Article
Urology & Nephrology
Shuang Liu, Lijie Zhang, Shuang Ma, Jing Xiao, Dong Liu, Rui Ding, Zhengyan Li, Zhanzheng Zhao
Summary: This study found that a higher Kt/V reach rate is associated with a better prognosis in incident PD patients. Patients in the dialysis adequacy group and dialysis intermittent adequacy group had significantly better clinical outcomes compared to the dialysis inadequacy group.
Article
Urology & Nephrology
Francesco Gaetano Casino, Javier Deira, Miguel A. Suarez, Jose Aguilar, Giovanni Santarsia, Carlo Basile
Summary: This study aimed to provide a specific value of GFAC for patients on a once-weekly hemodialysis schedule by establishing a predicting equation for GFAC in this setting. The results showed a linear relationship between GFAC and Kru/V, which could improve the accuracy of estimating the single pool Kt/V in this setting. A simple replacement of 0.008 with the mean observed GFAC (0.0035) could suffice in clinical practice.
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Fazl-e-Mateen, Sajad Ahmad, Irfan Elahi, Muhammad Anees
Summary: This study compares different methods of calculating the adequacy of hemodialysis in terms of Kt/V. The results show that the online clearance monitoring method slightly underestimates the Kt/V value compared to the Daugirdas formula and the normogram.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Jilin Chen, Jinling Wang, Ying Liu, Guangben Zhao, Fengdi Gao, Menghong Hu, Weidong Wang, Hong-li Lin
Summary: This study aimed to assess the all-cause mortality and associated risk factors in young and elderly haemodialysis patients in China. The results showed that the all-cause mortality was higher in elderly patients, and cardiovascular disease, cerebrovascular disease, and low serum albumin were identified as risk factors for all-cause mortality in elderly patients.
Article
Urology & Nephrology
Peiyun Liu, Suh Chien Pang, Huihua Li, Ru Yu Tan, Ren Kwang Alvin Tng, Shien Wen Sheryl Gan, Hui Lin Lina Choong, Tze Tec Chong, Chieh Suai Tan
Summary: The study found that arteriovenous fistulas in elderly patients have comparable outcomes to non-elderly patients, but require more interventions to assist maturation, necessitating early access creation to allow for the time needed for maturation delay.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Hematology
Robert Ekart, Luka Varda, Nina Vodosek Hojs, Benjamin Dvorsak, Nejc Piko, Sebastjan Bevc, Radovan Hojs
Summary: In hemodialysis patients with AV fistula, routine measurement of Kt/V during online HDF procedures is beneficial for early detection of hemodynamically significant stenosis in AV fistula. After angioplasty, there was a significant improvement in Kt/V in the active group, with no statistically significant differences in Kt/V between the two groups at 3 and 8 weeks post-procedure.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Ali AlSahow, Daniel Muenz, Mohammed A. Al-Ghonaim, Issa Al Salmi, Mohamed Hassan, Ali H. Al Aradi, Abdullah Hamad, Saeed M. G. Al-Ghamdi, Faissal A. M. Shaheen, Anas Alyousef, Brian Bieber, Bruce M. Robinson, Ronald L. Pisoni
Summary: In the Gulf Cooperation Council, a relatively large proportion of hemodialysis patients have low Kt/V levels. Study findings suggest that increasing blood flow rate to equal or greater than 350 mL/min and dialysis time to equal or greater than 4 hours thrice weekly can reduce the prevalence of low Kt/V, particularly improving survival rates among women.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Yi-Kong Chen, Chih-Sheng Chu, Sheng-Wen Niu, Hugo You-Hsien Lin, Pei-Hua Yu, Feng-Ching Shen, Yu-Lin Chao, I-Ching Kuo, Chi-Chih Hung, Jer-Ming Chang
Summary: Kt/V and URR measurements are indicators of dialysis adequacy. Both URR and Kt/V are positively associated with nutritional factors and female sex, and negatively associated with body weight and heart failure. Higher URR and Kt/V values are associated with higher survival rates, but Kt/V may have weaker prognostic value in women.
SCIENTIFIC REPORTS
(2023)
Article
Transplantation
David A. Jaques, Belen Ponte, Fadi Haidar, Anne Dufey, Sebastian Carballo, Sophie De Seigneux, Patrick Saudan
Summary: This study examines the outcomes of patients initiating dialysis with different modalities, and finds that starting with I-HD is associated with improved survival and can be maintained for a significant amount of time. Diabetes is identified as a risk factor for transitioning to TW-HD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Chun-yan Su, Xin-hong Lu, Wen Tang, Pei-yu Wang, Tao Wang
Summary: This study suggests that anuric patients can achieve nitrogen balance and maintain good nutritional status with appropriate dietary protein intake, even with a low Kt/V.
