Article
Chemistry, Physical
Gagandeep Kaur, Vishaldeep Kaur, Navneet Kaur, Charanleen Kaur, Kritika Sood, Asifkhan Shanavas, Tapasi Sen
Summary: A multifunctional core-shell nanostructure of silicon oxide@noble metal was synthesized and demonstrated to have dual applications in SERS enhancement and photothermal annihilation of breast cancer cells.
Article
Chemistry, Multidisciplinary
Pietro Grisoli, Lorenzo De Vita, Chiara Milanese, Angelo Taglietti, Yuri Diaz Fernandez, Margaux Bouzin, Laura D'Alfonso, Laura Sironi, Silvia Rossi, Barbara Vigani, Paola Sperandeo, Alessandra Polissi, Piersandro Pallavicini
Summary: This study successfully prepared PVA films embedded with silver nanoparticles, NIR-absorbing photothermal gold nanostars, or a combination of both. The slow but prolonged release of silver ions from the films exhibited strong antimicrobial effects against bacteria, while the films also showed rapid hyperthermal bactericidal action upon NIR laser irradiation. The biocompatibility of all films was confirmed, with negligible impact on human fibroblast viability observed.
Article
Chemistry, Multidisciplinary
Jun Hou, Yanbao Zhao, Lei Sun, Xueyan Zou
Summary: Gold nanomaterials with surface features have gained significant interest in cancer research. In this study, gold nanostar carriers coated with mesoporous silica were developed for controlled drug release and showed photothermal-chemo therapeutic effect.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Nesma El-Sayed, Khalil Elbadri, Alexandra Correia, Helder A. Santos
Summary: Gold nanostars (GNSs) as a photothermal agent have shown great potential for melanoma treatment. Delivery of GNSs using fast dissolving microneedles (MNs) provides a promising approach for painless and convenient therapy. PEG-stabilized GNSs can absorb near-infrared light and release heat, showing an instant lethal effect on melanoma cells upon laser irradiation. Loading GNSs in PVP MNs enables effective transdermal delivery and fast dissolution, resulting in elevated skin temperature after laser irradiation.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Yaling He, Muhammad Rizwan Younis, Chao Jiang, Gang He, Jin He, Yinling Zhang, Hengke Liu, Peng Huang, Jing Lin
Summary: Gas therapy using self-assembled gold nanovesicles loaded with ammonium sulfide has shown great promise for precision cancer theranostics. These nanovesicles can generate hydrogen sulfide in situ under near-infrared activation, leading to tumor cell killing. The nanovesicles exhibit high encapsulation efficiency and photothermal effect, resulting in effective tumor ablation in vivo.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Shih-Hua Tan, Sibidou Yougbare, Hsuan-Ya Tao, Che-Chang Chang, Tsung-Rong Kuo
Summary: Plasmonic gold nanoisland film (AuNIF), fabricated using a seed-mediated growth approach, demonstrated intricate structure with maximum plasmonic absorption at 624 nm. The AuNIF showed increased capture efficiency of E. coli compared to glass substrate, and was utilized as a SERS substrate for enhancing Raman signal. Additionally, AuNIF exhibited superior photothermal effect and efficiency in photothermal killing of E. coli, making it a promising platform for bacterial theranostics combining SERS detection and photothermal therapy.
Article
Chemistry, Multidisciplinary
Caterina Dallari, Claudia Capitini, Martino Calamai, Andrea Trabocchi, Francesco Saverio Pavone, Caterina Credi
Summary: Gold nanoparticles have unique physicochemical and optical functionalities that make them ideal for spectroscopy-based detection techniques, particularly for SERS. By conjugating different moieties to the nanoparticles, their plasmonic properties can be combined with the specific recognition capabilities of antibodies for analysis of biological fluids in clinical settings.
Article
Oncology
Asrin Pakravan, Mehdi Azizi, Fariborz Rahimi, Farhad Bani, Farideh Mahmoudzadeh, Roya Salehi, Mehrdad Mahkam
Summary: A novel GNSs@Dox-Pol nanostructure was prepared for combined chemo-photothermal therapy of breast cancer cells, demonstrating high cell mortality and apoptotic effects.
CANCER NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuanwei Pan, Xuehua Ma, Chuang Liu, Jie Xing, Suqiong Zhou, Badri Parshad, Tanja Schwerdtle, Wenzhong Li, Aiguo Wu, Rainer Haag
Summary: A targeted and RA-loaded nanoplatform was developed to effectively suppress the growth of breast cancer stem cells and tumor formation through multivalent targeted capability and synergistic effect of photothermal therapy.
Review
Pharmacology & Pharmacy
Atieh Jahangiri-Manesh, Marziyeh Mousazadeh, Shirinsadat Taji, Abbas Bahmani, Atefeh Zarepour, Ali Zarrabi, Esmaeel Sharifi, Mostafa Azimzadeh
Summary: This review provides a comprehensive overview of the properties, synthesis methods, toxicity, and therapeutic applications of gold nanorods. Gold nanorods have unique physical, optical, and chemical properties that make them suitable for various biomedical applications, including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. The review discusses the potential, challenges, and future perspectives of gold nanorods in the field of biomedicine.
