Article
Toxicology
Odwa Mbanga, Ewa Cukrowska, Mary Gulumian
Summary: Investigating the biodurability and persistence of titanium dioxide nanoparticles (TiO2 NPs) is crucial for understanding their impact on human health and the environment. This study examined the dissolution kinetics of TiO2 NPs in different simulated fluids and media, revealing limited dissolution in all the fluids tested. Acidic biological media showed higher dissolution rates than alkaline media, and high ionic strength seawater resulted in higher dissolution compared to freshwater. The dissolution kinetics followed first order reaction kinetics, characterized by low dissolution rates and long half-times, indicating the persistence of TiO2 NPs in the body and environment.
TOXICOLOGY IN VITRO
(2022)
Article
Cell Biology
Daniel M. Marko, Michael S. Finch, Ahmad Mohammad, Adam J. MacNeil, Panagiota Klentrou, Rebecca E. K. MacPherson
Summary: Neurodegenerative diseases like Alzheimer's disease are becoming more common in our aging society. This study found that postexercise serum can affect APP processing in the brain, potentially pushing the cascade towards a nonamyloidogenic pathway.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Panagiota Papaspyridakou, Michail Lykouras, Malvina Orkoula
Summary: “A novel method for the detection and quantification of ethanol and methanol in human urine, saliva, and blood serum using Raman spectroscopy was developed. Calibration curves were created for each alcohol-biological fluid system to determine the detection limits. Methanol had lower detection limits, but were still below intoxication levels, while ethanol had detectable concentrations below permissible limits. Saliva showed the lowest detection limits for both alcohols.”
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Food Science & Technology
Anita R. Iskandar, Aditya Reddy Kolli, Albert Giralt, Laurent Neau, Maria Fatarova, Athanasios Kondylis, Laura Ortega Torres, Shoaib Majeed, Celine Merg, Maica Corciulo, Keyur Trivedi, Emmanuel Guedj, Stefan Frentzel, Florian Calvino, Philippe Alexandre Guy, Nikolai Ivanov, Manuel C. Peitsch, Julia Hoeng
Summary: The fate of nebulized trehalose in human airway tissues and its potential adverse effects were investigated, showing that trehalose was metabolized into glucose without causing significant adverse effects. This in vitro testing approach may aid in selecting excipients for future inhalation products.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Chemistry, Physical
Jing Luo, Huali Yu, Binyang Lu, Dehui Wang, Xu Deng
Summary: This review provides an up-to-date summary of research progress on superhydrophobic biological fluid-repellent surfaces (SBFRSs), focusing on the repellent mechanism and application. It introduces the physical and chemical principles for designing superhydrophobic surfaces, emphasizes the influences of solid-liquid interactions on wettability and compatibility, and discusses the recent applications of SBFRSs in biomedical fields. The review also discusses the outlook and challenges in employing SBFRSs, providing comprehensive guidance for their preparation and clinical applications.
Article
Otorhinolaryngology
Kazuhiro Omura, Bing Han, Hironobu Nishijima, Satoshi Aoki, Teru Ebihara, Kenji Kondo, Nobuyoshi Otori, Hiromi Kojima, Tatsuya Yamasoba, Shu Kikuta
Summary: The study revealed that the distribution and differentiation degree of mature olfactory sensory neurons are heterogeneous throughout the olfactory epithelium. Resection of the anterior or superior superior turbinate potentially damages olfactory function, while resection of the inferior or posterior superior turbinate or widening of the superior meatus is a safer alternative that does not damage mature olfactory sensory neurons or alter airflow to the olfactory cleft.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Microbiology
Taeyong Kwon, Natasha N. Gaudreault, David A. Meekins, Chester D. McDowell, Konner Cool, Juergen A. Richt
Summary: Genetic evolution of SARS-CoV-2 leads to the continuous emergence of novel virus variants, posing a significant concern to global public health. Five of these variants have been classified to date into variants of concern (VOCs); Alpha, Beta, Gamma, Delta, and Omicron. Studies have shown that the stability of these variants varies in human biological fluids.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
A. Hrioua, A. Loudiki, A. Farahi, M. Bakasse, S. Lahrich, S. Saqrane, M. A. El Mhammedi
Summary: Amoxicillin is widely used for human therapy, but its excessive utilization and effluents from pharmaceutical industries can pose environmental and health risks. The extensive use in food animal production may lead to undesirable residues in food. Therefore, new electroanalytical techniques are required for the detection and quantification of amoxicillin in various samples.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Wael Talaat, Mohamed M. Y. Kaddah, Reda Mohammed Keshk
Summary: A new fluorescent sensor was introduced for the analysis of nucleoside analogues trifluridine and tipiracil, showing high sensitivity, good accuracy, and high selectivity. The method successfully analyzed raw materials, tablets, and biological fluids, demonstrating a quenching effect in the interaction between the synthesized fluorophore and the studied drugs.
