Article
Reproductive Biology
Svenja Claassen, Joerg Aurich, Ingrid Walter, Camille Gautier, Christine Aurich
Summary: This study analyzed the relationship between anti-Mullerian hormone (AMH) concentration in blood and ovarian tissue in female cats. The results showed that AMH protein was expressed in all endocrine structures of the cat ovary, but its usefulness for assessing individual cat ovarian function is limited.
Article
Psychology, Biological
Christiana K. Miller, Amy A. Halbing, Heather B. Patisaul, John Meitzen
Summary: This study on rodents reveals interactions between novelty and estrous cycle phases affecting locomotor and anxiety-related behaviors in females, while novelty impacts male rodents differently under red and white light. Light exposure increases anxiety-related behaviors in both genders but only reduces locomotor behavior in females.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Cell Biology
Yiran Zhou, Han Yan, Wenjun Liu, Chengqing Hu, Yuan Zhou, Ruya Sun, Yida Tang, Chao Zheng, Jichun Yang, Qinghua Cui
Summary: This study provides a comprehensive transcriptomic landscape of female mice during different phases of the reproductive cycle, revealing the widespread regulation of neuro-functions, immune functions, and blood coagulation. The study also identifies key transcription factors and pathways involved in the estrous cycle. Moreover, the study demonstrates the significant impact of the estrous cycle on the cardiovascular system and highlights the enhanced efficacy of certain hypotensive drugs during the estrus phase. Overall, this research contributes valuable insights for investigating the reproductive cycle and precision medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
I. Rajesh, M. Gobikrushanth, J. E. Carrelli, M. Oba, D. J. Ambrose
Summary: The study aimed to determine the repeatability of anogenital distance (AGD) in different physiological states in cows. The results showed that AGD had high repeatability during the estrous cycle, gestation, and lactation, except during late gestation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Nutrition & Dietetics
Yaxue Cao, Min Yang, Jie Song, Xuemei Jiang, Shengyu Xu, Lianqiang Che, Zhengfeng Fang, Yan Lin, Chao Jin, Bin Feng, De Wu, Lun Hua, Yong Zhuo
Summary: FGF21, a hormone released in the liver, has been identified as an important endocrine signal for dietary protein intake. This study investigated the role of FGF21 and hypothalamic changes in controlling estrous cyclicity by dietary protein intake. The research found that severe dietary protein restriction resulted in the cessation of estrous cyclicity and ovarian follicle development, and hepatic FGF21 and hypothalamic Kiss-1 were partially required for this process.
Article
Biology
Sara Pagliarani, Chiara Palmieri, Michael McGowan, Frank Carrick, Jackson Boyd, Stephen D. Johnston, Dongbao Chen
Summary: The koala has recently been listed as an endangered species due to challenges associated with habitat fragmentation, climate change, and disease. This article presents the findings of two PhD theses, providing a detailed description of the female koala reproductive anatomy and histology. The research focuses on artificial insemination and the histopathological changes in the urogenital system caused by Chlamydia spp. infections.
Article
Endocrinology & Metabolism
Klaudia Barabas, Gergely Kovacs, Viola Vertes, Erzsebet Kovesdi, Peter Faludi, Ildiko Udvaracz, Daniel Pham, Dora Reglodi, Istvan M. Abraham, Zsuzsanna Nagy
Summary: This study found that embryonic deletion of PACAP significantly alters the structure and function of the GnRH-kisspeptin neuronal network, leading to changes in fertility. Specifically, PACAP KO mice experienced altered estrous cycles with longer periods of diestrus and decreased time in estrus. Furthermore, the number of kisspeptin neurons decreased in the ARC region, while ERα expression levels showed differential changes in different brain regions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Cathryn A. Cutia, Leanna K. Leverton, Xiyu Ge, Rana Youssef, Lori T. Raetzman, Catherine A. Christian-Hinman
Summary: Clinical evidence suggests that there are differential outcomes of comorbid conditions in patients with temporal lobe epilepsy (TLE) based on the lateralization of the seizure focus. This study evaluated the effects of targeting left or right dorsal hippocampus in a model of TLE, and found that it produced different outcomes in granule cell dispersion, body weight gain, and reproductive endocrine dysfunction in female mice. The findings suggest that lateralization of the epileptogenic insult may contribute to similar reproductive endocrine outcomes.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Food Science & Technology
Maria Rosa Ramos Nieto, Marianela Lasagna, Gabriel Cao, Gloria Alvarez, Clarisa Santamaria, Maria Eugenia Rodriguez Girault, Nadia Bourguignon, Noelia Di Giorgio, Clara Ventura, Mariana Mardirosian, Horacio Rodriguez, Victoria Lux-Llantos, Claudia Cocca, Mariel Nunez
Summary: The study found that chronic exposure to low concentrations of CPF affects ovarian steroid synthesis in female rats, leading to changes in the estrous cycle of animals, as well as proliferative changes in the uterus.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Laura Yesenia Castillo, Jorge Rios-Carrillo, Juan Carlos Gonzalez-Orozco, Ignacio Camacho-Arroyo, Jean-Pascal Morin, Rossana C. Zepeda, Gabriel Roldan-Roldan
Summary: This study found that male rats are more susceptible to anxiety induced by BPA exposure during puberty compared to female rats, as evidenced by an increase in passive-coping behaviors and changes in brain gene expression. These findings highlight the importance of considering sex differences in peripubertal behavioral toxicology studies.
