Article
Medicine, General & Internal
Hongwei Lin, Jie Shen, Yu Zhu, Lihui Zhou, Fan Wu, Zongchi Liu, Shengxiang Zhang, Renya Zhan
Summary: Serum CCL23 levels are associated with initial clinical severity, delayed cerebral ischemia (DCI), and functional outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Junlin Lu, Liang Wang, Runting Li, Fa Lin, Yu Chen, Debin Yan, Jun Yang, Ruinan Li, Zhipeng Li, Haibin Zhang, Heze Han, Kexin Yuan, Ke Wang, Yihang Ren, Xiaolin Chen, Yuanli Zhao, Jizong Zhao
Summary: This study aimed to assess the clinical prognosis differences between different treatment timings in poor-grade (Hunt and Hess grade 4-5) aneurysmal subarachnoid hemorrhage patients. The treated 127 poor-grade aneurysmal subarachnoid hemorrhage patients were divided into three groups based on treatment timing. Patients who received treatment on days 3 to 10 had a higher risk of developing delayed cerebral ischemia and poor prognosis at 3 months. Early intervention, especially for patients older than 55 years or diagnosed with intraventricular hematoma, is suggested for better outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Laszlo Zavori, Reka Varnai, Tihamer Molnar, Balazs Szirmay, Nelli Farkas, Attila Schwarcz, Peter Csecsei
Summary: This study found that early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) affects the level of orosomucoid (ORM). Serum ORM levels can serve as a marker for assessing the extent of EBI-induced damage and are associated with delayed cerebral ischemia (DCI) and unfavorable long-term functional outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dora Spantler, Tihamer Molnar, Diana Simon, Timea Berki, Andras Buki, Attila Schwarcz, Peter Csecsei
Summary: This study found that the levels of CX3CL1 and MCP-3 are associated with the development of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage. IP-10, MCP-3, and MIP-1b also show significant associations with the functional outcome after aneurysmal subarachnoid hemorrhage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Keshav Jayaraman, Meizi Liu, Gregory J. Zipfel, Umeshkumar Athiraman
Summary: Studies have shown that pre-treatment with sevoflurane or desflurane can alleviate large artery vasospasm and neurologic deficits caused by SAH. Further research is needed to confirm and understand the mechanisms of these protective effects in both preclinical and clinical settings, considering the frequent clinical use and safety profile of these anesthetics.
Article
Medical Laboratory Technology
Bing Xu, Yang Zhou, Zhenbo Zhang, Jiasen Ma, Keqiong Lv
Summary: Serum NLRP3 may serve as an inflammatory biomarker for assessing the severity, delayed cerebral ischemia, and poor functional outcome after aneurysmal subarachnoid hemorrhage (aSAH). The concentration of serum NLRP3 is significantly correlated with multiple indicators and can independently predict the occurrence of delayed cerebral ischemia and poor 90-day outcome.
CLINICA CHIMICA ACTA
(2022)
Article
Clinical Neurology
Michael Veldeman, Daniel Lepore, Anke Hoellig, Hans Clusmann, Christian Stoppe, Gerrit Alexander Schubert, Walid Albanna
Summary: The study evaluated the predictive and confirmative value of procalcitonin (PCT) levels in the context of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH). Results indicated that early higher PCT levels were associated with the later development of DCI and unfavorable outcome, especially in infection-free patients where PCT levels were related to DCI and cerebral infarction.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Inez Koopman, Philippine B. van Wijngaarden, Gabriel J. E. Rinkel, Mervyn D. I. Vergouwen
Summary: This study investigated the proportion of aSAH patients in a good clinical condition who developed devastating DCI and characterized these patients by aneurysm location, blood pressure instability, and cerebral ischemia. The results showed a low proportion of patients developing devastating DCI, and the majority of these patients had blood pressure instability. Further research is needed to examine the impact of reducing blood pressure fluctuations on the incidence of devastating DCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Andrew M. Nguyen, Craig A. Williamson, Aditya S. Pandey, Kyle M. Sheehan, Venkatakrishna Rajajee
Summary: Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) can lead to worse outcomes, and the presence of moderate-to-severe large-vessel vasospasm (LVV) on screening CT angiography (CTA) between days 4-8 is an independent predictor of DCI. However, the diagnostic accuracy is moderate, highlighting the need for additional risk-stratification strategies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ilari Rautalin, Seppo Juvela, Michael L. Martini, Robert Loch Macdonald, Miikka Korja
Summary: Increasing age, thick aSAH, obesity, and preadmission hypertension are risk factors for delayed cerebral ischemia (DCI) in good-grade patients with aneurysmal subarachnoid hemorrhage (aSAH).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Suzuki, Fumihiro Kawakita, Reona Asada
Summary: Delayed cerebral ischemia (DCI) is a preventable and treatable condition that occurs after aneurysmal subarachnoid hemorrhage (SAH). The pathology of DCI is multifactorial, with neuroelectric disruptions playing a significant role. These disruptions, such as excitotoxicity, cortical spreading depolarization, and epileptiform discharges, can trigger each other and increase metabolic demand. If metabolic demand exceeds impaired blood supply, relative ischemia occurs, leading to DCI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hideki Nakajima, Fumihiro Kawakita, Hiroki Oinaka, Yume Suzuki, Mai Nampei, Yotaro Kitano, Hirofumi Nishikawa, Masashi Fujimoto, Yoichi Miura, Ryuta Yasuda, Naoki Toma, Hidenori Suzuki
Summary: This study reveals that plasma levels of SPARC, a matricellular protein, are increased after subarachnoid hemorrhage (SAH). Higher levels of SPARC are associated with the development of delayed cerebral ischemia (DCI) in SAH patients, independent of angiographic vasospasm.
