An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Translation of poly(A) tails leads to precise mRNA cleavage

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Ribosomopathies: There’s strength in numbers

(2017) Eric W. Mills et al.   SCIENCE

Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

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Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways

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Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update

(2016) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice

(2016) Kirsty Sawicka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

(2016) Beate M. Lichtenberger et al.   Nature Communications

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

(2016) Eric W. Mills et al.   Cell Reports

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

(2016) Kai Kretzschmar et al.   Cell Reports

Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles

(2016) Amélie Rezza et al.   Cell Reports

Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3′UTRs In Vivo

(2015) David J. Young et al.   CELL

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

Dom34 Rescues Ribosomes in 3′ Untranslated Regions

(2014) Nicholas R. Guydosh et al.   CELL

Picrosirius Red Staining

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Deep Sequencing Shows Multiple Oligouridylations Are Required for 3′ to 5′ Degradation of Histone mRNAs on Polyribosomes

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Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

(2014) Rui Liu et al.   NUCLEIC ACIDS RESEARCH

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

(2014) Gunsmaa Nyamsuren et al.   Stem Cell Research

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen

(2014) Kifayathullah Liakath-Ali et al.   Nature Communications

Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments

(2014) Liana F Lareau et al.   eLife

The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

(2013) Mahalia E. Page et al.   Cell Stem Cell

Protein synthesis rate is the predominant regulator of protein expression during differentiation

(2013) A. R. Kristensen et al.   Molecular Systems Biology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Diverse epigenetic strategies interact to control epidermal differentiation

(2012) Klaas W. Mulder et al.   NATURE CELL BIOLOGY

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Structure of the no-go mRNA decay complex Dom34–Hbs1 bound to a stalled 80S ribosome

(2011) Thomas Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNMT1 maintains progenitor function in self-renewing somatic tissue

(2010) George L. Sen et al.   NATURE

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis

(2010) Kim B Jensen et al.   Nature Protocols

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

Crystal Structure of the Eukaryotic Ribosome

(2010) A. Ben-Shem et al.   SCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE