Article
Multidisciplinary Sciences
Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi, Zheng-Gang Liu
Summary: The study reveals ZBP1 as a key regulator of tumor necroptosis, mediating the process during tumor development and serving as a potential drug target to control tumor metastasis. ZBP1 expression is closely related to tumor necrosis, and can trigger necroptosis under glucose deprivation.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tianshi Yu, Chanin Nantasenamat, Supicha Kachenton, Nuttapat Anuwongcharoen, Theeraphon Piacham
Summary: This study used cheminformatic analysis and machine learning modeling to investigate the chemical space, scaffolds, structure-activity relationship, and landscape of human androgen receptor antagonists. The findings revealed differences in physicochemical properties between potent/active class molecules and intermediate/inactive class molecules. Low scaffold diversity was observed, especially in the potent/active class molecules, indicating the need for developing molecules with novel scaffolds. The study also identified significant activity cliff generators and provided insights and guidelines for the development of novel androgen receptor antagonists.
Article
Oncology
Craig Furman, Xiaoling Puyang, Zhaojie Zhang, Zhenhua J. Wu, Deepti Banka, Kiran B. Aithal, Lee A. Albacker, Ming-Hong Hao, Sean Irwin, Amy Kim, Meagan Montesion, Alyssa D. Moriarty, Karthikeyan Murugesan, Tuong-Vi Nguyen, Victoria Rimkunas, Tarek Sahmoud, Michael J. Wick, Shihua Yao, Xun Zhang, Hao Zeng, Frederic H. Vaillancourt, David M. Bolduc, Nicholas Larsen, Guo Zhu Zheng, Sudeep Prajapati, Ping Zhu, Manav Korpal
Summary: H3B-6545 is an ER alpha covalent antagonist that demonstrates promising preclinical activity against CDK4/6i naive and resistant ER alpha(WT) and ER alpha(MUT) tumors.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Plant Sciences
Magali Charvin, Thierry Halter, Romain Blanc-Mathieu, Pierre Barraud, Magali Aumont-Nicaise, Francois Parcy, Lionel Navarro
Summary: DNA methylation decreases binding of Arabidopsis WRKY transcription factors to their genomic regions and binding sites in vitro. Methylation of a single cytosine in the W-box motif repels DNA binding of AtWRKY40 in vitro through steric hindrance. This methylation-dependent mechanism could potentially be widespread across different plant species.
Article
Multidisciplinary Sciences
Satyanarayan Rao, Amy L. Han, Alexis Zukowski, Etana Kopin, Carol A. Sartorius, Peter Kabos, Srinivas Ramachandran
Summary: Plasma TF footprints can be used to diagnose breast cancer and identify different states and prognosis of tumors. This provides new possibilities for clinical applications.
Article
Biochemistry & Molecular Biology
El Mehdi Bouricha, Mohammed Hakmi, Jihane Akachar, Fouad Zouaidia, Azeddine Ibrahimi
Summary: This study identified three potential compounds that may inhibit the ERα signaling pathway and could be used to treat hormone therapy-resistant breast cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Ge Sun, Yuntao Wei, Baosheng Zhou, Manlin Wang, Ruina Luan, Yu Bai, Hao Li, Shan Wang, Dantong Zheng, Chunyu Wang, Shengli Wang, Kai Zeng, Shuchang Liu, Lin Lin, Mingcong He, Qiang Zhang, Yue Zhao
Summary: A study found that BAP18 cooperates with CTCF to participate in the transcriptional activation of ER alpha-related enhancers, increasing their accessibility and promoting enhancer RNA transcription. BAP18 also interacts with SMARCA1/BPTF to accelerate the recruitment of CTCF to ER alpha-related enhancers. Depletion of BAP18 increases sensitivity to anti-estrogen and anti-enhancer treatment in MCF7 cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Han Bai, Jianjun Yu, Shidong Jia, Xiaoran Liu, Xu Liang, Huiping Li
Summary: The study revealed that breast cancer patients with TP53 mutations had a worse prognosis, especially in hormone receptor positive/ HER2 negative and triple negative cohorts. Patients with non-missense mutations in the DNA-binding domain (DBD) had worse breast cancer-related survival.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Sawako Shindo, Satoru Kakizaki, Toshiyuki Sakaki, Yuki Kawasaki, Tsutomu Sakuma, Masahiko Negishi, Ryota Shizu
Summary: Nuclear receptors collectively regulate biological functions and have diverse roles beyond transcription activation. While most are activated by ligand binding, some are phosphorylated. The physiological relevance of phosphorylation in nuclear receptor activity has been confirmed, especially within conserved domains. This review focuses on estrogen and androgen receptors and highlights phosphorylation as a potential drug target.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yenan Fu, Xi Zhang, Xiao Liu, Peng Wang, Wenhui Chu, Wei Zhao, Yunling Wang, Guangbiao Zhou, Yu Yu, Hongquan Zhang
Summary: The DNMT1-PAS1-PH20 axis plays an important role in controlling breast cancer growth and metastasis. PAS1 suppresses PH20 expression by recruiting SUV39H1 for methylation, leading to its silencing. Targeting this axis could be a potential therapeutic strategy for breast cancer.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Dayoung Lee, Seungki Baek, Young-Youb Kim, Yongbin Bang, Han Na Jung, Hyung-Jun Im, Yoon-Kyu Song
Summary: In this study, hybrid nanospheres composed of DNA and proteins were developed for cancer targeting. The nanospheres showed excellent biocompatibility, high drug payload capacity, and in vivo imaging ability. The feasibility of cancer targeting and drug-loading capacity were tested, and the nanospheres were proven to have selective internalization in cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Hephzibah Cathryn R., George Priya Doss C.
Summary: In this study, the effect of mutations on P53 protein was investigated using molecular dynamics simulation. The results showed that the mutations led to loss of hydrogen bonds between DNA binding bases and caused significant movements of the zinc-binding domain.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Microbiology
Yizhao Luan, Zehua Tang, Yao He, Zhi Xie
Summary: In this study, evidence was provided showing that coevolving residues in TF domains contribute to DNA binding specificity. It was demonstrated that the coevolving residues are more likely to coevolve with other TF subclass-determining sites and mutation of these coevolving residues could significantly reduce the stability of the TF-DNA complex. Overall, this study expands our understanding of the interaction among coevolving residues in TFs and their importance in transcriptional regulation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Analytical
Takamichi Miyata, Hazuki Shimamura, Ryutaro Asano, Wataru Yoshida
Summary: This study establishes a universal design for fusion protein construction using the SnoopTag/SnoopCatcher protein ligation system. Fusion proteins constructed with this system show specific binding activity to methylated and unmethylated CpG sites. By using these fusion proteins in a dual-color bioluminescence resonance energy transfer (BRET) assay, the global DNA methylation level can be quantified in genomic DNA. These results demonstrate that the SnT/SnC protein ligation system can be used to detect target modifications in genomic DNA based on BRET.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Kirsten G. M. Aspros, Michael J. Emch, Xiyin Wang, Malayannan Subramaniam, Megan L. Hinkle, Esther P. B. Rodman, Matthew P. Goetz, John R. Hawse
Summary: Triple negative breast cancer (TNBC) accounts for a high percentage of breast cancer morbidities and mortalities and requires a better understanding of its biology and novel therapeutic approaches. Estrogen receptor beta (ER beta) is expressed in approximately 20% of primary TNBC tumors and is associated with favorable prognostic features. However, the exact mechanisms by which ER beta inhibits cancer progression are not fully understood. This study demonstrates that the direct interaction between ER beta and DNA is essential for its ability to regulate gene expression and suppress TNBC cell proliferation.
