Article
Medicine, Research & Experimental
Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel
Summary: Two interlinked studies examined the therapeutic LTD for chronic peripheral nerve injury pain, with the clinical trial showing non-significant results and the mechanistic study indicating improvement in mechanical hyperalgesia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Josep C. Benitez-Martinez, Beatriz Garcia-Haba, Samuel Fernandez-Carnero, Daniel Pecos-Martin, Eleuterio A. Sanchez Romero, Francisco Selva-Sarzo, Juan Nicolas Cuenca-Zaldivar
Summary: This study aimed to examine the impact of a tape with magnetic particles applied to the lumbar area on abductor muscle strength and surface electromyography in individuals with non-specific chronic low back pain. The results showed that the tape application increased the muscle strength of the Gluteus Medius and hip musculature.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Health Care Sciences & Services
Marta Correyero-Leon, Rocio Llamas-Ramos, Javier Calvo-Rodrigo, Jorge Juan Alvarado-Omenat, Ines Llamas-Ramos
Summary: The study aims to evaluate the effectiveness of transcutaneous posterior tibial nerve stimulation (TTNS) in patients with primary dysmenorrhea (PD). The study will be a single-blind randomized clinical trial, with participants randomly assigned to either the experimental (TTNS) or placebo (simulated stimulation) group. Various measurements will be taken to assess pain intensity, duration, severity, impact on quality of life, as well as overall improvement and satisfaction.
Article
Medicine, General & Internal
Lihua He, Keping Tan, Xianming Lin, Hui Yi, Xueliang Wang, Jiangsong Zhang, Jietao Lin, Lizhu Lin
Summary: The study showed that TENS significantly reduced pain in pancreatic cancer patients without increasing analgesic medication consumption. The pain relief provided by TENS lasted up to 3 weeks after treatment, demonstrating an alternative therapy option for pancreatic cancer pain.
Article
Anesthesiology
Canan Bursali, Feyza Unlu Ozkan, Meryem Yilmaz Kaysin, Nimet Dortcan, Ilknur Aktas, Duygu Geler Kulcu
Summary: This study aimed to evaluate the effectiveness of r-TMS treatment in patients with FBSS, and results showed significant improvements in DN4, ODI, BDI, and PSQI scores in the r-TMS group compared to the sham group. Both groups experienced improvements in VAS scores, but the r-TMS group maintained these improvements at the third month follow-up. However, limitations included the small number of patients and short follow-up periods.
Article
Medicine, General & Internal
Nuria Viudes-Sarrion, Fernando Aleixandre-Carrera, Patricia Beltra, Francisco Javier Ortega, Francisco Javier Molina-Paya, Enrique Velasco, Miguel Delicado-Miralles
Summary: This study investigated the effects of electrical stimulation of a mixed nerve on blood flow. The results showed that the stimulation mainly affected the perfusion of forearm muscles, but had little impact on the blood flow in major arm arteries.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Anne Njogu, Si Qin, Yujie Chen, Lizhen Hu, Yang Luo
Summary: The study showed that TENS therapy can effectively alleviate labor pain and shorten the active labor phase.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Rehabilitation
Thiru M. Annaswamy, Kegan J. Cunniff, Mitchell Kroll, Lori Yap, Matthew Hasley, Chung-Kuang Lin, Jason Petrasic
Summary: In patients with uncomplicated chronic low back pain, the use of a back brace in addition to education and exercise instruction did not provide any pain relief compared to education and exercise instruction alone. Due to unlikely significant changes in results, the study was halted.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Clinical Neurology
Charles Ethan Paccione, Audun Stubhaug, Lien My Diep, Leiv Arne Rosseland, Henrik Borsting Jacobsen
Summary: The study explored the treatment effectiveness of active and sham transcutaneous vagus nerve stimulation (tVNS) and meditative-based diaphragmatic breathing (MDB) for fibromyalgia, but did not find significant changes in heart rate variability or pain intensity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Eric J. Roseen, Adlin Pinheiro, Chelsey M. Lemaster, Dorothy Plumb, Shihwe Wang, A. Rani Elwy, Chris C. Streeter, Susan Lynch, Erik Groessl, Karen J. Sherman, Janice Weinberg, Robert B. Saper
Summary: This study investigated the effects of yoga and education on patients with chronic low back pain and found that yoga was not more effective than education in improving pain and disability outcomes. However, participants in the yoga group reported greater improvements and higher satisfaction with treatment.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Anesthesiology
Saida Rezaiguia-Delclaux, Florent Laverdure, Thibaut Genty, Audrey Imbert, Catherine Pilorge, Priscilla Amaru, Celine Sarfati, Francois Stephan
Summary: The study showed that adding TOF monitoring to clinical monitoring did not affect ICU mortality or days on mechanical ventilation in ARDS patients, but did increase atracurium consumption compared to clinical assessment alone.
