Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 12, Pages 1809-1812Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1437432
Keywords
Daphne mezereum; D. striata; Thymelaeaceae; anti-proliferative activity; human tumour cells; antioxidant activity
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In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing beta-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. D. mezereum dichloromethane extract showed a remarkable anti-proliferative with an IC50 of 6.08 mu g/mL against LNCaP cells. Experimental data indicate that Daphne species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs. [GRAPHICS] .
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