Article
Neurosciences
Andrea Stocco, Catherine Sibert, Zoe Steine-Hanson, Natalie Koh, John E. Laird, Christian J. Lebiere, Paul Rosenbloom
Summary: The study analyzed functional MRI data to reveal the connection between the CMC architecture and human brain function, finding that CMC outperformed other models in various cognitive domains and tasks. These results suggest that a common set of architectural principles underpins both human brain function and artificial intelligence.
Article
Multidisciplinary Sciences
Elizabeth L. Johnson, Jack J. Lin, David King-Stephens, Peter B. Weber, Kenneth D. Laxer, Ignacio Saez, Fady Girgis, Mark D'Esposito, Robert T. Knight, David Badre
Summary: Flexible behavior relies on gating mechanisms that selectively encode task-relevant information in working memory. This study identifies rapid changes in regional and inter-regional activities in patients with intracranial EEG, highlighting the role of neocortical gating mechanisms in predicting behavioral output. The results demonstrate information accumulation and filtering processes in neocortical networks, providing evidence for a rapid neocortical theta network mechanism for flexible information encoding.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Summary: Studies have found that certain brain regions are activated during attentional deployment via long-term memories. We conducted an analysis of task-based functional connectivity to study the communication between these brain regions underlying long-term memory guided attention. Our results showed that different subnetworks, such as default mode, cognitive control, and dorsal attention, contribute differently to long-term memory guided attention, and the connectivity at the network level shifts based on attentional demands. We also found specific nodes within these subnetworks that play a crucial role in facilitating long-term memory guided attention.
Article
Multidisciplinary Sciences
Su Hyoun Park, Anne K. Baker, Vinit Krishna, Sean C. Mackey, Katherine T. Martucci
Summary: The brain corticostriatal circuits play a crucial role in understanding chronic pain. In this study, the authors investigated the connectivity of the nucleus accumbens (NAcc) - medial prefrontal cortex (MPFC) circuit in patients with fibromyalgia. They found that the connectivity of this circuit was significantly reduced in fibromyalgia patients compared to healthy controls. The connectivity between the NAcc and subcortical brain regions was also reduced in fibromyalgia. These findings provide novel evidence of altered corticostriatal and mesolimbic circuits in chronic pain.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Christelle Langley, Naoki Masuda, Simon Godwin, Giovanni De Marco, Angela Davies Smith, Rosemary Jones, Jared Bruce, Ngoc Jade Thai
Summary: This study aimed to establish the role of the basal ganglia in fatigue in multiple sclerosis (MS) using functional connectivity measures. The results suggest that decreased local functional connectivity within the basal ganglia plays a key role in cognitive fatigue in MS. Increased global functional connectivity between the basal ganglia and the cortex may serve as a compensatory mechanism to reduce the impact of fatigue in MS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Sara Maria Pani, Kristina Sabaroedin, Jeggan Tiego, Mark A. Bellgrove, Alex Fornito Turner
Summary: This study found a covariance between dorsal corticostriatal connectivity and psychosis-like experiences in non-clinical individuals, with lower connectivity between certain brain regions associated with more severe PLEs. The neural circuit between the dorsal caudate and dorsolateral PFC may play a role in mediating risk for general psychosis-related psychopathology.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2021)
Article
Biology
Swati Agrawal, Rinku Sharma, Vijayakumar Chinnadurai
Summary: The study investigates the interactions of learning and memory associated regions using functional connectivity and neurovascular approach, revealing significant connectivity between the medial temporal lobe and basal ganglia during feedback learning and memory retrieval. The results demonstrate the significant role of frontal-parietal EEG powers in MTL-basal ganglia relationships during declarative memory retrieval.
JOURNAL OF BIOSCIENCES
(2021)
Article
Neuroimaging
Floris B. Tijhuis, Tommy A. A. Broeders, Fernando A. N. Santos, Menno M. Schoonheim, Joep Killestein, Cyra E. Leurs, Quinten van Geest, Martijn D. Steenwijk, Jeroen J. G. Geurts, Hanneke E. Hulst, Linda Douw
Summary: The study found an association between fatigue symptoms in multiple sclerosis patients and dynamic functional connectivity in the brain. Reduced dynamic connectivity may be related to higher fatigue levels, while increased dynamics in non-fatigued patients could represent a protective network organization against fatigue or early network dysfunction.
NEUROIMAGE-CLINICAL
(2021)
Article
Geriatrics & Gerontology
Vineeth Radhakrishnan, Cecile Gallea, Romain Valabregue, Syam Krishnan, Chandrasekharan Kesavadas, Bejoy Thomas, Praveen James, Ramshekhar Menon, Asha Kishore
Summary: This study validated the structural connectivity within the cerebellum-basal ganglia reciprocal network in a larger dataset of human subjects across a wider age range. It found age-related neurodegeneration in the subcortical cerebello-basal ganglia tracts and their association with different cognitive functions. These findings have significant implications for understanding neurodevelopmental and neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Fabian Hirsch, Afra Wohlschlaeger
Summary: This study investigates the impact of subcortical structures on the topological features of cortical networks using a multivariable approach and graph-theoretic tools. The results show that the overall architecture of cortical networks becomes more integrated after accounting for subcortical influences. Specifically, "transmodal" systems become more connected with the rest of the network while "unimodal" networks show the opposite effect. These findings provide new insights into the interplay between subcortex and cortical networks.
Article
Geriatrics & Gerontology
Clara Rodriguez-Sabate, Ingrid Morales, Manuel Rodriguez
Summary: This study investigates the impact of aging on the functional connectivity of the basal ganglia motor circuit. The results show significant changes in connectivity induced by aging, which may contribute to motor handicaps in older individuals during motor task execution and at rest.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Liangjun Chen, Ya Wang, Zhengwang Wu, Yue Shan, Tengfei Li, Sheng-Che Hung, Lei Xing, Hongtu Zhu, Li Wang, Weili Lin, Gang Li
Summary: This study investigates the volumetric development and surface area expansion of six subcortical structures during the first two postnatal years. The results show that each structure undergoes rapid nonlinear growth after birth, which slows down at a structure-specific age. Additionally, there are positive associations between certain subcortical structures and language learning as well as fine motor skills.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Alexandra Sobczaka, Mushfa Yousuf, Nico Bunzeck
Summary: This study investigated the responses and functional connectivity of different brain regions during reward and punishment anticipation in a social incentive delay task. The findings suggest that the functional connectivity patterns of the basal forebrain and mesolimbic areas are associated with the emotional valence of social feedback.
Article
Neurosciences
Zongxin Tan, Guanya Li, Wenchao Zhang, Jia Wang, Yang Hu, Hao Li, Lei Zhang, Shuai Lv, Zhenzhen Jia, Xiaohua Li, Yu Han, Guangbin Cui, Peter Manza, Nora D. Volkow, Yongzhan Nie, Gang Ji, Gene-Jack Wang, Yi Zhang
Summary: This study found an association between obesity and alterations in intrinsic functional connectivity, with dynamic functional connectivity analysis revealing more detailed node information, uncovering some associations that traditional connectivity analysis cannot see.
Article
Clinical Neurology
Audrey Riou, Jean-Francois Houvenaghel, Thibaut Dondaine, Sophie Drapier, Paul Sauleau, Dominique Drapier, Joan Duprez, Murielle Guillery, Florence Le Jeune, Marc Verin, Gabriel Robert
Summary: The study revealed the involvement of the cerebellum in nonmotor domains of PD, with differential but overlapping patterns of metabolic correlations, suggesting the involvement of cerebello-thalamo-striatal-cortical loops.