Article
Radiology, Nuclear Medicine & Medical Imaging
Huiru Li, Jing Yang, Li Yin, Huawei Zhang, Feifei Zhang, Ziqi Chen, Zhiyun Jia, Qiyong Gong
Summary: Previous studies have shown regional brain alterations and functional connectivity in depressed suicidal patients. This study aimed to explore the GM of depressed suicidal brains from the single-subject structural network level. Results showed decreased segregation and weaker integration in the GM network of suicidal patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neuroimaging
Gretel Sanabria-Diaz, Jean-Francois Demonet, Borja Rodriguez-Herreros, Bogdan Draganski, Ferath Kherif, Lester Melie-Garcia
Summary: The study found that both ApoE4 and disease progression independently modulated the global topological network properties in MCI patients. Converters to AD showed lower clustering index in regions associated with neurodegeneration in AD. The topological organization of SSGMNets was able to predict cognitive and memory measures.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Ying Chen, Du Lei, Hengyi Cao, Running Niu, Fuqin Chen, Lizhou Chen, Jinbo Zhou, Xinyu Hu, Xiaoqi Huang, Lanting Guo, John A. Sweeney, Qiyong Gong
Summary: Altered topological organization of brain structural covariance networks has been observed in patients with attention deficit hyperactivity disorder (ADHD), showing higher global and local efficiency, clustering coefficient, and shorter path length. These alterations in ADHD patients are associated with abnormal centrality in corticostriatal circuitry and are related to the severity of symptoms and cognitive performance. Different subtypes of ADHD can be differentiated based on nodal attributes in specific brain regions.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Baolin Wu, Ying Chen, Xipeng Long, Yuan Cao, Hongsheng Xie, Xiuli Wang, Neil Roberts, Qiyong Gong, Zhiyun Jia
Summary: This study found disrupted topological organization of gray matter structural networks in adolescents with major depressive disorder (MDD), with lower cluster coefficient and local efficiency compared to healthy controls. Abnormal nodal centralities were observed in various brain regions, including the prefrontal-subcortical-limbic areas and visual cortex regions. These findings suggest the importance of impaired local segregation and abnormal nodal centralities in understanding the neurobiology of adolescent-onset MDD.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Ying Chen, Xun Yang, Xun Zhang, Hengyi Cao, Qiyong Gong
Summary: This study investigated the structural brain networks in social anxiety disorder (SAD) using structural MRI. The results showed that the SAD patients had less optimized topological configuration in the brain's gray matter networks, with decreased clustering coefficient and characteristic path length. Altered topological properties were found in the fronto-limbic and sensory processing systems, and these changes were associated with illness duration and symptom severity in SAD.
Article
Health Care Sciences & Services
Yoko Shigemoto, Noriko Sato, Norihide Maikusa, Daichi Sone, Miho Ota, Yukio Kimura, Emiko Chiba, Kyoji Okita, Tensho Yamao, Moto Nakaya, Hiroyuki Maki, Elly Arizono, Hiroshi Matsuda
Summary: Recent developments in image analysis have allowed for the evaluation of brain networks and prediction of brain age from gray matter images. This study examined the effects of age and sex on gray matter networks in a large sample of healthy individuals. The findings revealed that while the brain network retained its small-world properties regardless of age, reduced small-world properties were observed with advancing age. Women showed higher network properties than men, but had faster age-related network declines, leading to no sex differences in participants aged >= 70 years. The study provides new insights into network alterations that occur with aging.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Anna Canal-Garcia, Emiliano Gomez-Ruiz, Mite Mijalkov, Yu-Wei Chang, Giovanni Volpe, Joana B. Pereira
Summary: This study integrates amyloid PET and gray matter MRI data into a multiplex connectome to explore the interaction between amyloid-beta pathology and brain atrophy in Alzheimer's disease (AD). The findings offer new insights into the pathological processes of AD beyond traditional graph theory analyses based on single brain networks.
