Article
Medicine, General & Internal
Francesco Radico, Augusto Di Castelnuovo, Alberto Aimo, Marco Zimarino, Juhani Knuuti, Serena Rossi, Luigi Emilio Pastormerlo, Luc Zyw, Enrico Orsini, Licia Iacoviello, Danilo Neglia, Michele Emdin, Giovanni de Gaetano, Raffaele De Caterina
Summary: The prognosis of angina patients without obstructive coronary artery disease (CAD) is heterogeneous, with non-obstructive CAD and myocardial ischemia at imaging tests both conferring a higher risk of cardiovascular events.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Article
Cardiac & Cardiovascular Systems
Yao Shen, Tingting Yan, Qian Peng, Baofeng Zhang, Ke Zhao, Zhan Yang
Summary: Patients with angina pectoris of coronary artery disease often experience moderate pain episodes and exhibit moderate to high levels of kinesiophobia. Factors such as personal monthly income, New York Heart Function Assessment classification, pain intensity, and pain resilience are associated with kinesiophobia. This study emphasizes the importance of addressing kinesiophobia in patients with coronary artery disease.
Article
Multidisciplinary Sciences
Ye-fei Li, Yu Zhang, Liang Chen, Kou-long Zheng, Hui-he Lu, Zhen-qiang Sheng
Summary: The ergonovine provocation test of radial artery showed high sensitivity, specificity, and safety in diagnosing coronary artery spasm, with an ROC curve area of 0.912, specificity of 92.86%, and sensitivity of 84.21%.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Daniel M. Blumenthal, Sidney E. Howard, Jennifer Searl Como, Sandra M. O'Keefe, Steven J. Atlas, Daniel M. Horn, Neil W. Wagle, Jason H. Wasfy, Robert W. Yeh, Joshua P. Metlay
Summary: Among stable outpatients with CAD receiving primary care through an integrated primary care network, 21.2% of surveyed patients reported experiencing angina at least once monthly. Several objective demographic and clinical characteristics were associated with angina frequency.
Article
Endocrinology & Metabolism
Claes Ohlsson, Maria Nethander, Anna-Karin Norlen, Matti Poutanen, Elias Freyr Gudmundsson, Thor Aspelund, Sigurdur Sigurdsson, Henrik Ryberg, Vilmundur Gudnason, Asa Tivesten
Summary: This study found an inverse association between serum levels of DHEA and testosterone and coronary artery calcification in elderly men, partially independently from each other. These results raise the question whether androgens produced by both the adrenals and the testes may contribute to male cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Kerstin Welen Schef, Per Tornvall, Joakim Alfredsson, Emil Hagstrom, Annica Ravn-Fischer, Stefan Soderberg, Troels Yndigegn, Tomas Jernberg
Summary: The objective of this study was to assess the prevalence of angina pectoris symptoms and investigate their relationship with coronary atherosclerosis in a middle-aged general population. The results showed that angina symptoms were common among the general population of Sweden, but were not strongly associated with obstructive coronary atherosclerosis. Sociodemographic and psychological factors were found to be highly associated with angina symptoms, regardless of the degree of coronary atherosclerosis.
