Article
Clinical Neurology
Emilie R. Hegelund, Amar J. Mehta, Laust H. Mortensen, Rudi G. J. Westendorp
Summary: A cohort study in Denmark from 2005 to 2018 found a significant decline in the incidence of dementia, mainly influenced by education, wealth, cerebrovascular health, and general health.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Franz Felix Konen, Malte Johannes Hannich, Philipp Schwenkenbecher, Matthias Grothe, Konrad Gag, Konstantin Fritz Jendretzky, Stefan Gingele, Kurt-Wolfram Suhs, Torsten Witte, Thomas Skripuletz, Marie Suesse
Summary: This study investigated the cerebrospinal fluid analysis and immune response in patients with early and late onset multiple sclerosis. The results showed that there was no difference in the frequency of cerebrospinal fluid-specific oligoclonal bands between early and late onset multiple sclerosis patients. However, the sensitivity of positive cerebrospinal fluid free light chains kappa fraction was lower in late onset progressive multiple sclerosis patients. The MRZ reaction had the same frequency of positivity in both early and late onset multiple sclerosis patients.
Article
Multidisciplinary Sciences
Bikramaditya Ghosh, Dimitrios Paparas
Summary: This study investigates the risk spillover and connectedness of agri commodities over the past six decades using extreme quantiles. The findings show that these commodities exhibit consistently high levels of risk spillover and connectedness, indicating their vulnerability to various shocks. Rice, Orange Juice, Chicken, Tea, and Groundnut Oil are consistent net receivers, while Palm Oil, Soyabeans, Maize, and Wheat are net emitters throughout. Additionally, there is a decreasing complexity of network connectedness with increased quantiles.
Article
Biochemistry & Molecular Biology
Yu Yang, Lan Wu, Yan Lv, Zhijing Miao, Yuchuan Wang, Jun Yan, Jingyun Li, Chanjuan Li, Hongjuan Ding
Summary: This study aimed to use lipidomics to provide evidence for the etiology and potential therapeutic approaches for late-onset preeclampsia (LOPE). The findings revealed that the abundance of unsaturated triglycerides increased in LOPE patients, and other lipids such as phosphatidylcholine, sphingomyelin, and phosphatidylserine also increased. Lipidomics may help identify the pathogenesis underlying placental dysfunction in LOPE patients and provide potential therapeutic targets in the future.
Article
Medicine, General & Internal
Jane E. Brumbaugh, Edward F. Bell, Barbara T. Do, Rachel G. Greenberg, Barbara J. Stoll, Sara B. DeMauro, Heidi M. Harmon, Susan R. Hintz, Abhik Das, Karen M. Puopolo
Summary: This study aimed to report the incidence of late-onset meningitis (LOM) during birth hospitalization and the neurodevelopmental outcomes at 18 to 26 months' corrected age in children born extremely preterm. The results showed a decreasing incidence of LOM, and both LOM and late-onset sepsis (LOS) were associated with an increased risk of death or neurodevelopmental impairment (NDI), with varying risk depending on the LOM pathogen.
Article
Clinical Neurology
Ermelinda De Meo, Massimo Filippi, Maria Trojano, Giancarlo Comi, Francasco Patti, Vincenzo Brescia Morra, Giuseppe Salemi, Marco Onofrj, Giacomo Lus, Eleonora Cocco, Mattia Fonderico, Valentina Torri Clerici, Giorgia Teresa Maniscalco, Paola Valentino, Antonio Bertolotto, Alessandra Lugaresi, Roberto Bergamaschi, Marco Rovaris, Patrizia Sola, Gioacchino Tedeschi, Ilaria Pesci, Umberto Aguglia, Paola Cavalla, Davide Maimone, Franco Granella, Marika Vianello, Marta Simone, Emilio Portaccio, Maria Pia Amato
Summary: This study aimed to describe and compare the disease course and prognosis of early and late onset pediatric multiple sclerosis. The results showed differences in clinical characteristics between the two groups, with early onset patients exhibiting more severe symptoms and longer disease progression.
ANNALS OF NEUROLOGY
(2022)
Article
Immunology
Kentaro Umemura, Atsuyoshi Mita, Yasunari Ohno, Yuichi Masuda, Kazuki Yoshizawa, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Atsushi Kamachi, Takamune Goto, Hidenori Tomida, Shiori Yamazaki, Akira Shimizu, Yuji Soejima
Summary: Renal function deteriorates slowly yet steadily after pediatric liver transplantation. Long-term careful surveillance is essential, especially in cases of repeated/refractory rejection or long-term high trough-level use of cyclosporine.