Article
Behavioral Sciences
Gabriel Guillen-Ruiz, Jonathan Cueto-Escobedo, Fabiola Hernandez-Lopez, Lina E. Rivera-Aburto, Emma Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: The study found that the effects of caffeine intake vary during different stages of the ovarian cycle in rats. In female rats during metestrus-diestrus, all doses of caffeine increased anxiety-like behavior, while during proestrus-estrus, only high doses had a slight increase in anxiety behavior. The observed effects may be associated with the naturally occurring low and high concentrations of steroid hormones during these phases.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Naira da Silva Mansano, Henrique Rodrigues Vieira, Roberta Araujo-Lopes, Raphael Escorsim Szawka, Jose Donato Jr, Renata Frazao
Summary: This study found that acute fasting can modulate the activity of the HPG axis and has gender-specific effects on Kisspeptin neurons. In female mice, fasting reduces the levels of luteinizing hormone and prolactin, while increasing follicle-stimulating hormone levels. Fasting also reduces Kisspeptin gene expression. Additionally, GABAergic transmission and the effects of neuropeptide Y on ARHKisspeptin neurons show gender differences.
Article
Environmental Sciences
Beatriz Yamada Costa, Luana Gasparini Santos, Priscila Marianno, Mariana Rae, Marina Gomes de Almeida, Malcon Carneiro de Brito, Rosangela Eichler, Rosana Camarini
Summary: Oxytocin and its analogue carbetocin are potential protective substances against drug addiction, particularly ethanol addiction. This study found that carbetocin effectively prevented ethanol-induced behavioral sensitization and reduced ethanol consumption.
Article
Psychology, Biological
Milene C. Carvalho, Karina Genaro, Christie R. A. Leite-Panissi, Thelma A. Lovick
Summary: Studies have shown that male and female rats in different estrous cycle stages exhibit different responses in anxiety-like tests. While males and proestrus females show a clear fear response in conditioning and testing, responses vary in other conditions, highlighting the importance of estrous cycle stage in behavioral testing.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Reproductive Biology
Suellen Ribeiro da Silva Scarton, Felipe Tsuzuki, Marina Trevizan Guerra, Dayane Priscila dos Santos, Aldair Casagrande dos Santos, Ana Tereza Bittencourt Guimaraes, Andrea Name Colado Simao, Celia Cristina Leme Beu, Glaura Scantamburlo Alves Fernades
Summary: This study investigated the reproductive effects of cyantraniliprole on adult female rats. Results indicate that cyantraniliprole could act as an endocrine disruptor, causing negative changes in the morphology and redox system of the uterus and ovaries.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Cell Biology
Cleverson Moraes de Oliveira, Leo Anderson Meira Martins, Arieli Cruz de Sousa, Ketlen da Silveira Moraes, Bruna Pasqualotto Costa, Moema Queiroz Vieira, Barbara Paranhos Coelho, Radovan Borojevic, Jarbas Rodrigues de Oliveira, Fatima Costa Rodrigues Guma
Summary: Resveratrol did not decrease the activation state of GRX and instead triggered a pro-activation effect at the 50 μM concentration. Despite the increase of TNF-α in culture media, the results on IL-6 and IL-10 secretion were in accordance with the anti-inflammatory role of Resveratrol in the model.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Leonardo de Moura Alvorcem, Renata Britto, Cristiane Cecatto, Ana Cristina Roginski, Francieli Rohden, Juliete Nathali Scholl, Fatima C. R. Guma, Fabricio Figueiro, Alexandre Umpierrez Amaral, Geancarlo Zanatta, Bianca Seminotti, Moacir Wajner, Guilhian Leipnitz
Summary: The study revealed that EMA inhibits mitochondrial respiration, particularly glutamate oxidation, and induces mitochondrial permeability transition, potentially contributing to the pathogenesis of cerebellar abnormalities in ethylmalonic encephalopathy (EE).
