Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression

Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis

(2017) Noriko Itoh et al.   JOURNAL OF NEUROIMMUNOLOGY

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Effect on Cognition of Estroprogestins Combined with Interferon Beta in Multiple Sclerosis: Analysis of Secondary Outcomes from a Randomised Controlled Trial

(2016) Laura De Giglio et al.   CNS DRUGS

Studying both sexes: a guiding principle for biomedicine

(2016) Janine Austin Clayton   FASEB JOURNAL

Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial

(2016) Rhonda R Voskuhl et al.   LANCET NEUROLOGY

Preclinical studies of sex differences: a clinical perspective

(2016) Rhonda Voskuhl   Biology of Sex Differences

Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome

(2015) Orhun H. Kantarci et al.   ANNALS OF NEUROLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

(2015) Karen Ann Ribbons et al.   PLoS One

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

(2014) S. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective effects of testosterone treatment in men with multiple sclerosis

(2014) Florian Kurth et al.   NeuroImage-Clinical

Sex as a determinant of relapse incidence and progressive course of multiple sclerosis

(2013) Tomas Kalincik et al.   BRAIN

X and Y Chromosome Complement Influence Adiposity and Metabolism in Mice

(2013) Xuqi Chen et al.   ENDOCRINOLOGY

The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease

(2013) L. K. Case et al.   GENOME RESEARCH

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY

(2012) Manda V Sasidhar et al.   ANNALS OF THE RHEUMATIC DISEASES

Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

(2012) Roberta Brambilla et al.   Journal of Neuroinflammation

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Sex-related factors in multiple sclerosis susceptibility and progression

(2012) Rhonda R. Voskuhl et al.   Nature Reviews Neurology

Identification of Cellular Infiltrates during Early Stages of Brain Inflammation with Magnetic Resonance Microscopy

(2012) Helmar Waiczies et al.   PLoS One

Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration

(2011) Rory D. Spence et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Temporal trends of disability progression in multiple sclerosis: findings from British Columbia, Canada (1975–2009)

(2011) Afsaneh Shirani et al.   Multiple Sclerosis Journal

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Cortical atrophy in experimental autoimmune encephalomyelitis: In vivo imaging

(2011) Allan MacKenzie-Graham et al.   NEUROIMAGE

Optic Neuritis and Retinal Ganglion Cell Loss in a Chronic Murine Model of Multiple Sclerosis

(2011) Thomas A. Quinn et al.   Frontiers in Neurology

Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis

(2010) Michael J. Chao et al.   HUMAN MOLECULAR GENETICS

The natural history of secondary progressive multiple sclerosis

(2010) M. Koch et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE

(2010) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Inflammation Triggers Synaptic Alteration and Degeneration in Experimental Autoimmune Encephalomyelitis

(2009) D. Centonze et al.   JOURNAL OF NEUROSCIENCE

Sex hormones, brain damage and clinical course of Multiple Sclerosis

(2009) V. Tomassini et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Purkinje cell loss in experimental autoimmune encephalomyelitis

(2009) Allan MacKenzie-Graham et al.   NEUROIMAGE

Parent-of-origin effect in multiple sclerosis: Observations from interracial matings

(2009) S. V. Ramagopalan et al.   NEUROLOGY

Interferon Gamma Allelic Variants

(2008) Orhun H. Kantarci et al.   ARCHIVES OF NEUROLOGY

Maternal Transmission of Multiple Sclerosis in a Dutch Population

(2008) Ilse A. Hoppenbrouwers et al.   ARCHIVES OF NEUROLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?

(2008) Arthur P. Arnold et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

A role for sex chromosome complement in the female bias in autoimmune disease

(2008) Deborah L. Smith-Bouvier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parent-of-origin effects in MS: Observations from avuncular pairs

(2008) B. M. Herrera et al.   NEUROLOGY

Multiple sclerosis patients show sexual dimorphism in cytokine responses to myelin antigens

(2007) Ioana R. Moldovan et al.   JOURNAL OF NEUROIMMUNOLOGY