Article
Education & Educational Research
Jill Fitzgerald, Jackie Eunjung Relyea, Jeff Elmore, Elfrieda H. Hiebert
Summary: The study examined shifts in academic vocabulary in a first-grade core reading program over six decades, finding a slight increase in the volume of science, social studies, and total academic words over time. While statistically higher in later years, the overall academic affinity of the program also saw an increase, but not significantly in practical terms.
READING RESEARCH QUARTERLY
(2021)
Article
Gastroenterology & Hepatology
Steven H. Chang, Nicolas Patel, Mengmeng Du, Peter S. Liang
Summary: Overall, colorectal cancer (CRC) incidence has decreased in the US, but has increased among younger adults. Whites and Hispanics experienced a significant increase in incidence, while Asians/Pacific Islanders and blacks did not. Males, left-sided tumors, and regional/distant disease showed a greater increase in early-onset CRC incidence.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Jessica L. Petrick, Lauren E. Barber, Shaneda Warren Andersen, Andrea A. Florio, Julie R. Palmer, Lynn Rosenberg
Summary: Colorectal cancer incidence rates have increased in American Indians/Alaskan Natives, Hispanics, and Whites, while rates of colorectal neuroendocrine tumors are increasing in all racial/ethnic groups. The disparity in early-onset CRC rates between Blacks and Whites has narrowed, with rates stabilizing in Blacks, but neuroendocrine tumor rates are rising. Blacks and American Indians/Alaskan Natives have the highest rates of both early- and late-onset CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rikhard Bjorn, Maunu Nissinen, Joonas Lehto, Markus Malmberg, Fredrik Yannopoulos, K. E. Juhani Airaksinen, Juha E. K. Hartikainen, Tuomo Nieminen, Fausto Biancari, Jarmo Gunn, Tuomas O. Kiviniemi
Summary: New-onset atrial fibrillation (NOAF) during surgical aortic valve replacement is associated with an increased risk of atrial fibrillation recurrence and all-cause mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Clinical Neurology
Lucia Romero-Pinel, Laura Bau, Elisabet Matas, Isabel Leon, Albert Munoz-Vendrell, Pablo Arroyo, Cristina Masuet-Aumatell, Antonio Martinez-Yelamos, Sergio Martinez-Yelamos
Summary: The age at onset of relapsing-remitting multiple sclerosis (RRMS) has increased over the past decades, according to this study.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Jose M. Serrano, Rebeca Mata, Iria Gonzalez, Silvia Del Castillo, Javier Muniz, Luis J. Morales, Maria Jesus Espinosa, Fernando Moreno, Rosa Jimenez, Carmen Cristobal, Catherine Graupner, Pedro Talavera, Carlos Gutierez Landaluce, Alejandro Curcio, Javier Alonso, Juan A. Guerra, Joaquin J. Alonso
Summary: This study aimed to assess predictors of early and late onset cardiotoxicity in breast cancer patients. The results showed that the incidence of late-onset cardiotoxicity is high but mostly subclinical. Early diastolic dysfunction after chemotherapy is a strong predictor of anthracycline cardiotoxicity.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Rheumatology
Reza Zonozi, Zachary S. Wallace, Karen Laliberte, Noah R. Huizenga, Jillian M. Rosenthal, Eugene P. Rhee, Frank B. Cortazar, John L. Niles
Summary: Late-onset neutropenia (LON) is a common and often incidental complication of rituximab treatment, with systemic lupus erythematosus and combination therapy with cyclophosphamide being independently associated with an increased risk of LON. Most episodes are asymptomatic, but fever and sepsis can complicate a significant proportion of cases. Filgrastim is commonly used for treatment, and recurrence of LON can occur in a subset of patients following rituximab rechallenge. Vigilant monitoring is warranted due to the potential for serious infections.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Clinical Neurology
Alessio Signori, Johannes Lorscheider, Sandra Vukusic, Maria Trojano, Pietro Iaffaldano, Jan Hillert, Robert Hyde, Fabio Pellegrini, Melinda Magyari, Nils Koch-Henriksen, Per Soelberg Sorensen, Tim Spelman, Anneke van Der Walt, Dana Horakova, Eva Havrdova, Marc Girard, Sara Eichau, Francois Grand'Maison, Oliver Gerlach, Murat Terzi, Serkan Ozakbas, Olga Skibina, Vincent Van Pesch, Maria Jose Sa, Julie Prevost, Raed Alroughani, Pamela A. McCombe, Riadh Gouider, Saloua Mrabet, Tamara Castillo-Trivino, Chao Zhu, Koen de Gans, Jose Luis Sanchez-Menoyo, Bassem Yamout, Samia Khoury, Maria Pia Sormani, Tomas Kalincik, Helmut Butzkueven