Article
Neurosciences
Jan Krzysztof Blusztajn, Nurgul Aytan, Thekkelnaycke Rajendiran, Tiffany J. Mellott, Tanu Soni, Charles F. Burant, Geidy E. Serrano, Thomas G. Beach, Honghuang Lin, Thor D. Stein
Summary: This study identified monogalactosyl diglycerides (MGDGs) as a central correlate of clinical and pathological progression in Alzheimer's disease (AD). The levels of MGDGs were found to be positively associated with AD-related traits in postmortem brain samples. These findings suggest the importance of MGDG metabolism in the progression of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Giulio Sansone, Lorenzo Pini, Alessandro Salvalaggio, Matteo Gaiola, Francesco Volpin, Valentina Baro, Marta Padovan, Mariagiulia Anglani, Silvia Facchini, Franco Chioffi, Vittorina Zagonel, Domenico D'Avella, Luca Denaro, Giuseppe Lombardi, Maurizio Corbetta
Summary: This study investigated the relationships between the brain's functional topological organization and the location of glioblastoma (GBM), as well as its association with overall survival (OS). The results showed that GBM core and edema preferentially overlapped with specific gray matter and white matter functional networks. Five main distribution patterns of GBM core were identified. Although the involvement of certain functional networks seemed to have some role in predicting survival, network-topology information was overall not very informative about OS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Mark A. Dubbelman, Sietske A. M. Sikkes, Jarith L. Ebenau, Mardou S. S. A. van Leeuwenstijn, Lior A. Kroeze, Calvin Trieu, Bart N. M. van Berckel, Charlotte E. Teunissen, Argonde C. van Harten, Wiesje M. van der Flier
Summary: Changes in self-perceived cognitive decline in relation to amyloid pathology and clinical progression were investigated in cognitively normal individuals. Study partner-reported complaints increased over time in amyloid-positive individuals, while self-perceived complaints remained stable. Higher baseline Cognitive Change Index (CCI) scores were associated with an increased risk of progression to mild cognitive impairment or dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Ray-Chang Tzeng, Yu-Wan Yang, Kai-Cheng Hsu, Hsin-Te Chang, Pai-Yi Chiu
Summary: The study found that CDR-SB in predementia or very mild dementia (VMD) stages strongly predicts progression to dementia or reversion to normal cognition. Therefore, CDR-SB could be a good indicator for monitoring the effectiveness of pharmacological and non-pharmacological interventions in populations without dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Deborah Pareto, Alex Rovira, Jaume Sastre-Garriga, Piotr Sowa, Einar A. Hogestol, Hanne F. Harbo, Barbara Bellenberg, Carsten Lukas, Serena Ruggieri, Claudio Gasperini, Tomas Uher, Manuela Vaneckova, Stefan Bittner, Ahmed E. Othman, Sara Collorone, Ahmed T. Toosy, Sven G. Meuth, Frauke Zipp, Frederik Barkhof, Olga Ciccarelli, Sergiu Groppa
Summary: This study investigated the prognostic value of longitudinal structural networks in predicting 5-year Expanded Disability Status Scale (EDSS) progression in relapsing-remitting multiple sclerosis (RRMS) patients. The study found that changes in network degree and global efficiency can predict disability accumulation independent of disease activity, and these network measures outperform conventional MRI predictors in predicting EDSS worsening.
Article
Neurosciences
Ruozhen Wu, Jianlan Gu, Dingwei Zhou, Yunn Chyn Tung, Nana Jin, Dandan Chu, Wen Hu, Jerzy Wegiel, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Summary: Both gray and white matters of AD brain contain seeding-competent tau that can template aggregation of hyperphosphorylated tau, but the seeding potency is markedly higher in gray matter than in white matter.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Won Jong Chwa, Cyrus A. Raji, Kat Toups, Ann Hathaway, Deborah Gordon, Henrianna Chung, Alan Boyd, Benjamin D. Hill, Sharon Hausman-Cohen, Mouna Attarha, Michael Jarrett, Dale E. Bredesen
Summary: This study investigated regional morphological responses to precision medicine-guided intervention in AD and MCI patients. The results suggest that precision medicine may help slow down WM and GM atrophy, although the observed changes were not statistically significant after multiple comparison correction. Improvements in cognitive scores were statistically significant, but may not necessarily have clinical significance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Amir Abbas Tahami Monfared, Michael J. Byrnes, Leigh Ann White, Quanwu Zhang
Summary: Alzheimer's disease is a leading cause of dementia in older individuals worldwide. The prevalence, incidence, and mortality of AD are increasing, highlighting the need for a better understanding of its epidemiology and progression. Risk factors for AD dementia include biomarkers, neurodegeneration, and being female. As new disease-modifying therapies emerge, the use of biomarkers alongside neurocognitive tests will play a crucial role in clinical practice.
