Article
Biochemistry & Molecular Biology
Zhuorui Song, Chengfeng Gao, Qinghua Jiang, Jinyu Xu, Liangliang Xiong, Kexin Liu, Dejuan Sun, Hua Li, Lixia Chen
Summary: Six new diterpenoid alkaloids were isolated from Delphinium forrestii var. vride, with forrestline F showing the strongest anti-inflammatory activity. It acted through multiple mechanisms by suppressing inflammatory cytokines, modulating NF-kappa B/MAPK and Nrf2/HO-1 signaling pathways.
Article
Biochemistry & Molecular Biology
Mohammad Alhilal, Yaser A. M. Sulaiman, Suzan Alhilal, Sobhi M. Gomha, Salama A. Ouf
Summary: This study isolated new alkaloids from Delphinium peregrinum and evaluated their antifungal activity against different dermatophyte fungal isolates. Peregrine (2) was found to be the most effective alkaloid, but the application of a mixture of alkaloids showed significant synergistic activity.
Article
Chemistry, Applied
Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen, Shuai Huang
Summary: A new C-19-diterpenoid alkaloid named gyalanutine A and fourteen known compounds were isolated from the plant of Delphinium gyalanum. The structure of gyalanutine A was determined to have an unusual lycoctonine-type skeleton. The compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Qi-Jing Fan, Gang-Zhong Zhou, Chu-Chu Xi, Bo Niu, Yan-Gang Cao, Fan Zhang, C. Benjamin Naman, Chun-Lei Zhang, Zheng-Yu Cao
Summary: Thirteen new benzamide alkaloids were isolated from Delphinium anthriscifolium. Compound 1 possesses a previously undescribed carbon framework. Compound 2 is an artifact formed during the extraction process. Compound 7 is glycosylated while compound 13 contains a chlorine substituent. Compounds 6, 8, and 10-12 showed significant inhibition of LPS-induced NO production in cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Organic
Lili Qin, Feng Xing, Lin Chen, Xianli Zhou
Summary: In this study, a new denudatine-type C-20-diterpenoid alkaloid named arcutisine was isolated from the roots of Aconitum fischeri var. arcuatum, along with 24 known compounds. The structures were elucidated through spectroscopic analyses. The isolation of compounds 1 and 2 from natural sources for the first time, and the weak anti-inflammatory activity of compounds 7 and 10 at a concentration of 40 μM were notable findings.
Article
Chemistry, Organic
Shuai Huang, Yuming Feng, Jiali Ren, Chuanlun Yang, Lin Chen, Xianli Zhou
Summary: In this study, four new diterpenoid alkaloids were isolated from the roots of Aconitum rockii, including three C-19-diterpenoid alkaloids and one C-20-diterpenoid alkaloid. Compound 13 showed highly potent antifeedant activity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Bu Xu, Yu-Zhu Li, Shuai Huang, Lin Chen, Yan-Yan Luo, Feng Gao, Xian-Li Zhou
Summary: Seven new diterpenoid alkaloids were isolated from Delphinium grandiflorum, along with eight reaction products and thirteen known compounds. Grandiflonines A and B have a unique C-20 diterpenoid alkaloid skeleton, with the configuration of C-18 inverted. The analgesic and anti-inflammatory activities of these compounds were evaluated, with deoxylappaconitine showing superior analgesic activity compared to lappaconitine.
Article
Biochemistry & Molecular Biology
Huanhuan Ma, Yunxia Ma, Zeren Dawa, Yufeng Yao, Meiqi Wang, Kaihui Zhang, Chenchen Zhu, Fangle Liu, Chaozhan Lin
Summary: This research identified four novel diterpenoid alkaloids from Delphinium brunonianum with activity reducing hepatocytes lipid accumulation. One of the alkaloids showed the strongest inhibitory effect. The study provides experimental evidence for the chemical composition of D. brunonianum and its potential in treating diseases related to lipid accumulation.
Article
Plant Sciences
Yang-Li Pu, Ling-Feng Tian, Lin Chen, Meng-Yi Deng, Jiang Xie, Shuai Huang, Xian-Li Zhou
Summary: Three new hetisine type C-20-diterpenoid alkaloids, trichophorines A-C (1-3), were isolated from Delphinium trichophorum, along with nine known alkaloids (4-12). Their structures were determined using spectroscopic methods. None of the compounds showed significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophage cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Organic
Jue Wang, Jin-bu Xu, Hong-bo Yang, Feng Gao, Xian-li Zhou, Lin Chen, Shuai Huang
Summary: Two new diterpenoid alkaloids and eight known ones were isolated from the root of Aconitum leucostomum. Compound 2 showed antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 1.54 mg/cm(2).
Review
Biochemistry & Molecular Biology
Ashraf M. A. Qasem, Ziyu Zeng, Michael G. Rowan, Ian S. Blagbrough
Summary: Norditerpenoid alkaloids (NDA) are complex natural products with important pharmacological activities. Research has shown that understanding the metabolism of NDA is crucial for their development as drugs.
NATURAL PRODUCT REPORTS
(2022)
Article
Chemistry, Applied
Yuan-Feng Yan, Ya-Rong Wang, Hong-Jun Jiang, Zong-Bao Ding, Tian-Peng Yin
Summary: Six diterpenoid alkaloids, including a previously undescribed compound, were isolated from a Delphinium plant. The potential anti-inflammatory effect of the new compound was evaluated.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Koji Wada, Masuo Goto, Hisano Tanaka, Megumi Mizukami, Yuji Suzuki, Kuo-Hsiung Lee, Hiroshi Yamashita
Summary: Although many diterpenoid alkaloids have been evaluated for their antiproliferative activity, little is known about the effects of hetisine-type C20-diterpenoid alkaloids and their derivatives. In this study, a total of 43 novel derivatives were prepared and their antiproliferative effects against human cancer cell lines were evaluated. The results showed that some newly synthesized derivatives exhibited significant suppressive effects, suggesting that these compounds could be potential candidates for overcoming triple-negative breast cancer.
Article
Plant Sciences
Tianpeng Yin, Yuanfeng Yan, Xing Li, Guowei Gong, Wenjun Wang
Summary: Three new diterpenoid alkaloids were isolated from the whole plants of Delphinium tatsienense Franch., a folk medicine in China for wind-toxin syndrome treatment. The structures of these alkaloids were determined through extensive spectroscopic analyses. Their potential anti-inflammatory effects were evaluated against NO production in LPS-stimulated RAW 264.7 macrophages.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Yali Wang, Dejuan Sun, Yanmei Chen, Jinyu Xu, Yang Xu, Xinyi Yue, Jingming Jia, Hua Li, Lixia Chen
Summary: Three new diterpenoid alkaloids and eight known alkaloids were isolated from Delphinium grandiflorum, with some compounds showing significant protective effects on H2O2-induced cardiomyocytes injury. Compound 6 was found to reduce oxidative damage by inhibiting cell death through the AMPK/AKT/mTOR signaling pathway in H2O2-induced H9C2 cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
