Article
Biochemistry & Molecular Biology
Kaige Du, Fei Lu, Chengzuo Xie, Haojie Ding, Yu Shen, Yafan Gao, Shaohong Lu, Xunhui Zhuo
Summary: This study revealed that infection with T. gondii can stimulate and mediate apoptosis in host cells through multiple pathways.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Immunology
Keon-Woong Yoon, Ki-Back Chu, Hae-Ji Kang, Min-Ju Kim, Gi-Deok Eom, Fu-Shi Quan
Summary: In this study, it was found that rVV vaccines induced immune responses against Toxoplasma gondii, including high levels of antibody and cellular responses, providing protection against lethal infection.
Article
Immunology
Jufeng Guo, Yingying Shen, Xia Lin, Honggang Chen, Jian Liu
Summary: The study found that Sch B may promote the differentiation of CD4(+) T cells into T(H)1 subset through regulating the STAT1/T-bet signaling pathway, without affecting T(H)2 and Treg cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jili Zhang, Jia Chen, Kun Lv, Bing Li, Biqing Yan, Lei Gai, Chaolu Shi, Xinnian Wang, Hongfei Si, Jiyu Zhang
Summary: Research suggests that myrislignan has anti-Toxoplasma gondii properties by affecting its oxidation-reduction process and inducing autophagy, ultimately leading to the parasite's death.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Wen Jiang, Mengyue Wang
Summary: Through studying the genotype of Toxoplasma gondii, it was found that there are genetic differences in Central and South America. From the perspective of pathogen virulence evolution, it is discovered that transmission route is a key factor causing global genetic differences in Toxoplasma gondii, and the diversity of hosts does not always increase its virulence differences. The reproductive mode of Toxoplasma gondii and frequent human trades are prerequisites for the development of its virulence.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Neurosciences
Damien Dupont, Jian-Sheng Lin, Francois Peyron, Hideo Akaoka, Martine Wallon
Summary: The study demonstrated that Toxoplasma gondii infection can lead to chronic alterations in sleep-wake states in mice, characterized by increased time spent awake, increased cortical EEG theta power density, and decreased slow-wave sleep. These effects can be alleviated by anti-inflammatory treatment with corticosteroid dexamethasone, shedding light on the neurodegenerative and neuropsychiatric disorders reported in infected patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Psychiatry
Adriana Lori, Dimitrios Avramopoulos, Alex W. Wang, Jennifer Mulle, Nicholas Massa, Erica J. Duncan, Abigail Powers, Karen Conneely, Charles F. Gillespie, Tanja Jovanovic, Kerry J. Ressler, Brad D. Pearce
Summary: The study found that the polygenic risk score for schizophrenia (SCZ-PRS) is significantly associated with uninfected individuals but not with those infected with Toxoplasma gondii. This highlights the importance of considering environmental risk factors in identifying subgroups with independent or different genetic components involved in the development of schizophrenia.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Cosme Alvarado-Esquivel, Sergio Estrada-Martinez, Alma Rosa Perez-Alamos, Agar Ramos-Nevarez, Karina Botello-Calderon, Angel Osvaldo Alvarado-Felix, Raquel Vaquera-Enriquez, Gustavo Alexis Alvarado-Felix, Antonio Sifuentes-Alvarez, Carlos Alberto Guido-Arreola, Elizabeth Rabago-Sanchez, Leandro Saenz-Soto
Summary: This study determined the association between Toxoplasma gondii infection and insomnia. The results showed that individuals with insomnia had a higher prevalence of anti-T. gondii IgG antibodies compared to those without insomnia. Men and individuals over the age of 50 were more susceptible to T. gondii infection-related insomnia.
Article
Oncology
James M. Hodge, Anna E. Coghill, Youngchul Kim, Noemi Bender, Stephanie A. Smith-Warner, Susan Gapstur, Lauren R. Teras, Tom K. Grimsrud, Tim Waterboer, Kathleen M. Egan
Summary: Two prospective cohort studies suggest a potential association between T gondii infection and increased risk of glioma, especially among participants with high antibody titers specific to the sag-1 antigen. Further studies with larger case numbers are needed to confirm this etiologic role for T gondii in glioma.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Immunology
Lindsay M. Snyder, Eric Y. Denkers
Summary: The gastrointestinal tract serves as a major entry point for pathogens, including Toxoplasma gondii. Host defense against Toxoplasma is primarily located in the intestinal mucosa, involving a coordinated response from epithelial cells, intraepithelial lymphocytes, and lamina propria cells. Infections may lead to bacterial dysbiosis and immune-mediated tissue damage in the intestine, highlighting the complex interactions between microbiota, epithelium, and immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Kehui Zhu, Kun Liu, Junsi Huang, Xueqiong Weng, Qiaoyun Chen, Tianyu Gao, Kebing Chen, Chunxia Jing, Jing Wang, Guang Yang
Summary: This study found that Toxoplasma gondii infection is a risk factor for osteoporosis, especially compound osteoporosis. Further diagnosis and treatment of T. gondii infection, especially in women, are necessary for patients with osteoporosis.