Article
Multidisciplinary Sciences
Zhe Feng, Yuanyuan Li, Siyi Chen, Jin Li, Tianxiang Wu, Yanyun Ying, Junyan Zheng, Yuhuang Zhang, Jianquan Zhang, Xiaoxiao Fan, Xiaoming Yu, Dan Zhang, Ben Zhong Tang, Jun Qian
Summary: The authors developed NIR-II fluorescent small molecules with high brightness and emission extending to 1900 nm, enabling high-contrast fluorescence imaging of deep tissues in vivo.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Yang Li, Ping Hu, Xiali Wang, Xu Hou, Fengzhen Liu, Xiaohong Jiang
Summary: This study developed Au@PDA-RGD NPs for targeted photothermal therapy of hepatocellular carcinoma, demonstrating their efficacy and mechanism of action in vitro and in vivo, indicating great potential for clinical applications.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ram Pada Das, Vishwa V. Gandhi, Beena G. Singh, Amit Kunwar
Summary: This study demonstrates that gelatin can serve as a stabilizing agent for the green synthesis of gold nanoparticles in varying shapes. The shape of the nanoparticles is primarily determined by the concentration of gelatin and the pH of the reaction mixture. Additionally, gelatin may act as a reducing agent at different pH levels to support nanoparticle formation.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Physical
Jiamin Ye, Qiang Wen, Ying Wu, Qinrui Fu, Xuan Zhang, Jianmin Wang, Shi Gao, Jibin Song
Summary: Gold nanorods have attracted great interest in the field of biomedicine due to their unique optical properties and excellent biocompatibility. However, traditional single gold nanorods cannot deliver medicine to lesion regions, limiting their application in therapy. In recent years, researchers have modified the surface of gold nanorods to integrate diagnosis and treatment, enabling bioimaging and cancer therapy, among other biomedical applications.
Article
Engineering, Biomedical
Yuanwei Pan, Suqiong Zhou, Chuang Liu, Xuehua Ma, Jie Xing, Badri Parshad, Wenzhong Li, Aiguo Wu, Rainer Haag
Summary: In this study, a method for efficient eradication of CSCs was developed by conjugating HK2 inhibitor, mitochondrial targeting molecule, and CSCs targeting agent onto a nanoplatform. The nanocomposite particles showed good biocompatibility and enhanced therapeutic efficacy by inhibiting metabolism and inducing cellular apoptosis. The treatment successfully suppressed CSC self-renewal and tumor growth, achieving eradication of CSCs.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Lavinia Doveri, Angelo Taglietti, Pietro Grisoli, Piersandro Pallavicini, Giacomo Dacarro
Summary: In this paper, researchers developed a versatile coating by self-assembling Prussian Blue nanoparticles onto a glass surface and decorating them with silver nanoparticles. This coating combines photothermal activity and intrinsic antibacterial properties, making it suitable for medical devices and implants.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Pawletko, Halina Jedrzejowska-Szypulka, Katarzyna Bogus, Alessia Pascale, Foroogh Fahmideh, Nicoletta Marchesi, Aniela Grajoszek, Daria Gendosz de Carrillo, Jaroslaw Jerzy Barski
Summary: Ischemic stroke is a leading cause of adult disability and death worldwide. In this study, a new thromboembolic model was used to induce focal cerebral ischemic stroke in rats. The effects of minocycline treatment on neuronal viability and neurodegeneration after stroke were evaluated. The results showed that minocycline administration increased neuron viability, reduced neurodegeneration, and resulted in a significant decrease in infarct volume. Additionally, motor tests demonstrated that reduced inflammation after minocycline treatment improved motor performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrea Ferrigno, Lucrezia Irene Maria Campagnoli, Annalisa Barbieri, Nicoletta Marchesi, Alessia Pascale, Anna Cleta Croce, Mariapia Vairetti, Laura Giuseppina Di Pasqua
Summary: The endogenous antioxidant defense, regulated by HuR, plays a crucial role in the pathogenesis of NAFLD. HuR controls the stability of MnSOD and HO-1 mRNA, two enzymes that protect liver cells from oxidative damage. In an NAFLD animal model, downregulation of HuR was observed along with reduced expression of MnSOD and HO-1, which correlated with oxidative stress and mitochondrial dysfunction. Targeting HuR could be a potential therapeutic strategy for preventing and treating NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Lavinia Doveri, Giacomo Dacarro, Yuri Antonio Diaz Fernandez, Matteo Razzetti, Angelo Taglietti, Giuseppe Chirico, Maddalena Collini, Ioritz Sorzabal-Bellido, Maider Esparza, Carlos Ortiz-de-Solorzano, Xabier Morales Urteaga, Chiara Milanese, Piersandro Pallavicini
Summary: Prussian blue (PB) is an FDA-approved drug that can be used orally at an acidic pH. However, there is a discrepancy in the stability of PB nanoparticles (PBnp) under physiological conditions. Some papers suggest stability at pH 7.4, while others report degradation in the pH range of 7-8. This study shows that PBnp is intrinsically unstable at pH <7, but can be protected by a polymeric coating at pH 7.4. Additionally, the formation of a protein corona in the presence of serum effectively prevents degradation of PBnp.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Nicoletta Marchesi, Pasquale Linciano, Lucrezia Irene Maria Campagnoli, Foroogh Fahmideh, Daniela Rossi, Giosue Costa, Francesca Alessandra Ambrosio, Annalisa Barbieri, Simona Collina, Alessia Pascale
