Article
Biochemistry & Molecular Biology
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yifei Yang, Dawei Yu, Xiaoyin Zhu, Guangying Du, Wenyan Wang, Fangxia Zou, Hongbo Wang, Rui Zhang, Liang Ye, Jingwei Tian
Summary: A novel series of dihydrotetrabenazine derivative analogs were synthesized and evaluated for their effects on VMAT2, with compound 13e showing promising affinity and inhibition. This compound also exhibited increased stability compared to other VMAT2 inhibitors and effectively suppressed locomotor activity in rats, suggesting its potential as a lead compound for TD treatment development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Behavioral Sciences
Gabriella E. DiCarlo, Mark T. Wallace
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted interests/repetitive behaviors. Over 1000 genes and 2000 copy number variants have been implicated in ASD. It is believed that there is not a single genetic cause or neurobiological basis for ASD, but rather multiple subtypes with different genetic and neurobiological perturbations. Dopamine dysfunction may be one potential subtype associated with ASD. This research provides a framework for subcategorizing ASD based on genetic changes, neurobiological differences, and behavioral features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Medicine, Research & Experimental
Roger L. Albin, Prabesh Kanel, Teus van Laar, Sygrid van der Zee, Stiven Roytman, Robert A. Koeppe, Peter J. H. Scott, Nicolaas Bohnen
Summary: This study examined the association between regional brain [F-18]FEOBV PET binding and the use of dopamine D2-like receptor agonist drugs in subjects with Parkinson's disease (PD). The results showed that chronic use of D2-like dopamine agonists in PD subjects did not lead to significant alterations in regional brain [F-18]FEOBV binding.
MOLECULAR PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Hana Horackova, Rona Karahoda, Veronika Vachalova, Helena Turkova, Cilia Abad, Frantisek Staud
Summary: The human placenta plays a crucial role in the transport of neurotransmitters dopamine and norepinephrine during fetal development. This study investigates the mechanisms involved in the uptake of these monoamines across the placental membranes. The findings provide insights into the physiological aspects of dopamine and norepinephrine transport and have pharmacological relevance for the safe use of neuroactive drugs during pregnancy.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Song
Summary: This study examines the pharmacological properties of selective reuptake inhibitors for dopamine, norepinephrine, and serotonin and finds antagonistic effects when they are used in combination. Furthermore, it suggests the presence of a potential secondary inhibitor binding site that affects inhibition.
Article
Biochemistry & Molecular Biology
Jennifer L. Myers, Maria Porter, Nicholas Narwold, Krishna Bhat, Brigitte Dauwalder, Gregg Roman
Summary: The study reveals a novel defect in olfactory memory acquisition in Drosophila white mutants, independent of visual defects. Mutants can reach wildtype performance levels with additional training. Dietary cholesterol intake and biogenic amine signaling may play a role in influencing the learning abilities of the mutants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, Zachary Freyberg
Summary: The study revealed the impact of age and sex differences on dopamine neuron vulnerability, with males exhibiting greater decreases in neuron number and locomotion during aging, and dynamic changes in VGLUT expression in dopamine neurons possibly serving as a compensatory mechanism. Female fruit flies were found to possess higher levels of VGLUT expression in dopamine neurons compared to males, and diminishing VGLUT expression eliminated their greater resilience to neuron loss. Optimal control over VGLUT expression in dopamine neurons was identified as essential for neuron survival and a potential therapeutic target for age- and PD-related neurodegeneration.
Review
Clinical Neurology
Emily Behling, Luis C. Farhat, Angeli Landeros-Weisenberger, Michael H. Bloch
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, acceptability, and tolerability of Vesicular monoamine transporter type 2 (VMAT2) inhibitors for chronic tic disorders (CTD), including Tourette syndrome (TS). The results showed that VMAT2 inhibitors did not have a significant effect on the short-term treatment of tic disorders and had no clinically meaningful impact on tic symptoms, but there were some adverse effects on tolerability and acceptability.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Elizabeth K. Wood, Natalia Gabrielle, Jacob Hunter, Andrea N. Skowbo, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, J. Dee Higley
Summary: Studies show that parental absence early in life can have negative effects on the developing central nervous system, particularly on monoamine systems. Furthermore, genotype can also affect the concentrations of these neurotransmitters.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Biochemistry & Molecular Biology
Subramanian Thangaleela, Durairaj Ragu Varman, Karunanithi Sivasangari, Koilmani Emmanuvel Rajan
Summary: Social defeat affects spatial learning and memory in goldfish, while MAO inhibitor pre-treatment can protect against this effect.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenyan Wang, Guangying Du, Shilan Lin, Jing Liu, Huijie Yang, Dawei Yu, Liang Ye, Fangxia Zou, Hongbo Wang, Rui Zhang, Jingwei Tian
Summary: Valbenazine and deutetrabenazine are two approved therapeutic drugs for tardive dyskinesia due to their action on vesicular monoamine transporter 2 (VMAT2). The compound 13e has been identified as a promising lead compound for the treatment of tardive dyskinesia, showing high affinity and inhibitory effects on VMAT2. The study found that the metabolic pathways and enzymes involved in the metabolism of 13e, as well as its high permeability and bioavailability, suggest its potential efficacy and safety for clinical development in the treatment of tardive dyskinesia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim
Summary: This study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Neurosciences
Hongyin Zhai, Yaofeng Zheng, Yiduo He, Yong Zhang, Zhikuan Guo, Wenzhe Cui, Li Sun
Summary: This case describes a 6-month-old male infant diagnosed with infantile parkinsonism-dystonia-2, caused by a mutation in the SLC18A2 gene resulting in brain dopamine-serotonin vesicular transport disease. The father carried the same mutation in a heterozygous state. Treatment with a dopamine agonist improved some symptoms.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Melanie Bourque, Marc Morissette, Therese Di Paolo
Article
Biochemistry & Molecular Biology
Anne-Francoise Close, Nidheesh Dadheech, Barbara Scoralick Villela, Claude Rouillard, Jean Buteau
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Endocrinology & Metabolism
Hend Jarras, Melanie Bourque, Andree-Anne Poirier, Marc Morissette, Katherine Coulombe, Therese Di Paolo, Denis Soulet
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Letter
Clinical Neurology
Amy E. Bouchard, Maya Dickler, Emmanuelle Renauld, Christophe Lenglos, Francine Ferland, Richard A. Edden, Claude Rouillard, Jean Leblond, Shirley Fecteau
Article
Neurosciences
Adjia Hamadjida, Lamia Sid-Otmane, Cynthia Kwan, Imane Frouni, Vaidehi Nafade, Dominique Bedard, Dave Gagnon, Marie-Josee Wallman, Claude Rouillard, Andre Parent, Martin Parent, Philippe Huot
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Immunology
Cynthia Lecours, Marie-Kim St-Pierre, Katherine Picard, Maude Bordeleau, Melanie Bourque, Ifeoluwa Oluleke Awogbindin, Amin Benadjal, Fernando Gonzalez Ibanez, Dave Gagnon, Leo Cantin, Martin Parent, Therese Di Paolo, Marie-Eve Tremblay
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Review
Neurosciences
Ifeoluwa Oluleke Awogbindin, Ismail Ogunbayode Ishola, Marie-Kim St-Pierre, Micael Carrier, Julie C. Savage, Therese Di Paolo, Marie-Eve Tremblay
NEUROSCIENCE LETTERS
(2020)
Article
Psychiatry
Amy E. Bouchard, Maya Dickler, Emmanuelle Renauld, Christophe Lenglos, Francine Ferland, Claude Rouillard, Jean Leblond, Shirley Fecteau
Summary: This study compared brain morphology between patients with Gambling Disorder and healthy individuals, finding differences in brain structure in Gambling Disorder patients. The findings contribute to a better understanding of the brain substrates of Gambling Disorder, which appear to be similar to those of substance use disorders and Internet Gaming Disorder.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Amandine Isenbrandt, Marc Morissette, Melanie Bourque, Jerome Lamontagne-Proulx, Katherine Coulombe, Denis Soulet, Therese Di Paolo
Summary: The study examined the effects of sex hormones on a mouse model of Parkinson's disease and the neuroprotective role of the 5 alpha-reductase inhibitor dutasteride. Results showed sex differences in mice MPTP toxicity and response to dutasteride, with implications of neuroinflammation.
Review
Neurosciences
Ifeoluwa O. Awogbindin, Benneth Ben-Azu, Babatunde A. Olusola, Elizabeth T. Akinluyi, Philip A. Adeniyi, Therese Di Paolo, Marie-Eve Tremblay
Summary: Since December 2019, humanity has been facing the devastating SARS-CoV-2 outbreak, resulting in over 3.1 million deaths globally. SARS-CoV-2 infection may lead to neurological symptoms and potentially cause chronic or permanent changes to neural tissues.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Marc Morissette, Melanie Bourque, Marie-Eve Tremblay, Therese Di Paolo
Summary: Inflammatory markers were found in the brains of Parkinson's disease patients. The study showed that MPEP reduced the development of L-Dopa-induced dyskinesias (LID) in MPTP-lesioned monkeys and decreased inflammatory markers in the brain. The results demonstrated increased inflammatory markers in the basal ganglia associated with LID and revealed the potential of MPEP in reducing LID and inflammatory response.
Article
Biochemical Research Methods
Valerie Brousseau, Patrick Caron, Jocelyn Trottier, Therese Di Paolo, Piotr Milkiewicz, Olivier Barbier
Summary: This study developed a method for quantification of 24S-hydroxycholesterol and its derivatives in human plasma and validated its clinical applications. The results indicate the accumulation of cerebrosterol and its conjugates in the plasma of cholestatic patients.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Pharmacology & Pharmacy
Andree-Anne Poirier, Melissa Cote, Hend Jarras, Nadhir Litim, Jerome Lamontagne-Proulx, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Martin Pelletier, Therese Di Paolo, Denis Soulet
Summary: This study demonstrates that dutasteride can prevent enteric neuronal damage in the MPTP mouse model of Parkinson's disease by anti-inflammatory and mitochondrial effects, suggesting that drug repurposing of dutasteride might be a promising avenue to treat enteric neuroinflammation in early PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Melanie Bourque, Laurent Gregoire, Waseema Patel, David Dickens, Ralph Snodgrass, Therese Di Paolo
Summary: N-methyl-D-aspartate (NMDA) receptors have been implicated in L-Dopa-induced dyskinesias (LID) in Parkinson's disease patients. L-4-chlorokynurenine (AV-101) is a pro-drug of 7-chlorokynurenic acid, a specific antagonist of the glycine co-agonist site of NMDA receptors. This study investigated the effects of AV-101 on LID in MPTP-lesioned monkeys and found that it reduced LID and maintained the antiparkinsonian activity of L-Dopa. AV-101 showed comparable antidyskinetic activity to amantadine but without adverse effects.
Letter
Clinical Neurology
Amy E. Bouchard, Maya Dickler, Emmanuelle Renauld, Christophe Lenglos, Francine Ferland, Claude Rouillard, Jean Leblond, Shirley Fecteau
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.