Article
Chemistry, Applied
Feng Qin, Li Luo, Yao Chen, Gang Wei, Chun-Ce Wei, Xiao-Hua Yang, Yi-Lin Fang, Heng-Shan Wang
Summary: A new phenylpropanoic acid congener and 26 known compounds were isolated from Zanthoxylum nitidum. The structures were determined through spectroscopic data and circular dichroism analyses. Most of the compounds were reported for the first time from Z. nitidum and some were also discovered for the first time from the genus Zanthoxylum and the Rutaceae family. Compound 27 showed significant cytotoxicity against HepG2 and T24 cancer cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Sheng-Li Niu, Tian-Meng Lv, Zhi-Fan Tong, Xin-Yu Li, Jing-Jing Xue, Jing Yuan, Ping Hu
Summary: Two new prenylated coumarins, along with four known analogues, were isolated from the roots of Zanthoxylum nitidum. The absolute configuration of one compound was determined by experimental ECD spectrum comparison. The new compounds exhibited moderate cell growth inhibitory activities against human leukemic HL-60 cell lines.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Feng Qin, Cai Yi Wang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang Kook Lee, Heng-Shan Wang
Summary: Several previously unknown alkaloids were isolated from Zanthoxylum nitidum, a plant with potential medicinal properties. One of these alkaloids showed significant anti-cancer activity by inhibiting proliferation and migration of cancer cells.
Article
Chemistry, Medicinal
Feng Qin, Fan-Fan Wang, Chun-Gu Wang, Yao Chen, Mei-Shan Li, Yan-Kui Zhu, Xiao-chao Huang, Cai-Wen Fan, Heng-Shan Wang
Summary: Novel lignans and quinic acids were isolated from Zanthoxylum nitidum var. tomentosum and their structures were confirmed. These compounds showed inhibitory effects on LPS-induced NO production, with compound 2 exhibiting the most significant activity. The mechanism of action of compound 2 in reducing neuroinflammation was elucidated through NLRP3/caspase1 signaling pathways.
Article
Medicine, Research & Experimental
Qi Zeng, Zhao-Jie Wang, Song Chen, Huan Wang, Tian-Zhen Xie, Xiang-Juan Xu, Mei-Ling Xiang, Yi-Chi Chen, Xiao-Dong Luo
Summary: This study investigated the bioactive compounds isolated from the roots of Zanthoxylum nitidum and found that two compounds showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). These compounds exhibited synergistic action with ampicillin, reducing the minimum inhibitory concentration (MIC) significantly, and had the ability to destroy bacterial biofilm when combined with ampicillin. In vitro, the combination treatment showed a strong scavenging effect on planktonic bacteria, and in vivo, it effectively cleared skin infection in a wound infection model. The investigation supported the traditional use of Z. nitidum in treating bacterial infections and may provide new natural products for the treatment of drug-resistant bacteria.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Feng Qin, Chun-Gu Wang, Mei-Shan Li, Jin-Jun Li, Gang Wei, Na Liao, Heng-Shan Wang
Summary: Multiple new compounds were purified from the extract of Zanthoxylum nitidum and their structures were determined through various analyses. Compounds 2, 3, and 10 showed inhibitory effects against five human cancer cell lines.
Article
Biochemistry & Molecular Biology
Na Liao, Mei-Shan Li, Feng Qin, Jing-Chen Jiang, Ri-Da Luo, Xian-Lan Chen, Mei-Mei Zhou, Yan-Kui Zhu, Heng-Shan Wang
Summary: A new compound, nitomentosin (1), was isolated from Zanthoxylum nitidum var. tomentosum along with sixteen known compounds (2-17). Compound 3 was identified as a new natural compound despite previous reports of it as a synthetic substance, while compound 15 was discovered for the first time in a plant. The chemotaxonomic significance of the isolated compounds was also discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Feng Qin, Mei-Shan Li, Jin-Jun Li, Yue Wang, Ke Wang, Jian-Yu Zhou, Dong Liang, Heng-Shan Wang
Summary: Four new sesquiterpenoids and six known coumarins were isolated from the extract of Zanthoxylum nitidum and their structures were elucidated. These compounds showed no cytotoxicity against five cancer cell lines.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Multidisciplinary Sciences
Yanxia Zhu, Yanfen Huang, Kunhua Wei, Junnan Yu, Jianping Jiang
Summary: This study provides transcriptomic resources for Chinese Dao-di herb Zanthoxylum nitidum through SMRT sequencing technology. A total of 16,163 transcripts were obtained, with 88% successfully annotated. Additionally, 6,255 long non-coding RNAs and 22,780 simple sequence repeats were identified. Out of 100 randomly selected primer pairs, 36 were verified as positive, with 20 showing polymorphism. These findings enrich the genetic resources of Z. nitidum, facilitating future research on relevant topics.
Article
Biochemistry & Molecular Biology
Qian-Nv Ye, Cheng-Bo Wang, Tian Chai, Jun Wang, Xian-Hua Meng, Xiao-Feng Shi, Jun-Li Yang
Summary: In this study, fifteen alkylamides were isolated and identified from the pericarps of Zanthoxylum armatum. These compounds showed potential neuroprotective activity against oxidative stress.