Article
Clinical Neurology
Hidenori Suzuki, Yoichi Miura, Ryuta Yasuda, Tetsushi Yago, Hisashi Mizutani, Tomonori Ichikawa, Takahiro Miyazaki, Yotaro Kitano, Hirofumi Nishikawa, Fumihiro Kawakita, Masashi Fujimoto, Naoki Toma
Summary: By studying the use of levetiracetam and perampanel in different time frames post-SAH, it was found that these antiepileptic drugs could reduce the risk of DCI. Additionally, perampanel may reduce the development of DCI by preventing microcirculatory disturbances.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Medicine, General & Internal
Sebastian R. Reder, Steffen Lueckerath, Axel Neulen, Katja U. Beiser, Nils F. Grauhan, Ahmed E. Othman, Marc A. Brockmann, Carolin Brockmann, Andrea Kronfeld
Summary: Predicting clinical outcomes in aSAH and DCI patients by assessing cerebral perfusion using a 2DPA time-contrast agent concentration model.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
William E. Spears, David M. Greer, Thanh N. Nguyen
Summary: This article describes the updated guidelines for aneurysmal subarachnoid hemorrhage, including preventive care, treatment modalities, complications, diagnosis and treatment of cerebral ischemia, and recovery.
Article
Clinical Neurology
Meng Wang, Ying Han, Chun-Juan Wang, Tao Xue, Hong-Qiu Gu, Kai-Xuan Yang, Heng-Yi Liu, Man Cao, Xia Meng, Yong Jiang, Xin Yang, Jing Zhang, Yun-Yun Xiong, Xing-Quan Zhao, Li-Ping Liu, Yi-Long Wang, Tian-Jia Guan, Zi-Xiao Li, Yong-Jun Wang
Summary: Short-term exposure to PM2.5 is significantly associated with hospital admission for stroke in individuals with pre-existing medical histories, especially in older or female patients with AF. Preventive measures to reduce PM2.5 concentrations are particularly important in individuals with other medical co-morbidities.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Yuying Liu, Xuan Tian, Thomas W. Leung, Liping Liu, David S. Liebeskind, Xinyi Leng
Summary: This study reviewed and analyzed the evidence on the associations between pretreatment collateral status and outcomes after endovascular treatment (EVT) for acute basilar artery occlusion (BAO). The results showed that good pretreatment collateral status was associated with favorable 90-day functional outcome, successful recanalization, and reduced 90-day mortality.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Yu Tian, Yuesong Pan, Mengxing Wang, Xia Meng, Xingquan Zhao, Liping Liu, Yongjun Wang, Yilong Wang
Summary: This study investigated the relationships between heart rate variability (HRV) combined with the ABCD2 score and adverse outcomes after acute minor stroke (MS) or transient ischemic attack (TIA). The combination of HRV and ABCD2 score efficiently stratified the risk of 1-year recurrent stroke after MS/TIA, and lower SDNN was independently related to recurrent stroke in patients with MS/TIA.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Immunology
Suyue Pan, Junlei Chang, Liping Liu, Xiaofeng Jia
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ying Gao, Yuesong Pan, Shangrong Han, Weiqi Chen, Jing Jing, Chunjuan Wang, Yingying Yang, Tingting Wang, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, S. Claiborne Johnston, Pierre Amarenco, Philip M. Bath, Yongjun Wang, Yilong Wang, INSPIRES Invest
Summary: This study aims to evaluate the efficacy and safety of intensive antiplatelet and statin treatments initiated within 24-72 hours of cerebral ischaemic events caused by intracranial or extracranial atherosclerosis. 6100 individuals aged 35-80 who have experienced a mild ischaemic stroke or high-risk transient ischaemic attack will be enrolled. The primary outcome is the occurrence of any new stroke within 90 days after randomisation.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Cell Biology
Liping Liu, Yan Liu, Yueyan Zhao
Summary: This study aimed to investigate the role and mechanism of circ_0008896 in Atherosclerosis (AS) using oxidized low-density lipoprotein (ox-LDL)-induced human aortic endothelial cell (HAECs). The results showed that circ_0008896 was upregulated in AS patients and ox-LDL-stimulated HAECs. Functionally, circ_0008896 knockdown reversed ox-LDL-induced inflammatory response, oxidative stress, apoptosis, and growth arrest in HAECs. Mechanistically, circ_0008896 functioned as a sponge for miR-188-3p to relieve the repression of miR-188-3p on its target NOD2.
