Article
Clinical Neurology
Michele Tinazzi, Christian Geroin, Enrico Marcuzzo, Sofia Cuoco, Roberto Ceravolo, Sonia Mazzucchi, Andrea Pilotto, Alessandro Padovani, Luigi Michele Romito, Roberto Eleopra, Mario Zappia, Alessandra Nicoletti, Carlo Dallocchio, Carla Arbasino, Francesco Bono, Giuseppe Magro, Benedetta Demartini, Orsola Gambini, Nicola Modugno, Enrica Olivola, Laura Bonanni, Elisabetta Zanolin, Alberto Albanese, Gina Ferrazzano, Rosa De Micco, Leonardo Lopiano, Giovanna Calandra-Buonaura, Martina Petracca, Marcello Esposito, Antonio Pisani, Paolo Manganotti, Lucia Tesolin, Francesco Teatini, Tommaso Ercoli, Francesca Morgante, Roberto Erro
Summary: The study compared the characteristics of patients with different FMDs phenotypes and found that while there were some differences, there was a large overlap between the phenotypes, suggesting that they may represent different expressions of the same disorder.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Emma A. Honkanen, Jaana Roenkae, Eero Pekkonen, Juho Aaltonen, Maija Koivu, Olli Eskola, Hazem Eldebakey, Jens Volkmann, Valtteri Kaasinen, Martin M. Reich, Juho Joutsa
Summary: Deep brain stimulation (DBS) of the globus pallidus interna (GPi) can significantly improve symptoms of cervical dystonia. This study used brain metabolic imaging to investigate the effects of GPi-DBS on brain metabolism in cervical dystonia. The results showed that GPi-DBS increases metabolic activity at the stimulation site and is related to modulation of specific networks. The study also found a strong correlation between stimulation amplitude and metabolic activity.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Gunther Deuschl, Jens Volkmann, Andrea A. Kuhn
Summary: This study retrospectively investigated the clinical results of deep brain stimulation (DBS) for cervical and generalized dystonia in 80 patients. The researchers modeled the optimal stimulation sites based on imaging and found that the optimal treatment for cervical dystonia involved modulation of the striatopallidofugal axis, while pallidothalamic bundles were responsible for optimal treatment of generalized dystonia. Additionally, the study showed a common network substrate in the form of connectivity to the cerebellum and somatomotor cortex for both types of dystonia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Xin-Yi Xie, Guo-zhen Lin, Qiang Huang, Chun-Bo Li, Mark Hallett, Valerie Voon, Ru-jing Ren, Sheng-di Chen, Gang Wang
Summary: The survey found that Chinese clinicians consider atypical movement disorders, multiple somatizations, and emotional disturbance to be essential for the diagnosis of functional movement disorders (FMD). However, lack of guidelines, physician knowledge, and training often limit their ability to manage patients with FMD. Efforts are needed to promote related research and establish practice guidelines in China in the future.