Article
Pharmacology & Pharmacy
Si-wei Rao, Yuan-yuan Duan, Han-qing Pang, Shao-hua Xu, Shou-qian Hu, Ke-guang Cheng, Dong Liang, Wei Shi
Summary: This study developed and applied a double spectrum-effect analysis strategy to explore the bioactive components in Zanthoxylum nitidum (Roxb.) DC. (ZN) and conducted rapid and comprehensive profiling and fingerprint analysis. A total of 48 compounds were identified or tentatively characterized in ZN, and the potential anti-inflammatory and antioxidant compounds were determined. The data obtained in this study is of great importance for improving the quality standardization of ZN and provides an efficient tool for discovering active components in complex systems such as traditional Chinese medicines (TCMs).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Jie Zhang, Zhaochen Wu, Nuan Han, Dongmei Wang
Summary: This study explored the function of ZbFAD2 and ZbFAD3 genes in the alkylamide biosynthesis pathway in Z. bungeanum. Their stable and transient expression in Arabidopsis thaliana and Nicotiana benthamiana were analyzed, and it was found that both genes are vital enzymes in alkylamide biosynthesis. The study not only helps to scale up alkylamide production, but also establishes the role of the uncharacterized genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jian-Hui Su, Ming-Qiang Wang, Li-Ping Zhu, Wei-Qun Yang, Shi-Qin Jiang, Zhong-Xiang Zhao, Zhang-Hua Sun
Summary: Phytochemical investigation of Zanthoxylum nitidum, a Chinese medicinal herb, resulted in the isolation of a new coumarin glycoside and several known compounds. The structures of these compounds were elucidated through spectroscopic methods and comparison with existing literature. One compound was isolated from Z. nitidum for the first time, while others were recovered from the Rutaceae family for the first time. The presence of two rare lignan glycosides in plants was also discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zeyu Qin, Yucheng Zou, Yipeng Zhang, Peng Wang, Hui Zhang
Summary: In this study, zanthoxylum bungeanum essential oil/beta-cyclodextrin inclusion complexes (ZBEO/beta-CD-ICs) were prepared by precipitation method and then incorporated into nanofiber films by electrospinning. The inclusion complexes changed the crystalline structure, enhanced molecular interaction, and improved thermal stability. The properties of the nanofiber films were influenced by the content of ZBEO/beta-CD-ICs, and the release behavior of ZBEO was affected by temperature and humidity. The increase in ZBEO content enhanced antibacterial and antioxidant activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Leonidah Kerubo Omosa, Vaderament-A Nchiozem-Ngnitedem, Justus Mukavi, Brenda Atieno Okoko, Helder Ombui Nyaboke, Ibrahim Hashim, Jackson Obegi Matundura, Thomas Efferth, Michael Spiteller
Summary: Chemical investigation of Zanthoxylum paracanthum root led to the discovery of a new alkamide derivative and 10 known compounds with cytotoxic activities against leukemia cell lines. Compound 6 showed strong cytotoxic activity against the multidrug-resistant leukemia cell line.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Papawarin Issarachot, Warissara Sangkaew, Wipawadee Sianglum, Dennapa Saeloh, Surasak Limsuwan, Supayang Piyawan Voravuthikunchai, Nantiya Joycharat
Summary: Derris reticulata, used in Thai folk remedies for diabetes treatment, contains compounds with antibacterial and antioxidant activities, especially showing potential inhibition against ?-glucosidase.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Surasak Limsuwan, Siriporn Jarukitsakul, Acharaporn Issuriya, Sasitorn Chusri, Nantiya Joycharat, Patcharawalai Jaisamut, Jongkon Saising, Korakot Wichitsa-nguan Jetwanna, Supayang Piyawan Voravuthikunchai
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Integrative & Complementary Medicine
Kanyatorn Yincharoen, Ademola Ezekiel Adekoya, Julalak Chokpaisarn, Nongluk Kunworarath, Patcharawalai Jaisamut, Surasak Limsuwan, Sasitorn Chusri
Summary: This study evaluated the antibacterial and anti-biofilm formation properties of three polyherbal household formulations against Gram-positive pathogens. It found that these formulations exhibited significant synergistic effects with certain antibiotics against these pathogens, potentially explaining their traditional effectiveness.
JOURNAL OF HERBAL MEDICINE
(2021)
Article
Plant Sciences
Ademola Ezekiel Adekoya, Sasitorn Chusri, Eugene Ong Boon Beng, Anthony Temitope Idowu
Summary: Ya-Tri-Phigut, a polyherbal tea, has been found to exhibit higher antioxidant capacities and ability to lower lipid peroxidation compared to Ya-Tri-Karsornmas, making it a potential nutraceutical agent for combating oxidative stress and related health diseases.