NEUROLOGY AND THERAPY
(2022)
Article
Clinical Neurology
Agnetha D. Fruijtier, Jetske van der Schaar, Ingrid S. van Maurik, Marissa D. Zwan, Philip Scheltens, Femke Bouwman, Yolande A. L. Pijnenburg, Bart N. M. van Berckel, Jarith Ebenau, Wiesje M. van der Flier, Ellen M. A. Smets, Leonie N. C. Visser
Summary: This study investigated the impact of six communication strategies on amyloid disclosure in mild cognitive impairment (MCI) patients. It found that risk communication best practices resulted in the highest information recall, while recall in emotional support was better than the basic and elaborate information strategies. Risk communication best practices also led to the highest uncertainty, while teach-back and emotional support contributed to the highest evaluations of the physician and information. Overall, risk communication best practices, attending to emotions, and teach-back techniques enhance information recall and contribute to positive care evaluations for amyloid-PET results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivar J. H. G. Wamelink, Joost P. A. Kuijer, Beatriz E. Padrela, Yi Zhang, Frederik Barkhof, Henk J. M. M. Mutsaerts, Jan Petr, Elsmarieke van de Giessen, Vera C. Keil
Summary: This study investigates the reproducibility of cerebral APT-CEST imaging in healthy tissue and gliomas at 3 T. The results indicate that cerebral APT-CEST shows good scan-rescan reproducibility in healthy tissue and tumors, and short-term measurement effects may be the dominant components for reproducibility.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Philipp Vollmuth, Martha Foltyn, Raymond Y. Huang, Norbert Galldiks, Jens Petersen, Fabian Isensee, Martin J. van den Bent, Frederik Barkhof, Ji Eun Park, Yae Won Park, Sung Soo Ahn, Gianluca Brugnara, Hagen Meredig, Rajan Jain, Marion Smits, Whitney B. Pope, Klaus Maier-Hein, Michael Weller, Patrick Y. Wen, Wolfgang Wick, Martin Bendszus
Summary: This study aimed to assess the reproducibility and standardization of treatment response assessment using artificial intelligence (AI) decision support in MRI. The results showed that AI decision support can provide better evaluation of treatment response in patients with lower-grade gliomas compared to manual measurements.
Review
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Douglas L. Arnold, Frederik Barkhof, Daniel M. Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G. Weinshenker, Maria A. Rocca
Summary: The use of MRI in the diagnosis of MS has evolved considerably, with the introduction of the 2017 McDonald criteria and new MRI markers. Artificial intelligence tools may complement human assessment in improving diagnosis and patient classification.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jochum J. Van 't Hooft, Wiesje Pelkmans, Jori Tomassen, Cas Smits, Nienke Legdeur, Anouk Den Braber, Frederik Barkhof, Bart Van Berckel, Maqsood Yaqub, Philip Scheltens, Yolande A. L. Pijnenburg, Pieter Jelle Visser, Betty M. Tijms
Summary: Hearing loss in older adults is associated with increased dementia risk, and the underlying mechanisms connecting the two remain unclear. This study found an association between hearing loss and biomarkers for dementia risk, and the association varied between different age groups. In older adults, hearing loss was associated with a decline in memory, global cognition, and language.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Lindner, Divya S. Bolar, Eric Achten, Frederik Barkhof, Antonio J. Bastos-Leite, John A. Detre, Xavier Golay, Matthias Guenther, Danny J. J. Wang, Sven Haller, Silvia Ingala, Hans R. Jaeger, Geon-Ho Jahng, Meher R. Juttukonda, Vera C. Keil, Hirohiko Kimura, Mai-Lan Ho, Maarten Lequin, Xin Lou, Jan Petr, Nandor Pinter, Francesca B. Pizzini, Marion Smits, Magdalena Sokolska, Greg Zaharchuk, Henk J. M. M. Mutsaerts
Summary: This article provides guidance on the clinical applications of arterial spin labeling (ASL) MRI, focusing on disease-specific considerations for sequence optimization and interpretation. It updates and expands on the recommendations from the 2015 ASL consensus paper, which lacked guidance on disease-specific parameters. The article covers various clinical scenarios, including acute ischemic stroke, brain tumors, and pediatric neuroradiology applications.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Emma M. Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M. Tijms, Luigi Lorenzini, Mara ten Kate, Lyduine E. Collij, Fiona Heeman, Roos M. Rikken, Sophie M. van der Landen, Marijke E. den Hollander, Sandeep S. Golla, Maqsood Yaqub, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Eco J. C. de Geus, Pieter Jelle Visser, Bart N. M. van Berckel, Anouk den Braber
Summary: The amyloid cascade hypothesis has played a significant role in Alzheimer's disease research and clinical trial designs. This study investigated the relationship between amyloid-beta and tau at the individual and twin-pair levels, aiming to rule out genetic and shared environmental effects as confounders. The findings suggest that the associations between amyloid-beta, tau, neurodegeneration, and cognition are unbiased by genetic factors, and the effects of amyloid-beta on neurodegeneration and cognitive decline are mediated by tau.
