Article
Biochemistry & Molecular Biology
Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. Oxidative stress is believed to be the main cause of PD, and antioxidants have shown potential for its treatment. The study investigated the effects of vitamin B12 (VB12) supplementation in cellular and animal models of PD, and found that VB12 reduced reactive oxygen species (ROS) generation, improved motor dysfunction, and protected against mitochondrial dysfunction and dopaminergic neuron loss. These findings suggest that vitamin supplementation may be a safer and more feasible approach for PD intervention compared to chemical drug treatment.
Review
Geriatrics & Gerontology
Yuxin Quan, Jisen Xu, Qing Xu, Zhiqing Guo, Ruwei Ou, Huifang Shang, Qianqian Wei
Summary: This meta-analysis summarizes the relationship between homocysteine, vitamin B12, folate, and Parkinson's disease (PD). The results show that PD patients have lower folate and vitamin B12 levels, but higher homocysteine levels compared to healthy individuals. PD is also significantly associated with hyperhomocysteinemia. Various factors are linked to homocysteine levels in PD patients. Further research is needed to fully understand their roles in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Food Science & Technology
Alexandra K. Loedin, Dave Speijer
Summary: The rise in veganism has led to concerns about potential deficiencies, with a focus on vitamin B-12 in this study. Research shows that a deficiency in B-12 can lead to DNA synthesis impairment and genomic instability, possibly contributing to cancer. This highlights the importance for vegans to be aware of their B-12 intake and consider supplementation or fortified products to prevent health issues.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Immunology
Tian-Ping Zhang, Rui Li, Li-Jun Wang, Fei Tang, Hong-Miao Li
Summary: In the Chinese Han population, there is no significant association between vitamin B12 level and single nucleotide polymorphisms (SNPs) in vitamin B12 metabolic genes with pulmonary tuberculosis (PTB). However, several SNPs in TCN2, CUBN, and MUT genes might be associated with multiple clinical manifestations in PTB.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Fatemeh Seifar, Ashok R. Dinasarapu, H. A. Jinnah
Summary: Numerous studies have found an association between low levels of uric acid (UA) and Parkinson's disease (PD), suggesting that low UA may contribute to oxidative stress and the degeneration of dopamine neurons, leading to the onset and progression of PD symptoms. However, recent research has raised questions about this explanation, proposing that low UA may be a biomarker rather than a causative factor for PD.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Mario Meloni, Giulio Riboldazzi, Roberta Zangaglia, Andrea Sturchio, Carlo Casali, Cherubino Di Lorenzo, Brigida Minafra, Mario Clerici
Summary: The etiology of Parkinson's disease (PD) likely involves genetic, environmental, mitochondrial dysfunction, oxidative stress, and inflammation factors, with Vitamin D and VDR gene playing a role in PD risk. Results show a strong association between VDR SNP FokI and PD, with gender-specific differences in risk factors. The study suggests potential differential modulation of Vitamin D/VDR axis in PD by VDR SNPs.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Antonia Pignolo, Sergio Mastrilli, Chiara Davi, Valentina Arnao, Paolo Aridon, Felipe Augusto dos Santos Mendes, Cesare Gagliardo, Marco D'Amelio
Summary: Vitamin D plays a crucial role in bone metabolism, calcium and phosphorous homeostasis, as well as brain development and neuroprotection. Patients with Parkinson's disease often have a high frequency of vitamin D deficiency, which may be related to disease severity and progression. However, the evidence regarding the use of vitamin D supplementation to reduce symptoms and disability in patients with Parkinson's disease is limited. Further clinical studies are needed to confirm the potential benefits and risks of vitamin D supplementation in this population.
Article
Nutrition & Dietetics
Min Cheol Chang, Sang Gyu Kwak, Soyoung Kwak
Summary: The meta-analysis found that high intake of vitamin E significantly reduced the risk of Parkinson's disease, while vitamin C intake did not show a significant protective effect. Further studies are needed to explore the exact mechanisms of vitamin E transportation and regulation in the central nervous system.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Jiamin Huang, Pipasha Khatun, Yuqing Xiong, Bingrui Liu, Yisu Zhao, Quanjun Lyu
Summary: This study found that higher dietary intake of vitamin B6 may be associated with a lower prevalence of cardiovascular disease (CVD) in the United States population. Conversely, there was no significant association between dietary intake of folate and vitamin B12 and the odds of CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Neurosciences
Yiti Liu, Maoyuan Gou, Xiaoyan Guo
Summary: Parkinson's disease (PD) patients may have higher levels of homocysteine and lower levels of vitamin B12 and folate. These substances may play a role in cognitive impairment and neuropathy in PD patients.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Kacper Szewczyk, Aleksandra Chojnacka, Magdalena Gornicka
Summary: Tocopherols and tocotrienols are natural compounds of plant origin, mainly sourced from vegetable oils and nuts. While alpha-tocopherol has the highest tissue concentration in the vitamin E family, current research suggests that tocotrienols may have greater antioxidant potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Teresa Maycas-Cepeda, Pedro Lopez-Ruiz, Cici Feliz-Feliz, Lidia Gomez-Vicente, Rocio Garcia-Cobos, Rafael Arroyo, Pedro J. Garcia-Ruiz
Summary: Amimia is correlated with motor and nonmotor symptoms, cognitive status, depression, and quality of life in PD patients. Blinking frequency is associated with amimia and motor symptoms. Amimia could serve as a useful marker of overall disease severity in PD, including cognitive decline.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maurizio Rolando, Stefano Barabino
Summary: Dry eye disease is a multifactorial condition that is caused by reduced tear secretion, increased tear water evaporation, or the production of poor-quality tears. Recent studies have found that vitamin D supplementation may be an effective alternative therapy for patients with DED who do not respond to conventional treatments, possibly due to its positive effect on modulating immune and inflammatory responses. This review focuses on the pathogenesis and treatment of DED, with a special emphasis on the potential role of systemic administration of vitamin D as a therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Vicente A. Benites-Zapata, Felipe L. Ignacio-Cconchoy, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Percy Herrera-Anazco
Summary: This study reviewed existing studies to assess differences in serum vitamin B12 levels among patients with and without thyroid disorders (TD), frequency of vitamin B12 deficiency, and presence of anti-parietal cell antibodies in TD patients. Results showed that patients with hypothyroidism had lower vitamin B12 levels compared to healthy participants, while no significant differences were observed in patients with hyperthyroidism, autoimmune thyroid disease (AITD), or subclinical hypothyroidism (SH). The frequencies of vitamin B12 deficiency were 27%, 6%, 27%, and 18% for hypothyroidism, hyperthyroidism, SH, and AITD respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Sabiye Akbulut
Summary: This study aimed to investigate the correlation between serum vitamin B12 and folate levels in Crohn's disease patients and disease activation, localization, duration, and age at onset. The results showed that vitamin B12 and folate levels were significantly lower in Crohn's disease patients compared to the control group. Regular monitoring and supplementation of vitamin B12 and folate are important for Crohn's disease patients.