ANESTHESIA AND ANALGESIA
(2021)
Article
Pharmacology & Pharmacy
Hala M. M. Bakry, Noha O. O. Mansour, Tawfik R. R. ElKhodary, Moetaza M. M. Soliman
Summary: This study aimed to examine the neuroprotective effect of metformin against paclitaxel-induced peripheral neuropathy (PN) in breast cancer patients. The results showed that the incidence of grade two or more PN was significantly lower in the metformin group. Patients in the metformin group had better quality of life and lower pain severity. Therefore, metformin can effectively prevent paclitaxel-induced PN and improve patient's quality of life.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Surgery
Cheau Yan Joan Gan, Koon Khee Chan, Jih Huei Tan, Henry Tan Chor Lip, Leong Liung Louis Ling, Zairul Azwan Mohd Azman
Summary: Despite the lack of significant pain reduction, the study showed that SCEA is a safe modality that more than 90% of patients favored as a substitute for pain relief during colonoscopy.
ANZ JOURNAL OF SURGERY
(2021)
Article
Obstetrics & Gynecology
Nicole B. Kurata, Reema J. Ghatnekar, Elizabeth Mercer, Jennifer M. Chin, Bliss Kaneshiro, Kelly S. Yamasato
Summary: The objective of this study was to evaluate the effect of transcutaneous electrical nerve stimulation (TENS) on opioid use after cesarean birth. The results showed that TENS treatment did not reduce opioid consumption, pain scores, or length of postoperative stay. There was also no evidence of a placebo effect of TENS on opioid use or pain scores.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Nursing
Louise Tonye-Geoffroy, Stephanie Mauboussin Carlos, Sophie Tuffet, Helene Fromentin, Laurence Berard, Judith Leblanc, Francoise Laroche
Summary: This study compared the pain relief effects of hypnosis and TENS combination versus TENS alone in chronic non-cancer pain patients, and found no significant difference between the two groups. Further research on non-pharmacological treatments tailored to specific patient characteristics is needed for patients with complex multidimensional pain conditions.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Medicine, Research & Experimental
Lisa Goudman, Ann De Smedt, Patrice Forget, Sam Eldabe, Maarten Moens
Summary: High-dose spinal cord stimulation (HD-SCS) shows significant and sustained reduction in pain medication use for patients with failed back surgery syndrome (FBSS), especially in neurostimulation-naive patients.
Article
Medicine, Research & Experimental
Sam Eldabe, Rui Duarte, Ashish Gulve, Heather Williams, Fay Garner, Morag Brookes, Grace Madzinga, Eric Buchser, Alan M. Batterham
Summary: The study compared the efficacy of burst and tonic sub-threshold stimulation at 500 Hz versus sham stimulation in reducing pain intensity in adult subjects with chronic back and leg pain using a spinal cord stimulation device. Results showed that T500 stimulation was significantly more effective than sham stimulation, while BST stimulation was practically equivalent to sham stimulation in patients habituated to tonic SCS.
Article
Medicine, Research & Experimental
Raymond Chadwick, Rebekah McNaughton, Sam Eldabe, Ganesan Baranidharan, Jill Bell, Morag Brookes, Rui V. Duarte, Jenny Earle, Ashish Gulve, Rachel Houten, Susan Jowett, Anu Kansal, Shelley Rhodes, Jennifer Robinson, Sara Griffiths, Rod S. Taylor, Simon Thomson, Harbinder Sandhu
Summary: The preference for a one-stage SCS procedure was overwhelming among participants, both before and after implantation. Reasons for this preference included saving time, avoiding worries about loose wires, having only one recovery period, and saving healthcare resources. The qualitative study findings supported the results of the TRIAL-STIM RCT.
