IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection

(2015) Michael H. Askenase et al.   IMMUNITY

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

(2015) Xiaodi Su et al.   NATURE IMMUNOLOGY

Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes

(2015) Kenichi Asano et al.   Nature Communications

Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks

(2015) Woo-Jeong Shon et al.   Scientific Reports

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Macrophages in intestinal homeostasis and inflammation

(2014) Calum C. Bain et al.   IMMUNOLOGICAL REVIEWS

Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization

(2014) Y Nakanishi et al.   Mucosal Immunology

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

SOCS Proteins in Macrophage Polarization and Function

(2014) Heather M. Wilson   Frontiers in Immunology

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

(2013) Yu Qiao et al.   IMMUNITY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD

(2012) Tatiana Goretsky et al.   AMERICAN JOURNAL OF PATHOLOGY

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Epigenetic regulation of macrophage polarization and function

(2012) Lionel B. Ivashkiv   TRENDS IN IMMUNOLOGY

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

(2010) Porfirio Nava et al.   IMMUNITY

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

Gene-specific control of the TLR-induced inflammatory response

(2008) Simmie L. Foster et al.   CLINICAL IMMUNOLOGY

Cooperative Regulation of Fc Receptor γ-Chain Gene Expression by Multiple Transcription Factors, Including Sp1, GABP, and Elf-1

(2008) Kyoko Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY