Article
Health Care Sciences & Services
Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
Summary: This study investigated the effects of tDCS on swallowing function in individuals with different COMT gene polymorphisms. The results showed that individuals with COMT Val/Val polymorphism experienced improvement in swallowing motor function after tDCS, while those with COMT Met carrier group did not show significant changes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Hanall Lee, Joon Ho Lee, Tae Lee Lee, Do-Kyung Ko, Nyeonju Kang
Summary: This study investigated the effectiveness of three different bilateral tDCS protocols on bimanual hand-grip force control capabilities in healthy young adults. The results showed that bilateral anodal stimulation significantly improved bilateral motor synergies, suggesting that promoting motor cortical activations between hemispheres is an additional option for enhancing interlimb coordination patterns.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Yifan Huang, Yinling Zhang, Yizhe Zhang, Xiaoqin Mai
Summary: This study found that transcranial direct current stimulation (tDCS) over the left primary motor cortex has a positive effect on verbal intelligence, but no effect on performance intelligence.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Alireza Majdi, Luuk van Boekholdt, Saeed Sadigh-Eteghad, Myles Mc Laughlin
Summary: Transcranial direct-current stimulation (tDCS) appears to improve cognitive function in patients with Alzheimer's disease (AD), particularly in memory and general cognition. However, more high-quality studies with standardized parameters and measures are needed due to the limited number of studies and high heterogeneity of the data.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Lindsay Griffin, Erin Kamarunas, Christina Kuo, Cynthia O'Donoghue
Summary: The purpose of this study was to determine the most effective amplitude criterion of anodal tDCS for promoting neuroplasticity in dysphagia rehabilitation. The results showed that during a swallowing task, healthy volunteers receiving 1 mA of anodal tDCS demonstrated a suppressed hemodynamic response, while those receiving 2 mA of anodal tDCS had an increase in the hemodynamic response. There was no significant effect on submental muscle contraction regardless of amplitude. Anodal tDCS was well tolerated in healthy adults.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Review
Clinical Neurology
Paloma Cristina Alves de Oliveira, Thiago Anderson Brito de Araujo, Daniel Gomes da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya
Summary: There was no significant short-term effect of tDCS alone on motor function, balance, gait, dyskinesias, or motor fluctuations in Parkinson's disease, regardless of brain area or the number of stimulated targets.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Rajan Kashyap, Sagarika Bhattacharjee, Ramaswamy Arumugam, Rose Dawn Bharath, Kaviraja Udupa, Kenichi Oishi, John E. Desmond, S. H. Annabel Chen, Cuntai Guan
Summary: The study introduced a dose-target determination index (DTDI) to quantify the focality of tDCS and found that individuals of different ages and genders show varying changes in focality when the current dose is increased. The nonlinear relationship between the injected tDCS current and the distribution of current density in the target ROI is predominant in older adults, with males exhibiting a stronger decline in focality. Higher current doses in older age can enhance the focality of stimulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Clinical Neurology
Shawn Hiew, Carine Nguemeni, Daniel Zeller
Summary: Transcranial direct current stimulation (tDCS) in multiple sclerosis (MS) shows inconsistent effects on motor symptoms but promising benefits in alleviating fatigue, pain, and cognitive symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Evangelia G. Chrysikou, Hannah M. Morrow, Austin Flohrschutz, Lauryn Denney
Summary: Research on the impact of activity on innovative thinking has shown that cathodal stimulation of the left ventrolateral prefrontal cortex can improve fluency in generating creative ideas, while bilateral stimulation of the ventrolateral PFC and excitatory stimulation of the occipital cortex do not alter task performance. This highlights the importance of methodological consistency in experiments and expands our understanding of the role of the left PFC in creative thinking.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Giulia Isadora Cenci, Rebeka Bustamante Rocha, Fernanda Ferreira Bomtempo, Gabriela Borges Nager, Guilherme Diogo Silva, Eberval Gadelha Figueiredo, Joao Paulo Mota Telles
Summary: This review examines the evidence of using tDCS for post-stroke dysphagia. Although most studies reported benefits, the high heterogeneity and differences in stroke types prevented direct comparison. Additionally, the inclusion of patients within 6 months after stroke may introduce bias.
NEUROLOGICAL SCIENCES
(2023)
Article
Psychology, Multidisciplinary
Ziyu Wang, Rongjuan Zhu, Xuqun You
Summary: This study manipulated task types and predictability to investigate the role of the DLPFC in task-switching performances, finding that anodal tDCS may have a stronger influence over the right DLPFC by changing the irrelevant task-set inhibition process. The right DLPFC is unlikely to act by performing exogenous adjustment of predictable task switching.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
E. L. Pavlova, R. V. Semenov, M. P. Pavlova-Deb, A. B. Guekht
Summary: This study investigated the effects of single-session premotor and primary motor transcranial direct current stimulation (tDCS) in chronic stroke patients and found that the premotor cortex is a promising candidate area for non-invasive stimulation in these patients.