CELL STRESS & CHAPERONES
(2023)
Article
Neurosciences
Na Wei, Yufei Wei, Ximing Nie, Xiran Liu, Xianglong Xiang, Yuesong Pan, Xia Meng, Liping Liu, Yongjun Wang
Summary: This study aimed to investigate the association between LVEF spectrum and 1-year clinical outcomes in patients with AIS or TIA. The results showed that LVEF <= 60% was associated with a higher risk of all-cause death within 1 year.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Xiaochuan Huo, Gaoting Ma, Xu Tong, Xuelei Zhang, Yuesong Pan, Thanh N. N. Nguyen, Guangxiong Yuan, Hongxing Han, Wenhuo Chen, Ming Wei, Jiangang Zhang, Zhiming Zhou, Xiaoxi Yao, Guoqing Wang, Weigen Song, Xueli Cai, Guangxian Nan, Di Li, A. Yi-Chou Wang, Wentong Ling, Chuwei Cai, Changming Wen, En Wang, Liyong Zhang, Changchun Jiang, Yajie Liu, Geng Liao, Xiaohui Chen, Tianxiao Li, Shudong Liu, Jinglun Li, Feng Gao, Ning Ma, Dapeng Mo, Ligang Song, Xuan Sun, Xiaoqing Li, Yiming Deng, Gang Luo, Ming Lv, Hongwei He, Aihua Liu, Jingbo Zhang, Shiqing Mu, Lian Liu, Jing Jing, Ximing Nie, Zeyu Ding, Wanliang Du, Xingquan Zhao, Pengfei Yang, Liping Liu, Yilong Wang, David S. S. Liebeskind, Vitor M. Pereira, Zeguang Ren, Yongjun Wang, Zhongrong Miao, ANGEL-ASPECT Investigators
Summary: In a trial conducted in China, endovascular therapy within 24 hours resulted in better outcomes for patients with large cerebral infarctions compared to medical management alone, but with increased risk of hemorrhage.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Xin Qiu, Yongbo Zhang, Hongqiu Gu, Yingyu Jiang, Yuesong Pan, Yong Jiang, Xia Meng, Yilong Wang, Xingquan Zhao, Hao Li, Xiujie Wang, Yongjun Wang, Zixiao Li, CHANCE Investigators
Summary: This study investigated the association between CYP2B6 polymorphisms and the efficacy of clopidogrel in patients with minor stroke or transient ischemic attack. The results showed no significant difference in the efficacy of aspirin plus clopidogrel compared with aspirin alone, regardless of the presence of CYP2B6 polymorphisms. Therefore, both carriers and noncarriers of CYP2B6 polymorphisms may benefit from aspirin plus clopidogrel treatment for secondary stroke prevention.