PARASITES & VECTORS
(2022)
Article
Immunology
Yawei Liu, Robert Bockermann, Mahdieh Hadi, Iman Safari, Belinda Carrion, Marie Kveiborg, Shohreh Issazadeh-Navikas
Summary: ADAM12 is identified as a costimulatory molecule in T cells that mimics CD28 signaling to activate and induce proliferation of Th1 cells. Lack of genomic ADAM12 in T cells diminishes T-bet and IFN gamma production in Th1 cells, providing a potential target for the treatment of Th1-mediated diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Jiating Chen, Wenzhong Liao, HongJuan Peng
Summary: Toxoplasma gondii can reverse tumor-induced immunosuppression by activating the host's immune system, leading to tumor growth inhibition. This has important implications for the development of more effective immunotherapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lokman Galal, Frederic Ariey, Meriadeg Ar Gouilh, Marie-Laure Darde, Azra Hamidovic, Franck Letourneur, Franck Prugnolle, Aurelien Mercier
Summary: This study analyzes 156 genomes of Toxoplasma gondii and provides estimates of the parasite's mutation rate and generation time. It reveals that a specific haplotype is associated with the spread of the parasite through cats, indicating its role in sexual reproduction.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Rajesh Mani, Mohamed H. Abdelaziz, Alexandra Michelon, Yasuhiro Suzuki
Summary: The human HLA-A2.1 molecule was found to effectively activate CD8(+) T cells to produce immune protection against cerebral infection caused by Toxoplasma gondii. Mice with HLA-A2.1 had more CD8(+) T cells producing IFN-gamma after infection, and the CD8(+) T cells from transgenic mice exhibited stronger inhibition and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Carolyn R. Sturge, Elise Burger, Megan Raetz, Lora V. Hooper, Felix Yarovinsky
JOURNAL OF IMMUNOLOGY
(2015)
Letter
Biochemistry & Molecular Biology
Jeongmin Song, Cara L. Wilhelm, Tamding Wangdi, Tomas Maira-Litran, Seung-Joo Lee, Megan Raetz, Carolyn R. Sturge, Julie Mirpuri, Jimin Pei, Nick V. Grishin, Stephen J. McSorley, Andrew T. Gewirtz, Andreas J. Baeumler, Gerald B. Pier, Jorge E. Galan, Felix Yarovinsky
Article
Microbiology
Elise Burger, Alessandra Araujo, Americo Lopez-Yglesias, Michael W. Rajala, Linda Geng, Beth Levine, Lora V. Hooper, Ezra Burstein, Felix Yarovinsky
CELL HOST & MICROBE
(2018)
Article
Immunology
Jason Z. Oh, Rajesh Ravindran, Benoit Chassaing, Frederic A. Carvalho, Mohan S. Maddur, Maureen Bower, Paul Hakimpour, Kiran P. Gill, Helder I. Nakaya, Felix Yarovinsky, R. Balfour Sartor, Andrew T. Gewirtz, Bali Pulendran
Review
Immunology
Carolyn R. Sturge, Felix Yarovinsky
INFECTION AND IMMUNITY
(2014)
Article
Microbiology
Americo H. Lopez-Yglesias, Ellie Camanzo, Andrew T. Martin, Alessandra M. Araujo, Felix Yarovinsky
Article
Immunology
Rachel S. Coombs, Matthew L. Blank, Elizabeth D. English, Yaw Adomako-Ankomah, Ifeanyi-Chukwu Samuel Urama, Andrew T. Martin, Felix Yarovinsky, Jon P. Boyle
INFECTION AND IMMUNITY
(2020)
Article
Microbiology
Americo H. Lopez-Yglesias, Elise Burger, Ellie Camanzo, Andrew T. Martin, Alessandra M. Araujo, Samantha F. Kwok, Felix Yarovinsky
Summary: The study demonstrates that early T-bet-dependent production of IFN-gamma by ILC1 and NK cells is essential for maintaining inflammatory DCs during infection, ultimately contributing to host resistance against the parasite Toxoplasma gondii. T-bet-dependent IFN-gamma plays a critical role in inducing IRF8 and sustaining inflammatory DCs at the infection site, protecting against acute susceptibility to T. gondii infection.
Article
Biology
Alessandra Araujo, Alexandra Safronova, Elise Burger, Americo Lopez-Yglesias, Shilpi Giri, Ellie T. Camanzo, Andrew T. Martin, Sergei Grivennikov, Felix Yarovinsky
Summary: The study reveals that IFN-gamma can directly affect the mitochondrial integrity of Paneth cells, potentially leading to a novel cell death mechanism. By investigating the impact of mTORC1 on Paneth cell death, promising new approaches for treating intestinal inflammation have been identified.
Meeting Abstract
Immunology
Americo H. Lopez-Yglesias, Elise Burger, Alessandra Araujo, Andrew T. Martin, Felix Yarovinsky
JOURNAL OF IMMUNOLOGY
(2018)