Article
Medicine, General & Internal
Goh Eun Chung, Hyo Eun Park, Heesun Lee, Min Joo Kim, Su-Yeon Choi, Jeong Yoon Yim, Ji Won Yoon
Summary: The study found that sarcopenic obesity (SO) was significantly associated with a higher prevalence of high coronary calcium scoring (CAC) in a health check-up population. After adjusting for known risk factors, individuals with SO exhibited a significantly higher odds of a high CAC score. These findings suggest a synergistic effect of sarcopenia and obesity in increasing atherosclerotic burden in coronary arteries, potentially leading to adverse cardiovascular events.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Megaly, Ramy Sedhom, Ayman Elbadawi, Kevin Buda, Mir B. Basir, Santiago Garcia, Emmanouil S. Brilakis, Stephane Rinfret, Khaldoon Alaswad
Summary: Data on myocardial infarction treatment in patients with previous coronary artery bypass grafting is limited. Among patients hospitalized with myocardial infarction, 10.3% had previous CABG. Patients with previous CABG were less likely to receive revascularization than those without CABG, and the association between CABG and risk of death varied in STEMI and NSTEMI patients. Revascularization was associated with a lower risk of in-hospital death in patients with previous CABG presenting with both STEMI and NSTEMI.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian P. Houbois, Gauri Karur, Jennifer Fratesi, Micheal C. McInnis
Summary: The prevalence of LCA in the study was 11%, with a majority being unilateral and having an average vessel length of 2 intercostal spaces. Gender had no significant impact on vessel distribution, and there was substantial agreement among observers in detecting LCA.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
Yana Polonskaya, Elena Kashtanova, Ivan S. Murashov, Evgenia Striukova, Alexey Kurguzov, Ekaterina M. Stakhneva, Viktoria S. Shramko, Nikolay A. Maslatsov, Aleksandr M. Chernyavsky, Yulia Ragino
Summary: The study investigated the relationship between matrix metalloproteinases and coronary artery calcification. Results showed the involvement of some MMPs, particularly MMP-9, in the calcification process. MMP-1, MMP-7, and MMP-12 were associated with CHD and may serve as potential biomarkers for further research.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Panagiotis Theofilis, Evangelos Oikonomou, Marios Sagris, Nikolaos Papageorgiou, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary artery disease is a prevalent condition with detrimental effects on affected individuals. Stable angina pectoris, its most frequent manifestation, can be challenging to manage despite available treatments. Various approaches have been developed for refractory angina pectoris, with enhanced external counterpulsation and coronary sinus reduction being recognized techniques. Clinical trial results for these techniques are encouraging but limited in sample size. Other intervention methods, such as transmyocardial laser revascularization and spinal cord stimulation, have controversial or negative results. Angiogenic therapy with targeted intramyocardial vascular endothelial growth factor injection or CD34+ cell therapy may be beneficial but further investigation is needed.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Beata Franczyk, Jill Dybiec, Weronika Frak, Julia Krzeminska, Joanna Kucmierz, Ewelina Mlynarska, Magdalena Szlagor, Magdalena Wronka, Jacek Rysz
Summary: This review focuses on the main pathophysiological mechanisms of coronary artery spasm (CAS), including endothelial dysfunction, chronic inflammation, oxidative stress, smooth muscle hypercontractility, atherosclerosis and thrombosis, and mutations leading to deficient ALDH2 activity. These findings offer novel insights into the underlying mechanisms of CAS and may guide the development of diagnostic and therapeutic targets for cardiovascular diseases in the future.
Article
Urology & Nephrology
Chan-Jung Liu, Wen-Huang Li, Chung-Hao Li, Jin-Shang Wu, Ze-Hong Lu, Yau-Sheng Tsai, Ting-Hsing Chao, Ho-Shiang Huang
Summary: Nephrolithiasis is significantly associated with coronary artery calcification, but not coronary luminal stenosis. However, the relationship between stone disease and CAD remains controversial, and further studies are needed to validate these findings.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ragnar O. Vilmundarson, An Duong, Fariborz Soheili, Hsiao-Huei Chen, Alexandre F. R. Stewart
Summary: The deletion allele in the 3' UTR of the IRF2BP2 gene is associated with increased risk of coronary artery disease, affecting inflammatory responses in macrophages and smooth muscle cells. Experimental results show that this allele modulates RNA binding protein interactions and contributes to coronary artery calcification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Social Sciences, Interdisciplinary
Hans Thulesius, Ulrika Sanden, Davorina Petek, Robert Hoffman, Tuomas Koskela, Bernardino Oliva-Fanlo, Ana Luisa Neves, Senada Hajdarevic, Lars Harrysson, Berit Skjodeborg Toftegaard, Peter Vedsted, Michael Harris
Summary: Through analyzing the survey responses, interviews, and literature, it is found that the timeliness of cancer diagnosis in primary care can be improved by implementing strategies such as pluralistic task shifting, cognitive task shifting, digital task shifting, and financial task shifting.
