, Adam A. Dmytriw, Justin E. Vranic, Anna K. Bonkhoff, Martin Bretzner, Joshua A. Hirsch, James D. Rabinov, Christopher J. Stapleton, Lee H. Schwamm, Natalia S. Rost, Thabele M. Leslie-Mazwi, Aman B. Patel, Robert W. Regenhardt
Summary: This study found that spoke-administered intravenous thrombolysis (IVT) in patients with large vessel occlusion stroke can reduce the procedure time, fluoroscopy time, and number of passes during mechanical thrombectomy (MT), while also improving reperfusion.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Fawaz Al-Mufti, Priyank Khandelwal, Tolga Sursal, Jared B. Cooper, Eric Feldstein, Krishna Amuluru, Jayaji M. More, Ambooj Tiwari, Amit Singla, Adam A. Dmytriw, Mariangela Piano, Luca Quilici, Guglielmo Pero, Leonardo Renieri, Nicola Limbucci, Mario Martinez-Galdamez, Miguel Schuller-Arteaga, Jorge Galvan, Juan Francisco Arenillas-Lara, Zafar Hashim, Sanjeev Nayak, Keith Desousa, Hai Sun, Pankaj K. Agarwalla, J. Sudipta Roychowdhury, Emad Nourollahzadeh, Tannavi Prakash, Andrew R. Xavier, J. Diego Lozano, Gaurav Gupta, Dileep R. Yavagal, Mohammad Elghanem, Chirag D. Gandhi, Stephan A. Mayer
Summary: Elevated NLR in COVID-19 patients with large vessel occlusion (LVO) strokes is associated with significantly worse outcomes and increased mortality. The severe neuro-inflammatory stress response related to COVID-19 may negate the potential benefits of successful thrombectomy.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Review
Clinical Neurology
Ran Xu, Qing Zhao, Tao Wang, Yutong Yang, Jichang Luo, Xiao Zhang, Yao Feng, Yan Ma, Adam A. Dmytriw, Ge Yang, Shengpan Chen, Bin Yang, Liqun Jiao
Summary: This study summarizes the applications of optical coherence tomography (OCT) in the diagnosis, treatment, and follow-up of cerebrovascular diseases, particularly in intracranial atherosclerotic stenosis (ICAS) and intracranial aneurysms (IAs). The limitations and future directions of OCT in the endovascular treatment of cerebrovascular diseases are also discussed.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neuroimaging
Jose Danilo Bengzon Diestro, Mahmoud Dibas, Nimer Adeeb, Robert W. Regenhardt, Justin E. Vranic, Adrien Guenego, Sovann Lay, Leonardo Renieri, Ali Al Balushi, Eimad Shotar, Kevin Premat, Kareem El Naamani, Guillaume Saliou, Markus A. Moehlenbruch, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Vedran Zupancic, Muhammad U. Hafeez, Caleb Rutledge, Hamid Rai, Vincent M. Tutino, Shervin Mirshani, Sherief Ghozy, Pablo Harker, Naif M. Alotaibi, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Oded Goren, Mariangela Piano, Anna Luisa Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M. Starke, Ameer Hassan, Arsalaan Salehani, Anh Nguyen, Jesse Jones, Marios Psychogios, Julian Spears, Carmen Parra-Farinas, Maria Bres Bullrich, Michael Mayich, Mohamed M. Salem, Jan-Karl Burkhardt, Brian T. Jankowitz, Ricardo A. Domingo, Thien Huynh, Rabih Tawk, Christian Ulfert, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Andrew F. Ducruet, Felipe C. Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Reddy Boddu, Christopher J. Stapleton, Jared Knopman, Pascal Jabbour, Stavropoula Tjoumakaris, Frederic Clarencon, Nicola Limbucci, Mohammad A. Aziz-Sultan, Hugo H. Cuellar-Saenz, Christophe Cognard, Aman B. Patel, Adam A. Dmytriw
Summary: There was no significant difference in both the occlusion rate and complications between ruptured and unruptured aneurysms treated with the WEB device, supporting the feasibility of using the WEB device to treat ruptured aneurysms.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Xuesong Bai, Fan Yu, Qiuyue Tian, Wei Li, Araman Sha, Wenbo Cao, Yao Feng, Bin Yang, Yanfei Chen, Peng Gao, Yabing Wang, Jian Chen, Adam A. Dmytriw, Robert W. Regenhardt, Renjie Yang, Zhaolin Fu, Qingfeng Ma, Jie Lu, Liqun Jiao
Summary: The study investigated the impact of microvascular tissue reperfusion and its influencing factors in acute ischemic stroke patients. The findings revealed that microvascular tissue reperfusion was strongly associated with good functional outcomes after successful reperfusion, and higher mTICI grade and lower perioperative glucose level may predict microvascular tissue reperfusion.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Engineering, Biomedical
Georgios Ntolkeras, Hongbae Jeong, Lilla Zollei, Adam A. Dmytriw, Ali Purvaziri, Michael H. Lev, P. Ellen Grant, Giorgio Bonmassar
Summary: This study developed a realistic high-resolution numerical model of a female pediatric body named "Athena" using MRI and CT scans of a 3.5-year-old healthy girl. The model has significance in radiofrequency safety studies for medical devices, neurostimulation research, and radiation dosimetry studies.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Robert W. Regenhardt, Anna Bonkhoff, Markus D. Schirmer, Alvin S. Das, Adam A. Dmytriw, Justin Vranic, Rajiv Gupta, James D. Rabinov, Christopher J. Stapleton, Thabele M. Leslie-Mazwi, Aman B. Patel, Natalia S. Rost
Meeting Abstract
Clinical Neurology
Amine Awad, Michael J. Young, Alexander Andreev, Adam A. Dmytriw, Justin Vranic, James D. Rabinov, Christopher Stapleton, Alvin S. Das, Aneesh B. Singhal, Natalia S. Rost, Aman B. Patel
Review
Clinical Neurology
Nishita Singh, Bijoy K. Menon, Adam A. Dmytriw, Robert W. Regenhardt, Joshua A. Hirsch, Aravind Ganesh
Summary: This review focuses on recent advances in thrombolysis for acute ischemic stroke, comparing alteplase and TNK in terms of clinical, imaging, and safety outcomes. It highlights the potential of TNK as an alternative choice, with similar efficacy and safety as alteplase. Further research is needed to determine the advantages and applications of TNK in different subgroups.