Summary: This study identifies different subgroups of patients with secondary progressive multiple sclerosis (SPMS) based on their longitudinal trajectories of disability. The findings suggest that SPMS patients progress at greatly different rates and the identification of distinct trajectories can guide better patient selection in future clinical trials. Additionally, the distinct trajectories may reflect heterogeneous pathological mechanisms of progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Oncology
Mathilde Adsersen, Lau Caspar Thygesen, Maria Kristiansen, Maiken Bang Hansen, Mette Asbjoern Neergaard, Morten Aagaard Petersen, Mogens Groenvold
Summary: The ageing population of immigrants in Europe will result in an increased demand for specialised palliative care. However, the admittance of immigrants to specialised palliative care in Europe has not been well studied.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, General & Internal
Nils Skajaa, Kasper Adelborg, Erzsebet Horvath-Puho, Kenneth J. Rothman, Victor W. Henderson, Lau Caspar Thygesen, Henrik Toft Sorensen
Summary: This study examined labor market participation and retirement among stroke patients and the general population, focusing on different subtypes of stroke. The results showed that most patients took sick leave within three weeks of diagnosis and were less likely to return to the labor market, especially those with intracerebral hemorrhage. The main reasons for non-participation in the labor market were sick leave and receipt of a disability pension.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Pediatrics
Selina K. K. Berg, Nina M. M. Birk, Anne B. B. Thorsted, Siri Rosenkilde, Louise B. B. Jensen, Ulrikka Nygaard, Henning Bundgaard, Lau C. C. Thygesen, Annette K. K. Ersboll, Susanne D. D. Nielsen, Anne V. V. Christensen
Summary: This study investigated the risk of weight changes among Danish children during the COVID-19 pandemic and explored the associations with psychological symptoms and long COVID symptoms. The results showed that 2-3-year-old children with COVID-19 had a higher likelihood of weight loss, while 4-18-year-old children had a lower likelihood of unintended weight gain. Any long COVID-related symptom was associated with weight changes regardless of COVID-19 status. There was no evidence of increasing obesity rates among Danish children post-pandemic.
Article
Clinical Neurology
Zsofia Kokas, Anett Jardanhazy, Daniel Sandi, Tamas Biernacki, Zsanett Fricska-Nagy, Judit Fuvesi, Halina Bartosik-Psujek, Vanja Basic Kes, Thomas Berger, Achim Berthele, Jelena Drulovic, Bernhard Hemmer, Dana Horakova, Alenka Horvat Ledinek, Eva Kubala Havrdova, Melinda Magyari, Konrad Rejdak, Cristina Tiu, Peter Turcani, Peter Klivenyi, Zsigmond Tamas Kincses, Laszlo Vecsei, Krisztina Bencsik
Summary: In most Central-Eastern European countries, the recommendations for multiple sclerosis (MS) care units are met, but there are still some deficiencies, such as the lack of speech therapists, specialists for continence, pain and spasticity, neuro-ophthalmologists, and otoneurologists. Although multiple disease-modifying therapies (DMTs) are reimbursed, not every center provides all available DMTs. Additionally, only Austria and the Czech Republic require national registry use. Therefore, in countries where MSCU recommendations are not fulfilled, a strictly regulated center system similar to the Austrian and Czech model, with a registry-based quality control, may ensure appropriate care for MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Anne Sofie Plum Christensen, Veronica Pisinger, Anne Friis Krarup, Peter Dalum, Lau Caspar Thygesen, Janne Schurmann Tolstrup
Summary: Excessive alcohol consumption among young people is a global public health concern due to its negative impact on short- and long-term well-being. This study investigated the association between weekly alcohol consumption and various measures of poor well-being among students aged 15-25 years in Denmark. The findings revealed a U-shaped relationship, where both non-drinkers and heavy drinkers had higher odds of poor well-being compared to moderate drinkers. Understanding these associations can contribute to reducing alcohol consumption and promoting well-being among young students.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Oncology
Cecilie Larsen, Kirstine S. Kirchhoff, Lena Saltbaek, Lau C. Thygesen, Randi V. Karlsen, Mads N. Svendsen, Beverley L. Hoeg, Trine A. Horsbol, Pernille E. Bidstrup, Helle G. Christensen, Christoffer Johansen, Susanne O. Dalton
Summary: This study investigates the association between education level and fear of recurrence (FCR) among breast cancer patients, and finds that patients with higher education levels have less FCR compared to those with lower education levels. Self-efficacy only mediates a small part of this association among patients within 5 years since diagnosis.