GROUNDED THEORY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Thomas Jensen, Pernille G. Thrane, Kevin K. W. Olesen, Morten Wurtz, Martin Bodtker Mortensen, Christine Gyldenkerne, Troels Thim, Bjarne Linde Norgaard, Jesper Moller Jensen, Steen Dalby Kristensen, Jens C. Nielsen, John W. Eikelboom, Michael Maeng
Summary: The study compared the risks of bleeding and ischemic events in patients with atrial fibrillation (AF) treated with anticoagulant monotherapy or dual therapy after 1 year of percutaneous coronary intervention (PCI). The results showed that the risks were similar between monotherapy and dual therapy, as well as between DOAC and VKA monotherapy.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Michael Maeng, Lars Kjoller-Hansen, Akiko Maehara, Zhipeng Zhou, Ori Ben-Yehuda, Hans Erik Botker, Thomas Engstrom, Mitsuaki Matsumura, Gary S. Mintz, Ole Froebert, Jonas Persson, Rune Wiseth, Alf I. Larsen, Lisette O. Jensen, Jan E. Nordrehaug, Oyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, Hans C. Rosen, Gregg W. Stone, David Erlinge
Summary: Patients with diabetes have a higher risk of major adverse cardiac events due to both treated culprit lesions and untreated nonculprit lesions. However, this study did not identify diabetes-related high-risk plaque characteristics using multimodality imaging.
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Hans Erik Botker, Jesper Moller Jensen, Michael Maeng, Jacob Fog Bentzon, Helle Kanstrup, Henrik Toft Sorensen, Jonathon Leipsic, Ron Blankstein, Khurram Nasir, Michael J. Blaha, Bjarne Linde Norgaard
Summary: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but its association with ASCVD risk is modified by the presence of coronary artery calcification (CAC). This study found that LDL-C is only associated with ASCVD events in patients with CAC, and not in those without CAC. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.
Article
Clinical Neurology
Jane Agergaard, Benjamin Yamin Ali Khan, Thomas Engell-Sorensen, Berit Schiottz-Christensen, Lars ostergaard, Eva K. Hejbol, Henrik D. Schroder, Henning Andersen, Jakob Udby Blicher, Thomas Holm Pedersen, Thomas Harbo, Hatice Tankisi, M. U. L. T. I. C. O. V. Consortium MULTICOV Consortium
Summary: This study examined 84 patients with long COVID using qEMG and sfEMG, and performed muscle biopsies in a subset of patients. The results showed that the mean MUP duration was decreased in >= 1 muscles in 52% of the patients, and the mean jitter was increased in 17% of the patients in the tibialis anterior and 25% in the extensor digitorum communis. Muscle biopsies revealed damage of terminal nerves and motor endplate with abundant basal lamina material. These findings suggest a muscle pathophysiology behind fatigue in long COVID.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Peter Ferdinandy, Ioanna Andreadou, Gary F. Baxter, Hans Erik Botker, Sean M. Davidson, Dobromir Dobrev, Bernard J. Gersh, Gerd Heusch, Sandrine Lecour, Marisol Ruiz-Meana, Coert J. Zuurbier, Derek J. Hausenloy, Rainer Schulz
Summary: Preconditioning, postconditioning, and remote conditioning of the myocardium have the potential to provide novel therapeutic paradigms for cardioprotection. However, the lack of rigorous preclinical evaluation and consideration of cardiovascular risk factors and comorbidities may be a major reason for the failure to develop cardioprotective drugs.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Dahl Kramer, Kasper Korsholm, Jesper Moller Jensen, Bjarne Linde Norgaard, Srikara Peelukhana, Thomas Herbst, Rodney Horton, Saibal Kar, Jacqueline Saw, Mohamad Alkhouli, Jens Erik Nielsen-Kudsk
Summary: This retrospective observational study investigated the cardiac CT findings during follow-up after Watchman FLX implantation, focusing on hypoattenuated thickening (HAT) and device-related thrombosis (DRT). The study found that subfabric hypoattenuation and flat sessile HAT were frequent CT findings, likely representing benign device healing and endothelialization, while pedunculated HAT and protruding HAT were infrequent findings that might represent DRT.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Rajkumar Rajanathan, Tina Myhre Pedersen, Halvor Osterby Guldbrandsen, Lenette Foldager Olesen, Morten B. Thomsen, Hans Erik Botker, Vladimir V. Matchkov
Summary: Heterozygous mice for the migraine-associated mutation (G301R) in the Na+,K+-ATPase alpha(2)-isoform have decreased expression of cardiovascular alpha(2)-isoform and exhibit a pro-contractile vascular phenotype associated with reduced cardiac efficiency. This study aims to assess the functional contribution of the alpha(2)-isoform to in vivo cardiovascular function and showed that the ouabain-induced vascular response was augmented in alpha(+/G301R)(2) mice, leading to suppressed cardiac function.