Article
Neuroimaging
Yi Li, Wenbo Cao, Xin Xu, Tianhua Li, Yanfei Chen, Yabing Wang, Jian Chen, Peng Gao, Bin Yang, Adam A. Dmytriw, Robert W. Regenhardt, Fei Chen, Qingfeng Ma, Jie Lu, Yuqi Liu, Chunliang Wang, Xuesong Bai, Liqun Jiao
Summary: This study aimed to investigate the impact of early venous filling (EVF) after mechanical thrombectomy (MT). The results showed that the EVF group had a higher rate of intracranial hemorrhage, symptomatic intracranial hemorrhage, and malignant cerebral edema. Additionally, the cortical veins subgroup of EVF had a higher mortality rate.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neurosciences
James Withers, Robert W. Regenhardt, Adam A. Dmytriw, Justin E. Vranic, Rudolph Marciano, Christopher J. Stapleton, Aman B. Patel
Summary: Headache and pulsatile tinnitus were the patient's symptoms. Treatment of the occlusive arteriovenous fistula with interventional radiology was successful. This case demonstrates that minimally invasive surgery is an effective alternative when conventional methods cannot be performed.
Article
Neuroimaging
Long Li, Bin Yang, Adam A. Dmytriw, Yanling Li, Haozhi Gong, Xuesong Bai, Chao Zhang, Jian Chen, Jia Dong, Yabing Wang, Peng Gao, Tao Wang, Jichang Luo, Xin Xu, Yao Feng, Xiao Zhang, Renjie Yang, Yan Ma, Liqun Jiao
Summary: This study investigated the potential threshold values in the functional assessment of intracranial atherosclerotic stenosis (ICAS) by studying the relation between pressure-derived indexes and perfusion parameters. The results showed that cut-off values of translesional pressure gradients (Pd/Pa=0.81 or Pa-Pd=8 mm Hg) were preliminary established in a highly selected subgroup with ICAS, which may facilitate clinical decision-making in the management of ICAS.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Ibrahim Alghamdi, Adam A. Dmytriw, Afsaneh Amirabadi, Samantha Lebarron, Vanessa Rea, Carmen Parra-Farinas, Prakash Muthusami
Summary: This retrospective study aimed to assess the frequency, imaging appearances, and risk factors of brain microemboli following pediatric neuroangiography using early diffusion-weighted MRI imaging. The study found that the occurrence of cerebral microemboli is uncommon in children after uncomplicated neuroangiography. However, the incidence approaches that reported in adults when there is underlying vasculopathy and the transradial technique is used. Additionally, there is a significant association between the number of angiographic runs and microemboli.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Adrien Guenego, Robert Fahed, Aymeric Rouchaud, Gregory Walker, Tobias D. Faizy, Peter B. Sporns, Mohamed Aggour, Pascal Jabbour, Andrea M. Alexandre, Pascal John Mosimann, Adam A. Dmytriw, Noemie Ligot, Niloufar Sadeghi, Chengbo Dai, Ameer E. Hassan, Vitor M. Pereira, Justin Singer, Jeremy J. Heit, Fabio Silvio Taccone, Michael Chen, Jens Fiehler, Boris Lubicz
Summary: Our study highlights the significant heterogeneity among the neurointerventional community regarding the diagnosis of vasospasm and endovascular management. Randomized trials and guidelines are needed to improve standard of care, determine optimal management approaches, and track outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Kareem El Naamani, Ching-Jen Chen, Roland Jabre, Hassan Saad, Jonathan A. Grossberg, Adam A. Dmytriw, Aman B. Patel, Mirhojjat Khorasanizadeh, Christopher S. Ogilvy, Ajith Thomas, Andre Monteiro, Adnan Siddiqui, Gustavo M. Cortez, Ricardo A. Hanel, Guilherme Porto, Alejandro M. Spiotta, Anthony J. Piscopo, David M. Hasan, Mohammad Ghorbani, Joshua Weinberg, Shahid M. Nimjee, Kimon Bekelis, Mohamed M. Salem, Jan-Karl Burkhardt, Akli Zetchi, Charles Matouk, Brian M. Howard, Rosalind Lai, Rose Du, Rawad Abbas, Georgios S. Sioutas, Abdelaziz Amllay, Alfredo Munoz, Elias Atallah, Nabeel A. Herial, Stavropoula Tjoumakaris, Michael Reid Gooch, Robert H. Rosenwasser, Pascal Jabbour
Summary: This study compares the rates of symptomatic strokes between direct and indirect revascularization surgeries for moyamoya and finds that both modalities have comparable rates of overall strokes. Therefore, the choice of revascularization modality can be made based on the patient's risk assessment.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)