Article
Neurosciences
Mahyar Firouzi, Kris Baetens, Manon Saeys, Catalina Duta, Chris Baeken, Frank Van Overwalle, Eva Swinnen, Natacha Deroost
Summary: In this study, the effects of conventional tDCS and high-definition tDCS on implicit motor sequence learning (IMSL) were compared. The results showed that conventional tDCS had positive effects on sequence-specific learning during the acquisition phase, but might have negative effects on long-term consolidation. On the other hand, high-definition tDCS had negative effects on sequence-specific learning during both the acquisition and long-term consolidation phases.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Tadeas Mares, Jakub Albrecht, Jozef Buday, Gabriela Podgorna, Thai Hong Le, Eva Magyarova, Katerina Poshor, Jakub Halik, Jan Buna, Vaclav Capek, Lenka Kostylkova, Johana Klasova, Vratislav Fabian, Martin Anders
Summary: In this study, a randomized, double-blinded, sham-controlled trial was conducted to investigate the effect of transcranial direct current stimulation (tDCS) on tinnitus. The results showed partial positive long-term effects of tDCS on auditory difficulties associated with tinnitus, as well as short-term negative effects on a specific aspect of general quality of life. However, the small sample size limited the statistical power of the analyzed items.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Nadja Doerig, Rosa J. Seinsche, Marius Moisa, Erich Seifritz, Christian C. Ruff, Birgit Kleim
Summary: Reappraisal of negative memories is crucial for mental health, and tDCS may enhance these effects, potentially optimizing treatment approaches for psychiatric disorders.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
G. Caravaglios, E. G. Muscoso, V Blandino, G. Di Maria, M. Gangitano, F. Graziano, F. Guajana, T. Piccoli
Summary: This study used electroencephalography to detect and compare resting-state networks in patients with amnesic mild cognitive impairment (aMCI) and healthy elderly (HE). The results showed that aMCI patients used some networks differently than HE, suggesting differences in network connectivity between the two groups, which may be related to Alzheimer's network disconnection.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Correction
Clinical Neurology
Vincenzo Di Stefano, Maria Vittoria De Angelis, Chiara Montemitro, Mirella Russo, Claudia Carrarini, Massimo di Giannantonio, Filippo Brighina, Marco Onofrj, David J. Werring, Robert Simister
NEUROLOGICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Daniela Di Lisi, Vincenzo Di Stefano, Filippo Brighina, Alfredo Ruggero Galassi, Giuseppina Novo
Summary: Transthyretin cardiac amyloidosis is a restrictive cardiomyopathy caused by the extracellular deposition of amyloid fibrils derived from plasma transthyretin. Early recognition and treatment are crucial for improving the prognosis. RNA-interfering drugs and stabilizers of the native tetramer structure of TTR have shown effectiveness in the treatment of different forms of cardiac amyloidosis.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Clinical Neurology
Giorgia Coratti, Martina Ricci, Anna Capasso, Adele D'amico, Valeria Sansone, Claudio Bruno, Sonia Messina, Federica Ricci, Tiziana Mongini, Michela Coccia, Gabriele Siciliano, Elena Pegoraro, Mara Turri, Massimiliano Filosto, Giacomo Comi, Riccardo Masson, Lorenzo Maggi, Irene Bruno, Maria Grazia D'Angelo, Antonio Trabacca, Veria Vacchiano, Maria Donati, Isabella Simone, Lucia Ruggiero, Antonio Varone, Lorenzo Verriello, Angela Berardinelli, Caterina Agosto, Antonella Pini, Maria Antonietta Maioli, Luigia Passamano, Filippo Brighina, Nicola Carboni, Matteo Garibaldi, Riccardo Zuccarino, Delio Gagliardi, Sabrina Siliquini, Stefano Previtali, Domenica Taruscio, Stefania Boccia, Maria Carmela Pera, Marika Pane, Eugenio Mercuri
Summary: This study aimed to assess the prevalence of SMA and treatment prescription in Italy. An online survey was conducted, and data on 1255 SMA patients were collected. The majority of patients (85%) were receiving one of the available treatments.
Article
Neurosciences
Paolo Alonge, Vincenzo Di Stefano, Antonino Lupica, Massimo Gangitano, Angelo Torrente, Antonia Pignolo, Bruna Maggio, Salvatore Iacono, Francesca Gentile, Filippo Brighina
Summary: This study retrospectively evaluated the electrophysiological and clinical score data of 15 CIDP patients receiving SCIg maintenance therapy. The results showed that SCIg therapy preserves nerve function in CIDP with good efficacy and safety. Electrophysiological studies are a useful tool for follow-up and prognostic assessment of CIDP.