Review
Radiology, Nuclear Medicine & Medical Imaging
Gilbert Hangel, Barbara Schmitz-Abecassis, Nico Sollmann, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo-Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernandez-Seara, Julia Furtner, Elies Fuster-Garcia, Matthew Grech-Sollars, N. Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Ozcan, Esin Ozturk-Isik, Senol Piskin, Kathleen M. Schmainda, Siri F. Svensson, Chih-Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes, Lydiane Hirschler, Marion Smits, Jan Petr, Kyrre E. Emblem
Summary: Preoperative clinical MRI protocols for gliomas still rely on conventional structural MRI, which does not provide information on tumor genotype and has limitations in the delineation of diffuse gliomas. The GliMR COST action aims to raise awareness about advanced MRI techniques in gliomas and their potential clinical translation. This review summarizes current methods, limitations, and applications of advanced MRI for the preoperative assessment of glioma, and evaluates the level of clinical validation of different techniques.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Dea Gogishvili, Eleonora M. Vromen, Sascha Koppes-den Hertog, Afina W. Lemstra, Yolande A. L. Pijnenburg, Pieter Jelle Visser, Betty M. Tijms, Marta Del Campo, Sanne Abeln, Charlotte E. Teunissen, Lisa Vermunt
Summary: This study used machine learning techniques to identify cerebrospinal fluid (CSF) biomarkers that predict the rate of cognitive decline in dementia patients. Longitudinal mini-mental state examination scores (MMSE) were used to create fast and slow progression groups. Random forest classifiers were trained on CSF proteomic profiles and a well-performing prediction model for the progression group was obtained. TNFRSF4 and TGF beta-1 emerged as the top markers for predicting cognitive decline.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Julia H. I. Wiersinga, Hanneke F. M. Rhodius-Meester, Frank J. Wolters, Marijke C. Trappenburg, Afina W. Lemstra, Frederik Barkhof, Mike J. L. Peters, Wiesje M. van der Flier, Majon Mueller
Summary: Orthostatic hypotension (OH) is associated with cognitive decline and dementia, possibly through cerebral small vessel disease (CSVD). This study found that longer duration and larger magnitude of blood pressure drop were associated with increased risk of CSVD, but these associations were largely explained by high supine blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Menno D. Stellingwerff, Murtadha L. Al-Saady, Kwok-Shing Chan, Adam Dvorak, Jose P. Marques, Shannon Kolind, Stefan D. Roosendaal, Nicole I. Wolf, Frederik Barkhof, Marjo S. van der Knaap, Petra J. W. Pouwels
Summary: This study demonstrates that MCR-DIMWI, METRICS, and NODDI are sensitive techniques for detecting changes in tissue microstructure in WM disorders. Differences between patients and controls were more pronounced in WM regions of interest than in deep GM. MCR-DIMWI-derived myelin water fractions showed more homogeneity and bilateral symmetry compared to METRICS.
JOURNAL OF NEUROIMAGING
(2023)
Letter
Clinical Neurology
Charles Wade, Thomas Williams, Robyn Labrum, Yogen Patel, Elisa Cali, Indran Davagnanam, Matthew E. Adams, Frederik Barkhof, Elaine Murphy, Jeremy Chataway, Henry Houlden, David S. Lynch
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