Article
Psychiatry
Beatrice Garcin, Nicolas Villain, Francine Mesrati, Lionel Naccache, Emmanuel Roze, Bertrand Degos
Summary: Functional motor disorders (FMD) are common and disabling conditions that predominantly affect women and young to middle-aged patients. Symptoms typically include acute or subacute onset, with a high prevalence of psychiatric comorbidity and history of trauma.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Review
Clinical Neurology
Sushma Kola, Kathrin LaFaver
Summary: This review discusses the latest advances in functional movement disorders, including risk factors, diagnosis, pathophysiology, neuroimaging studies, and treatment. There has been an increased interest in studying functional movement disorders in recent years, and international collaborative efforts have made progress in diagnosing and treating the disease. Neuroimaging studies have revealed functional and structural changes in motor and emotional brain circuits associated with functional movement disorders. Virtual therapy has also been widely used during the COVID-19 pandemic.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Clinical Neurology
Martje E. van Egmond, Tjerk J. Lagrand, Gintaute Lizaitiene, Marenka Smit, Marina A. J. Tijssen
Summary: Adult-onset dystonia can be acquired, inherited or idiopathic. Recent advances in neuroimmunology and genetic diagnostics have increased our understanding of the disease. To ensure early diagnosis and prevent unnecessary investigations, a new five-step diagnostic approach has been designed. The approach focuses on early identification of treatable forms of dystonia, both acquired and genetic. This novel diagnostic method can aid clinicians in deciding when to perform additional tests, including genetic testing, and facilitate timely treatment.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Grace A. Bailey, Anna Rawlings, Fatemeh Torabi, William Owen Pickrell, Kathryn J. Peall
Summary: This study reveals a higher rate of psychiatric diagnoses and prescriptions in individuals diagnosed with idiopathic dystonia compared to controls. There may be a bidirectional relationship between idiopathic dystonia and psychiatric disorders, particularly mood disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Food Science & Technology
Matteo Costanzo, Daniele Belvisi, Isabella Berardelli, Annalisa Maraone, Viola Baione, Gina Ferrazzano, Carolina Cutrona, Giorgio Leodori, Massimo Pasquini, Antonella Conte, Giovanni Fabbrini, Giovanni Defazio, Alfredo Berardelli
Summary: Botulinum toxin type A (BoNT-A) effectively improves non-motor symptoms in patients with cervical dystonia (CD), such as psychiatric disturbances, pain, and disability, while having no impact on sleep disorders. The motor and non-motor changes induced by BoNT-A show a similar time course, but are independent of each other.
Article
Clinical Neurology
Adrian Andrzej Chrobak, Jakub Rusinek, Malgorzata Dec-Cwiek, Karolina Porebska, Marcin Siwek
Summary: This study aimed to evaluate the degree of overlap among the most commonly used CD rating scales identified in the literature review.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Noemi Piramide, Elisabetta Sarasso, Aleksandra Tomic, Elisa Canu, Igor N. Petrovic, Marina Svetel, Silvia Basaia, Natasa Dragasevic Miskovic, Vladimir S. Kostic, Massimo Filippi, Federica Agosta
Summary: This study found altered brain functional connectivity (FC) in the motor circuit of patients with functional dystonia (FD), involving areas related to emotional processes and sense of agency. Compared to young healthy controls, fixed FD patients showed decreased FC between M1 and bilateral precuneus. On the other hand, compared to old healthy controls, mobile FD patients exhibited decreased FC between bilateral primary sensory cortices and parieto-occipital areas, as well as increased FC with right associative visual cortex and bilateral ventral-PCC.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sotirios Grigoriou, Elena Espa, Per Odin, Jonathan Timpka, Gustaf von Grothusen, Andreas Jakobsson, M. Angela Cenci
Summary: This study aimed to compare the temporal and topographic profiles of abnormal involuntary movements (AIMs) in Parkinson's disease patients under treatment with L-DOPA and the dopamine agonist ropinirole. The results showed that the combination of L-DOPA and ropinirole resulted in lower peak severity but longer duration of AIMs. This study paves the way for the introduction of a combined L-DOPA-ropinirole challenge test in the early clinical evaluation of antidyskinetic treatments.