Review
Medicine, General & Internal
Davide Norata, Marta Peri, Giuseppe Roberto Giammalva, Antonino Lupica, Federica Paolini, Lorena Incorvaia, Giuseppe Badalamenti, Valerio Gristina, Antonio Galvano, Antonio Russo, Domenico Gerardo Iacopino, Mauro Silvestrini, Viviana Bazan, Filippo Brighina, Vincenzo Di Stefano
Summary: Von Hippel-Lindau (VHL) disease is an autosomal dominant condition that predisposes affected individuals to a variety of malignant and benign neoplasms. The accumulation of hypoxia-inducible factor (HIF)-1 alpha, a transcription factor involved in various biological processes, is the key turning point of this disease. Understanding the molecular pathways is important for targeted therapies and surgical intervention in VHL disease.
Article
Biochemistry & Molecular Biology
Vincenzo Di Stefano, Ewan Thomas, Paolo Alonge, Valerio Giustino, Guglielmo Pillitteri, Ignazio Leale, Angelo Torrente, Antonia Pignolo, Davide Norata, Salvatore Iacono, Antonino Lupica, Antonio Palma, Giuseppe Battaglia, Filippo Brighina
Summary: This study evaluated the effects of patisiran treatment in patients with ATTRv amyloidosis. The results showed that after 9 months of treatment, there were significant changes in body composition, with an increase in muscle mass and a decrease in fat mass. Additionally, the patients' physical performance also improved.
Article
Clinical Neurology
Angelo Torrente, Paolo Alonge, Vincenzo Di Stefano, Roberta Baschi, Raffaele Ornello, Edvige Correnti, Antonino Lupica, Cecilia Camarda, Gabriella Farinella, Vincenzo Raieli, Simona Sacco, Roberto Monastero, Filippo Brighina
Summary: This study describes the characteristics of patients who develop new-onset headache following SARS-CoV-2 infection. The results show that the timing and characteristics of headache vary among patients, and the response to treatment also varies.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Cell Biology
Claudia Vinciguerra, Salvatore Iacono, Liliana Bevilacqua, Annamaria Landolfi, Giuseppe Piscosquito, Federica Ginanneschi, Giuseppe Schiro, Vincenzo Di Stefano, Filippo Brighina, Paolo Barone, Carmela Rita Balistreri
Summary: The prevalence, onset, pathophysiology, and clinical course of neuromuscular disorders (NMDs) can differ significantly between males and females. Genetic inheritance plays a familiar role in sex differences in NMDs, but hormonal and genetic factors can also influence the clinical presentation and severity of acquired forms. This review summarizes the sex-related differences in both acquired and inherited NMDs, highlighting the distinctive biological roles of these factors.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Clinical Neurology
Simona Maccora, Nadia Bolognini, Carlo Mannina, Angelo Torrente, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Guido Sireci, Filippo Brighina
Summary: This study aimed to investigate the influence of estradiol on the sound-induced flash illusion (SIFI) and found that high estradiol levels during ovulation led to reduced perception of SIFI in women, indicating an enhanced excitability of the visual cortex. Additionally, migraine women perceived fewer flashes in the illusion compared to controls, independent of the menstrual cycle phase.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Alessia Bianchi, Maria Aprile, Giuseppe Schiro, Claudia Gasparro, Salvatore Iacono, Michele Andolina, Maurizio Marrale, Irene Gattuso, Giuseppe La Tona, Massimo Midiri, Cesare Gagliardo, Giuseppe Salemi, Paolo Ragonese
Summary: The aim of this study was to investigate the association between fetal microchimeric cells (fMCs) and magnetic resonance imaging (MRI) features in women with multiple sclerosis (MS). The results suggested that fMCs could accumulate in different brain areas, leading to brain atrophy in MS patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Laura Pilati, Angelo Torrente, Salvatore Di Marco, Salvatore Ferlisi, Giulia Notaro, Marika Romano, Paolo Alonge, Lavinia Vassallo, Ludovica Ferrau, Massimo Autunno, Rosario Grugno, Cecilia Camarda, Filippo Brighina
Summary: The use of monoclonal antibodies targeting CGRP or CGRPr has revolutionized migraine management, with high efficacy and few side effects. This study assessed the effect of erenumab on chronotype in chronic migraine, showing a shift from morning to intermediate chronotype. Patients who responded to treatment also experienced progressive sleep efficiency reduction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Article
Food Science & Technology
Angelo Torrente, Paolo Alonge, Laura Pilati, Andrea Gagliardo, Lavinia Vassallo, Vincenzo Di Stefano, Antonino Lupica, Irene Quartana, Giovanna Viticchi, Mauro Silvestrini, Marco Bartolini, Cecilia Camarda, Filippo Brighina
Summary: A single session of onabotulinumtoxinA did not affect patients' sleep quality or psychological symptoms, but it significantly reduced the frequency of migraine attacks.
Meeting Abstract
Clinical Neurology
Francesca Brambillasca, Annamaria Porreca, Marco Luigetti, Filomena My, Fiore Manganelli, Alessandro Barilaro, Maurizio Inghilleri, Filippo Brighina, Francesco Logullo, Vittoria Cianci, Stefania Morino, Laura Obici, Grazia Foti, Antonio Di Muzio, Maria Grazia Chiappini, Davide Pareyson, Clara Chisari, Roberto Massa
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)