FRONTIERS IN MEDICINE
(2023)
Article
Geochemistry & Geophysics
Tanya Singh, Pranav R. Kshirsagar, Anindita Das, Kunal Yadav, Sweta Mallik, M. B. L. Mascarenhas-Pereira, Tresa Remya A. Thomas, Mamatha S. Shivaramu, P. A. LokaBharathi, N. H. Khadge, B. Nagender Nath, Prashant K. Dhakephalkar, Sridhar D. Iyer, Dwijesh Ray, A. B. Valsangkar, Anita Garg, C. Prakash Babu, Ravindra J. Waghole, Shailesh S. Waghmare, Jyutika M. Rajwade, Kishore M. Paknikar
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS
(2019)
Article
Biophysics
Nimisha Singh, Jyutika Rajwade, K. M. Paknikar
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Biotechnology & Applied Microbiology
R. G. Chikte, K. M. Paknikar, Jyutika M. Rajwade, J. Sharma
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2019)
Review
Chemistry, Multidisciplinary
Prajakta Tambe, Pramod Kumar, Kishore M. Paknikar, Virendra Gajbhiye
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Biotechnology & Applied Microbiology
Nida Sayed, Prajakta Tambe, Pramod Kumar, Sachin Jadhav, Kishore M. Paknikar, Virendra Gajbhiye
Article
Biophysics
Leila Fotooh Abadi, Pramod Kumar, Virendra Gajbhiye, Kishore M. Paknikar, Smita Kulkarni
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Snehal Jamalpure, Gauri Panditrao, Prabir Kumar Kulabhusan, A. S. Sahul Hameed, K. M. Paknikar, Manali Joshi, J. M. Rajwade
JOURNAL OF MOLECULAR MODELING
(2020)
Article
Fisheries
Snehal Jamalpure, S. Vimal, A. Nafeez Ahmed, A. S. Sahul Hameed, Kishore M. Paknikar, Jyutika M. Rajwade
Summary: Macrobrachium rosenbergii nodavirus (MrNV) causes white tail disease (WTD) in larval, post-larval, and juvenile stages of the giant freshwater prawn M. rosenbergii. An antibody-based lateral flow assay (LFA) was developed and optimized for early detection of MrNV in the post-larval stage with high specificity, reproducibility, and sensitivity. The LFA showed good agreement with the 'gold standard' qRT-PCR test, demonstrating high sensitivity (100%) and specificity (90%).
Article
Biophysics
Gokul Patil, Arun Torris, P. R. Suresha, Sachin Jadhav, Manohar Badiger, Vandana Ghormade
Summary: An efficient multimodal topical hemostat was developed by ionically crosslinking chitosan and gelatin to fabricate a robust xerogel with high porosity. The composite exhibited improved blood clotting in vitro, good biocompatibility, and achieved faster hemostasis compared to commercial products in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cell Biology
Ambuja Navalkar, Satyaprakash Pandey, Namrata Singh, Komal Patel, Debalina Datta, Bhabani Mohanty, Sachin Jadhav, Pradip Chaudhari, Samir K. Maji
Summary: The formation of wild-type p53 amyloid was found to confer oncogenic properties to non-cancerous cells, promoting enhanced survival, apoptotic resistance, increased proliferation, and migration through cell generations. Tumorigenic potential of p53 amyloid-transformed cells was further confirmed in mouse xenografts, where p53 amyloids were present.
JOURNAL OF CELL SCIENCE
(2021)
Review
Cardiac & Cardiovascular Systems
Nida Irfan Sayed-Pathan, Pramod Kumar, Kishore M. Paknikar, Virendra Gajbhiye
Summary: Myocardial infarction is a major contributor to ischemic heart diseases, impacting many lives globally. miRNAs are seen as regulators of cardiomyocyte survival, repair, and regeneration. Changes in gene expression in cardiomyocytes postinfarction may lead to cardiac disarray.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Fisheries
Nafeez Ahmed Abdul, Abdul Majeed Seepoo, Taju Gani, Vimal Sugumar, Suryakodi Selvam, Badhusha Allahbagash, Abdul Nazar Abdul Kuthoos, Ramesh Kumar Palsamy, Paknikar Kishore M., Jyutika M. Rajwade, Sait Sahul Hameed Azeez
Summary: Five novel permanent cell lines have been established from different tissues of snubnose pompano, characterized and cryopreserved successfully. These cell lines demonstrated good growth and passage characteristics, and were found suitable for virological and foreign gene expression studies.
JOURNAL OF FISH DISEASES
(2022)
Correction
Nanoscience & Nanotechnology
R. Haghniaz, R. Umrani, K. Paknikar
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Neha Kulkarni-Dwivedi, Pratikshkumar R. Patel, Bhupendra Shravage, Rinku D. Umrani, Kishore M. Paknikar, Sachin H. Jadhav
Summary: This study demonstrates that the use of folic acid-conjugated lanthanum strontium manganese oxide nanoparticles (Fol-LSMO NPs) in hyperthermia and chemotherapy can induce apoptosis and autophagy in breast cancer cells, resulting in effective anticancer activity.
Article
Chemistry, Multidisciplinary
Nimisha Singh, Kishore M. Paknikar, Jyutika Rajwade
ENVIRONMENTAL SCIENCE-NANO
(2019)