Article
Cardiac & Cardiovascular Systems
Gregory Wood, Pia Hedegaard Johnsen, Anders Lehmann Dahl Pedersen, Christian Alcaraz Frederiksen, Steen Hvitfeldt Poulsen, Hans Erik Botker, Won Yong Kim
Summary: Remote ischaemic conditioning (RIC) applied before primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction does not improve left ventricular function 3 months after infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Cecilia Hvitfeldt Fuglsang, Lars Pedersen, Morten Schmidt, Jan Vandenbroucke, Hans Erik Botker, Henrik Toft Sorensen
Summary: This study used Danish national registries to examine the impact of migraine on the risk of premature myocardial infarction (MI) and ischemic/hemorrhagic stroke among men and women. They found that migraine was associated with similarly increased risk of premature ischemic stroke among both men and women, but there may be an increased risk of MI and hemorrhagic stroke only among women.
Article
Cardiac & Cardiovascular Systems
Roni Nielsen, Kristian Hylleberg Christensen, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Jacob Seefeldt, Casper Homilius, Ebbe Boedtkjer, Mads Jonsson Andersen, Henrik Wiggers, Niels Moller, Hans Erik Botker, Soren Mellemkjaer
Summary: The study demonstrates that 3-hydroxybutyrate (3-OHB) infusion in patients with PAH or CTEPH can decrease pulmonary vascular resistance, improve cardiac output, and enhance right ventricular function. Experimental rat studies also support the relaxing effect of ketone bodies on pulmonary arteries.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Rajkumar Rajanathan, Claudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Botker, Vladimir V. Matchkov
Summary: This study investigated the expression of two isoforms (alpha(1) and alpha(2)) of the Na+,K+-ATPase in the cardiovascular system, and the contribution of the alpha(2)-isoform to cardiac contractility. The study found that hearts with the alpha(+/G301R)(2) mutation exhibited greater contractility and a stronger response to ouabain, which was associated with increased systolic work.
Article
Biochemistry & Molecular Biology
Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa
Summary: This review summarizes the roles of reactive oxygen species (ROS) in myocardial ischemia/reperfusion injury and cardioprotection. It emphasizes the need for cardioprotection beyond rapid reperfusion in acute myocardial infarction and discusses the pathomechanisms of myocardial ischemia/reperfusion, different modes of cell death in myocardial infarction, and interventions to protect the ischemic/reperfused myocardium. The second part focuses on ROS, providing an overview of molecular and cellular mechanisms involved in ischemia/reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Jonatan Gerard Nirmalan, Anders Kramer, Kasper Korsholm, Jesper Moller Jensen, Jens Erik Nielsen-Kudsk
Summary: In left atrial appendage occlusion (LAAO), mean, area-, and perimeter-derived diameters are more accurate measures for device sizing compared to the maximum diameter.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)