Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

(2016) Alem W Kahsai et al.   Nature Chemical Biology

A rapid pro-hemostatic approach to overcome direct oral anticoagulants

(2016) Nabil K Thalji et al.   NATURE MEDICINE

Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant

(2016) Erin E. Soule et al.   Nucleic Acid Therapeutics

Inhibition of factor IXa by the pegnivacogin system during cardiopulmonary bypass: a potential substitute for heparin. A study in baboons

(2015) Alain Bel et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity

(2015) Deborah M. Siegal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemostatic and Thrombotic Issues in Cardiac Surgery

(2015) Marco Ranucci   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Atomic description of the immune complex involved in heparin-induced thrombocytopenia

(2015) Zheng Cai et al.   Nature Communications

Probing the Coagulation Pathway with Aptamers Identifies Combinations that Synergistically Inhibit Blood Clot Formation

(2014) Kristin M. Bompiani et al.   CHEMISTRY & BIOLOGY

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

(2013) M. E. Jaax et al.   BLOOD

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis

(2013) B. C. Lechtenberg et al.   BLOOD

A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa

(2013) Genmin Lu et al.   NATURE MEDICINE

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery

(2013) Yvonne P.J. Bosch et al.   THROMBOSIS RESEARCH

PDB_REDO: constructive validation, more than just looking for errors

(2012) Robbie P. Joosten et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Parenteral Anticoagulants

(2012) David A. Garcia et al.   CHEST

Oral Direct Factor Xa Inhibitors

(2012) Calvin H. Yeh et al.   CIRCULATION RESEARCH

Correcting pervasive errors in RNA crystallography through enumerative structure prediction

(2012) Fang-Chieh Chou et al.   NATURE METHODS

Activation of the Hemostatic System During Cardiopulmonary Bypass

(2011) Roman M. Sniecinski et al.   ANESTHESIA AND ANALGESIA

Molecular Recognition at the Active Site of Factor Xa: Cation-π Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water

(2011) Laura M. Salonen et al.   CHEMISTRY-A EUROPEAN JOURNAL

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Heparin-Induced Thrombocytopenia

(2010) Gowthami M. Arepally et al.   Annual Review of Medicine

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Thrombin in Myocardial Ischemia-Reperfusion During Cardiac Surgery

(2009) Peter Raivio et al.   ANNALS OF THORACIC SURGERY

Novel factor Xa inhibitors: a patent review

(2009) Modesto de Candia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase

(2009) Sai K. Buddai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombelastography

(2009) Håkon Reikvam et al.   TRANSFUSION AND APHERESIS SCIENCE

Anticoagulant therapy during cardiopulmonary bypass

(2008) Maryam Yavari et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13

(2008) W. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA

Elevated Levels of Prothrombin Fragment 1 + 2 Indicate High Risk of Thrombosis

(2007) Satoshi Ota et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS