Article
Pediatrics
Ercan Ayaz, H. Nursun Ozcan, Berna Oguz, Mithat Haliloglu
Summary: This study aims to identify distinctive imaging findings, demographic characteristics, and prognosis of pediatric non-Wilms renal tumors. The study found that age is the most important factor in distinguishing different tumors, and the aggressiveness of the tumor also affects the prognosis.
PEDIATRIC RADIOLOGY
(2022)
Article
Pathology
Alyaa Al-Ibraheemi, Juan Putra, Harrison K. Tsai, Samantha Cano, Va Lip, R. Seth Pinches, Tamara Restrepo, Sanda Alexandrescu, Katherine A. Janeway, Sekhar Duraisamy, Marian H. Harris, Alanna J. Church
Summary: Alterations in the BCOR gene, including ITDs of exon 15, are important oncogenic changes defining several diagnostic entities. BCOR ITDs have been identified in pediatric cancers and targeted RNA sequencing successfully detected these alterations, supporting the use of this technique in pediatric tumors. An exploration of post-analytic algorithms for improving BCOR ITD detection using DNA panels was also conducted.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Obstetrics & Gynecology
Sei-Gyung K. Sze
Summary: Although Wilms tumor is the most common renal tumor of childhood, congenital mesoblastic nephroma is the most common neonatal renal tumor. Most neonatal renal tumors present as low stage and favorable histology, with very good outcomes. Treatment for most neonatal renal tumors is primary radical nephrectomy alone, but adjuvant chemotherapy or radiation may be indicated based on histology or biology. Distant metastatic disease suggests a diagnosis of malignant rhabdoid tumor of the kidney or clear cell sarcoma of the kidney, which has a poor prognosis.
CLINICS IN PERINATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zita Kepes, Alexandra Barkoczi, Judit P. Szabo, Ibolya Kalman-Szabo, Viktoria Arato, Ildiko Garai, Peter Arkosy, Istvan Joszai, Adam Deak, Istvan Kertesz, Istvan Hajdu, Gyorgy Trencsenyi
Summary: The study aimed to establish a rat model for studying hypercholesterolemia and cancer simultaneously. By providing different diets, we successfully induced hypercholesterolemia and observed higher tumor mass in the pretreated tumor-bearing animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Choeum Kang, Hyun Joo Shin, Haesung Yoon, Jung Woo Han, Chuhl Joo Lyu, Mi Jung Lee
Summary: This study reviewed CT scans of children with CCSK and Wilms' tumor between 2010 to 2019. It found that engorged perinephric vessels were more common in CCSK patients, and higher values of Tmax/muscle and Tmax/vein were observed in the CCSK group, which can serve as important indicators for diagnosing CCSK.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Gupta Aviral, Mishra C. Sarvesh, Jaiswal Sushila, M. S. Ansari
Summary: The differential diagnosis for an abdominal mass in a 2-year-old child is broad and includes various tumors, with Wilms' tumor and neuroblastoma being the most common. Clear cell sarcoma of the kidney (CCSK) is a rare tumor in children.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Pediatrics
Jun-Jun Dong, Xing-Yue He, Xing Liu, Tao Lin, Da-Wei He, Feng Liu, Guang-Hui Wei
Summary: This study investigated the clinical characteristics and outcomes of CCSK patients at the Children's Hospital of Chongqing Medical University, China. It found that the majority of patients were male with a median age of 24 months. Most patients underwent radical nephrectomy followed by chemotherapy, and some received radiotherapy. The 5-year event-free survival rate was 63.9% and the overall survival rate was 78.8%.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Oncology
Vikram Singh, Kirti Gupta, Aastha Saraswati, Nitin J. Peters, Amita Trehan
Summary: The immunohistochemistry results of cyclin D1 and BCOR can help differentiate CCSK from its morphologic mimics, providing clinical significance in distinguishing these renal tumors.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2021)
Article
Medicine, General & Internal
Meghadipa Mandal, Sanghamitra Mukherjee, Tushar Kanti Das
Summary: Paediatric renal neoplasms are rare diseases with significant clinical and radiological overlap, making histopathology essential for determining the nature of the tumor. Wilms tumor is the major histologic variant, while congenital mesoblastic nephroma has a favorable prognosis.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Chenghao Zhanghuang, Zhaoxia Zhang, Tao Mi, Jinkui Wang, Liming Jin, Jiayan Liu, Maoxian Li, Mujie Li, Xin Wu, Zhang Wang, Dawei He
Summary: This study aimed to investigate the potential of DCH, an MMP inhibitor, in reversing EMT and exerting antitumor effects in MRTK. The results showed that DCH inhibited the proliferation, migration, and invasion of MRTK cells in vitro, and also reversed EMT. In addition, DCH resulted in cytoskeletal rearrangements of the cells.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Pathology
Akash Pramod Sali, Sridhar Epari, T. S. Nagaraj, Ayushi Sahay, Girish Chinnaswamy, Prakash Shetty, Aliasgar Moiyadi, Tejpal Gupta
Summary: This study examined the histomorphological and immunohistochemical spectrum of atypical teratoid/rhabdoid tumors, finding that they can occur in noninfantile age groups and frequently overexpress cyclin D1. Alterations in the MYC gene are almost nonexistent in these tumors.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Obstetrics & Gynecology
Prajakta Aloorkar Patil, Gayatri Vemarapu
Summary: Congenital mesoblastic nephroma is a rare renal tumor commonly found in early infancy. Prenatal detection of the tumor through ultrasound is important for timely neonatal management, although it may be difficult to differentiate from fetal renal tumors.
JOURNAL OF FETAL MEDICINE
(2021)
Article
Surgery
Ashish Lal Shrestha, Prinsa Shrestha, Aakash Mishra, Anjali Pandit
Summary: We report a case of a four-year-old boy who was diagnosed with clear cell sarcoma of the kidney (CCSK) that was initially mistaken for cystic Wilms' tumor. After appropriate treatment, he was tumor-free at six years follow-up. It is important to differentiate CCSK from Wilms' tumor for optimal management and prognosis.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Review
Oncology
Juhi Jain, Kathryn S. Sutton, Andrew L. Hong
Summary: Recent clinical trials have made significant improvements in the care of children with pediatric tumors, particularly in standardizing treatment for rare cancers such as bilateral Wilms tumor. While there have been improvements in event free and overall survival for many pediatric renal tumors in recent trials, there are still subsets of rarer cancers with poor outcomes that require new therapeutic strategies. Future trials aim to balance treatment toxicity and efficacy for those with good outcomes while exploring novel therapeutics for those with poor outcomes.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Urology & Nephrology
Xavier Bonet, Marco Oderda, Davide Campobasso, Jean-Luc Hoepffner
Summary: This case report describes a rare case of a 29-year-old male with a history of WT who presented with a prostatic mass, which was later diagnosed as PER. The diagnostic and therapeutic journey of this case highlights the importance of considering the possibility of prostatic sarcoma, especially in patients with a history of WT.