Article
Clinical Neurology
Megan Reid, Steven D. Mitchell, Katharine M. Mitchell, Christos Sidiropoulos
Summary: This study aimed to evaluate the efficacy of an intense outpatient physical rehabilitation program for patients with functional movement disorders (FMD). Results showed significant improvements in motor and gait outcomes in FMD patients treated with physical rehabilitation. These findings support the continued use of rehabilitation therapy and the need for further research on more effective multidisciplinary approaches.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Sanjay Pandey, Juho Joutsa, Raja Mehanna, Aparna Wagle Shukla, Federico Rodriguez-Porcel, Alberto J. Espay
Summary: Poststroke movement disorders (PSMDs) are a common cause of secondary movement disorders. However, there are many knowledge gaps in terms of clinical definitions, stroke symptom latencies, and biomarkers for vulnerability for or resilience against developing PSMDs. After summarizing the existing evidence, a roadmap for future research is proposed to fill these gaps and resolve the related controversies. Further research is needed in the phenomenology, classification, diagnostic criteria, and pathophysiology of PSMDs, as well as the development of treatment guidelines.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
B. Ellement, Y. Jasaui, K. Kathol, E. Nosratmirshekarlou, T. Pringsheim, J. Sarna, B. L. Callahan, D. Martino
Summary: This study found that most CD patients perform normally on social perception and behavior tests, but there are impairments in belief reasoning (theory of mind) and empathy. Better performance in affect naming is associated with anxiety, depression and social phobia severity, while worse performance in empathy is associated with depression severity. Patients with CD had more difficulties in fearful face identification. social perception abilities in CD patients with more severe anxiety and depression suggest efficient modulation and self-adaptation of social cognitive skills.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Carlo Alberto Artusi, Elisa Montanaro, Roberto Erro, Nils Margraf, Christian Geroin, Andrea Pilotto, Luca Magistrelli, Francesca Spagnolo, Alberto Marchet, Lidia Sarro, Sofia Cuoco, Marta Sacchetti, Marianna Riello, Barbara Capellero, Paola Berchialla, Bettina Moeller, Beeke Vullriede, Maurizio Zibetti, Augusto Maria Rini, Paolo Barone, Cristoforo Comi, Alessandro Padovani, Michele Tinazzi, Leonardo Lopiano
Summary: Pisa syndrome and camptocormia in patients with Parkinson's disease are associated with neuropsychological functioning. Pisa syndrome patients showed worse visuospatial performances and subjective visual vertical perception, while camptocormia patients did not exhibit significant differences. Furthermore, more than 60% of patients with these postural abnormalities had reduced awareness of their condition.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Ilaria A. Di Vico, Jon Stone, Laura Mcwhirter, Marianna Riello, Maria Elisabetta Zanolin, Michela Colombari, Mirta Fiorio, Michele Tinazzi
Summary: This study aimed to examine the failure rate of nonlitigant, non-compensation-seeking FMD patients on three different PVTs and compared their performance to healthy controls and healthy simulators. The results showed that FMD patients had low failure rates on two of the tests, similar to the performance of healthy controls, but significantly different from that of healthy simulators.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mohammad Al-Wardat, Christian Geroin, Tommaso Schirinzi, Mohammad Etoom, Michele Tinazzi, Antonio Pisani, Silvia Natoli
Summary: Axial postural abnormalities and pain are significant factors affecting the quality of life in Parkinson's disease patients. This study aimed to assess the characteristics of pain and other non-motor symptoms in PD patients with Pisa syndrome and camptocormia. The results showed that PD patients with Pisa syndrome or camptocormia experience more musculoskeletal, chronic, and fluctuation pain compared to PD patients without axial postural abnormalities, suggesting different etiologies of pain and potential differences in treatment approaches.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Editorial Material
Clinical Neurology
Alessandro Dinoto, Enrico Marcuzzo, Vanessa Chiodega, Francesco Dall'Ora, Sara Mariotto, Michele Tinazzi
Summary: This study found that serum neurofilament light chain (NfL) levels are similar in patients with functional motor disorders (FMDs) and healthy controls, indicating the lack of neuroaxonal damage. These results have important implications for pathogenesis and clinical practice, suggesting that serum NfL may serve as a promising diagnostic biomarker to differentiate functional and structural neurological disorders.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Francesca Magrinelli, Clarissa Rocca, Roberto Simone, Riccardo Zenezini Chiozzi, Zane Jaunmuktane, Niccolo E. Mencacci, Michele Tinazzi, Sandeep Jayawant, Andrea H. H. Nemeth, German Demidov, Henry Houlden, Kailash P. P. Bhatia