Review
Clinical Neurology
Timothy R. Deer, Sam Eldabe, Steven M. Falowski, Marc A. Huntoon, Peter S. Staats, Isaac R. Cassar, Nathan D. Crosby, Joseph W. Boggs
Summary: PNS is an effective tool for chronic pain treatment, with recent studies showing sustained pain reduction and proposing a new theory for pain management.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Colin Green, Sam S. Eldabe, Rod S. Taylor, Mehdi Zahra, Simon Eggington
Summary: The SubQStim study analyzed healthcare resource use and cost of FBSS patients receiving subcutaneous nerve field stimulation. The treatment group had significantly higher costs largely due to device acquisition/implantation, with potential benefits in reducing pain medication and healthcare visits. Further long-term cost-effectiveness analyses are needed to fully evaluate the benefits of stimulation.
Article
Medicine, Research & Experimental
Lisa Goudman, Rui Duarte, Ann De Smedt, Sue Copley, Sam Eldabe, Maarten Moens
Summary: The study analyzed differences in prescription practices of SCS implantation patients between Belgium and the United Kingdom, revealing that NSAIDs and neuropathic mood agents are more frequently used in the UK. After three months of SCS, a decrease in medication use is observed in both countries, with higher reductions in Belgium, presumably due to strict regulations concerning reimbursement criteria.
Article
Anesthesiology
Sam Eldabe, Sue Copley, Ashish Gulve, Ganesan Baranidharan, Beatrice Bretherton, Anu Kansal, Grace Madzinga, Morag Brookes, Simon Thomson, Rui Duarte
Summary: This study aimed to report on the long-term follow-up of DRG stimulation for intractable chronic pain. The findings showed that DRG stimulation can effectively relieve pain and improve quality of life in patients suffering from neuropathic pain. However, there was a high revision rate within the first 24 months and some patients experienced shorter than expected battery life.
Article
Anesthesiology
Zied Zaghdoudi, Sam Eldabe, Sue Copley, Haythem Abbes, Philippe Temperli, Eric Buchser
Summary: Medial branch blockade of the lumbar facet joints is generally considered safe, but a rare case of neurological damage occurred after the procedure, likely due to accidental intra-arterial injection of particulate methylprednisolone causing blockage and ischemia.
Review
Clinical Neurology
Sam Eldabe, Ilona Obara, Catherine Panwar, David Caraway
Summary: The development of biomarkers for chronic pain offers opportunities for better management and prevention. Despite some progress, there is still a need for further research and development.
PAIN RESEARCH & MANAGEMENT
(2022)
Editorial Material
Anesthesiology
Sam Eldabe, Christopher Gilligan, Rod S. Taylor, Kiran V. Patel, Rui V. Duarte
Article
Medicine, General & Internal
Giovanni E. Ferreira, Christina Abdel-Shaheed, Martin Underwood, Nanna B. Finnerup, Richard Day, Andrew McLachlan, Sam Eldabe, Joshua R. Zadro, Christopher G. Maher
Summary: This study provides a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for different pain conditions. The results show that antidepressants are effective in some pain conditions, particularly proton pump inhibitors, postoperative pain, neuropathic pain, and fibromyalgia. However, there is insufficient evidence to support the efficacy of antidepressants in other pain conditions. A more nuanced approach is needed when prescribing antidepressants for pain conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Editorial Material
Anesthesiology
Sam Eldabe, Christopher Gilligan, Rod S. Taylor, Kiran V. Patel, Rui V. Duarte
Review
Anesthesiology
Sam Eldabe, Sarah Nevitt, Sue Copley, Michelle Maden, Lisa Goudman, Salim Hayek, Nagy Mekhail, Maarten Moens, Phillipe Rigoard, Rui Duarte
Summary: This study investigated the impact of industry funding and geographical location on spinal cord stimulation (SCS) therapy. The results showed no significant differences between industry-funded and non-industry-funded studies in terms of outcomes compared to usual care. However, pain intensity and comparisons between high-frequency SCS and low-frequency SCS seemed to be influenced by industry funding.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Editorial Material
Anesthesiology
Peter S. Staats, Rod S. Taylor, Christopher Gilligan, Samir Sheth, Kiran V. Patel, Rui V. Duarte, Sam Eldabe
Review
Anesthesiology
Xander Zuidema, Bastiaan de Galan, Brigitte Brouwer, Steven Cohen, Sam Eldabe, Charles Argoff, Frank Huygen, Jan Van Zundert
Summary: Painful diabetic polyneuropathy (PDPN) is a common symptom in patients with diabetes, causing significant impact on quality of life. The diagnosis and treatment methods are evolving, focusing on precise pain-phenotyping and genotyping, as well as mechanism-based pharmacological treatments. Proper control of glucose levels and prevention of risk factors are essential in treatment.