Article
Multidisciplinary Sciences
Samuele Vinanzi, Angelo Cangelosi, Christian Goerick
Summary: Robots are likely to become important social actors in the future, requiring human-like cognitive abilities such as intention reading and trust. A developmental artificial cognitive architecture integrating unsupervised machine learning and probabilistic models can enable a humanoid robot to cooperate effectively, with intention reading aiding in goal prediction and trust enhancing the likelihood of a positive outcome.
Article
Agricultural Engineering
Adrieli Sachett, Matheus Gallas-Lopes, Radharani Benvenutti, Matheus Marcon, Gean Pablo S. Aguiar, Ana Paula Herrmann, J. Vladimir Oliveira, Anna M. Siebel, Angelo Piato
Summary: Curcumin has been shown to have various beneficial properties, but its low bioavailability limits its therapeutic potential. Micronization can enhance the bioavailability by reducing particle size. In this study, micronized curcumin exhibited superior antioxidant effects both in vitro and in vivo compared to regular curcumin. However, it was unable to fully block the behavioral effects induced by chronic stress.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biophysics
Qianyu Wang, Yujie Liu, Jonatan C. Campillo-Brocal, Amparo Jimenez-Quero, Gaston A. Crespo, Maria Cuartero
Summary: A novel amperometric biosensor for quantitative determination of glycine in diverse biological fluids was developed, showing fast response time, high specificity, and wide linear range. The biosensor design optimization and unique analytical features position it as a forefront technology for decentralized clinical applications and sport performance monitoring.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Mohammadreza Mahdavijalal, Homayon Ahmad Panahi, Ali Niazi, Atefeh Tamaddon
Summary: In this study, a smart modified nano-adsorbent (SMNA) based on tungsten disulfide (WS2) was synthesized for the solid-phase extraction of Bicalutamide (BLT) from human plasma and urine samples. The drug loading capacity of SMNA was increased by grafting a thermo-sensitive polymer onto WS2 nano-sheets. The proposed method provided efficient extraction of BLT and rapid release through light irradiation. It exhibited favorable performance in terms of drug recovery and analytical linearity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Physics, Multidisciplinary
Rafael M. Gutierrez, George T. Shubeita, Chandrashekhar U. Murade, Jianfeng Guo
Summary: Living cells are complex systems that exhibit exotic physical phenomena such as entropy and microscale forces competing to generate complex behaviors like phase transitions. In the age of big data, entropy methods may provide significant insights into these systems, offering valuable information for interdisciplinary researchers in thermodynamics and biophysics modeling.
Article
Multidisciplinary Sciences
Luke Campagnola, Stephanie C. Seeman, Thomas Chartrand, Lisa Kim, Alex Hoggarth, Clare Gamlin, Shinya Ito, Jessica Trinh, Pasha Davoudian, Cristina Radaelli, Mean-Hwan Kim, Travis Hage, Thomas Braun, Lauren Alfiler, Julia Andrade, Phillip Bohn, Rachel Dalley, Alex Henry, Sara Kebede, Mukora Alice, David Sandman, Grace Williams, Rachael Larsen, Corinne Teeter, Tanya L. Daigle, Kyla Berry, Nadia Dotson, Rachel Enstrom, Melissa Gorham, Madie Hupp, Samuel Dingman Lee, Kiet Ngo, Philip R. Nicovich, Lydia Potekhina, Shea Ransford, Amanda Gary, Jeff Goldy, Delissa McMillen, Trangthanh Pham, Michael Tieu, La'Akea Siverts, Miranda Walker, Colin Farrell, Martin Schroedter, Cliff Slaughterbeck, Charles Cobb, Richard Ellenbogen, Ryder P. Gwinn, C. Dirk Keene, Andrew L. Ko, Jeffrey G. Ojemann, Daniel L. Silbergeld, Daniel Carey, Tamara Casper, Kirsten Crichton, Michael Clark, Nick Dee, Lauren Ellingwood, Jessica Gloe, Matthew Kroll, Josef Sulc, Herman Tung, Katherine Wadhwani, Krissy Brouner, Tom Egdorf, Michelle Maxwell, Medea McGraw, Christina Alice Pom, Augustin Ruiz, Jasmine Bomben, David Feng, Nika Hejazinia, Shu Shi, Aaron Szafer, Wayne Wakeman, John Phillips, Amy Bernard, Luke Esposito, Florence D. D'Orazi, Susan Sunkin, Kimberly Smith, Bosiljka Tasic, Anton Arkhipov, Staci Sorensen, Ed Lein, Christof Koch, Gabe Murphy, Hongkui Zeng, Tim Jarsky
Summary: Through the application of a synaptic physiology analysis platform and dataset, we have revealed principles that link cell type to synaptic properties and intralaminar circuit organization. Excitatory and inhibitory synapse dynamics differ between cell subclasses, and synaptic properties are heterogeneous in most subclass-to-subclass connections. Excitatory-to-excitatory synaptic dynamics in the human cortex are distinct from those in the mouse cortex and vary across different layers.