Article
Health Care Sciences & Services
Anne Katrine Graudal Levinsen, Trille Kristina Kjaer, Thomas Maltesen, Erik Jakobsen, Ismail Gogenur, Michael Borre, Peer Christiansen, Robert Zachariae, Soren Laurberg, Peter Christensen, Niels Kroman, Signe Benzon Larsen, Thea Helene Degett, Lisbet Rosenkrantz Holmich, Peter de Nully Brown, Christoffer Johansen, Susanne K. Kjaer, Lau Caspar Thygesen, Susanne Oksbjerg Dalton
Summary: Cancer survivors use more healthcare services compared to cancer-free individuals. There is a correlation between educational level and healthcare use, with survivors with lower education being more likely to use general practitioner and acute healthcare services.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Simone G. Kjeld, Lau C. Thygesen, Dina Danielsen, Gitte S. Jakobsen, Marie P. Jensen, Teresa Holmberg, Lotus S. Bast, Lisbeth Lund, Charlotta Pisinger, Susan Andersen
Summary: This study examined the effects of a school-based multi-component intervention on students' smoking behavior. The overall intervention did not show significant effects, but significant reduction in smoking was found in certain subgroups. The study suggests the need to develop relevant intervention programs for high-risk groups and ensure their full implementation.
Article
Immunology
Selina Kikkenborg Berg, Helle Wallach-Kildemoes, Line Ryberg Rasmussen, Ulrikka Nygaard, Nina Marie Birk, Henning Bundgaard, Annette Kjaer Ersboll, Lau Caspar Thygesen, Susanne Dam Nielsen, Anne Vinggaard Christensen
Summary: This study investigated the changes in symptom-specific hospital contacts among 12-18-year-olds following two doses of BNT162b2 COVID-19 vaccine compared to unvaccinated peers. National register data was used to match vaccinated and unvaccinated adolescents based on sex and age. Differences between the vaccinated and unvaccinated were found in symptom-specific hospital contacts, with higher rates observed for some symptoms among the vaccinated and higher rates for others among the unvaccinated. Monitoring of specific symptoms is important post-vaccination, considering the risk of infection and symptoms following COVID-19 infection.
Article
Psychology, Clinical
Ziggi Ivan Santini, Lau Caspar Thygesen, Steinar Krokstad, Lars Ole Bonde, Robert J. Donovan, Vibeke Koushede, Anita Jensen, Ai Koyanagi, Ola Ekholm
Summary: This study aims to assess the associations between engagement in arts and culture activities and incident/persistent depression as well as mental wellbeing among Danish adults. The results showed a negative correlation between engagement in arts and culture activities and the risk of incident and persistent depression, as well as higher odds for moderate mental wellbeing.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Oncology
Heidi Amalie Rosendahl Jensen, Trine Allerslev Horsbol, Lau Caspar Thygesen, Michael Davidsen, Anne Illemann Christensen, Ola Ekholm
Summary: This study examines the accuracy of self-reported cancer history and its negative predictive value using registry data as the criterion standard. The results show that the negative predictive value is consistently high, but sensitivity varies greatly across different cancer types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Nils Iorgen Koch-Henriksen, Lau Caspar Thygesen, Per Soelberg Sorensen, Melinda Magyari
Summary: This study demonstrates the use of instrumental variables to reduce bias in observational studies and confirms the effectiveness of treatment in delaying disability in multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Chemistry, Analytical
Spyridon Kontaxis, Estela Laporta, Esther Garcia, Matteo Martinis, Letizia Leocani, Lucia Roselli, Mathias Due Buron, Ana Isabel Guerrero, Ana Zabala, Nicholas Cummins, Srinivasan Vairavan, Matthew Hotopf, Richard J. B. A. Dobson, Vaibhav Narayan, Maria Libera La Porta, Gloria Dalla Costa, Melinda Magyari, Per Soelberg Sorensen, Carlos Nos, Raquel Bailon, Giancarlo Comi, RADAR CNS Consortium
Summary: The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). The study collected the 2MWDs as evaluated by clinicians and derived from accelerometer data from 154 pwMS, along with MS-related clinical outcomes. The results showed that estimating the 2MWD using a wearable device yielded a low error rate and had strong correlations with clinical outcomes.
Article
Clinical Neurology
Josefine Windfeld-Mathiasen, Henrik Horwitz, Johanna Balslev Andersen, Elisabeth Framke, Christina Gade, Jon Traerup Andersen, Melinda Magyari
Summary: This retrospective matched cohort study investigated the impact of exposure to interferon-beta during pregnancy on the risk of significant infections in early childhood. The study included 510 children born to mothers with multiple sclerosis who were exposed to interferon-beta in utero. The results showed that exposure to interferon-beta had little to no impact on the risk of acquiring significant infections during the first five years of childhood.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)