Article
Clinical Neurology
Piers Klein, Xiaochuan Huo, Yimin Chen, Mohamad Abdalkader, Zhongming Qiu, Simon Nagel, Jean Raymond, Liping Liu, James E. Siegler, Daniel Strbian, Thalia S. Field, Shadi Yaghi, Muhammad M. Qureshi, Jelle Demeestere, Volker Puetz, Anne Berberich, Patrik Michel, Urs Fischer, Johannes Kaesmacher, Hiroshi Yamagami, Fana Alemseged, Georgios Tsivgoulis, Wouter J. Schonewille, Wei Hu, Xinfeng Liu, Chuanhui Li, Xunming Ji, Brian Drumm, Soma Banerjee, Simona Sacco, Else C. Sandset, Espen Saxhaug Kristoffersen, Peter Slade, Robert Mikulik, Michele Romoli, Francesco Diana, Kailash Krishnan, Permesh Dhillon, Jin Soo Lee, Ekkehard Kasper, Hormuzdiyar Dasenbrock, Mai Duy Ton, Rytis Masiliunas, Anita Ante Arsovska, Joao Pedro Marto, Adam A. Dmytriw, Robert W. Regenhardt, Gisele Sampaio Silva, Timo Siepmann, Dapeng Sun, Hongfei Sang, Jose Danilo Diestro, Pengfei Yang, Mahmoud H. Mohammaden, Fengli Li, Hesham E. Masoud, Alice Ma, Aravind Ganesh, Jianmin Liu, Lukas Meyer, Diederik W. J. Dippel, Goetz Thomalla, Mark Parsons, Adnan I. Qureshi, Mayank Goyal, Albert J. Yoo, Bertrand Lapergue, Osama O. Zaidat, Hui-Sheng Chen, Bruce C. V. Campbell, Tudor G. Jovin, Raul G. Nogueira, Zhongrong Miao, Gustavo Saposnik, Thanh N. Nguyen
Summary: The imaging modality used for selecting patients for endovascular thrombectomy (EVT) in the late window varies among clinicians with different specialty training. In an international survey, interventionists were more likely to proceed directly to EVT and prefer less advanced imaging techniques compared to non-interventionists. When faced with uncertainty, non-interventionists were more likely to follow clinical guidelines, while interventionists relied more on their assessment of evidence.
CLINICAL NEURORADIOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Yuan Xu, Wei-Qi Chen, Meng-Xing Wang, Yue-Song Pan, Zi-Xiao Li, Li-Ping Liu, Xing-Quan Zhao, Yi-Long Wang, Hao Li, Yong-Jun Wang, Xia Meng
Summary: This study aimed to assess the management of LDL-C and goal achievement in patients with ischemic stroke or TIA, as well as the association between baseline LDL-C level, LLT, and stroke recurrence. A post hoc analysis of the CNSR-III showed a mild increase in LDL-C goal achievement rate among stroke and TIA patients in mainland China. Lower baseline LDL-C level was significantly associated with a decreased short- and long-term risk of ischemic stroke.
Article
Behavioral Sciences
Yu Tian, Shan Li, Yingying Yang, Xueli Cai, Jing Jing, Suying Wang, Xia Meng, Lerong Mei, Aoming Jin, Dongxiao Yao, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang
Summary: The study aimed to investigate the potential vascular risk factors for deep medullary veins (DMVs) and their associations with cerebral small vessel disease (CSVD). The results showed that DMVs were associated with age, sex, body mass index, blood pressure, and other vascular factors. They were also related to the presence and total burden of CSVD, as well as specific imaging markers. However, these associations disappeared after adjusting for potential confounders.
BRAIN AND BEHAVIOR
(2023)
Article
Geriatrics & Gerontology
Hongyu Zhou, Weiqi Chen, Yue Suo, Xia Meng, Xingquan Zhao, Mengxing Wang, Liping Liu, Hao Li, Yuesong Pan, Yongjun Wang
Summary: The Nelson equation reliably predicts the risks of new-onset and long-term kidney function decline in patients with acute ischemic stroke or transient ischemic attack, which can help clinicians screen high-risk patients and improve clinical care.
CLINICAL INTERVENTIONS IN AGING
(2023)
Article
Clinical Neurology
Hongyu Zhou, Yuesong Pan, Weiqi Chen, Yue Suo, Hongyi Yan, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, Yongjun Wang
Summary: This study investigated the impact of smoking on dual antiplatelet therapy in patients with minor stroke or transient ischemic attack (TIA) under different levels of glycated albumin (GA). The results showed that smokers did not benefit from this therapy, while non-smokers had a certain risk reduction.
CEREBROVASCULAR DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoqin Zhang, Yongjia Xiang, Jie Yao, Xin Hu, Yangyun Wang, Liping Liu, Yan Wang, Yi Wu
Summary: In this study, an efficient automatic segmentation model of pelvic floor muscles with MRI was proposed based on DenseUnet, which achieved muscle volume calculation and provided a reference for assessing pelvic floor function. The improved DenseUnet showed good segmentation performance, time efficiency, and accuracy compared to manual segmentation.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)