ISRAEL JOURNAL OF PLANT SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Sutticha Ruangchuay, Qiang-qiang Wang, Liang-yi Wang, Jing Lin, Yong-chao Wang, Guo-huan Zhong, Katesarin Maneenoon, Ze-bo Huang, Sasitorn Chusri
Summary: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Furthermore, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood. Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were identified.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Pharmacology & Pharmacy
Patcharawalai Jaisamut, Subhaphorn Wanna, Atcharaporn Thanakoon, Supanit Saejew, Nutkawan Saowapark, Waramporn Suchato, Preyanuch Chumvong, Tanpisit Kosawiwat, Phonsinee Momaklua, Sasitorn Chusri
Summary: This study focused on developing and evaluating herbal tablets incorporating a Thai traditional medicinal extract using microwave-assisted extraction. The addition of maltodextrin improved the flowability of dry granules and led to enhanced antioxidant activity. The formulated tablets passed quality control tests and remained stable during storage under accelerated conditions for 90 days.
Article
Food Science & Technology
Phanita Vonghirundecha, Sasitorn Chusri, Pisipong Meunprasertdee, Thammarat Kaewmanee
Summary: This study aimed to achieve the microencapsulation of Moringa oleifera leaf extract and phenolic-rich fraction, and evaluate their antioxidant properties and stability. The results showed that microencapsulation improved antioxidant activity and stability, indicating the potential application of Moringa oleifera leaf extracts in the functional food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Plant Sciences
Sineenart Sanpinit, Kotchakorn Moosigapong, Siriporn Jarukitsakul, Kawinsak Jatutasri, Acharaporn Issuriya, Nantiya Joycharat, Katesarin Maneenoon, Patcharawalai Jaisamut, Sasitorn Chusri, Supayang Piyawan Voravuthikunchai, Korakot Wichitsa-nguan Jetwanna, Surasak Limsuwan
Summary: This study revealed that certain extracts from 35 herbal formulations in Thai traditional medicine exhibit anti-acidogenic effects against Streptococcus mutans and anti-quorum sensing activities. Specifically, THF-DC 02, THF-DC 04, THF-DC 20, and THF-DC 29 showed promising results in inhibiting acidogenesis or quorum sensing.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Jongkon Saising, Katesarin Maneenoon, Oraphan Sakulkeo, Surasak Limsuwan, Friedrich Gotz, Supayang Piyawan Voravuthikunchai
Summary: This study investigated the traditional knowledge and use of medicinal plants for the treatment of skin diseases among traditional healers in Songkhla province, Thailand. The findings revealed a variety of medicinal plants used in the treatment of skin disorders, with Fabaceae, Rubiaceae, and Zingiberaceae being the most commonly cited families. Oryza sativa L. and Zingiber montanum (J. Koenig) Link ex A.Dietr. were the most preferred plants combined in the prescriptions.
Article
Integrative & Complementary Medicine
Patcharawalai Jaisamut, Channong Tohlang, Subhaphorn Wanna, Acharaporn Thanakun, Thawatchai Srisuwan, Surasak Limsuwan, Wissava Rattanachai, Jarinee Suwannachot, Sasitorn Chusri
Summary: In the traditional medical system in Thailand, a polyherbal formulation called Nawametho decoction has been used as a lipid-lowering agent, but there is a lack of evidence supporting its effectiveness. This study aimed to formulate and evaluate a tablet containing Nawametho decoction and examine its feasibility for patients with borderline hyperlipidemia through a clinical trial. The results showed that Nawametho decoction can significantly decrease serum triglycerides in patients.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Apichaya Niyomchan, Wasapon Chatgat, Bodin Chatawatee, Thaweeporn Keereekoch, Patcharawalai Jaisamut, Sasitorn Chusri, Nongluk Kunworarath
Summary: This study describes the antihyperlipidemic properties of NawaTab, a tablet formulation developed from a traditional Thai herbal mixture, in a high-fat diet-induced hyperlipidemic rat model. The results suggest that NawaTab can effectively reduce serum lipid levels, but has no preventive effects on hepatic steatosis and adipose tissue accumulation.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Chemistry, Applied
Acharaporn Issuriya, Kawinsak Jatutasri, Sineenart Sanpinit, Sasitorn Chusri, Supayang Piyawan Voravuthikunchai, Thammarat Kaewmanee, Sathianpong Phoopha, Korakot Wichitsa-nguan Jetwanna, Surasak Limsuwan
Summary: This study aimed to explore the potential use of Rhodomyrtus tomentosa ethanol leaf extract (RTEL) as a natural anti-staphylococcal controlling agent in food systems. The results showed that RTEL effectively inhibited the growth of Staphylococcus aureus and had no observed adverse effects at doses up to 300 mg/kg body weight/day. RTEL could be used in food products, such as salad dressing, without affecting consumer acceptability while successfully killing the pathogen within a few hours of exposure.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2023)
Article
Plant Sciences
Patcharawalai Jaisamut, Subhaphorn Wanna, Surasak Limsuwan, Sasitorn Chusri, Kamonthip Wiwattanawongsa, Ruedeekorn Wiwattanapatapee
Summary: The study proposed a drug delivery system to enhance the oral bioavailability of quercetin and resveratrol. The self-microemulsifying formulation significantly improved the oral bioavailability of the combined compounds, without compromising their biological activities, showing promising potential for future research.
