Editorial Material
Biology
Alexandre Faille, Alan J. Warren
Summary: Understanding how streptomycin binds to the small subunit of the mitoribosome may aid in the development of less toxic derivatives of this antibiotic.
Review
Cell Biology
A. Denise R. Garcia
Summary: The Sonic hedgehog (Shh) molecular signaling pathway is a key regulator of neurodevelopment, with diverse functions in various cell types and developmental stages. In addition to its roles in development, Shh signaling continues into adulthood and is now recognized as an important regulator of astrocyte function. Astrocytes play essential roles in nervous system functions, including synapse formation, coordination of CNS inflammatory responses, and Shh signaling mediates communication between neurons and astrocytes, influencing astrocyte identity, synaptic organization, and inflammation regulation.
Editorial Material
Biochemistry & Molecular Biology
Simon W. Townsend, Alexis Hervais-Adelman
Summary: The study found that dogs and humans may segment speech in similar ways when listening to it.
Article
Endocrinology & Metabolism
Samuel M. Lockhart, Stephen O'Rahilly
Summary: Colchicine, an anti-inflammatory agent commonly used to treat gout, exerts its effects in mice by inducing the hormone GDF-15 in the liver, as demonstrated by Weng et al. in the latest issue of Nature Metabolism.
Article
Business
Yi-Hou Huang, Woan-lih Liang, Quang-Thai Truong, Yanzhi Wang
Summary: This study found that U.S. listed firms with a higher percentage of old directors are more likely to engage in innovation activities, especially in companies with less experienced board members, low meeting frequency of boards, lower institutional ownership, CEO duality, and/or a less competitive product market.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Editorial Material
Microbiology
James E. Crowe, Robert H. Carnahan
Summary: The paper provides a comprehensive investigation into the molecular and functional basis of 17D vaccine responses, as well as the differences in antibody neutralization between the 17D and related African lineage strains and contemporary Central/South American strains.
CELL HOST & MICROBE
(2022)
Editorial Material
Cell & Tissue Engineering
Daniel Rosenblum, Shruti Naik
Summary: By utilizing single-cell transcriptomics to study human skin cells, Reynolds et al. (2021) identified fetal programs in dermatological diseases, shedding light on potential mechanisms driving inflammatory pathology.
Review
Chemistry, Multidisciplinary
Athanassios K. Boudalis
Summary: This review presents the history of study on spin triangles, discusses the parallel development of new experimental investigations and new theoretical ideas, as well as their chemical diversity and relevance to spintronic devices and new physics.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Editorial Material
Immunology
Christina D. Camell
Summary: In this study, advanced techniques such as single-cell RNA sequencing, flow cytometry, and mass cytometry were used to describe age-related differences in the immune system, specifically focusing on the accumulation of age-associated T cells that contribute to inflammaging.
Review
Medical Laboratory Technology
Giuseppe Lippi, Francois Mullier, Emmanuel J. Favaloro
Summary: D-dimer measurement is important in the diagnosis, exclusion, and prognostication of venous thromboembolism and disseminated intravascular coagulation. Its clinical applications are expanding to include other diseases such as acute aortic dissection, acute intestinal ischemia, and cerebral venous thrombosis, as well as the management of COVID-19.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Plant Sciences
Filipa Lara Lopes, Carlos Galvan-Ampudia, Benoit Landrein
Summary: Recent studies have revealed the critical role of the feedback loop between WUS and CLV3 in maintaining the stem cell niche in the shoot apical meristem of plants. WUS promotes stem cell fate and is inhibited by CLV3, ensuring the stability of this niche. Furthermore, WUS can integrate both internal and external cues to enable the shoot meristem to adapt to various environmental changes.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Editorial Material
Pharmacology & Pharmacy
Vega Miguel-Ruano, Juan A. Hermoso
Summary: A recent study by Martelli and colleagues unveiled a new class of antimycobacterials based on N-thio-beta-lactams, with an inhibitory mechanism that provides an unexpected route to combat drug-resistant strains of Mycobacterium tuberculosis. This discovery sheds light on potential alternative approaches to tackle drug resistance in tuberculosis.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Theano Penlioglou, Anca Pantea Stoian, Nikolaos Papanas
Summary: The review summarizes the latest data on the relationship between diabetes mellitus and stroke, including risk factors, prevention, and biomarkers. Progress has been made in prevention and early diagnosis, but there are still crucial points that remain controversial and need further clarification.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Martijn A. Nolte, Esther N. M. Nolte-'t Hoen, Coert Margadant
Summary: Integrins, transmembrane receptors promoting cell adhesion and migration, play a crucial role in regulating endocytosis and exocytosis across a variety of cell types by interacting with intracellular trafficking machinery. Recent insights have shown integrins' involvement in processes like degranulation, mechanotransduction, cell-cell communication, antibody production, virus entry, and Toll-like receptor signaling.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Article
Computer Science, Information Systems
Mianzhe Han, Yuki Todo, Zheng Tang
Summary: The study proposed a mechanism for motion direction detection based on Barlow's inhibitory scheme, showing good performance and high detection accuracy in experiments, outperforming traditional Convolution Neural Network (CNN) in terms of accuracy, calculation speed, and cost.
Article
Neurosciences
Benjamin L. Murphy-Baum, W. Rowland Taylor
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Benjamin L. Murphy-Baum, W. Rowland Taylor
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Biology
Varsha Jain, Benjamin L. Murphy-Baum, Geoff deRosenroll, Santhosh Sethuramanujam, Mike Delsey, Kerry R. Delaney, Gautam Bhagwan Awatramani
Article
Multidisciplinary Sciences
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J. Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Summary: The study reveals that acetylcholine signals are transmitted through a rapid co-activation mechanism, activating receptors on multiple neurons surrounding the release site. Additionally, while acetylcholine signals are direction-selective locally, they do not show global directionality, facilitating information transfer at a local scale.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Benjamin L. Murphy-Baum, Gautam B. Awatramani
Summary: The ability of neurons to perform parallel computations in their dendritic arbor improves their computational capacity. Direction-selective ganglion cells in the mouse retina are able to compute the direction of moving objects multiple times as they traverse their receptive fields, allowing them to rapidly detect changes in motion direction. The parallel processing capacity of neurons can be maintained even during intense synaptic activity.
Article
Biology
Prerna Srivastava, Geoff de Rosenroll, Akihiro Matsumoto, Tracy Michaels, Zachary Turple, Varsha Jain, Santhosh Sethuramanujam, Benjamin L. Murphy-Baum, Keisuke Yonehara, Gautam Bhagwan Awatramani
Summary: In this study, the input kinetics across individual starburst dendrites were directly measured using a two-photon glutamate sensor. The study found that signals from proximal dendrites were relatively sustained, mainly influenced by excitatory network interactions. Computational modeling demonstrated the importance of input kinetics in shaping direction selectivity. These results provide support for the "space-time wiring" model.