CLINICAL NEPHROLOGY
(2022)
Article
Transplantation
Robin Lengton, Esmee M. van der Willik, Esther N. M. de Rooij, Yvette Meuleman, Saskia Le Cessie, Wieneke M. Michels, Marc Hemmelder, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study investigated the association between residual estimated glomerular filtration rate (eGFR), dialysis adequacy, or serum phosphate level and chronic kidney disease-associated pruritus (CKD-aP) in incident dialysis patients. The results showed that higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related to a lower burden of CKD-aP in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Lisa Beguin, Thierry Krummel, Nathalie Longlune, Roula Galland, Cecile Couchoud, Thierry Hannedouche
Summary: The study found that a higher dose of dialysis is associated with better survival regardless of the indicator used. Even after considering factors such as renal transplantation, the dialysis dose still plays a crucial role in patient survival. Certain factors were identified to predict a higher dose of dialysis, emphasizing the importance of optimal dialysis dosage.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Transplantation
Wisam Bitar, Jaakko Helve, Eero Honkanen, Virpi Rauta, Mikko Haapio, Patrik Finne
Summary: This study compared the survival rate of patients on automated peritoneal dialysis (APD), continuous ambulatory peritoneal dialysis (CAPD), and home hemodialysis (HD). The results showed that the survival rates of patients on home HD and APD were similar, while CAPD patients had a lower survival rate.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Miho Murashima, Takayuki Hamano, Masanori Abe, Ikuto Masakane
Summary: This study examined the outcomes of a combination of peritoneal dialysis (PD) and once-weekly haemodialysis (PD + HD) compared to thrice-weekly haemodialysis (HD) in terms of mortality. The results showed that PD + HD therapy was associated with similar or potentially lower mortality compared to thrice-weekly HD. This suggests that PD + HD therapy could be a good option.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Anita van Eck van der Sluijs, Alferso C. Abrahams, Maarten B. Rookmaaker, Marianne C. Verhaar, Willem Jan W. Bos, Peter J. Blankestijn, Friedo W. Dekker, Merel van Diepen, Gurbey Ocak
Summary: This study found that incident dialysis patients treated with hemodialysis (HD) had a higher risk of bleeding compared to those treated with peritoneal dialysis (PD). Specifically, HD patients with a history of prior bleeding were at an increased risk of bleeding.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Transplantation
Priya Vart, Raphael Duivenvoorden, Casper F. M. Franssen, Marc H. Hemmelder, Kitty J. Jager, Luuk B. Hilbrands, Marlies Noordzij, Daniel Abramowicz, Carlo Basile, Adrian Covic, Marta Crespo, Ziad A. Massy, Alberto Ortiz, J. Emilio Sanchez, Emily Petridou, Colin White, Ron T. Gansevoort
Summary: Due to the vulnerability of chronic kidney disease patients to infectious diseases, the COVID-19 pandemic has had a devastating impact on the nephrology community. Lessons from the European Renal Association COVID-19 Database project provide recommendations for improving preparedness for future health crises. Challenges faced include limited collaboration, lack of common data architecture, and sub-optimal data quality. Aligning research initiatives, strengthening electronic health records, and involving experts in study design and data analysis will be crucial in responding to the next pandemic.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Alferso C. Abrahams, Marlies Noordzij, Eric Goffin, J. Emilio Sanchez, Casper F. M. Franssen, Priya Vart, Kitty J. Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H. Hemmelder, Raphael Duivenvoorden, Luuk B. Hilbrands, Ron T. Gansevoort
Summary: This study analyzed the clinical course and outcomes of COVID-19 in a group of PD patients and found that PD patients had a higher mortality rate compared to HD patients. Most COVID-19 survivors achieved functional and mental recovery within 3 months.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Peter J. Blankestijn, Robin W. M. Vernooij, Carinna Hockham, Giovanni F. M. Strippoli, Bernard Canaud, Joergen Hegbrant, Claudia Barth, Adrian Covic, Krister Cromm, Andrea Cucui, Andrew Davenport, Matthias Rose, Marietta Torok, Mark Woodward, Michiel L. Bots
Summary: This study suggests that high-dose hemodiafiltration is more beneficial for patients with kidney failure compared to standard hemodialysis. A randomized controlled trial involving 1360 patients showed that those who received high-dose hemodiafiltration had a lower risk of death.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Clinical Neurology
Mehmet Kanbay, Carina Ureche, Sidar Copur, Alexandra M. M. Covic, Cem Tanriover, Bugra H. H. Esen, Mert Sekmen, Asiye Kanbay, Adrian Covic
Summary: Obstructive sleep apnea (OSA) is common in patients with chronic kidney disease and can lead to serious complications. Kidney transplantation does not have a significant effect on the progression of OSA.