Summary: This study identified a novel exonic AluYa5 insertion causing NKX2-1-related disorder, which is challenging to detect in routine diagnostics. MEI analysis of short-read sequencing data or targeted long-read sequencing could reveal the molecular diagnosis of unresolved movement disorder cases.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Christoph Wiest, Francesca Morgante, Flavie Torrecillos, Alek Pogosyan, Shenghong He, Fahd Baig, Ilaria Bertaina, Michael G. Hart, Mark J. Edwards, Erlick A. Pereira, Huiling Tan
Summary: This study explores the effects of subthalamic nucleus (STN) stimulation on Parkinson's disease and dystonia, and finds that stimulation-induced spectral changes are present in both conditions. These findings suggest that STN stimulation can be used for other disorders with excessive oscillatory peaks.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marialuisa Gandolfi, Mirta Fiorio, Christian Geroin, Paolo Torneri, Zoe Menaspa, Nicola Smania, Nir Giladi, Michele Tinazzi
Summary: Functional gait disorders (FGDs) are disabling symptoms of Functional Motor Disorders. Our study aimed to investigate the effect of different dual task paradigms on spatio-temporal gait parameters in FGDs. The results showed that FGDs patients had poorer gait performance and less automaticity and steadiness compared to healthy controls. However, dual tasking affected gait performance but not automaticity and steadiness in FGDs.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Belen Gonzalez-Herrero, Francesca Morgante, Javier Pagonabarraga, Biba Stanton, Mark J. Edwards
Summary: Recent observations suggest a high co-occurrence of autism spectrum disorder (ASD) in people with functional neurological disorder (FND), but little systematic data is available on their relationship. This study aimed to assess the self-reported autistic traits and prevalence of ASD in individuals with FND and their first-degree relatives. The findings showed that 8% of respondents with FND had a previous diagnosis of ASD and 24% reported a first-degree relative with ASD. Moreover, 69% of respondents exhibited clinically significant ASD and 21% displayed autistic traits. Further research is needed to explore the prevalence and impact of ASD in individuals with FND.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Clinical Neurology
Sandy M. Cartella, Francesca Morgante
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Mattia Siciliano, Rosa De Micco, Andrea Gerardo Russo, Fabrizio Esposito, Valeria Sant'Elia, Lucia Ricciardi, Francesca Morgante, Antonio Russo, Jennifer G. Goldman, Carlo Chiorri, Gioacchino Tedeschi, Luigi Trojano, Alessandro Tessitore
Summary: This study identified three distinct memory-related phenotypes in patients with mild cognitive impairment related to Parkinson's disease (PD-MCI) through cluster analysis. These phenotypes were associated with motor and non-motor features as well as patients' quality of life. The findings contribute to understanding the pathophysiological mechanisms underlying PD-MCI and its subtypes and guiding appropriate treatments.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Veronica Bruno, Beatrice Achen, Francesca Morgante, Roberto Erro, Susan H. Fox, Mark J. Edwards, Anette Schrag, Maria Stamelou, Silke Appel-Cresswell, Giovanni Defazio, K. Ray Chaudhuri, Sarah Pirio Richardson, Hyder A. Jinnah, Davide Martino
Summary: This study developed and validated a new rating instrument, Pain in Dystonia Scale (PIDS), to assess pain in adult-onset idiopathic dystonia (AOID). The PIDS evaluates pain severity, functional impact, and external modulating factors. It demonstrated high-level psychometric properties in patients with cervical dystonia (CD).
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Belen Gonzalez-Herrero, Ilaria Antonella Di Vico, Erlick Pereira, Mark Edwards, Francesca Morgante
Summary: Tremor is a symptom of dystonia and can be treated with oral medications, botulinum neurotoxin, or brain surgery. This study evaluated the outcome of different treatments for upper limb dystonic tremors and found that botulinum neurotoxin and surgery had better efficacy compared to oral medications, which had higher side effects and dropout rates. Further research is needed for better patient selection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Glynn Harrison-Jones, Xiaocong Li Marston, Francesca Morgante, K. Ray Chaudhuri, Guillermo Castilla-Fernandez, Valentina Di Foggia
Summary: This study found that initiating COMT inhibition with opicapone is likely to decrease healthcare resource utilization compared to initiation with entacapone in people with Parkinson's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Edoardo Monfrini, Alessio Di Fonzo, Francesca Morgante
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Belen Gonzalez-Herrero, Francesca Morgante
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)