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Caroline Crespo da Costa, Leo Anderson Meira Martins, Andre Peres Koth, Jessica Marques Obelar Ramos, Fatima Theresinha Costa Rodrigues Guma, Cleverson Moraes de Oliveira, Nathalia Stark Pedra, Geferson Fischer, Eduarda Santa Helena, Carolina Rosa Gioda, Paulo Roberto Stefani Sanches, Antonio Sergio Varela Junior, Mayara Sandrielly Pereira Soares, Roselia Maria Spanevello, Giovana Duzzo Gamaro, Izabel Cristina Custodio de Souza
Summary: The research found that static magnetic field stimulation could affect the oxidative status and survival rate of healthy astrocytes, especially leading to necrosis after long-term stimulation; unlike substantial changes in mitochondrial function, the mitochondrial network of brain astrocytes did not show significant alterations.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Francieli Rohden, Luciele Varaschini Teixeira, Luis Pedro Bernardi, Pamela Cristina Lukasewicz Ferreira, Mariana Colombo, Geciele Rodrigues Teixeira, Fernanda dos Santos de Oliveira, Elizabeth Obino Cirne Lima, Fatima Costa Rodrigues Guma, Diogo Onofre Souza
Summary: Nasally administered human adipose tissue mesenchymal stem cell-derived extracellular vesicles show potential neuroprotective properties in ischemic stroke, improving the blood-brain barrier, reducing infarct volume, and recovering motor and behavioral impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mariana Ilha, Leo A. Meira Martins, Ketlen da Silveira Moraes, Camila K. Dias, Marcos P. Thome, Fernanda Petry, Francieli Rohden, Radovan Borojevic, Vera M. T. Trindade, Fabio Klamt, Florencia Barbe-Tuana, Guido Lenz, Fatima C. R. Guma
Summary: This study demonstrates that Cav-1 may modulate mitochondrial function and structural reorganization in hepatic stellate cell activation, making it a potential candidate marker for chronic liver diseases and a molecular target for therapeutic intervention.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Leticia Rodrigues, Krista Mineia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: In this study, the researchers investigated the role of S100B, a neurotrophic protein, in brain injury and neuroregeneration. Using S100Btg mice with increased expression of the S100B gene, they found enhanced proliferation and migration of progenitor cells, as well as reduced levels of GFAP, ApoE, and BDNF in certain brain regions. The study highlights the importance of the S100Btg model in evaluating the role of S100B in neuroregenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana Cristina de Bem Alves, Ana Elisa Speck, Hemelin Resende Farias, Leo Meira Martins, Naiara Souza dos Santos, Gabriela Pannata, Ana Paula Tavares, Jade de Oliveira, Angelo R. Tome, Rodrigo A. Cunha, Aderbal S. Aguiar Jr
Summary: Caffeine enhances exercise performance by altering neuroplasticity and mitochondrial metabolism.
PURINERGIC SIGNALLING
(2023)
Article
Information Science & Library Science
Carolina Bittencourt Gomes, Luciana Calabro, Suzana Rachel de Oliveira, Leo Anderson Meira Martins, Diogo Onofre Souza, Ediane Maria Gheno
Summary: This article evaluated the characteristics of grantees in the Health Sciences area of the National Council for Scientific and Technological Development. Various indicators were used to assess 1,634 researchers with current grants in 2021. The study found differences in the distribution of articles among Committees and the influence of article numbers on the level of grants. It provides important insights for public policies in Science and Technology and contributes to the field by evaluating the Health Sciences area using diverse indicators.
Article
Neurosciences
Priscila Centeno Crespo, Leo Anderson Meira Martins, Clara Camacho Dos Reis, Liciane Fernandes Medeiros, Vanessa Leal Scarabelot, Giovana Duzzo Gamaro, Mayara Sandrielly Pereira Soares, Roselia Maria Spanevello, Francieli Moro Stefanello, Izabel Cristina Custodio De Souza
Summary: This study analyzed the effects of transcranial direct current stimulation (tDCS) on biochemical parameters in rats with neuropathic pain. The results showed that tDCS increased the total sulfhydryl content in the spinal cord of rats, positively modulating neuropathic pain.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Education & Educational Research
Adriana Rosa Marques, Leo Anderson Meira Martins
Summary: This article reflects on the Eurocentric epistemic heritage in Western culture and calls for an intercultural, decolonial, and inter-epistemological discussion in the context of a project on oral health education for traditional indigenous peoples. The research shows that the implementation of the project resulted in a resizing of knowledge, as Western and traditional knowledge intersected and informed each other.
CADERNOS EDUCACAO TECNOLOGIA E SOCIEDADE
(2022)
Article
Neurosciences
Julia D. Moreira, Leticia Vicari Siqueira, Alexandre P. Muller, Lisiane O. Porciuncula, Lucia Vinade, Diogo O. Souza
Summary: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) can positively influence the glutamatergic system and prevent seizure-related memory deficits.
NUTRITIONAL NEUROSCIENCE
(2022)