Summary: In this study, the researchers found a strong association between HuD and several nervous system diseases through an interaction network analysis. They focused on the relationship between HuD and BDNF, and discovered that folic acid can regulate BDNF expression by modulating HuD. These findings suggest that BDNF could be a therapeutic target for neurological and psychiatric diseases, and folic acid may act as an epigenetic modulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lucrezia Irene Maria Campagnoli, Angelica Varesi, Annalisa Barbieri, Nicoletta Marchesi, Alessia Pascale
Summary: The human microbiota refers to a diverse range of microorganisms that live in different parts of the human body, including the gut, oral cavity, skin, and eyes. Recent studies have shown that the ocular surface microbiota plays a crucial role in maintaining ocular surface homeostasis and preventing colonization by pathogens. There is also emerging evidence of a potential connection between the gut microbiota and ocular health, with a gut-eye axis being implicated in the pathogenesis of various eye diseases. Understanding this link could lead to the development of new therapeutic approaches for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
B. Albini, M. Parmigiani, G. Pellegrini, A. Taglietti, P. Galinetto
Summary: The increasing environmental pollution calls for new sampling strategies for in-situ monitoring and rapid identification. Surface Enhanced Raman Spectroscopy (SERS) has emerged as a promising analytical technique in this regard. This study investigates the SERS response of colloidal gold nanostars (GNS) coated with silver of varying thickness. It demonstrates the optimal SERS signal at a specific silver thickness and successfully applies the optimized GNS@Ag to glass supported SERS substrates for the detection of harmful and toxic pollutants.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Piersandro Pallavicini, Luca Preti, Maria L. Protopapa, Daniela Carbone, Laura Capodieci, Yuri A. Diaz Fernandez, Chiara Milanese, Angelo Taglietti, Lavinia Doveri
Summary: A synthetic approach was developed to prepare silica gel monoliths embedded with well separated silver or gold spherical nanoparticles with different diameters. The oxidation and removal of silver nanoparticles from silica was achieved using Fe3+, O-2/cysteine, and HNO3, while aqua regia was necessary for gold nanoparticles. NP-imprinted silica powders were obtained by grinding the monoliths, which showed efficient reuptake of silver ultrafine nanoparticles and remarkable size selectivity based on the match between nanoparticle radius and cavity curvature. The materials and methods described in this paper may provide an efficient solution for capturing and safely disposing of silver ultrafine nanoparticles from environmental waters.
Review
Chemistry, Multidisciplinary
Serena Schiavi, Miriam Parmigiani, Pietro Galinetto, Benedetta Albini, Angelo Taglietti, Giacomo Dacarro
Summary: Detecting and quantifying micro- and nanoplastics (MNPs) in the environment is a crucial task. This review focuses on recent results using plasmonic noble metal materials for MNP detection. Various techniques including surface plasmon resonance, plasmon enhanced fluorescence, UV-Vis spectroscopy, and surface enhanced Raman scattering are discussed, highlighting their advantages and drawbacks.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Marco Altomare, Shanshan Qin, Viktoriia A. Saveleva, Zdenek Badura, Ondrej Tomanec, Anca Mazare, Giorgio Zoppellaro, Alberto Vertova, Angelo Taglietti, Alessandro Minguzzi, Paolo Ghigna, Patrik Schmuki
Summary: This article describes a self-assembling and self-activating photocatalytic system formed by illuminating reduced anatase TiO2 nanoparticles in an aqueous Ni2+ solution. The system forms a Ni+/TiO2/Ti3+ photocatalyst that can produce H-2 at a higher rate over time. The formation of defects in the semiconductor under UV illumination plays a crucial role in self-assembly and self-activation, enabling the formation of monovalent nickel (Ni+) surface states that act as electron relays for hydrogen generation from water.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Okkeh, Lorenzo De Vita, Giovanna Bruni, Lavinia Doveri, Paolo Minzioni, Elisa Restivo, Maddalena Patrini, Piersandro Pallavicini, Livia Visai
Summary: In this study, PEG-GNPs@TBO and PEG-GNSs@TBO nanoparticles were synthesized and found to have effective antimicrobial photodynamic inactivation (aPDI) effects, inhibiting the formation of Staphylococcus biofilms. In biofilm eradication treatments, PEG-GNSs@TBO showed better results in reducing viable counts of MRSA and S. epidermidis RP62A preformed biofilms compared to untreated samples. The aPDI treatment with PEG-GNSs@TBO caused significant changes in the integrity and morphology of biofilms, and the generation of reactive oxygen species (ROS) was observed.