Review
Immunology
Daniel de la Nava, Kadir Mert Selvi, Marta M. Alonso
Summary: Immunotherapy has made significant advancements in cancer treatment, but there is still a gap in pediatric solid tumor research. Oncolytic virotherapy has emerged as a feasible strategy with tumor-specific effects, safety profile, and the ability to trigger anti-tumor immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Nutrition & Dietetics
M. Catherine DeSoto
Summary: The important role of nutrition in neural functioning and mental health is still under recognized. This Special Issue aims to provide authoritative information on this topic. The editorial suggests that the combination of social isolation, lack of exercise, and remaining indoors during 2020 may change Gene x Environment interactions for anxiety and depression. The recent environmental changes may exacerbate the problem of nutritional deficiencies. Key research, specific genetic examples, and theoretical implications regarding natural selection are discussed.
Editorial Material
Biochemical Research Methods
Konrad Fischer, Angelika Schnieke
Summary: Xenotransplantation has long been considered as a viable option for end-stage organ failure. The recent successful case of David Bennett Sr., who received a pig heart transplant, signifies a milestone in this field. Over the years, there have been challenges in overcoming physiological hurdles, ensuring technological advancements, and addressing ethical and safety concerns. However, the development of genetic engineering tools has played a crucial role in breaking down these barriers and making porcine organs more compatible for human transplantation.
TRANSGENIC RESEARCH
(2022)
Article
Medicine, Research & Experimental
Xintao Qiu, Lisha G. Brown, Jennifer L. Conner, Holly M. Nguyen, Nadia Boufaied, Sarah Abou Alaiwi, Ji-Heui Seo, Talal El Zarif, Connor Bell, Edward O'Connor, Brian Hanratty, Mark Pomerantz, Matthew L. Freedman, Myles Brown, Michael C. Haffner, Peter S. Nelson, Felix Y. Feng, David P. Labbe, Henry W. Long, Eva Corey
Summary: This study provides insight into the differences in the AR cistrome before treatment and identifies a signature that can distinguish between SPT-responding and -non responding tumors, offering the potential to identify patients who would benefit from SPT therapy.
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Diogo C. Haussen, Jens Fiehler
Summary: Our Japanese colleagues have successfully completed the first randomized clinical trial of thrombectomy in patients with Alberta Stroke Program Early CT Score 3 to 5, demonstrating an impressive therapeutic effect. The use of magnetic resonance imaging for patient selection and low utilization of alteplase therapy make it unique compared to studies conducted outside of Japan. However, it does not show any benefit when using the traditional metric-modified Rankin Scale score 0-2. We find the results of RESCUE-Japan LIMIT encouraging and a strong motivation to continue and complete further studies.
Article
Engineering, Biomedical
Nan Hu, Li Zhu, Li Zhang, Jing Wang, Yanhua Wang, Jing Luo, Lan He, Zhiming Hao, Long Zhang
Summary: Oral delivery of TNF-alpha shRNA mediated by non-pathogenic yeast can effectively inhibit the inflammatory response in rheumatoid arthritis without toxic effects on peripheral blood and major organs.
MATERIALS TODAY BIO
(2022)
Article
Multidisciplinary Sciences
Pia Spangenberger, Sonja Maria Geiger, Sarah-Christin Freytag
Summary: This study investigated the potential of using immersive virtual reality (iVR) technologies to enhance nature relatedness. The results showed that participants who felt more immersed in their experience reported higher levels of nature relatedness. However, simply experiencing nature through immersive VR did not directly impact nature relatedness. Participants in the iVR condition were more likely to identify with the tree and reflect on their own role towards nature. The study highlights the importance of immersion and suggests further research is needed to understand the beneficial potential of using immersive VR for nature relatedness.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dhuha F. N. Bani-Wais, Ali H. Ad'hiah
Summary: Interleukin-40 (IL-40) levels are significantly up-regulated in patients with rheumatoid arthritis (RA). In this case-control study, a genetic variant (rs2004339) of the C17orf99 gene was found to be associated with an increased risk of RA among Iraqi women. Serum IL-40 levels were also elevated in RA patients, particularly in newly diagnosed cases, and were affected by the genetic variant rs2310998. These findings suggest the importance of IL-40 in the pathogenesis of RA.
MOLECULAR IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yeri Alice Rim, Yoojun Nam, Narae Park, Ji Hyeon Ju
Summary: Minicircles, as non-viral vectors, have shown promise in delivering genes efficiently and safely into cells, particularly in studies related to cartilage tissues and diseases like osteoarthritis and rheumatoid arthritis.
Article
Pharmacology & Pharmacy
Xiaohua Chen, Bailing Zhou, Yan Gao, Kaiyu Wang, Jieping Wu, Ming Shuai, Ke Men, Xingmei Duan
Summary: Rheumatoid arthritis (RA) is a common autoimmune disease that causes severe cartilage damage and disability. In this study, a siRNA-based therapy using a cationic delivery micelle was developed for efficient treatment of RA. The LPCE micelle was able to deliver siRNA to macrophages with high efficiency and exhibited strong siRNA protection ability and safety. Administration of the siRNA/LPCE complex showed potent anti-inflammatory effects against RA in a mouse model.
Article
Orthopedics
J. P. M. Vrouwe, J. J. M. Meulenberg, N. B. Klarenbeek, A. Navas-Canete, M. Reijnierse, G. Ruiterkamp, L. Bevaart, R. J. Lamers, M. Kloppenburg, R. G. H. H. Nelissen, T. W. J. Huizinga, J. Burggraaf, I. M. C. Kamerling
Summary: The study investigated the safety and tolerability of local gene therapy with ART-I02 in patients with inflammatory hand arthritis. Local adverse events were observed in some patients, leading to discontinuation of the study due to insufficient local tolerability, despite the absence of systemic side effects.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Immunology
Jing-Wen Chen, Wen-Shuang Zhang, Chang-Song Lin, Qiang Xu
Summary: Rheumatoid arthritis (RA) is a complex chronic disease. Treatment options include disease modifying anti-rheumatic drugs (DMARDs) and biologic or targeted synthetic DMARDs. Dual therapy may be beneficial for difficult-to-treat RA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
V. Kalidasan, Kumitaa Theva Das
Summary: The development of gene editing technology has directly impacted the public health system, but has also raised concerns about risks and uncertainties among the public. Malaysia faces challenges in how to best regulate gene editing in terms of regulations, biosafety, and biosecurity. Although biosafety regulations have been established, there is still a need to address the potential of genetically modified organisms as bioweapons.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Multidisciplinary Sciences
Viswanathan Mohan, Venkatesan Radha
Summary: Precision Medicine and Personalized Medicine are two terms that are used interchangeably but have subtle differences. Precision Medicine involves obtaining scientific information and deciding treatment, while Personalized Medicine considers other factors about the patient. This review focuses on Precision Diabetes and discusses suitable treatment strategies and personalized treatment plans for different subtypes of diabetes.
PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY
(2022)