SLEEP AND BREATHING
(2023)
Article
Medicine, General & Internal
Carina Ureche, Gianina Dodi, Alexandra Covic, Alina Nedelcu, Simona R. Volovat, Radu A. Sascau, Cristian Statescu, Adrian Covic
Summary: This study aimed to determine the association between echocardiographic parameters and biomarkers of cardiac fibrosis in patients with end-stage renal disease. The results showed a significant correlation between echocardiographic parameters and biomarkers, especially a strong association between the collagen-derived biomarker PICP and cardiac function indicators.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Luminita Voroneanu, Alexandru Burlacu, Crischentian Brinza, Andreea Covic, Gheorghe G. Balan, Ionut Nistor, Cristina Popa, Simona Hogas, Adrian Covic
Summary: This study systematically reviewed the gut microbiota composition in patients with chronic kidney disease (CKD). The results showed that CKD patients had decreased microbiota diversity and decreased abundance of Roseburia. Gut dysbiosis was also associated with peritonitis and enhanced inflammatory activity. Additionally, synbiotic and probiotic therapies were found to have a beneficial effect on gut flora composition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Titus Andrian, Lucian Siriteanu, Andreea Simona Covic, Cristina Alexandra Ipate, Adelina Miron, Corneliu Morosanu, Irina-Draga Caruntu, Adrian Covic
Summary: Rates of late allograft loss have improved slowly in the last decades. Well described traditional risk factors that influence allograft survival include cardiovascular events, rejection, infections and post-transplant neoplasia. Here, we critically evaluate the influence of several non-immunological, non-traditional risk factors and describe their impact on allograft survival and cardiovascular health of kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Carina Ureche, Gianina Dodi, Adela Mihaela Serban, Andreea Simona Covic, Luminita Voroneanu, Simona Hogas, Radu Andy Sascau, Cristian Statescu, Adrian Covic
Summary: Patients with chronic kidney disease have an increased risk of death, and collagen biomarkers such as PICP may be valuable in predicting mortality in ESRD patients.
Review
Transplantation
Mehmet Kanbay, Sidar Copur, Abdullah B. Yildiz, Andreea Covic, Adrian Covic, Paola Ciceri, Lorenza Magagnoli, Mario Cozzolino
Summary: Multiple risk factors for chronic kidney disease have been identified, and prematurity and intrauterine growth restriction (IUGR) have been associated with an increased risk for CKD. This review aims to evaluate the association between CKD risk and prematurity, low birthweight, and IUGR, along with potential underlying pathophysiological mechanisms.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Transplantation
Mehmet Kanbay, Carlo Basile, Yuri Battaglia, Alessandro Mantovani, Furkan Yavuz, Francesco Pizzarelli, Valerie A. Luyckx, Adrian Covic, Vassilios Liakopoulos, Sandip Mitra, EuDial Working Group of ERA
Summary: The definition of the elderly as individuals aged 65 years or older fails to consider the genetic, lifestyle, and overall health differences that contribute to significant heterogeneity among older adults. With the global aging population, the prevalence of chronic diseases, including chronic kidney disease (CKD), is increasing. Frailty is highly prevalent in this population and needs to be assessed to inform medical decisions. Choosing the optimal treatment pathway for elderly and frail patients with kidney failure is complex due to the presence of comorbidities associated with low survival rates and impaired quality of life. Multidisciplinary management involving healthcare professionals from various specialties is recommended. Current studies are mainly retrospective and observational, and lack adjustment for confounders or addressing biases, making it difficult to guide treatment decisions. Prospective studies and systematic reviews are needed to address these issues.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Alexandru Burlacu, Mariana Floria, Crischentian Brinza, Adrian Covic
Summary: This meta-analysis aimed to compare the efficacy and safety endpoints of ticagrelor and clopidogrel in end-stage kidney disease (ESKD) patients on chronic dialysis presenting with acute or chronic coronary syndromes (ACS or CCS). The results showed no significant difference in efficacy or safety outcomes between ticagrelor and clopidogrel. Further randomized controlled trials are needed to establish the optimal antiplatelet therapy in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Andreea Covic, Irina Draga Caruntu, Alexandru Burlacu, Simona Eliza Giusca, Adrian Covic, Anca Elena Stefan, Crischentian Brinza, Gener Ismail
Summary: Rituximab appears to be effective and safe in managing hepatitis C-associated cryoglobulinemic vasculitis, either alone or in combination with antiviral therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Adelina Miron, Ionut Nistor, Corneliu Morosanu, Lucian Siriteanu, Adrian Covic
Summary: This study investigated the prevalence and impact of erectile dysfunction (ED) after kidney transplantation. The results showed that the prevalence of sexual dysfunction increased with age, and only a small percentage of patients had a normal sexual function. Additionally, the use of alpha-blockers and aspirin was associated with ED.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Urology & Nephrology
Sidar Copur, Furkan Yavuz, Adrian Covic, Mehmet Kanbay
Summary: Chronic kidney disease is a common cause of mortality and morbidity in adults, with limited therapeutic options. Kidney transplantation is the gold standard treatment, but has limitations. Recent studies have shown the potential of converting diseased kidney cells into functional ones, leading to a novel therapy called autologous selected renal cell transplantation. Although clinical studies on this therapy are limited, it shows promise and larger studies are needed to establish its therapeutic potential.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Urology & Nephrology
Mehmet Kanbay, Carina Ureche, Sidar Copur, Alexandra M. Covic, Cem Tanriover, Mert Sekmen, Adrian Covic
Summary: Kidney transplantation significantly improves endothelial dysfunction in patients with end-stage renal disease, leading to a reduction in cardiovascular risk. However, further research is needed to understand the potential re-emergence of endothelial dysfunction in the long-term postoperative period.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)